Enantiomeric Helical Constructions Induced by Dimeric Gelators Derived from Cholesterol

  • 仁 可娜

Student thesis: Master's Thesis


Two dimeric pyridine derivatives containing cholesteryl group were synthesized The connecting group between cholesterol and pyridine contains benzene rings and amide groups The structures of the compounds are changed by varying the relative positions of amide groups on the benzene rings (at para and meta) Gelation properties of the synthesized two compounds (PyPC and PyMC) were studied From gelation results PyMC has higher gelation ability than PyPC The results suggest that connecting position affect polarity of molecules thus it leads to the difference of molecular interaction resulting in different gelation behavior of the two compounds The morphologies and packing arrangements of xerogels were studied using SEM TEM 1H-NMR XRD and CD spectra SEM measurements observe the formation of nanotube structures with helical structures TEM measurements reveal that the molecular structures nature of solvents show significant effect on the morphologies of the gel networks It was observed that PyPC in dodecanol forms nanotube structures in which the nanotubes were constructed by twisted fibers Interestingly TEM observations show that both left and right handed helical constructions were formed although the system is chiral system However CD analysis indicates the existence of helical constructions The results suggest that both left and right handed helical constructions shown in TEM images should be unequal amount
Date of Award2014 Aug 21
Original languageEnglish
SupervisorJui-Hsiang Liu (Supervisor)

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