The risk assessment of co-exposure to glyphosate and heavy metals in chronic kidney disease

Abstract

The issue of risk of kidney disease caused by glyphosate is very important when the exposure of glyphosate is growing recently The aim of this study is to evaluate the influence of co-exposure to glyphosate and heavy metals in chronic kidney disease This research recruited 56 patients with chronic kidney disease as cases and recruited 100 healthier as controls The current study analyzed the concentration of glyphosate aminomethylphosphonic acid (AMPA) arsenic lead and cadmium in urine or blood and further to compare the concentrations between case and control groups The questionnaire interview for patients with CKD will find out whether dietary pattern that might with high risk Finally the estimated daily intake (EDI) was used to estimate the exposure of glyphosate and the Hzard Quotient (HQ) was used to describe the risk of glyphosate The result showed that the significant differences were observed in glyphosate AMPA arsenic cadmium and creatinine between the two groups and those showed the increasing trend by the worse of CKD Urine glyphosate level showed significant positive correlations with the consumption quantity of vegetable oils and melons; AMPA has a significant positive correlation with bovine offal HQ of two groups were far less than 1 which meant that the exposure of glyphosate in this study has no significant non-carcinogenic risk to humans but it’s not concsistent with the biomarker in CKD patients

Date of Award	2020
Original language	English
Supervisor	Hsiu-Ling Chen (Supervisor)