Progression of Chronic Kidney Disease and Change of Quality of Life

  • 陳 秉鈺

Student thesis: Master's Thesis


Background: Quality of life (QOL) measures are tools of patient reported outcomes Chronic kidney disease (CKD) is known associated with a decreased QOL Previous studies were mostly cross-sectional survey and focused on the relationships of QOL and hard outcomes (cardiovascular event and death) Our study aimed to evaluate QOL changes when CKD stage progressed Method: We conducted a questionnaire survey in the nephrology clinic in two hospitals in Southern Taiwan (one tertiary center and one community hospital) The scores of WHO Quality of Life-BREF (WHOQOL-BREF) and demographic data were obtained during each visit Total 945 patients completed survey and 1314 WHOQOL-BREF questionnaires were analyzed We used mixed effects model to study factors associated with QOL questions Results: The associations between QOL scores and age albumin level anemia and health care services corroborated with previous reports After adjustments for age sex marital status education level hospital level body mass index (BMI) CKD stage hemoglobin albumin follow-up time we found QOL deteriorated when CKD stages advanced in all aspects except social domain beginning with item scores of “sleep” and “positive feelings” in CKD stage 3B followed by “energy & fatigue” “spirituality” “self-esteemed” and “recreation” in stage 4 Conclusions: Progression of CKD associates with negative impacts on QOL Future studies are warranted to explore the possible monitoring of QOL for early detection of CKD progression
Date of Award2017 Jul 21
Original languageEnglish
SupervisorJung-Der Wang (Supervisor)

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