傳染性疾病及訊息研究中心

研究成果 1989 2020

Article
5 引文 (Scopus)

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J-Y. & Liou, J. P., 2019 一月 15, 於 : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

研究成果: Article

Benzamides
Histone Deacetylases
Tubulin
Heterografts
Inhibitory Concentration 50
67 引文 (Scopus)

2,2′-Diphenyl-1-picrylhydrazyl radical-scavenging active components from adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) hulls

Kuo, C. C., Chiang, W., Liu, G. P., Chien, Y. L., Chang, J-Y., Lee, C. K., Lo, J. M., Huang, S. L., Shih, M. C. & Kuo, Y. H., 2002 十月 9, 於 : Journal of Agricultural and Food Chemistry. 50, 21, p. 5850-5855 6 p.

研究成果: Article

Coix
Coix lacryma-jobi
1-Butanol
Scavenging
butanol
12 引文 (Scopus)

2-Amino-3,4,5-Trimethoxybenzophenones as Potent Tubulin Polymerization Inhibitors

Chuang, H. Y., Chang, J-Y., Lai, M. J., Kuo, C. C., Lee, H. Y., Hsieh, H. P., Chen, Y. J., Chen, L. T., Pan, W. Y. & Liou, J. P., 2011 三月 7, 於 : ChemMedChem. 6, 3, p. 450-456 7 p.

研究成果: Article

Tubulin Modulators
Inhibitory Concentration 50
Cells
Lead compounds
Colchicine
42 引文 (Scopus)

2-Amino and 2′-aminocombretastatin derivatives as potent antimitotic agents

Chang, J. Y., Yang, M. F., Chang, C. Y., Chen, C. M., Kuo, C. C. & Liou, J. P., 2006 十月 1, 於 : Journal of Medicinal Chemistry. 49, 21, p. 6412-6415 4 p.

研究成果: Article

Antimitotic Agents
Inhibitory Concentration 50
Tubulin Modulators
Colchicine
Structure-Activity Relationship
6 引文 (Scopus)

2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition

Nepali, K., Kumar, S., Huang, H. L., Kuo, F. C., Lee, C. H., Kuo, C. C., Yeh, T. K., Li, Y. H., Chang, J. Y., Liou, J. P. & Lee, H. Y., 2016 一月 1, 於 : Organic and Biomolecular Chemistry. 14, 2, p. 716-723 8 p.

研究成果: Article

HSP90 Heat-Shock Proteins
Dione
Tubulin
Antineoplastic Agents
Inhibitory Concentration 50
57 引文 (Scopus)

4- And 5-aroylindoles as novel classes of potent antitubulin agents

Liou, J. P., Wu, C. Y., Hsieh, H. P., Chang, C. Y., Chen, C. M., Kuo, C. C. & Chang, J. Y., 2007 九月 6, 於 : Journal of Medicinal Chemistry. 50, 18, p. 4548-4552 5 p.

研究成果: Article

Inhibitory Concentration 50
Tubulin Modulators
Colchicine
Tubulin
Polymerization
63 引文 (Scopus)

5-Amino-2-Aroylquinolines as highly potent tubulin polymerization inhibitors

Nien, C. Y., Chen, Y. C., Kuo, C. C., Hsieh, H. P., Chang, C. Y., Wu, J. S., Wu, S. Y., Liou, J. P. & Chang, J-Y., 2010 三月 11, 於 : Journal of Medicinal Chemistry. 53, 5, p. 2309-2313 5 p.

研究成果: Article

Tubulin Modulators
Inhibitory Concentration 50
Cell Line
Colchicine
Tubulin
42 引文 (Scopus)

5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. Part 2. The impact of bridging groups at position C-2

Lee, H. Y., Chang, J. Y., Nien, C. Y., Kuo, C. C., Shih, K. H., Wu, C. H., Chang, C. Y., Lai, W. Y. & Liou, J. P., 2011 十二月 22, 於 : Journal of Medicinal Chemistry. 54, 24, p. 8517-8525 9 p.

研究成果: Article

Tubulin Modulators
Sulfones
Sulfides
HT29 Cells
Tubulin
61 引文 (Scopus)

7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents

Chang, J. Y., Hsieh, H. P., Chang, C. Y., Hsu, K. S., Chiang, Y. F., Chen, C. M., Kuo, C. C. & Liou, J. P., 2006 十一月 16, 於 : Journal of Medicinal Chemistry. 49, 23, p. 6656-6659 4 p.

