奈米醫學研究中心

2024

Discovery of Dual MER/AXL Kinase Inhibitors as Bifunctional Small Molecules for Inhibiting Tumor Growth and Enhancing Tumor Immune Microenvironment

Li, M. C., Lai, Y. L., Kuo, P. H., Reddy, J. S., Chen, C. M., Manimala, J., Wang, P. C., Wu, M. S., Chang, C. Y., Yang, C. M., Lin, C. Y., Huang, Y. C., Chiu, C. H., Chang, L., Lin, W. H., Yeh, T. K., Yen, W. C. & Hsieh, H. P., 2024 7月 11, 於: Journal of Medicinal Chemistry. 67, 13, p. 10906-10927 22 p.

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Macrophage-mediated controlled release of cysteine protease inhibitor from PLGA-PEG/hydroxyapatite microspheres for targeting cathepsin S in Alzheimer's disease

Yang, I. H., Kuan, C. Y., Zhang, S. L., Chen, Z. Y., Li, C. H., Liang, Y. J., Kuo, W. T., Chang, C. T., Lin, J., Hsieh, H. P., Chang, J. Y. & Lin, F. H., 2024 6月 24, 於: European Polymer Journal. 214, 113151.

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Targeting cathepsin S promotes activation of OLF1-BDNF/TrkB axis to enhance cognitive function

Lee, H. W., Chen, S. J., Tsai, K. J., Hsu, K. S., Chen, Y. F., Chang, C. H., Lin, H. H., Hsueh, W. Y., Hsieh, H. P., Lee, Y. F., Chiang, H. C. & Chang, J. Y., 2024 12月, 於: Journal of biomedical science. 31, 1, 46.

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1 引文斯高帕斯（Scopus）

2023

A dual nociceptin and mu opioid receptor agonist exhibited robust antinociceptive effect with decreased side effects

Hsu, Y. T., Chen, S. R., Chang, Y. C., Chang, H. F., Yeh, T. K., Chuang, J. Y., Loh, H. H., Hsieh, H. P., Ueng, S. H. & Yeh, S. H., 2023 10月 5, 於: European Journal of Medicinal Chemistry. 258, 115608.

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1 引文斯高帕斯（Scopus）

Concise Nanotherapeutic Modality for Cancer Involving Graphene Oxide Dots in Conjunction with Ascorbic Acid

Shih, C-Y., Wang, P-T., Chung, W-P., Wang, W-H., Chiang, I-T., Su, W-C., Huang, W-L. & Teng, H., 2023 4月 26, 於: Nanoscale.

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1 引文斯高帕斯（Scopus）

Development of Furanopyrimidine-Based Orally Active Third-Generation EGFR Inhibitors for the Treatment of Non-Small Cell Lung Cancer

Li, M. C., Coumar, M. S., Lin, S. Y., Lin, Y. S., Huang, G. L., Chen, C. H., Lien, T. W., Wu, Y. W., Chen, Y. T., Chen, C. P., Huang, Y. C., Yeh, K. C., Yang, C. M., Kalita, B., Pan, S. L., Hsu, T. A., Yeh, T. K., Chen, C. T. & Hsieh, H. P., 2023 2月 23, 於: Journal of Medicinal Chemistry. 66, 4, p. 2566-2588 23 p.

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8 引文斯高帕斯（Scopus）

Distinct Features of Plasma Ultrashort Single-Stranded Cell-Free DNA as Biomarkers for Lung Cancer Detection

Cheng, J., Swarup, N., Li, F., Kordi, M., Lin, C. C., Yang, S. C., Huang, W. L., Aziz, M., Kim, Y., Chia, D., Yeh, Y. M., Wei, F., Zheng, D., Zhang, L., Pellegrini, M., Su, W. C. & Wong, D. T. W., 2023 11月 1, 於: Clinical Chemistry. 69, 11, p. 1270-1282 13 p.

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2 引文斯高帕斯（Scopus）

Electroactive membrane fusion-liposome for increased electron transfer to enhance radiodynamic therapy

Chen, Y. C., Li, Y. T., Lee, C. L., Kuo, Y. T., Ho, C. L., Lin, W. C., Hsu, M. C., Long, X., Chen, J. S., Li, W. P., Su, C. H., Okamoto, A. & Yeh, C. S., 2023 12月, 於: Nature Nanotechnology. 18, 12, p. 1492-1501 10 p.

