YPIsBP: A Repository of Yeast Phosphoinositides-Binding Proteins

Abstract

Phosphoinositides (PIs) are a class of phospholipids composed of phosphatidylinositol (PtdIns) and its seven phosphorylated forms Phosphoinositides with its binding protein play important roles in various functions such as endocytosis vesicle transport regulation of calcium ions signal transmission etc Obviously it is necessary to understand the interaction and binding relationship between proteins and Phosphoinositides However none of the existing lipid databases provide detailed information on the relationship between protein and Phosphoinositides of any species Therefore we rigorously collected various research data and literature including protein microarray lipid array QuickGO and the Internet and established the first yeast protein database that binds to phosphoinositide (A Repository of Yeast PIs-Binding Proteins YPIsBP) There are a total of 679 PIs-binding proteins and it also provides three types of protein domain information (lipid-binding lipid-related and other) In addition to providing users with protein binding information in YPIsBP it also provides PIs-binding and possible domain enrichment analysis And through a visualization network diagram the relationship between proteins domains and Phosphoinositides can be observed more easyly As well as providing current knowledge this database also allows users to explore the interaction between Phosphoinositides and proteins YPIsBP is available at: http://cosbi7 ee ncku edu tw/YPIsBP/

Date of Award	2021
Original language	English
Supervisor	Wei-Sheng Wu (Supervisor)