Association of vascular cell adhesion molecule 1 and renal function in patients with peripheral artery occlusive disease

Abstract

Introduction Poor renal function is a known independent risk factor for peripheral artery occlusive disease (PAOD) The clinical severity of PAOD was also more remarkable in patient with poor renal function In end-stage renal disease (ESRD) patients under hemodialysis (HD) soluble Vascular Cell Adhesion Molecule 1 (sVCAM-1) is an independent predictor of all cause and cardiovascular death We proposed that VCAM-1 may play a significant role in PAOD patients with poor renal function Method Fifty-one patients with PAOD diagnosed by angiography were recruited and their serum was obtained before percutaneous transluminal angioplasty According to the baseline renal function the recruited patients were divided as “Normal” group “chronic renal disease (CKD)” group and “Hemodialysis (HD)” group Serum was obtained during angiography The level of sVCAM-1 was analyzed by ELISA On the other hand specimens of PAD amputated tissue and traumatic amputated tissue were collected respectively and immnohistochemical stain was performed to clarify the histopathological role of the sVCAM-1 IHC result was quantified by HistoQuest VCAM-1 among the tissue was extracted and then analyzed by ELISA too Results In PAOD patients serum level of sVCAM-1 was elevated in the HD group compared with the normal renal function group (p

Date of Award	2016 Feb 17
Original language	English
Supervisor	Ping-Yen Liu (Supervisor)