Bidirectional association between diabetes mellitus and acute pancreatitis

  • 沈 修年

Student thesis: Doctoral Thesis


Both the incidence of acute pancreatitis (AP) and the prevalence of diabetes mellitus (DM) are increasing in most Western countries DM may develop after AP Therefore it is not surprising to find a higher prevalence of DM in patients with AP Interestingly the incidence of AP is also much higher in patients with DM Given the lack of epidemiological data on AP in Taiwan and the interesting interrelation of DM and AP this research aims to describe the epidemiology of AP in Taiwan and to further explore the bidirectional association between these two diseases Using Taiwan’s National Health Insurance Research Database we first analyzed 107 349 patients with first-attack AP between 2000 and 2009 and found that the incidence of first-attack AP was average 0 37 per 1 000 person-years and changed only slightly We then investigated a study cohort enrolling age-and-sex-matched groups of patients with (n=547 554) and without (n=584 373) DM over an 8-year follow-up period We found that the incidence of AP was 2 98 and 1 68 per 1 000 person-years for patients with and without DM respectively; representing a covariate adjusted hazard ratio (HR) of 1 53 (95% confidence interval [CI] 1 49-1 58) in a Cox regression model DM was also significantly associated with an increased HR of severe AP (1 46 95% CI 1 36-1 57) and especially of AP with local complications (1 65 95% CI 1 14-2 39) Finally we investigated another study cohort enrolling 2 966 AP patients and 11 864 non-AP general controls individually matched on age and sex The incidence of DM in the first partition of time (
Date of Award2015 Jul 3
Original languageEnglish
SupervisorChung-Yi Li (Supervisor)

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