傳染性疾病及訊息研究中心

研究成果 1989 2019

2015
18 引文 (Scopus)

Novel Nrf2/ARE Activator, trans-Coniferylaldehyde, Induces a HO-1-Mediated Defense Mechanism through a Dual p38α/MAPKAPK-2 and PK-N3 Signaling Pathway

Chen, H. H., Wang, T. C., Lee, Y. C., Shen, P. T., Chang, J-Y., Yeh, T. K., Huang, C. H., Chang, H. H., Cheng, S. Y., Lin, C. Y., Shih, C., Chen, C. T., Liu, W. M., Chen, C. H. & Kuo, C. C., 2015 八月 14, 於 : Chemical Research in Toxicology. 28, 9, p. 1681-1692 12 p.

研究成果: Article

Heme Oxygenase-1
Antioxidants
Edible Plants
Oxidative stress
p38 Mitogen-Activated Protein Kinases
11 引文 (Scopus)

Novel oxime-bearing coumarin derivatives act as potent Nrf2/ARE activators in vitro and in mouse model

Chang, K. M., Chen, H. H., Wang, T. C., Chen, I. L., Chen, Y. T., Yang, S. C., Chen, Y. L., Chang, H. H., Huang, C. H., Chang, J-Y., Shih, C., Kuo, C. C. & Tzeng, C. C., 2015 十二月 1, 於 : European Journal of Medicinal Chemistry. 106, p. 60-74 15 p.

研究成果: Article

Bearings (structural)
Coumarins
Oximes
Antioxidants
Luciferases
11 引文 (Scopus)

O6-methylguanine DNA methyltransferase repairs platinum-DNA adducts following cisplatin treatment and predicts prognoses of nasopharyngeal carcinoma

Chen, S. H., Kuo, C. C., Li, C. F., Cheung, C. H. A., Tsou, T. C., Chiang, H. C., Yang, Y. N., Chang, S. L., Lin, L. C., Pan, H. Y., Chang, K. Y. & Chang, J. Y., 2015 九月 1, 於 : International Journal of Cancer. 137, 6, p. 1291-1305 15 p.

研究成果: Article

Methyltransferases
Platinum
DNA Repair
DNA
Protein Methyltransferases
2013
11 引文 (Scopus)

Activation of PPAR-α induces cell cycle arrest and inhibits transforming growth factor-β1 induction of smooth muscle cell phenotype in 10T1/2 mesenchymal cells

Lien, S. C., Wei, S. Y., Chang, S. F., Chang, M. D. T., Chang, J. Y. & Chiu, J. J., 2013 五月 1, 於 : Cellular Signalling. 25, 5, p. 1252-1263 12 p.

研究成果: Article

Peroxisome Proliferator-Activated Receptors
Transforming Growth Factors
Cell Cycle Checkpoints
Smooth Muscle Myocytes
Phenotype
14 引文 (Scopus)

Allergies and Risk of Head and Neck Cancer: An Original Study plus Meta-Analysis

Hsiao, J. R., Ou, C. Y., Lo, H. I., Huang, C. C., Lee, W. T., Huang, J. S., Chen, K. C., Wong, T. Y., Tsai, S. T., Yen, C. J., Wu, Y. H., Hsueh, W. T., Yang, M. W., Wu, S. Y., Chang, J. Y., Chang, K. Y., Lin, C. L., Wang, F. T., Wang, Y. H., Weng, Y. L. 及其他2, Yang, H. C. & Chang, J. S., 2013 二月 1, 於 : PloS one. 8, 2, e55138.

研究成果: Article

Allergies
Head and Neck Neoplasms
meta-analysis
hypersensitivity
Meta-Analysis
15 引文 (Scopus)

A Novel Synthetic Microtubule Inhibitor, MPT0B214 Exhibits Antitumor Activity in Human Tumor Cells through Mitochondria-Dependent Intrinsic Pathway

Chiang, N. J., Lin, C. I., Liou, J. P., Kuo, C. C., Chang, C. Y., Chen, L. T. & Chang, J. Y., 2013 三月 12, 於 : PloS one. 8, 3, e58953.

