Wall Shear Stress Imaging for Human Femoral Artery Based on Ultrafast Ultrasound Vector Velocity Estimation

Abstract

Peripheral vascular disease (PAD) is a major vascular disease However the symptoms of PAD are not obvious at the early stage Therefore if the intravascular parameters can be obtained in time it means a significant for early diagnosis and treatment Wall shear stress is a kind of friction exerted on the artery wall by the flowing blood which has been considered as an important parameter in hemodynamics Excessively high WSS may cause endothelial cell damage plaque or aneurysm rupture etc At present there are still many problems in measuring the wall shear stress in vivo For example only the average value at a fixed position can be obtained but the WSS is a value that changes with time Therefore it is necessary to obtain dynamic wall shear stress information in vivo In this study WSS imaging based on ultrasound vector Doppler velocity estimation was proposed to measure the femoral artery in vivo In the phantom experiments the reliability was verified to straight phantom with three different flow velocity The experimental results show that the average systole WSS of the straight phantom at different flow velocity is 0 55 pa 0 70 pa and 0 86 pa respectively Moreover a stenosis phantom has been designed to understand the distribution of non-regular vessel The relatively high WSS are obtained at the narrowed compare with straight parts of the stenosis phantom In in vivo experiments the WSS image was successfully applied to the bifurcation of the femoral artery and the average systole WSS in the common femoral artery superficial femoral artery and deep femoral artery were 0 41 pa 0 49 pa and 0 26 pa respectively In this paper Technique of WSS imaging based on ultrasound vector velocity estimation was proposed and successfully applied to measure for the human femoral artery

Date of Award	2020
Original language	English
Supervisor	Chih-Chung Huang (Supervisor)