A New Rehabilitation Model for the Patients with Obstructive Sleep Apnea Syndrome- A Randomized Controlled Trial

Abstract

Background and objective: Obstructive sleep apnea (OSA) is characterized with complete or partial obstruction of upper airway during sleep The vulnerable sites of upper airway collapses are consequences of sleep state-dependent reductions in pharyngeal muscle tone According to phenotypic approach oropharyngeal muscle dysfunction has been indicated for conventional oropharyngeal therapy which was proven limited only for mild and moderate OSA However the severe OSA was implied to involve more than other pathogenesis especially related to the circulorespiratory loops Therefore the purpose of the study is divided into two phases (1) to develop a new rehabilitation model using a systematic review and (2) to investigate the clinical effects of a new rehabilitation model on OSA conducting a clinical trial Methods: The statement of Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) was followed to develop a comprehensive rehabilitation model for OSA Subsequently thirty-one subjects with newly diagnosed moderate and severe OSA were randomized receiving the rehabilitation program submitted from prior review study The intervention group was conducted a 12-week intervention including 20-min oropharyngeal muscle training 15-min respiratory muscle training and 45-min general endurance training while the control group was kept on waiting for 12 weeks Polysomnography (PSG) data oropharyngeal and respiratory muscle performance were measured at baseline and after 12 weeks Results: A total of 8 studies with 203 patients were included to meta-synthesize the respondent indications that the patients with middle aged BMI

Date of Award	2020
Original language	English
Supervisor	Ching-Hsia Hung (Supervisor)