Optical Resolution via Crosslinked Self-assembly β-Cyclodextrin

  • 蘇 祐尼

Student thesis: Master's Thesis

Abstract

The self-assembly of supramolecular β-cyclodextrins was fabricated via good solvent/poor solvent method The presence of sodium ions was expected to facilitate the formation of cross-linked columnar construction by coordinating with polar hydroxyl groups on β-cyclodextrin When the self-assembled β-cyclodextrin was cross-linked by glutraldehyde an interesting double helix construction was observed indicating better cross-linking properties However the dual presence of sodium chloride and glutaraldehyde may cause unwanted interactions between sodium and hydroxyl groups leading to the inhibition of glutaraldehyde crosslinking resulting in the reduction of β-cyclodextrin self-assembly crosslinking and incompletely crosslinked constructions The high reactivity of diisocyanatohexane impeded the formation of highly ordered crosslinked construcstion of self-assembled β-cyclodextrin The results of the optical resolution of various racemic mixtures with the synthesized cross-linked β-cyclodextrin reveal that the chiral cavities of the synthesized cross-linked β-cyclodextrin may serve some chiral binding sites for enantiomers distinguishing
Date of Award2017 Jul 22
Original languageEnglish
SupervisorJui-Hsiang Liu (Supervisor)

Cite this

Optical Resolution via Crosslinked Self-assembly β-Cyclodextrin
祐尼, 蘇. (Author). 2017 Jul 22

Student thesis: Master's Thesis