研究成果: Article

Mitochondria
tubulin
Human Activities
Microtubules
microtubules
36 引文 (Scopus)
cathepsin S
Xanthine Oxidase
Autophagy
Cell death
DNA Damage
33 引文 (Scopus)

Caffeic acid phenethyl ester suppresses proliferation and survival of TW2.6 human oral cancer cells via inhibition of akt signaling

Kuo, Y. Y., Lin, H. P., Huo, C., Su, L. C., Yang, J., Hsiao, P. H., Chiang, H. C., Chung, C. J., Wang, H. D., Chang, J. Y., Chen, Y. W. & Chuu, C. P., 2013 五月, 於 : International journal of molecular sciences. 14, 5, p. 8801-8817 17 p.

研究成果: Article

Mouth Neoplasms
esters
Esters
cancer
Cells
30 引文 (Scopus)

Cholestane-3β, 5α, 6β-triol Suppresses Proliferation, Migration, and Invasion of Human Prostate Cancer Cells

Lin, C. Y., Huo, C., Kuo, L. K., Hiipakka, R. A., Jones, R. B., Lin, H. P., Hung, Y., Su, L. C., Tseng, J. C., Kuo, Y. Y., Wang, Y. L., Fukui, Y., Kao, Y. H., Kokontis, J. M., Yeh, C. C., Chen, L., Yang, S. D., Fu, H. H., Chen, Y. W., Tsai, K. K. C. 及其他2, Chang, J. Y. & Chuu, C. P., 2013 六月 13, 於 : PloS one. 8, 6, e65734.

研究成果: Article

prostatic neoplasms
Prostatic Neoplasms
Cells
cadherins
cells
16 引文 (Scopus)

Dissecting the EGFR-PI3K-AKT pathway in oral cancer highlights the role of the EGFR variant III and its clinical relevance

Chang, K. Y., Tsai, S. Y., Chen, S. H., Tsou, H. H., Yen, C. J., Liu, K. J., Fang, H. L., Wu, H. C., Chuang, B. F., Chou, S. W., Tang, C. K., Liu, S. Y., Lu, P. J., Yen, C. Y. & Chang, J. Y., 2013 七月 2, 於 : Journal of biomedical science. 20, 1, 43.

研究成果: Article

1-Phosphatidylinositol 4-Kinase
Mouth Neoplasms
Phosphatidylinositols
Epidermal Growth Factor Receptor
Phosphotransferases
37 引文 (Scopus)

Epigenetic regulation of the X-linked tumour suppressors BEX1 and LDOC1 in oral squamous cell carcinoma

Lee, C. H., Wong, T. S., Chan, J. Y. W., Lu, S. C., Lin, P., Cheng, A. J., Chen, Y. J., Chang, J. S. M., Hsiao, S. H., Leu, Y. W., Li, C. I., Hsiao, J-R. & Chang, J-Y., 2013 七月 1, 於 : Journal of Pathology. 230, 3, p. 298-309 12 p.

研究成果: Article

Epigenomics
Squamous Cell Carcinoma
Neoplasms
Methylation
High-Throughput Screening Assays
32 引文 (Scopus)

Microtubule-associated histone deacetylase 6 supports the calcium store sensor STIM1 in mediating malignant cell behaviors

Chen, Y. T., Chen, Y. F., Chiu, W. T., Liu, K. Y., Liu, Y. L., Chang, J. Y., Chang, H. C. & Shen, M. R., 2013 七月 15, 於 : Cancer Research. 73, 14, p. 4500-4509 10 p.

研究成果: Article

Histone Deacetylases
Microtubules
Calcium
Uterine Cervical Neoplasms
Epithelial Cells
21 引文 (Scopus)

MPT0B098, a novel microtubule inhibitor that destabilizes the hypoxia-inducible factor-1α mRNA through decreasing nuclear-cytoplasmic translocation of RNA-binding protein HuR

Cheng, Y. C., Liou, J. P., Kuo, C. C., Lai, W. Y., Shih, K. H., Chang, C. Y., Pan, W. Y., Tseng, T-C. & Chang, J-Y., 2013 七月 1, 於 : Molecular Cancer Therapeutics. 12, 7, p. 1202-1212 11 p.

