A comparative study of curcumin curcumin C3 complex nanoparticles encapsulated with chitosan and different molar ratios of ?- and β-cyclodextrin inclusion complexes

Abstract

Curcumin the bright yellow pigment of turmeric (Curcuma longa) possesses pleiotropic medicinal properties that have been widely used in the treatments of inflammatory diseases cancer bacterial diseases etc Apart from curcumin other curcumionoids mainly demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC) also show medicinal properties but not as effective as curcumin Despite the therapeutic properties curcumin and curcuminoids are not approved for clinical use due to its poor solubility and low bioavailability To overcome this limitation nanoparticles and inclusion complexes of curcumin are widely used In this study we used curcumin-C3 complex a combination of all three curcuminoids as starting material and used two different approaches to test its effectiveness Firstly nanoparticles of curcumin and curcumin-C3 were prepared and then these nanoparticles were encapsulated in chitosan Secondly the curcumin and curcumin-C3 were combined with ? and β-CD to form inclusion complexes using different molar ratios of cyclodextrins (1:1 1:3 1:5) These nanoparticles and inclusion complexes were characterized in both solid and solution forms by nuclear magnetic resonance Fourier transform infrared spectroscopy X-ray diffraction and transmission electron microscopy The nanoparticles were characterized by nanoparticle tracking analysis Additionally in vitro assays using curcumin-C3 nanoparticles and inclusion complexes showed improved entrapment efficiency of 90 4% and 97 8% respectively Our findings suggest that curcumin-C3 nanoparticle are effective than native curcumin For inclusion complexes ?-CD at molar ratio 1:3 and 1:5 is suitable carrier for curcumin-C3 Compared to curcumin curcumin-C3 shows more potency due to synergistic effect of three curcuminoids

Date of Award	2020
Original language	English
Supervisor	Fu-Yung Huang (Supervisor)