The Effect of Monoamine Oxidase B (MAOB) rs1799836 G Allele Polymorphism on The Executive Functions in Parkinson’s Disease Patients

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Student thesis: Doctoral Thesis

Abstract

Objective: Executive dysfunction is an important cognitive disturbance in patients with Parkinson’s disease (PD) However the role of monoamine oxidase B (MAOB) which is an important enzyme in dopamine metabolism in the executive function of patients with PD remains debated The objective of this study is to investigate the effect of MAOB single nucleotide polymorphism (SNP) in intron 13 (rs1799836) on the executive function in PD patients Methods: Sixty-four PD patients were enrolled in this study Participants were individually administered part III of the Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS–UPDRS) Mini-Mental State Examination (MMSE) and neuropsychological tests Ten-milliliter venous blood was then collected for genotyping The results of neuropsychological tests were examined by one-way ANOVA Kruskal-Wallis test or Quade’s rank analysis of covariance Results: Male PD patients with G allele in MAOB SNP in intron 13 showed lower performance on the number of word counts in Verbal Fluency test during 15 to 30 seconds (H(1 N=42) = 5 623 p = 018 η2 = 137) but higher on the span difference in Digit Span Subtest of Wechsler Adult Intelligence Scale-Third Edition (DS) (H(1 N=42) = 5 421 p = 020 η2 = 132) On the other hand even though female PD patients showed a significant difference in the forward span in DS (H(2 N=22) = 7 059 p = 029 η2 = 336) there is no significant difference in the post-hoc analysis After pooling all participants analysis done by Quade’s rank analysis of covariance with covariates of sex and education showed no significant difference in all neuropsychological measurements Conclusion: In summary G allele in MAOB SNP in intron 13 benefits the working memory function but decreases the cognitive flexibility in male PD patients
Date of Award2020
Original languageEnglish
SupervisorRwei-Ling Yu (Supervisor)

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