研究成果: Article

Hypoxia-Inducible Factor 1
RNA-Binding Proteins
Microtubules
Messenger RNA
Sulfonamides
43 引文 (Scopus)

Randomised clinical trial: Comparison of two everolimus dosing schedules in patients with advanced hepatocellular carcinoma

Shiah, H. S., Chen, C. Y., Dai, C. Y., Hsiao, C. F., Lin, Y. J., Su, W. C., Chang, J. Y., Whang-Peng, J., Lin, P. W., Huang, J. D. & Chen, L. T., 2013 一月 1, 於 : Alimentary Pharmacology and Therapeutics. 37, 1, p. 62-73 12 p.

研究成果: Article

Hepatocellular Carcinoma
Appointments and Schedules
Randomized Controlled Trials
Hepatitis B Surface Antigens
Alanine Transaminase
2012
4 引文 (Scopus)

Application of Suzuki arylation, Sonogashira ethynylation and Rosenmund-von Braun cyanation in the exploration of substitution effects on the anticancer activity of 2-aroylquinolines

Lee, H. Y., Lee, L. W., Nien, C. Y., Kuo, C. C., Lin, P. Y., Chang, C. Y., Chang, J. Y. & Liou, J. P., 2012 一月 1, 於 : Organic and Biomolecular Chemistry. 10, 48, p. 9593-9600 8 p.

研究成果: Article

colchicine
Colchicine
Tubulin
Substitution reactions
substitutes
14 引文 (Scopus)

Arginine deprivation as a new treatment strategy for head and neck cancer

Huang, C-C., Tsai, S-T., Kuo, C. C., Chang, J. S., Jin, Y. T., Chang, J-Y. & Hsiao, J-R., 2012 十二月 1, 於 : Oral Oncology. 48, 12, p. 1227-1235 9 p.

研究成果: Article

Argininosuccinate Synthase
Head and Neck Neoplasms
Arginine
Squamous Cell Carcinoma
Therapeutics
7 引文 (Scopus)

Differences in the frequencies of K-ras c12-13 genotypes by gender and pathologic phenotypes in colorectal tumors measured using the allele discrimination method

Chow, L., Lin, P-C., Chang, J. S., Chu, P. Y., Lee, P. K., Chen, S. N., Cheng, Y. M., Lee, J-C., Chang, J-Y. & Liu, T. W., 2012 一月 1, 於 : Environmental and Molecular Mutagenesis. 53, 1, p. 22-31 10 p.

研究成果: Article

Colorectal Neoplasms
Alleles
Genotype
Phenotype
Mutation
13 引文 (Scopus)

Modulation of chemotactic and pro-inflammatory activities of endothelial progenitor cells by hepatocellular carcinoma

Shih, Y. T., Wang, M. C., Peng, H. H., Chen, T. F., Chen, L., Chang, J-Y. & Chiu, J. J., 2012 三月 1, 於 : Cellular Signalling. 24, 3, p. 779-793 15 p.

研究成果: Article

Hepatocellular Carcinoma
CCR6 Receptors
Endothelial Cells
Stem Cells
Chemotaxis
10 引文 (Scopus)

Targeted Casp8AP2 methylation increases drug resistance in mesenchymal stem cells and cancer cells

Lee, K. D., Pai, M. Y., Hsu, C. C., Chen, C. C., Chen, Y. L., Chu, P. Y., Lee, C. H., Chen, L. T., Chang, J-Y., Huang, T. H. M., Hsiao, S. H. & Leu, Y. W., 2012 六月 15, 於 : Biochemical and Biophysical Research Communications. 422, 4, p. 578-585 8 p.

研究成果: Article

Methylation
Stem cells
Mesenchymal Stromal Cells
Drug Resistance
Cells
42 引文 (Scopus)

Targeting cathepsin S induces tumor cell autophagy via the EGFR-ERK signaling pathway

Chen, K. L., Chang, W. S. W., Cheung, C-H., Lin, C. C., Huang, C. C., Yang, Y. N., Kuo, C. P., Kuo, C. C., Chang, Y. H., Liu, K. J., Wu, C. M. & Chang, J-Y., 2012 四月 1, 於 : Cancer Letters. 317, 1, p. 89-98 10 p.

