Assessment of the Reuse of Noninvasive Hemoglobin Sensors in Clinical Practice

  • 謝 志成

Student thesis: Master's Thesis


Anemia is a disease state of reduced red blood cell concentration Its routine diagnosis method is invasive phlebotomy that measures the amount of hemoglobin in the blood sample Currently a commercially available device (Masimo Radical-7 Pulse CO-Oximetry system Masimo Irvine CA) basing on multiple wavelength photoplethysmography may be applied instead for non-invasive hemoglobin (SpHb) measurement The variations of reuse of the disposable sensor patch with and without modification are investigated in this study Firstly five ways of the sensor patch modifications are employed in a simulation study The signal correlation coefficient between the first-used sensor patch and reused sensor patch is computed for comparison Then 146 subjects with informed consents are recruited for clinical tests The bias the precision and the sensitivity/specificity for anemia diagnosis are compared In the simulation study a large biases in SpHb measurements among five groups are found even with a new SpHb patch (>2g/dl) The correlation coefficient between the first-used SpHb patch and the reused SpHb patch is above 0 95 In the clinical study there are 74 subjects in group A for sensor patch reuse without modification and 72 subjects in group B for sensor patch reuse with a window of plastic film The sensitivity for anemia defined as less than 12g/dl are 76 9% (group A) and 71 4% (group B) respectively While the specificity are 87 5% (group A) and 94 1% (group B) respectively When the anemia defined as less than 10g/dl the overall specificity of SpHb is up to 99 2% The SpHb is correlated well with the actual hemoglobin level (Spearman's rho=0 776 p
Date of Award2017 Aug 22
Original languageEnglish
SupervisorKuo-Sheng Cheng (Supervisor)

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