Stroma of oral submucous fibrosis can promote oral field cancerization

Abstract

Oral submucous fibrosis (OSF) is a premalignant condition which is related to oral cancer formation Concept of field cancerization fit the clinical outcome of various kinds of malignant tumor such as oral cancer breast cancer and hepatocellular carcinoma Carcinogen-exposed tissue fields develop clonal malignant cells during evolution of neoplastic lesions But the mechanism of field cancerization was not well understood Cancer as a disease of unbalancing epithelial–mesenchymal interactions and extracellular matrix regulation was well accepted Tumor microenvironment and its stromal cell had been convinced to play an important role on carcinogenesis metastasis and drug resistance In recent year many researchers proposed that field cancerization was determinant primarily by the stroma but it lack human tissue evidence OSF is a stromal disease and related to cancer formation Therefore we would like to determine whether OSF cases were highly associated with multiple oral filed tumorgenesis We survey OSF cases in NCKU hospital and higher incidence of multiple primary oral cancer was noted (P

Date of Award	2014 Sept 4
Original language	English
Supervisor	Yuh-Ling Chen (Supervisor)