研究成果: Article

cathepsin S
MAP Kinase Signaling System
Autophagy
Neoplasms
Apoptosis
2011
12 引文 (Scopus)

2-Amino-3,4,5-Trimethoxybenzophenones as Potent Tubulin Polymerization Inhibitors

Chuang, H. Y., Chang, J-Y., Lai, M. J., Kuo, C. C., Lee, H. Y., Hsieh, H. P., Chen, Y. J., Chen, L. T., Pan, W. Y. & Liou, J. P., 2011 三月 7, 於 : ChemMedChem. 6, 3, p. 450-456 7 p.

研究成果: Article

Tubulin Modulators
Inhibitory Concentration 50
Cells
Lead compounds
Colchicine
42 引文 (Scopus)

5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. Part 2. The impact of bridging groups at position C-2

Lee, H. Y., Chang, J. Y., Nien, C. Y., Kuo, C. C., Shih, K. H., Wu, C. H., Chang, C. Y., Lai, W. Y. & Liou, J. P., 2011 十二月 22, 於 : Journal of Medicinal Chemistry. 54, 24, p. 8517-8525 9 p.

研究成果: Article

Tubulin Modulators
Sulfones
Sulfides
HT29 Cells
Tubulin
34 引文 (Scopus)

Antimutagenic constituents of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) with potential cancer chemopreventive activity

Chen, H. H., Chiang, W., Chang, J. Y., Chien, Y. L., Lee, C. K., Liu, K. J., Cheng, Y. T., Chen, T. F., Kuo, Y. H. & Kuo, C. C., 2011 六月 22, 於 : Journal of Agricultural and Food Chemistry. 59, 12, p. 6444-6452 9 p.

研究成果: Article

Coix
Coix lacryma-jobi
antimutagenic activity
hulls
neoplasms
34 引文 (Scopus)

Aurora kinase inhibitor patents and agents in clinical testing: An update (2009 - 10)

Cheung, C-H., Coumar, M. S., Chang, J-Y. & Hsieh, H. P., 2011 六月 1, 於 : Expert Opinion on Therapeutic Patents. 21, 6, p. 857-884 28 p.

研究成果: Review article

Aurora Kinases
Patents
Neoplasms
Cell Cycle
Databases
8 引文 (Scopus)

BPR0C261 is a novel orally active antitumor agent with antimitotic and anti-angiogenic activities

Hu, C. B., Chen, C. P., Yeh, T. K., Song, J. S., Chang, C. Y., Chuu, J. J., Tung, F. F., Ho, P. Y., Chen, T. W., Lin, C. H., Wang, M. H., Chang, K. Y., Huang, C. L., Lin, H. L., Li, W. T., Hwang, D. R., Chern, J. H., Hwang, L. L., Chang, J. Y., Chao, Y. S. 及其他1, Chen, C. T., 2011 一月 1, 於 : Cancer Science. 102, 1, p. 182-191 10 p.

研究成果: Article

Antimitotic Agents
Antineoplastic Agents
Neoplasms
Tubulin
Nude Mice
13 引文 (Scopus)

BPR1K653, a novel aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells

Cheung, C. H. A., Lin, W. H., HsuJohn, J. T. A., Hour, T. C., Yeh, T. K., Ko, S., Lien, T. W., Coumar, M. S., Liu, J. F., Lai, W. Y., Shiao, H. Y., Lee, T. R., Hsieh, H. P. & Chang, J. Y., 2011 八月 24, 於 : PloS one. 6, 8, e23485.

研究成果: Article

Aurora Kinases
phosphotransferases (kinases)
Cells
neoplasms
Neoplasms
13 引文 (Scopus)

Combination of arsenic trioxide and BCNU synergistically triggers redox-mediated autophagic cell death in human solid tumors

Kuo, C. C., Wu, T., Chen, L. T., Shiah, H. S., Wu, C. M., Cheng, Y. T., Pan, W. Y., Liu, J. F., Chen, K. L., Yang, Y. N., Chen, S. N. & Chang, J. Y., 2011 十二月 15, 於 : Free Radical Biology and Medicine. 51, 12, p. 2195-2209 15 p.

