Electromagnetic radiation stimulated nanoplatform in biomedical applications: imaging wound healing and cancer therapy

  • 王 柳鈞

Student thesis: Doctoral Thesis

Abstract

In this research we developed three different kinds of nanoparticles that can be responsive by electromagnetic radiation triggered for biomedical application including the long-lasting luminescence nanoparticles for X-ray induced imaging biocompatible polymer for accelerate wound healing and coordination polymers nanoparticles for radical therapy combine with photothermal therapy under 808 nm laser irradiation In chapter 2 we fabricated chromium-doped zinc gallate ZnGa2O4:Cr3+ (ZGC) material is viewed as a long-lasting luminescent phosphor which can avoid tissue autofluorescence interference for in vivo imaging detection Herein we describe the process by which we obtained dispersed and well-defined concave cubic ZGC finding much stronger long-lasting luminescence in UV and X-ray excitation for the dispersed cubic ZGC compared with the agglomerative form that cannot be excited using X-rays with a low dose of 0 5 Gy The cubic ZGC revealed a specific accumulation in liver and 0 5 Gy used at the end of X-ray excitation was sufficient for imaging of deep-seated hepatic tumors In chapter 3 we synthesized the uniform and biocompatible polypyrrole nanoparticles (NPs) with modification of bicarbonate on the PPY NPs to generate heat upon 808 nm laser irradiation Bicarbonate can be decomposed into CO2 at 42°C thus the particles were designed to reveal 808 nm laser induced CO2 generation for the purpose of the facilitation of wound healing The topical drop of the colloidal solution was applied on the incisional wound followed by exposure of 808 nm laser light to yield CO2 resulting in the observation of the accelerated wound healing In chapter 4 we have discovered a proton-induced metal replacement reaction to bring up strong NIR absorption ex nihilo following the acidic corrosion of CFPB analogs Regardless of the structure of the final etching product the acid corrosion concomitant of metal replacement process has endowed the formation of Fe3+-N≡C-Fe2+ generating the characteristic of NIR band The CFPB nanocages derived from CFPB nanocubes found the promising biomedical applications in photothermal and radical treatments Further modification of UCST polymer on CFPB nanocages enable the property to trigger by single laser irradiate
Date of Award2020
Original languageEnglish
SupervisorChen-Sheng Yeh (Supervisor)

Cite this

'