The association between the use of efavirenz and the occurrence of depressive disorders among HIV-treated patients

  • 李 佳雯

Student thesis: Master's Thesis

Abstract

The use of highly active antiretroviral therapy (HAART) could improve the survival among people living with human immunodeficiency virus (HIV) One of the antiretroviral drugs – efavirenz could cause short-term side effects of central nervous system However it remained controversial as to whether efavirenz would cause depression or even suicidal attempt when applied for a longer period of time The study purpose was to determine the association between the use of efavirenz and depressive disorders This study analyzed HIV-infected patients who stayed in the registry for more than 6 months after HIV diagnosis and took HAART for more than 6 months Data were retrieved from the National Health Insurance Research Database from 2000 to 2010 The HIV-infected patients were categorized into efavirenz-treated group and non-efavirenz-treated group After up to 11 years of follow-up the incidence rate of depressive disorders for the efavirenz-treated group was estimated at 12 2/1 000 person-year (PY) while that for the control group was 12 5/1 000 PY (p=0 822) The Cox proportional hazard model suggested that the independent risk factors for the onset of depressive disorders among people living with HIV after HAART included a insurance premium of less than 17820 New Taiwan Dollars (NTD) (adjusted hazard ratio [aHR] 2 59 95% confidence interval [CI] 1 79-3 76 p
Date of Award2015 Jul 15
Original languageEnglish
SupervisorChung-Yi Li (Supervisor)

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