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10 引文斯高帕斯（Scopus）

Influence of Ring Strain on the Formation of Rearrangement vs Cyclization Isotwistane Products in the Acyl Radical Reaction of Bicyclo[2.2.2]octanone

Chen, C. M., Lin, S. K., Hsieh, C. T., Reddy, J. S., Teoh, Y. N., Cheng, M. J. & Hsieh, H-P., 2023 11月 3, 於: Organic Letters. 25, 43, p. 7757-7762 6 p.

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Novel metal peroxide nanoboxes restrain Clostridioides difficile infection beyond the bactericidal and sporicidal activity

Yang, L. X., Lai, Y. H., Cheung, C. I., Ye, Z., Huang, T. C., Wang, Y. C., Chin, Y. C., Chia, Z. C., Chen, Y. J., Li, M. J., Tseng, H. Y., Tsai, Y. T., Zhang, Z. B., Chen, K. H., Tsai, B. Y., Shieh, D. B., Lee, N. Y., Tsai, P. J. & Huang, C. C., 2023 11月, 於: Bioengineering and Translational Medicine. 8, 6, e10593.

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1 引文斯高帕斯（Scopus）

Real-life analysis of neoadjuvant-therapy-associated benefits for pathological complete response and survival in early breast cancer patients - role of trastuzumab in HER2+ BC and platinum in TNBC

Chung, W. P., Yang, C. T., Yang, S. R., Su, C. Y., Su, H. W., Liu, S. Y. & Ou, H. T., 2023 1月 24, 於: Frontiers in Oncology. 12, 1022994.

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Tetrapodal ZnO nanomaterial synthesis for antibacterial fluoroethylene vinyl ether polymer coating

Yeh, Y., Wu, P., Li, J., Wang, S., Huang, J., Chuang, K., Tsai, T. & Kao, L., 2023 8月 1, 於: Materials Letters. 344, 134435.

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4 引文斯高帕斯（Scopus）

2022

Development of a cancer cells self-activating and miR-125a-5p expressing poly-pharmacological nanodrug for cancer treatment

Chang, Y. C., Shieh, M. C., Chang, Y. H., Huang, W. L., Su, W. C., Cheng, F. Y. & Cheung, C. H. A., 2022 8月, 於: International journal of molecular medicine. 50, 2, 102.

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2 引文斯高帕斯（Scopus）

FTY720 in resistant human epidermal growth factor receptor 2-positive breast cancer

Chung, W. P., Huang, W. L., Liao, W. A., Hung, C. H., Chiang, C. W., Cheung, C. H. A. & Su, W. C., 2022 12月, 於: Scientific reports. 12, 1, 241.

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6 引文斯高帕斯（Scopus）

Identification of Entry Inhibitors against Delta and Omicron Variants of SARS-CoV-2

Lee, R. K. L., Li, T. N., Chang, S. Y., Chao, T. L., Kuo, C. H., Pan, M. Y. C., Chiou, Y. T., Liao, K. J., Yang, Y., Wu, Y. H., Huang, C. H., Juan, H. F., Hsieh, H. P. & Wang, L. H. C., 2022 4月 1, 於: International journal of molecular sciences. 23, 7, 4050.

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19 引文斯高帕斯（Scopus）

Low expression of cytosolic NOTCH1 predicts poor prognosis of breast cancer patients

Chen, Y-L., Lee, K-T., Wang, C-Y., Shen, C-H., Chen, S-C., Chung, W-P., Hsu, Y-T., Kuo, Y-L., Chen, P-S., Cheung, C. H. A., Chang, C-P., Shen, M-R. & Hsu, H-P., 2022, 於: American Journal of Cancer Research. 12, 5, p. 2084-2101 18 p.

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Melem-derived poly(heptazine imide) for effective charge transport and photocatalytic reforming of cellulose into H₂ and biochemicals under visible light

Nimbalkar, D. B., Nguyen, V. C., Shih, C. Y. & Teng, H., 2022 11月 5, 於: Applied Catalysis B: Environmental. 316, 121601.

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25 引文斯高帕斯（Scopus）

Natural product myricetin is a pan-KDM4 inhibitor which with poly lactic-co-glycolic acid formulation effectively targets castration-resistant prostate cancer

Liu, J. S., Fang, W. K., Yang, S. M., Wu, M. C., Chen, T. J., Chen, C. M., Lin, T. Y., Liu, K. L., Wu, C. M., Chen, Y. C., Chuu, C. P., Wang, L. Y., Hsieh, H. P., Kung, H. J. & Wang, W. C., 2022 12月, 於: Journal of biomedical science. 29, 1, 29.

