Independent Epigenetic Prognostic Marker Panel Mining and Examining for Cancers Personalized Medicine through Genome-scale Analysis

Abstract

Achieving early detection of the onset of cancer is a major goal of cancer research The early presence of aberrant DNA methylation makes the use of DNA methylation biomarkers an attractive possibility for early detection Altered DNA methylation is ubiquitous in human cancers and specific methylation changes are often correlated with clinical features DNA methylation biomarkers provide a range of opportunities for early detection diagnosis prognosis therapeutic stratification and post-therapeutic monitoring How to evaluate the obtained biomarkers is an another important issue in personalized medicine In the dissertation we propose a novel strategy can be used to stratify glioblastoma multiform (GBM) patients through the epigenetic states of genes associated with human embryonic stem cell (hESC) identity and the refined prognostic marker panel was extracted Then an evaluated mechanism for measuring the confident quality of biomarkers was established through high-grade serous ovarian cancer (HGSOC) and breast cancer One could utilize the developed package for evaluating the quality of biomarkers in any stage of development The dissertation contributed to 1) a strategy was established for stratifying cancer patients; 2) the refined prognostic marker panels are strong connected with literature with the potential for considering into clinical assay for patients’ stratification and future personalized medicine interventions; 3) a statistical examining mechanism was established for the confident quality of biomarkers measuring

Date of Award	2014 Aug 21
Original language	English
Supervisor	Jung-Hsien Chiang (Supervisor)