研究成果: Article

Sulfonamides
Tubulin Modulators
KB Cells
Colchicine
Microtubules
8 引文 (Scopus)
betel
Tobacco
Head and Neck Neoplasms
Mastication
tobacco
2 引文 (Scopus)

Acquired hemophilia A: Report of two cases

Chen, Y. C., Chang, J. Y., Hsueh, E. J., Wan, H. L. & Chao, T. Y., 1998 九月 1, 於 : Chinese Medical Journal (Taipei). 61, 9, p. 538-544 7 p.

研究成果: Article

Hemorrhage
Factor VIII
Cyclophosphamide
Uterus
Episiotomy
11 引文 (Scopus)

Activation of PPAR-α induces cell cycle arrest and inhibits transforming growth factor-β1 induction of smooth muscle cell phenotype in 10T1/2 mesenchymal cells

Lien, S. C., Wei, S. Y., Chang, S. F., Chang, M. D. T., Chang, J. Y. & Chiu, J. J., 2013 五月 1, 於 : Cellular Signalling. 25, 5, p. 1252-1263 12 p.

研究成果: Article

Peroxisome Proliferator-Activated Receptors
Transforming Growth Factors
Cell Cycle Checkpoints
Smooth Muscle Myocytes
Phenotype
14 引文 (Scopus)

Allergies and Risk of Head and Neck Cancer: An Original Study plus Meta-Analysis

Hsiao, J. R., Ou, C. Y., Lo, H. I., Huang, C. C., Lee, W. T., Huang, J. S., Chen, K. C., Wong, T. Y., Tsai, S. T., Yen, C. J., Wu, Y. H., Hsueh, W. T., Yang, M. W., Wu, S. Y., Chang, J. Y., Chang, K. Y., Lin, C. L., Wang, F. T., Wang, Y. H., Weng, Y. L. 及其他2, Yang, H. C. & Chang, J. S., 2013 二月 1, 於 : PloS one. 8, 2, e55138.

研究成果: Article

Allergies
Head and Neck Neoplasms
meta-analysis
hypersensitivity
Meta-Analysis
2 引文 (Scopus)

Allergy symptoms, serum total immunoglobulin E, and risk of head and neck cancer

Liao, H. C., Wu, S-Y., Ou, C-Y., Hsiao, J-R., Huang, J-S., Tsai, S-T., Huang, C-C., Wang, D-Y., Lee, W-T., Chen, K-C., Fang, S-Y., Wu, J-L., Huang, T-T., Wu, Y-H., Hsueh, W-T., Yen, C-J., Yang, M-W., Lin, F-C., Lai, Y-H., Chang, J-Y. 及其他6, Lin, C. L., Wang, Y. H., Weng, Y. L., Yang, H. C., Chen, Y. S. & Chang, J. S., 2016 九月 1, 於 : Cancer Causes and Control. 27, 9, p. 1105-1115 11 p.

研究成果: Article

Head and Neck Neoplasms
Immunoglobulin E
Hypersensitivity
Serum
Odds Ratio

Allogeneic bone marrow transplantation for fourteen patients with severe aplastic anemia

Hsueh, E. J., Hwang, W. S., Huang, S. H., Chao, T. Y., Chang, J-Y. & Wang, C. C., 1996 四月 1, 於 : Chinese Medical Journal (Taipei). 57, 4, p. 247-253 7 p.

研究成果: Article

Aplastic Anemia
Homologous Transplantation
Bone Marrow Transplantation
Graft vs Host Disease
Transplants
1 引文 (Scopus)
Cell Polarity
Cell Movement
Tubulin
Pseudopodia
Acetylation
17 引文 (Scopus)

A novel bis-benzylidenecyclopentanone derivative, BPR0Y007, inducing a rapid caspase activation involving upregulation of Fas (CD95/APO-1) and wild-type p53 in human oral epidermoid carcinoma cells

Juang, S. H., Pan, W. Y., Kuo, C. C., Liou, J. P., Hung, Y. M., Chen, L. T., Hsieh, H. P. & Chang, J-Y., 2004 七月 15, 於 : Biochemical Pharmacology. 68, 2, p. 293-303 11 p.

