To examine the chemical compounds docking on FGF9 RNA 5'UTR and IRES binding site by using virtual screening

Abstract

Our lab previously published that overexpression of FGF9 protein is happened when the tumor cells under hypoxia pressure Also the mechanism of FGF9 protein overexpression is found through non-canonical IRES-mediated translation However it is a time-consuming and costly approach to go through new drug development and to find the specific small molecular drugs to inhibit FGF9 IRES-mediated translation Therefore we conducted a high-throughput screening in this research to dock the small molecular compounds and FGF9 mRNA 5’UTR and IRES predicted binding sites by using Discovery Studio software in order to find the small molecular compounds which are able to inhibit FGF9 IRES-mediated translation We analyze the FDA-approved drug database and NCI database by using CDOCKER program from Discovery Studio In this research our objective is using the CDOCKER program from Discovery Studio to select the small molecular candidates for further study

Date of Award	2020
Original language	English
Supervisor	Hsiao-Fang Sun (Supervisor)