Evaluation of Electrophysiological Signals and Tissue of Brain with Deep Brain Stimulation on Epileptic Rats

Abstract

Epilepsy is one of the most common neurological disorders with a prevalence of 0 6–0 8% of the world’s population Two-thirds of the patients achieve sufficient seizure control from anticonvulsive medication and another 8–10% could benefit from respective surgery For the remaining 25% of patients no sufficient treatment is currently available Epilepsy is caused by abnormal discharges in the brain thus electroencephalogram (EEG) has been an especially valuable clinical tool for the evaluation seizure detection and treatment of epilepsy Brain stimulation with closed-loop seizure control has recently been proposed as an innovative and effective alternative At present two invasive epilepsy control system developed by NeuroPace called RNS and Medtronic called the Intercept? Epilepsy Control System had been completed U S FDA clinical trials In this study we designed and operated a wireless and portable seizure control/monitor system with an a-month-long experiment to examine and clarify the effect of brain tissue with electrode implantation and electrical stimulation The experiment was divided into control group and experiment group We carefully measured impedance of the brain tissue and weight which above two groups during the whole experiment To evaluate the effect of brain tissue with deep brain stimulation impedance spectra and histological slice were used in this study The results showed that electrical stimulation changes structure of brain tissue including impedance and neuroglial cell volume increased it also influenced cell resistance There is no affect to physiological of daily life There was no correlation between impedance changes and efficiency of seizure suppression

Date of Award	2014 Aug 28
Original language	English
Supervisor	Sheng-Fu Liang (Supervisor)