研究成果: Article

Caspases
Squamous Cell Carcinoma
Up-Regulation
Chemical activation
Cells
58 引文 (Scopus)
Sulfonamides
Human Activities
Microtubules
Phosphorylation
Multidrug Resistance-Associated Proteins
6 引文 (Scopus)

A novel peroxisome proliferator-activated receptor α/γ agonist, BPR1H0101, inhibits topoisomerase II catalytic activity in human cancer cells

Kao, Y. H., Hsieh, H. P., Chitlimalla, S. K., Pan, W. Y., Kuo, C. C., Tsai, Y. C., Lin, W. H., Chuang, S. E. & Chang, J. Y., 2008 二月 1, 於 : Anti-Cancer Drugs. 19, 2, p. 151-158 8 p.

研究成果: Article

Type II DNA Topoisomerase
Peroxisome Proliferator-Activated Receptors
Human Activities
KB Cells
Neoplasms
15 引文 (Scopus)

A Novel Synthetic Microtubule Inhibitor, MPT0B214 Exhibits Antitumor Activity in Human Tumor Cells through Mitochondria-Dependent Intrinsic Pathway

Chiang, N. J., Lin, C. I., Liou, J. P., Kuo, C. C., Chang, C. Y., Chen, L. T. & Chang, J. Y., 2013 三月 12, 於 : PloS one. 8, 3, e58953.

研究成果: Article

Mitochondria
tubulin
Human Activities
Microtubules
microtubules
34 引文 (Scopus)

Antimutagenic constituents of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) with potential cancer chemopreventive activity

Chen, H. H., Chiang, W., Chang, J. Y., Chien, Y. L., Lee, C. K., Liu, K. J., Cheng, Y. T., Chen, T. F., Kuo, Y. H. & Kuo, C. C., 2011 六月 22, 於 : Journal of Agricultural and Food Chemistry. 59, 12, p. 6444-6452 9 p.

研究成果: Article

Coix
Coix lacryma-jobi
antimutagenic activity
hulls
neoplasms
11 引文 (Scopus)

Antitumor activities and pharmacokinetics of silatecans DB-67 and DB-91

Yeh, T. K., Li, C. M., Chen, C. P., Chuu, J. J., Huang, C. L., Wang, H. S., Shen, C. C., Lee, T. Y., Chang, C. Y., Chang, C. M., Chao, Y. S., Lin, C. T., Chang, J. Y. & Chen, C. T., 2010 二月 1, 於 : Pharmacological Research. 61, 2, p. 108-115 8 p.

研究成果: Article

Pharmacokinetics
Camptothecin
Lactones
Topoisomerase I Inhibitors
Neoplasms
106 引文 (Scopus)

Antitumor Agents. 111.† New 4-Hydroxylated and 4-Halogenated Anilino Derivatives of 4'-Demethylepipodophyllotoxin as Potent Inhibitors of Human DNA Topoisomerase II

Lee, K. H., Beers, S. A., Mori, M., Wang, Z. Q., Kuo, Y. H., Li, L., Liu, S. Y., Chang, J-Y., Han, F. S. & Cheng, Y. C., 1990 一月 1, 於 : Journal of Medicinal Chemistry. 33, 5, p. 1364-1368 5 p.

研究成果: Article

Topoisomerase II Inhibitors
Type II DNA Topoisomerase
Antineoplastic Agents
Etoposide
Podophyllotoxin
120 引文 (Scopus)

Antitumor Agents. 113. New 4β-Arylamino Derivatives of 4-O-Demethylepipodophyllotoxin and Related Compounds as Potent Inhibitors of Human DNA Topoisomerase II

Wang, Z. Q., Kuo, Y. H., Schnur, D., Bowen, J. P., Liu, S. Y., Han, F. S., Chang, J. Y., Cheng, Y. C. & Lee, K. H., 1990 一月 1, 於 : Journal of Medicinal Chemistry. 33, 9, p. 2660-2666 7 p.

研究成果: Article

Topoisomerase II Inhibitors
Type II DNA Topoisomerase
Etoposide
Antineoplastic Agents
Sulfur Compounds
67 引文 (Scopus)
Topoisomerase II Inhibitors
Type II DNA Topoisomerase
Antineoplastic Agents
Ether
Oxygen Compounds
13 引文 (Scopus)
Topoisomerase II Inhibitors
Type II DNA Topoisomerase
Antineoplastic Agents
Derivatives
DNA
30 引文 (Scopus)

Antitumor AHMA linked to DNA minor groove binding agents: Synthesis and biological evaluation

Rastogi, K., Chang, J. Y., Pan, W. Y., Chen, C. H., Chou, T. C., Chen, L. T. & Su, T. L., 2002 九月 26, 於 : Journal of Medicinal Chemistry. 45, 20, p. 4485-4493 9 p.

