The Effect of Insulin Resistance on Cognitive Function in Euthymic Bipolar Disorder

Abstract

Previous studies suggested that metabolic disturbances highly prevail among bipolar disorder (BD) also considerable evidence confirmed both cognitive function and social cognition impairments exist In this study insulin resistance was used as a metabolic function index to determine the effects of insulin resistance on cognitive function and social cognition Study samples consisted of 77 BD (7 non-euthymic BD) and 242 health control (HC) all underwent blood tests with survey and evaluation on their demographics and clinical variables We compared the differences in metabolic function indexes cognitive function and social cognition between the BD and health control In addition we employed two-way ANOVA to examine the effects of disease and insulin resistance on cognitive function and social cognition The results indicated the fasting insulin level HOMA-IR value and prevalence of insulin resistance in the BD group were significantly higher than HC group BD group performed significantly worse than HC group in each cognitive function test and the social cognition test After controlling for age ANOVA test showed a significant interaction effect on the executive function test In addition within-group comparison indicated BD patients with insulin resistance performed significantly worse than BD patients without insulin resistance on the social cognition test This study found that BD patients with insulin resistance had poor executive function and social cognition performance than BD patients without insulin resistance and which reflected the prefrontal function may be modified by the interaction of BD and poor metabolic function

Date of Award	2019
Original language	English
Supervisor	Po-See Chen (Supervisor)