Computational modeling of coronary bifurcation stenting：analysis of biomechanical impact between different stenting strategy

Abstract

Coronary artery disease has become one of the major cause of death and huge health burden in modern era Many risk factors have been proven to be correlated with acute coronary syndrome including diabetes mellitus hypertension dyslipidemia and smoking etc The prevalence of coronary artery disease has been shown to be effectively controlled with the promotion of preventive medicine Nevertheless there are still many clinical unmet needs which are waited for further investigation In modern era percutaneous coronary intervention has become the first choice to treat coronary artery stenosis Although this technology is widely accepted and extraordinary successful to deal with coronary artery disease precise coronary imaging and stenting procedures remain a lot of unsolved challenges particularly in complicated vessel structure such as severe calcified tortuous diffuse lesions and bifurcation region Notably recent studies have demonstrated the promising character of computational simulation such as finite element analysis as a useful support to the operational planning Assorted interventional strategies have been recommended However no perfect solution has been verified yet In this case the major goal of this dissertation is that a superior comprehension of the biomechanical impact among different bifurcation strategies might be helpful to ameliorate the unresolved issues in coronary intervention Accordingly this thesis focused on serial structure solid model which was generated to facilitate studying clinical unresolved issues particularly in provisional stenting process for bifurcation lesions

Date of Award	2018 Jul 31
Original language	English
Supervisor	Jin-Jia Hu (Supervisor)