研究成果: Article

Netropsin
DNA
Type II DNA Topoisomerase
Solubility
Cell Line
4 引文 (Scopus)

A phase i clinical study of immunotherapy for advanced colorectal cancers using carcinoembryonic antigen-pulsed dendritic cells mixed with tetanus toxoid and subsequent IL-2 treatment John T Kung

Liu, K. J., Chao, T. Y., Chang, J. Y., Cheng, A. L., Ch'Ang, H. J., Kao, W. Y., Wu, Y. C., Yu, W. L., Chung, T. R. & Whang-Peng, J., 2016 八月 24, 於 : Journal of biomedical science. 23, 1, 64.

研究成果: Article

Tetanus Toxoid
Carcinoembryonic Antigen
Immunotherapy
Dendritic Cells
Interleukin-2
17 引文 (Scopus)

A phase I study of weekly docetaxel, 24-hour infusion of high-dose fluorouracil/leucovorin and cisplatin in patients with advanced gastric cancer

Chen, L. T., Liu, T. W., Wu, C. W., Chung, T. R., Shiah, H. S., Jan, C. M., Ming Liu, J., Whang-Peng, J. & Chang, J-Y., 2002 十二月 1, 於 : Oncology. 63, 3, p. 239-247 9 p.

研究成果: Article

docetaxel
Leucovorin
Fluorouracil
Cisplatin
Stomach Neoplasms
4 引文 (Scopus)

Application of Suzuki arylation, Sonogashira ethynylation and Rosenmund-von Braun cyanation in the exploration of substitution effects on the anticancer activity of 2-aroylquinolines

Lee, H. Y., Lee, L. W., Nien, C. Y., Kuo, C. C., Lin, P. Y., Chang, C. Y., Chang, J. Y. & Liou, J. P., 2012 一月 1, 於 : Organic and Biomolecular Chemistry. 10, 48, p. 9593-9600 8 p.

研究成果: Article

colchicine
Colchicine
Tubulin
Substitution reactions
substitutes
21 引文 (Scopus)

Arecoline arrests cells at prometaphase by deregulating mitotic spindle assembly and spindle assembly checkpoint: Implication for carcinogenesis

Wang, Y. C., Tsai, Y. S., Huang, J. L., Lee, K. W., Kuo, C. C., Wang, C. S., Huang, A. M., Chang, J. Y., Jong, Y. J. & Lin, C. S., 2010 四月 1, 於 : Oral Oncology. 46, 4, p. 255-262 8 p.

研究成果: Article

Arecoline
Prometaphase
M Phase Cell Cycle Checkpoints
Spindle Apparatus
Carcinogenesis
14 引文 (Scopus)

Arginine deprivation as a new treatment strategy for head and neck cancer

Huang, C. C., Tsai, S. T., Kuo, C. C., Chang, J. S., Jin, Y. T., Chang, J. Y. & Hsiao, J. R., 2012 十二月 1, 於 : Oral Oncology. 48, 12, p. 1227-1235 9 p.

研究成果: Article

Argininosuccinate Synthase
Head and Neck Neoplasms
Arginine
Squamous Cell Carcinoma
Therapeutics
8 引文 (Scopus)

BPR0C261 is a novel orally active antitumor agent with antimitotic and anti-angiogenic activities

Hu, C. B., Chen, C. P., Yeh, T. K., Song, J. S., Chang, C. Y., Chuu, J. J., Tung, F. F., Ho, P. Y., Chen, T. W., Lin, C. H., Wang, M. H., Chang, K. Y., Huang, C. L., Lin, H. L., Li, W. T., Hwang, D. R., Chern, J. H., Hwang, L. L., Chang, J. Y., Chao, Y. S. 及其他1, Chen, C. T., 2011 一月 1, 於 : Cancer Science. 102, 1, p. 182-191 10 p.