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15 引文斯高帕斯（Scopus）

Novel FLT3/AURK multikinase inhibitor is efficacious against sorafenib-refractory and sorafenib-resistant hepatocellular carcinoma

Lai, Y. L., Wang, K. H., Hsieh, H. P. & Yen, W. C., 2022 12月, 於: Journal of biomedical science. 29, 1, 5.

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13 引文斯高帕斯（Scopus）

PI3K inhibitors in trastuzumab-resistant HER2-positive breast cancer cells with PI3K pathway alterations

Chung, W-P., Huang, W-L., Lee, C-H., Hsu, H-P., Huang, W-L., Liu, Y-Y. & Su, W-C., 2022, 於: American Journal of Cancer Research. 12, 7, p. 3067-3082 16 p.

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Plasma contains ultrashort single-stranded DNA in addition to nucleosomal cell-free DNA

Cheng, J., Morselli, M., Huang, W. L., Heo, Y. J., Pinheiro-Ferreira, T., Li, F., Wei, F., Chia, D., Kim, Y., He, H. J., Cole, K. D., Su, W. C., Pellegrini, M. & Wong, D. T. W., 2022 7月 15, 於: iScience. 25, 7, 104554.

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15 引文斯高帕斯（Scopus）

2021

Biocompatible hole scavenger-assisted graphene oxide dots for photodynamic cancer therapy

Shih, C. Y., Huang, W. L., Chiang, I. T., Su, W. C. & Teng, H., 2021 5月 14, 於: Nanoscale. 13, 18, p. 8431-8441 11 p.

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19 引文斯高帕斯（Scopus）

Briarenols W–Z: Chlorine-Containing Polyoxygenated Briaranes from Octocoral Briareum stechei (Kükenthal, 1908)

Chen, Y. Y., Zhang, Y. L., Lee, G. H., Tsou, L. K., Zhang, M. M., Hsieh, H. P., Chen, J. J., Ko, C. Y., Wen, Z. H. & Sung, P. J., 2021 2月, 於: Marine Drugs. 19, 2, 77.

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4 引文斯高帕斯（Scopus）

Chitosan with various degrees of carboxylation as hydrogel electrolyte for pseudo solid-state supercapacitors

Lin, C. H., Wang, P. H., Lee, W. N., Li, W. C. & Wen, T. C., 2021 5月 15, 於: Journal of Power Sources. 494, 229736.

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35 引文斯高帕斯（Scopus）

Chlorinated briarane diterpenoids from octocoral Briareum stechei (Kükenthal, 1908)

Huynh, T. H., Lee, G. H., Tanaka, J., Hsieh, H. P., Kelvin Tsou, L., Zhang, M. M., Kuo, T. J., Wen, Z. H., Lu, C. K. & Sung, P. J., 2021 4月 13, 於: Tetrahedron Letters. 69, 152976.

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3 引文斯高帕斯（Scopus）

Colloidal assemblies composed of polymeric micellar/emulsified systems integrate cancer therapy combining a tumor-associated antigen vaccine and chemotherapeutic regimens

Huang, C. Y., Lin, S. Y., Hsu, T. A., Hsieh, H. P. & Huang, M. H., 2021 7月, 於: Nanomaterials. 11, 7, 1844.

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2 引文斯高帕斯（Scopus）

Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization

Li, M. C., Lin, W. H., Wang, P. C., Su, Y. C., Chen, P. Y., Fan, C. M., Chen, C. P., Huang, C. L., Chiu, C. H., Chang, L., Chen, C. T., Yeh, T. K. & Hsieh, H. P., 2021 11月 15, 於: European Journal of Medicinal Chemistry. 224, 113673.

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13 引文斯高帕斯（Scopus）

Development of a Robust Scale-Up Synthetic Route for BPR1K871: A Clinical Candidate for the Treatment of Acute Myeloid Leukemia and Solid Tumors

Reddy, J. S., Chen, C. M., Coumar, M. S., Sun, H. Y., Sun, N. & Hsieh, H. P., 2021 4月 16, 於: Organic Process Research and Development. 25, 4, p. 817-830 14 p.

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4 引文斯高帕斯（Scopus）

Development of the CK-MB-1 trastuzumab-resistant HER2-positive breast cancer cell line and xenograft animal models

Chung, W. P., Huang, W. L., Liao, W. A., Huang, W. L., Liu, Y. Y. & Su, W. C., 2021 4月, 於: Cancer medicine. 10, 7, p. 2370-2379 10 p.

