Effect of anti-malarial drug Artesunate on rat glioma cell growth

Abstract

Glioblastoma multiforme (GBM) is the most malignant brain tumor in adults GBM is characterized as a tumor with a poor prognosis and GMB bearing patients have a low survival rate Artesunate (ART) is currently used as an anti-malarial drug and has many anti-cancer activities ART has been shown to cause a profound cytotoxic effect on different cancer cell lines presenting a new candidate for cancer chemotherapy Thus this study attempted to evaluate ART treatment for anti-glioma To analyze the cell growth of C6 rat glioma after ART treatment MTT assay and colony formation assay were conducted In addition the scratch and transwell assay was used to investigate the migration and invasion ability after ART treatment The results showed that ART effectively inhibited the proliferation and colony forming of glioma cells Moreover ART suppressed glioma cell migration and invasion Accordingly we conclude that ART holds potential for anti-glioma progression which can be further developed for its therapeutic effectiveness for the survival rate of patient in the future

Date of Award	2019
Original language	English
Supervisor	Shun-Fen Tzeng (Supervisor)