研究成果: Article

Antimitotic Agents
Antineoplastic Agents
Neoplasms
Tubulin
Nude Mice
181 引文 (Scopus)

BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo

Kuo, C. C., Hsieh, H. P., Pan, W. Y., Chen, C. P., Liou, J. P., Lee, S. J., Chang, Y. L., Chen, L. T., Chen, C. T. & Chang, J. Y., 2004 七月 1, 於 : Cancer Research. 64, 13, p. 4621-4628 8 p.

研究成果: Article

Antimitotic Agents
Human Activities
KB Cells
Neoplasms
Colchicine
13 引文 (Scopus)

BPR1K653, a novel aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells

Cheung, C. H. A., Lin, W. H., HsuJohn, J. T. A., Hour, T. C., Yeh, T. K., Ko, S., Lien, T. W., Coumar, M. S., Liu, J. F., Lai, W. Y., Shiao, H. Y., Lee, T. R., Hsieh, H. P. & Chang, J. Y., 2011 八月 24, 於 : PloS one. 6, 8, e23485.

研究成果: Article

Aurora Kinases
phosphotransferases (kinases)
Cells
neoplasms
Neoplasms
14 引文 (Scopus)

C 35 terpenoids from the bark of Calocedrus macrolepis var. formosana with activity against human cancer cell lines

Hsieh, C. L., Tseng, M. H., Shao, Y. Y., Chang, J-Y., Kuo, C. C., Chang, C. Y. & Kuo, Y. H., 2006 十一月 1, 於 : Journal of Natural Products. 69, 11, p. 1611-1613 3 p.

研究成果: Article

Cupressaceae
Terpenes
Human Activities
Cells
KB Cells
33 引文 (Scopus)

Caffeic acid phenethyl ester suppresses proliferation and survival of TW2.6 human oral cancer cells via inhibition of akt signaling

Kuo, Y. Y., Lin, H. P., Huo, C., Su, L. C., Yang, J., Hsiao, P. H., Chiang, H. C., Chung, C. J., Wang, H. D., Chang, J. Y., Chen, Y. W. & Chuu, C. P., 2013 五月, 於 : International journal of molecular sciences. 14, 5, p. 8801-8817 17 p.

研究成果: Article

Mouth Neoplasms
esters
Esters
cancer
Cells
51 引文 (Scopus)
KB Cells
Camptothecin
DNA Breaks
Cell Line
Proteins
28 引文 (Scopus)

Cancer cells acquire mitotic drug resistance properties through beta i-tubulin mutations and alterations in the expression of beta-tubulin isotypes

Cheung, C. H. A., Wu, S. Y., Lee, T. R., Chang, C. Y., Wu, J. S., Hsieh, H. P. & Chang, J. Y., 2010 十一月 1, 於 : PloS one. 5, 9, p. 1-11 11 p., e12564.

研究成果: Article

drug resistance
Tubulin
tubulin
Drug Resistance
Microtubules
8 引文 (Scopus)
cathepsin S
Protein-Tyrosine Kinases
Endosomes
Epidermal Growth Factor
STAT3 Transcription Factor
24 引文 (Scopus)

Chamaecypanone C, a novel skeleton microtubule inhibitor, with anticancer activity by trigger caspase 8-Fas/FasL dependent apoptotic pathway in human cancer cells

Hsieh, C. C., Kuo, Y. H., Kuo, C. C., Chen, L. T., Cheung, C-H., Chao, T. Y., Lin, C. H., Pan, W. Y., Chang, C. Y., Chien, S. C., Chen, T. W., Lung, C. C. & Chang, J-Y., 2010 五月 1, 於 : Biochemical Pharmacology. 79, 9, p. 1261-1271 11 p.

研究成果: Article

Caspase 8
Skeleton
Microtubules
Cells
Neoplasms
25 引文 (Scopus)

Changes in DNA methylation are associated with the development of drug resistance in cervical cancer cells

Chen, C. C., Lee, K. D., Pai, M. Y., Chu, P. Y., Hsu, C. C., Chiu, C. C., Chen, L. T., Chang, J-Y., Hsiao, S. H. & Leu, Y. W., 2015 十月 13, 於 : Cancer Cell International. 15, 1, 98.

研究成果: Article

DNA Methylation
Drug Resistance
Uterine Cervical Neoplasms
Methylation
oxaliplatin
76 引文 (Scopus)

Characterization of camptothecin-resistant chinese hamster lung cells

Chang, J. Y., Dethlefsen, L. A., Barley, L. R., Zhou, B. S. & Cheng, Y. C., 1992 六月 9, 於 : Biochemical Pharmacology. 43, 11, p. 2443-2452 10 p.