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Discovery of BPR1R024, an Orally Active and Selective CSF1R Inhibitor that Exhibits Antitumor and Immunomodulatory Activity in a Murine Colon Tumor Model

Lee, K. H., Yen, W. C., Lin, W. H., Wang, P. C., Lai, Y. L., Su, Y. C., Chang, C. Y., Wu, C. S., Huang, Y. C., Yang, C. M., Chou, L. H., Yeh, T. K., Chen, C. T., Shih, C. & Hsieh, H. P., 2021 10月 14, 於: Journal of Medicinal Chemistry. 64, 19, p. 14477-14497 21 p.

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26 引文斯高帕斯（Scopus）

Extracellular vesicle mir-200c enhances gefitinib sensitivity in heterogeneous egfr-mutant nsclc

Lin, C. C., Wu, C. Y., Tseng, J. T. C., Hung, C. H., Wu, S. Y., Huang, Y. T., Chang, W. Y., Su, P. L. & Su, W. C., 2021 3月, 於: Biomedicines. 9, 3, 243.

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9 引文斯高帕斯（Scopus）

Hydroxyapatite formation with the interface of chitin and chitosan

Lin, C. H., Chen, Y. S., Huang, W. L., Hung, T. C. & Wen, T. C., 2021 1月, 於: Journal of the Taiwan Institute of Chemical Engineers. 118, p. 294-300 7 p.

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8 引文斯高帕斯（Scopus）

Mimicking H3 Substrate Arginine in the Design of G9a Lysine Methyltransferase Inhibitors for Cancer Therapy: A Computational Study for Structure-Based Drug Design

Chandar Charles, M. R., Li, M. C., Hsieh, H. P. & Coumar, M. S., 2021 3月 9, 於: ACS Omega. 6, 9, p. 6100-6111 12 p.

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5 引文斯高帕斯（Scopus）

Overcoming vincristine resistance in cancer: Computational design and discovery of piperine-inspired P-glycoprotein inhibitors

Syed, S. B., Lin, S. Y., Arya, H., Fu, I. H., Yeh, T. K., Charles, M. R. C., Periyasamy, L., Hsieh, H. P. & Coumar, M. S., 2021 1月, 於: Chemical Biology and Drug Design. 97, 1, p. 51-66 16 p.

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10 引文斯高帕斯（Scopus）

2020

Amorphous Multimetal Alloy Oxygen Evolving Catalysts

Cai, W., Yang, H., Zhang, J., Chen, H. C., Tao, H. B., Gao, J., Liu, S., Liu, W., Li, X. & Liu, B., 2020 6月 1, 於: ACS Materials Letters. 2, 6, p. 624-632 9 p.

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48 引文斯高帕斯（Scopus）

A selective Aurora-A 5′-UTR siRNA inhibits tumor growth and metastasis

Lai, C. H., Chen, R. Y., Hsieh, H. P., Tsai, S. J., Chang, K. C., Yen, C. J., Huang, Y. C., Liu, Y. W., Lee, J. C., Lai, Y. C., Hung, L. Y. & Lin, B. W., 2020 3月 1, 於: Cancer Letters. 472, p. 97-107 11 p.

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14 引文斯高帕斯（Scopus）

Comprehensively Probing the Contribution of Site Activity and Population of Active Sites toward Heterogeneous Electrocatalysis

Chen, H. C., Chen, T. L., Lin, S. C., Hsu, C. S., Chan, T. S., Liao, M. Y. & Chen, H. M., 2020 4月 6, 於: ChemCatChem. 12, 7, p. 1926-1933 8 p.

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12 引文斯高帕斯（Scopus）

Design of a potent anticancer lead inspired by natural products from traditional Indian medicine

Arya, H., Yadav, C. S., Lin, S. Y., Syed, S. B., Charles, M. R. C., Kannadasan, S., Hsieh, H. P., Singh, S. S., Gajurel, P. R. & Coumar, M. S., 2020 8月 12, 於: Journal of Biomolecular Structure and Dynamics. 38, 12, p. 3563-3577 15 p.

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5 引文斯高帕斯（Scopus）

Design of drug-like hepsin inhibitors against prostate cancer and kidney stones

Blay, V., Li, M. C., Ho, S. P., Stoller, M. L., Hsieh, H. P. & Houston, D. R., 2020 7月, 於: Acta Pharmaceutica Sinica B. 10, 7, p. 1309-1320 12 p.

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8 引文斯高帕斯（Scopus）

Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors

Lin, S. Y., Chang, C. F., Coumar, M. S., Chen, P. Y., Kuo, F. M., Chen, C. H., Li, M. C., Lin, W. H., Kuo, P. C., Wang, S. Y., Li, A. S., Lin, C. Y., Yang, C. M., Yeh, T. K., Song, J. S., Hsu, J. T. A. & Hsieh, H. P., 2020 5月, 於: Bioorganic Chemistry. 98, 103689.

