Development of Self-assembled DNA-Nanoparticle Nanostructures for Surface Enhanced Raman Spectroscopy (SERS)

Abstract

At present lots of people do the research of the surface-enhanced Raman scattering and they also got the great Raman enhancement effect But it is not easy to synthesize high reproducibility and uniformity structures If we want to apply the surface-enhanced Raman scattering signal into development we have to overcome this challenge This study use nanoparticles and DNA to synthesize the self-assembly of 3-dimensional crystal structure which are able to order regularly and closely According to those associated studies silver and gold nanoparticles are able to enhance abundantly signals in Raman spectra Compare gold to silver silver has more enhancive effect than the gold Hence we use silver to pack around the gold nanoparticles We can enhance Raman signal successfully through adding different length or sequences of DNA and adjusting the silver thickness around nanoparticles which will affect the gap between two nanoparticles We want to find the best stability enhancements and produce the reproducibility and uniformity structures

Date of Award	2014 Aug 21
Original language	English
Supervisor	Wen-Tai Chiu (Supervisor)