研究成果: Article

Camptothecin
Cricetulus
Type I DNA Topoisomerase
Lung
Etoposide
30 引文 (Scopus)

Cholestane-3β, 5α, 6β-triol Suppresses Proliferation, Migration, and Invasion of Human Prostate Cancer Cells

Lin, C. Y., Huo, C., Kuo, L. K., Hiipakka, R. A., Jones, R. B., Lin, H. P., Hung, Y., Su, L. C., Tseng, J. C., Kuo, Y. Y., Wang, Y. L., Fukui, Y., Kao, Y. H., Kokontis, J. M., Yeh, C. C., Chen, L., Yang, S. D., Fu, H. H., Chen, Y. W., Tsai, K. K. C. 及其他2, Chang, J. Y. & Chuu, C. P., 2013 六月 13, 於 : PloS one. 8, 6, e65734.

研究成果: Article

prostatic neoplasms
Prostatic Neoplasms
Cells
cadherins
cells
3 引文 (Scopus)
Fanconi Anemia
Recombinational DNA Repair
Cisplatin
Fanconi Anemia Complementation Group D2 Protein
Genes
4 引文 (Scopus)

Combination chemoimmunotherapy with interferon-alpha and cisplatin in patients with advanced non-small cell lung cancer

Chao, T. Y., Hwang, W. S., Yang, M. J., Chang, J. Y., Wang, C. C., Hseuh, E. J., Huang, S. H. & Chen, W. C., 1995 一月 1, 於 : Chinese Medical Journal (Taipei). 56, 4, p. 232-238 7 p.

研究成果: Article

Interferon-alpha
Non-Small Cell Lung Carcinoma
Cisplatin
Squamous Cell Carcinoma
Adenocarcinoma
13 引文 (Scopus)

Combination of arsenic trioxide and BCNU synergistically triggers redox-mediated autophagic cell death in human solid tumors

Kuo, C. C., Wu, T., Chen, L. T., Shiah, H. S., Wu, C. M., Cheng, Y. T., Pan, W. Y., Liu, J. F., Chen, K. L., Yang, Y. N., Chen, S. N. & Chang, J. Y., 2011 十二月 15, 於 : Free Radical Biology and Medicine. 51, 12, p. 2195-2209 15 p.

研究成果: Article

Carmustine
Autophagy
Cell death
Oxidation-Reduction
Tumors
32 引文 (Scopus)

Combined modalities of resistance in an oxaliplatin-resistant human gastric cancer cell line with enhanced sensitivity to 5-fluorouracil

Chen, C. C., Chen, L. T., Tsou, T. C., Pan, W. Y., Kuo, C. C., Liu, J. F., Yeh, S. C., Tsai, F. Y., Hsieh, H. P. & Chang, J-Y., 2007 七月 31, 於 : British Journal of Cancer. 97, 3, p. 334-344 11 p.

研究成果: Article

oxaliplatin
Fluorouracil
Stomach Neoplasms
Cell Line
Thymidylate Synthase
19 引文 (Scopus)

Concise syntheses of N-aryl-5,6,7-trimethoxyindoles as antimitotic and vascular disrupting agents: Application of the copper-mediated Ullmann-type arylation

Lee, H. Y., Chang, J. Y., Chang, L. Y., Lai, W. Y., Lai, M. J., Shih, K. H., Kuo, C. C., Chang, C. Y. & Liou, J. P., 2011 五月 7, 於 : Organic and Biomolecular Chemistry. 9, 9, p. 3154-3157 4 p.

研究成果: Article

Tubulin Modulators
Antimitotic Agents
disrupting
Stilbenes
stilbene
161 引文 (Scopus)

Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents

Liou, J. P., Chang, Y. L., Kuo, F. M., Chang, C. W., Tseng, H. Y., Wang, C. C., Yang, Y. N., Chang, J. Y., Lee, S. J. & Hsieh, H. P., 2004 八月 12, 於 : Journal of Medicinal Chemistry. 47, 17, p. 4247-4257 11 p.

研究成果: Article

Structure-Activity Relationship
Stomach
Substitution reactions
Skeleton
Polymerization