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9 引文斯高帕斯（Scopus）

Dynamic Reoxidation/Reduction-Driven Atomic Interdiffusion for Highly Selective CO₂Reduction toward Methane

Chang, C. J., Lin, S. C., Chen, H. C., Wang, J., Zheng, K. J., Zhu, Y. & Chen, H. M., 2020 7月 15, 於: Journal of the American Chemical Society. 142, 28, p. 12119-12132 14 p.

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217 引文斯高帕斯（Scopus）

Electric Field–Induced Release and Measurement (EFIRM): Characterization and Technical Validation of a Novel Liquid Biopsy Platform in Plasma and Saliva

Tu, M., Cheng, J., Chen, Y. L., Jea, W. C., Chen, W. L., Chen, C. J., Ho, C. L., Huang, W. L., Lin, C. C., Su, W. C., Ye, Q., Deignan, J., Grody, W., Li, F., Chia, D., Wei, F., Liao, W., Wong, D. T. W. & Strom, C. M., 2020 8月, 於: Journal of Molecular Diagnostics. 22, 8, p. 1050-1062 13 p.

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16 引文斯高帕斯（Scopus）

Identification of novel quinoline inhibitor for EHMT2/G9a through virtual screening

Charles, M. R. C., Mahesh, A., Lin, S. Y., Hsieh, H. P., Dhayalan, A. & Coumar, M. S., 2020 1月, 於: Biochimie. 168, p. 220-230 11 p.

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12 引文斯高帕斯（Scopus）

Induction of robust immune responses by cpg-odn-loaded hollow polymeric nanoparticles for antiviral and vaccine applications in chickens

Lin, S. Y., Yao, B. Y., Hu, C. M. J. & Chen, H. W., 2020, 於: International journal of nanomedicine. 15, p. 3303-3318 16 p.

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23 引文斯高帕斯（Scopus）

In situ X-ray diffraction and X-ray absorption spectroscopy of electrocatalysts for energy conversion reactions

Chang, C. J., Zhu, Y., Wang, J., Chen, H. C., Tung, C. W., Chu, Y. C. & Chen, H. M., 2020 10月 7, 於: Journal of Materials Chemistry A. 8, 37, p. 19079-19112 34 p.

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105 引文斯高帕斯（Scopus）

Strong Catalyst-Support Interactions in Electrochemical Oxygen Evolution on Ni-Fe Layered Double Hydroxide

Gu, H., Shi, G., Chen, H. C., Xie, S., Li, Y., Tong, H., Yang, C., Zhu, C., Mefford, J. T., Xia, H., Chueh, W. C., Chen, H. M. & Zhang, L., 2020 10月 9, 於: ACS Energy Letters. 5, 10, p. 3185-3194 10 p.

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52 引文斯高帕斯（Scopus）

Synthetic Immunogenic Cell Death Mediated by Intracellular Delivery of STING Agonist Nanoshells Enhances Anticancer Chemo-immunotherapy

Chattopadhyay, S., Liu, Y. H., Fang, Z. S., Lin, C. L., Lin, J. C., Yao, B. Y. & Hu, C. M. J., 2020 4月 8, 於: Nano letters. 20, 4, p. 2246-2256 11 p.

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92 引文斯高帕斯（Scopus）

The exosome-mediated autocrine and paracrine actions of plasma gelsolin in ovarian cancer chemoresistance

Asare-Werehene, M., Nakka, K., Reunov, A., Chiu, C. T., Lee, W. T., Abedini, M. R., Wang, P. W., Shieh, D. B., Dilworth, F. J., Carmona, E., Le, T., Mes-Masson, A. M., Burger, D. & Tsang, B. K., 2020 2月 13, 於: Oncogene. 39, 7, p. 1600-1616 17 p.

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101 引文斯高帕斯（Scopus）

The nonalcoholic fatty liver disease-like phenotype and lowered serum VLDL are associated with decreased expression and DNA hypermethylation of hepatic ApoB in male offspring of ApoE deficient mothers fed a with Western diet

Chen, H. C., Chen, Y. Z., Wang, C. H. & Lin, F. J., 2020 3月, 於: Journal of Nutritional Biochemistry. 77, 108319.

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19 引文斯高帕斯（Scopus）

Tumor-agnostic inhibitors in oncology: A new phase for precision medicine

Li, M. C. & Hsieh, H. P., 2020 12月, 於: Journal of the Chinese Chemical Society. 67, 12, p. 2216-2224 9 p.

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1 引文斯高帕斯（Scopus）

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