Detecting the distribution and endocrine disrupting activity of benzophenone-type UV filters parabens and bisphenols in wastewater treatment plants

  • ? 容嘉

Student thesis: Doctoral Thesis


Experimental studies indicated that some chemicals can act as endocrine disruptors In this study yeast-based reporter gene assays were used to detect the change or removal of endocrine disrupting activities in wastewater treatment plants (WWTPs) Liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis was performed to analyze the concentrations of target endocrine disrupting compounds (EDCs) in WWTP samples including 8 benzophenone-type UV filters (BPs) 6 parabens (PBs) and 3 bisphenols Anti-androgenic activities were found in two WWTP effluent samples (KY: 697 7 Flutamide-EQ ?g/L AP: 380 9 Flutamide-EQ ?g/L) All water phase samples of influent and primary sedimentation tank effluent showed estrogenic activities (12 0~56 4 17β-Estradiol-EQ ng/L) All samples exhibited anti-mineralocorticoid activities (7 1~1210 5 Spironolactone-EQ ?g/L) Anti-progesterone activities were mostly detected in water phase samples especially in WWTPs influent 2-Hydroxy-4-methoxy benzophenone (BP3) were detected frequently which corresponded to its high usage The highest concentration of PBs was found in the influent of KY (9279 5 ng/L) Bisphenol S was the major bisphenol in this study and the concentrations ranged from n d to 136 5 ng/L The comparison of bioassays and chemical analysis showed that the target compounds were not the major EDCs in the samples Also the risk quotients of target compounds were much lower than one
Date of Award2020
Original languageEnglish
SupervisorPei-Hsin Chou (Supervisor)

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