基因體醫學中心

研究成果

2018

Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-β2 to promote chemoresistance in colorectal cancer

Tang, Y. A., Chen, Y. F., Bao, Y., Mahara, S., Yatim, S. M. J. M., Oguz, G., Lee, P. L., Feng, M., Cai, Y., Tan, E. Y., Fong, S. S., Yang, Z. H., Lan, P., Wu, X. J. & Yu, Q., 2018 六月 26, 於 : Proceedings of the National Academy of Sciences of the United States of America. 115, 26, p. E5990-E5999

研究成果: Article

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42 引文 斯高帕斯(Scopus)
2017

A histone deacetylase inhibitor enhances expression of genes inhibiting Wnt pathway and augments activity of DNA demethylation reagent against nonsmall-cell lung cancer

Shieh, J. M., Tang, Y. A., Hu, F. H., Huang, W. J., Wang, Y. J., Jen, J., Liao, S. Y., Lu, Y. H., Yeh, Y. L., Wang, T. W., Lin, P. & Wang, Y. C., 2017 五月 15, 於 : International Journal of Cancer. 140, 10, p. 2375-2386 12 p.

研究成果: Article

11 引文 斯高帕斯(Scopus)
79 引文 斯高帕斯(Scopus)
1 引文 斯高帕斯(Scopus)
2016

Oncoprotein ZNF322A transcriptionally deregulates alpha-adducin, cyclin D1 and p53 to promote tumor growth and metastasis in lung cancer

Jen, J., Lin, L. L., Chen, H. T., Liao, S. Y., Lo, F. Y., Tang, Y. A., Su, W. C., Salgia, R., Hsu, C. L., Huang, H. C., Juan, H. F. & Wang, Y. C., 2016 五月 5, 於 : Oncogene. 35, 18, p. 2357-2369 13 p.

研究成果: Article

24 引文 斯高帕斯(Scopus)
2015

Deregulation of SLIT2-mediated Cdc42 activity is associated with esophageal cancer metastasis and poor prognosis

Tseng, R. C., Chang, J. M., Chen, J. H., Huang, W. R., Tang, Y. A., Kuo, I. Y., Yan, J. J., Lai, W. W. & Wang, Y. C., 2015 一月 1, 於 : Journal of Thoracic Oncology. 10, 1, p. 189-198 10 p.

研究成果: Article

18 引文 斯高帕斯(Scopus)
34 引文 斯高帕斯(Scopus)
2014

A histone deacetylase inhibitor YCW1 with antitumor and antimetastasis properties enhances cisplatin activity against non-small cell lung cancer in preclinical studies

Huang, W. J., Tang, Y. A., Chen, M. Y., Wang, Y. J., Hu, F. H., Wang, T. W., Chao, S. W., Chiu, H. W., Yeh, Y. L., Chang, H. Y., Juan, H. F., Lin, P. & Wang, Y. C., 2014 四月 28, 於 : Cancer Letters. 346, 1, p. 84-93 10 p.

研究成果: Article

18 引文 斯高帕斯(Scopus)

DNMT3B overexpression by deregulation of FOXO3a-mediated transcription repression and MDM2 overexpression in lung cancer

Yang, Y. C., Tang, Y. A., Shieh, J. M., Lin, R. K., Hsu, H. S. & Wang, Y. C., 2014 九月, 於 : Journal of Thoracic Oncology. 9, 9, p. 1305-1315 11 p.

研究成果: Article

19 引文 斯高帕斯(Scopus)
2013
11 引文 斯高帕斯(Scopus)

Lack of association of C-Met-N375S sequence variant with lung cancer susceptibility and prognosis

Shieh, J. M., Tang, Y. A., Yang, T. H., Chen, C. Y., Hsu, H. S., Tan, Y. H. C., Salgia, R. & Wang, Y. C., 2013, 於 : International Journal of Medical Sciences. 10, 8, p. 988-994 7 p.

研究成果: Article

21 引文 斯高帕斯(Scopus)
2012

MDM2 overexpression deregulates the transcriptional control of RB/E2F leading to DNA methyltransferase 3A overexpression in lung cancer

Tang, Y. A., Lin, R. K., Tsai, Y. T., Hsu, H. S., Yang, Y. C., Chen, C. Y. & Wang, Y. C., 2012 八月 15, 於 : Clinical Cancer Research. 18, 16, p. 4325-4333 9 p.

研究成果: Article

34 引文 斯高帕斯(Scopus)

Mitochondrial apoptosis and FAK signaling disruption by a novel histone deacetylase inhibitor, HTPB, in antitumor and antimetastatic mouse models

Shieh, J. M., Wei, T. T., Tang, Y. A., Huang, S. M., Wen, W. L., Chen, M. Y., Cheng, H. C., Salunke, S. B., Chen, C. S., Lin, P., Chen, C. T. & Wang, Y. C., 2012 一月 18, 於 : PloS one. 7, 1, e30240.

研究成果: Article

17 引文 斯高帕斯(Scopus)
2011

A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways

Chen, J. Y., Tang, Y. A., Huang, S. M., Juan, H. F., Wu, L. W., Sun, Y. C., Wang, S. C., Wu, K. W., Balraj, G., Chang, T. T., Li, W. S., Cheng, H. C. & Wang, Y. C., 2011 一月 15, 於 : Cancer Research. 71, 2, p. 473-483 11 p.

研究成果: Article

72 引文 斯高帕斯(Scopus)
2010

A novel histone deacetylase inhibitor exhibits antitumor activity via apoptosis induction, F-actin disruption and gene acetylation in lung cancer

Tang, Y. A., Wen, W. L., Chang, J. W., Wei, T. T., Tan, Y. H. C., Salunke, S., Chen, C. T., Chen, C. S. & Wang, Y. C., 2010, 於 : PloS one. 5, 9, p. 1-13 13 p., e12417.

研究成果: Article

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41 引文 斯高帕斯(Scopus)

Dysregulation of p53/Sp1 control leads to DNA methyltransferase-1 overexpression in lung cancer

Lin, R. K., Wu, C. Y., Chang, J. W., Juan, L. J., Hsu, H. S., Chen, C. Y., Lu, Y. Y., Tang, Y. A., Yang, Y. C., Yang, P. C. & Wang, Y. C., 2010 七月 15, 於 : Cancer Research. 70, 14, p. 5807-5817 11 p.

研究成果: Article

113 引文 斯高帕斯(Scopus)

The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients

Lin, R. K., Hsieh, Y. S., Lin, P., Hsu, H. S., Chen, C. Y., Tang, Y. A., Lee, C. F. & Wang, Y. C., 2010 二月 1, 於 : Journal of Clinical Investigation. 120, 2, p. 521-532 12 p.

研究成果: Article

147 引文 斯高帕斯(Scopus)
2008

Role of extracellular signal-regulated kinase (ERK) signaling in nucleotide excision repair and genotoxicity in response to As(III) and Pb(II)

Li, J. P., Wang, C. Y., Tang, Y. A., Lin, Y. W. & Yang, J. L., 2008 十二月 24, 於 : Pure and Applied Chemistry. 80, 12, p. 2735-2750 16 p.

研究成果: Article

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2005

Promoter hypermethylation is the predominant mechanism in hMLH1 and hMSH2 deregulation and is a poor prognostic factor in nonsmoking lung cancer

Hsu, H. S., Wen, C. K., Tang, Y. A., Lin, R. K., Li, W. Y., Hsu, W. H. & Wang, Y. C., 2005 八月 1, 於 : Clinical Cancer Research. 11, 15, p. 5410-5416 7 p.

研究成果: Article

55 引文 斯高帕斯(Scopus)