Survival difference between young age and old age of colon cancer SEER data based

Abstract

Colorectal cancer is the second leading cause of cancer death in the United States and is an important contributor to cancer morbidity The majority of patients with colorectal cancer (CRC) are older than 65 years and our population is aging Aging may increase the susceptibility of various tissues to initiation of carcinogenesis and facilitates promotion and progression of carcinogenesis However about 20% of patients of colorectal cancer are associated with familial clustering and first-degree relatives of patients with colorectal adenomas or invasive colorectal cancer are at risk for colorectal cancer This group of patients are general younger and may have different genomic expression Whether the prognosis of young age and old age in colon cancer are the same is still debated We used Surveillance Epidemiology and End Results Program (SEER) database to study survival difference between young age and old age of colon cancer Patients diagnosed with colon cancer from the SEER database (1995-2008) were analyzed Only adenocarcinoma was included A total of 261 523 patients with a median follow-up of 32 months were included The cutoff point of age is 50 years Median survival and 5-year survival rate of patients with the same stage of young and old group were evaluated The colon cancer study group included 129 969 men (49 7%) and 131 554 women (50 3%) Of the 261 523 patients with colon cancer 91 7% are old age and 8 3% are young age The colon cancer incidence of old age was 9 times greater than the young age incidence Mean age of the older group patients was 72 5 years and 43 74 years for young group The gender ratio among colon cancer in young group was similar with old group The right site tumors are more common in old group Unlike women with breast cancer that young women generally face more aggressive stages and lower survival rates patients diagnosed with colon cancer of young group have better survival than old group in all stages possible due to less comorbidities and better tolerance to treatment

Date of Award	2014 Sept 4
Original language	English
Supervisor	Jenq-Chang Lee (Supervisor)