Identification of potential risk factors in the incidence and progression of malignant gliomas

Abstract

Stroke and brain cancer are two distinct diseases However the relationship between both diseases has rarely been examined This study investigated the longitudinal risk for developing brain cancer in ischemic stroke patients To study this the study first reviewed the malignant gliomas previously with or without stroke using brain magnetic resonance imaging (MRI) images and the past histories Two glioblastoma multiforme (GBM) patients had the previous ischemic stroke history Particularly both GBM specimens displayed strong hypoxia-inducible factor 1? (HIF-1?) expression in immunohistochemical (IHC) staining To elucidate the significance of this relationship the study used a nationwide population-based cohort in Taiwan to investigate the risk for the incidence of brain cancer in patients previously with or without ischemic stroke The incidence of all tumors in the stroke group was lower than that in the control group with an adjusted hazard ratio (HR) of 0 79 (95% confidence interval [CI]: 0 74-0 84) in both gender and age older than 60 years But the ischemic stroke patients had higher risk of developing only brain cancer with an adjusted HR of 3 09 (95% CI: 1 80-5 30) and otherwise had lower risk of developing head and neck digestive respiratory bone and skin as well as other tumors all with p

Date of Award	2018 Jan 31
Original language	English
Supervisor	Wen-Tsan Chang (Supervisor)