研究成果: Article

Carmustine
Autophagy
Cell death
Oxidation-Reduction
Tumors
19 引文 (Scopus)

Concise syntheses of N-aryl-5,6,7-trimethoxyindoles as antimitotic and vascular disrupting agents: Application of the copper-mediated Ullmann-type arylation

Lee, H. Y., Chang, J. Y., Chang, L. Y., Lai, W. Y., Lai, M. J., Shih, K. H., Kuo, C. C., Chang, C. Y. & Liou, J. P., 2011 五月 7, 於 : Organic and Biomolecular Chemistry. 9, 9, p. 3154-3157 4 p.

研究成果: Article

Tubulin Modulators
Antimitotic Agents
disrupting
Stilbenes
stilbene
5 引文 (Scopus)

Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036

Yang, Y. N., Chou, K. M., Pan, W. Y., Chen, Y. W., Tsou, T. C., Yeh, S. C., Cheung, C-H., Chen, L. T. & Chang, J-Y., 2011 十月 1, 於 : Cancer Letters. 309, 1, p. 110-118 9 p.

研究成果: Article

DNA Repair
Drug Resistance
DNA
KB Cells
Neoplasms
17 引文 (Scopus)

Identification of salt-inducible kinase 3 as a novel tumor antigen associated with tumorigenesis of ovarian cancer

Charoenfuprasert, S., Yang, Y. Y., Lee, Y. C., Chao, K. C., Chu, P. Y., Lai, C. R., Hsu, K. F., Chang, K. C., Chen, Y. C., Chen, L. T., Chang, J. Y., Leu, S. J. & Shih, N. Y., 2011 八月 18, 於 : Oncogene. 30, 33, p. 3570-3584 15 p.

研究成果: Article

Neoplasm Antigens
Ovarian Neoplasms
Carcinogenesis
Phosphotransferases
Salts
13 引文 (Scopus)

Induction chemotherapy with gemcitabine, oxaliplatin, and 5-fluorouracil/leucovorin followed by concomitant chemoradiotherapy in patients with locally advanced pancreatic cancer: A Taiwan cooperative oncology group phase II study

Ch'Ang, H. J., Lin, Y. L., Wang, H. P., Chiu, Y. F., Chang, M. C., Hsu, C. H., Tien, Y. W., Chen, J. S., Hsieh, R. K., Lin, P. W., Shan, Y-S., Cheng, A. L., Chang, J-Y., Whang-Peng, J., Hwang, T. L. & Chen, L. T., 2011 十二月 1, 於 : International Journal of Radiation Oncology Biology Physics. 81, 5

研究成果: Article

oxaliplatin
gemcitabine
Induction Chemotherapy
Leucovorin
Taiwan
46 引文 (Scopus)

Investigations of survivin: The past, present and future

Cheung, C. H. A., Cheng, L. T., Chang, K. Y., Chen, H. H. & Chang, J. Y., 2011 一月 1, 於 : Frontiers in Bioscience. 16, 3, p. 952-961 10 p.

研究成果: Article

Cells
Neoplasms
Aurora Kinase B
Oncology
Chemotherapy
3 引文 (Scopus)

Labdanecaryophyllic acid, a novel cytotoxic C35 terpenoid from Calocedrus macrolepis var. formosana

Hsien, C. L., Tseng, M. H., Pan, R. N., Chang, J. Y., Kuo, C. C., Lee, T. H. & Kuo, Y. H., 2011 一月 26, 於 : Tetrahedron Letters. 52, 4, p. 515-517 3 p.

研究成果: Article

Cupressaceae
KB Cells
Sesquiterpenes
Diterpenes
Terpenes
76 引文 (Scopus)
1-Phosphatidylinositol 4-Kinase
Head and Neck Neoplasms
Human Activities
Growth
Autophagy
3 引文 (Scopus)

Novel terpenoids from Calocedrus macrolepis var. formosana

Hsieh, C. L., Tseng, M. H., Pan, R. N., Chang, J. Y., Kuo, C. C., Lee, T. H. & Kuo, Y. H., 2011 十月 1, 於 : Chemistry and Biodiversity. 8, 10, p. 1901-1907 7 p.

研究成果: Article

Cupressaceae
KB Cells
Diterpenes
Terpenes
Bioactivity
56 引文 (Scopus)

Scaffold-hopping strategy: Synthesis and biological evaluation of 5,6-fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents

Tung, Y. S., Coumar, M. S., Wu, Y. S., Shiao, H. Y., Chang, J-Y., Liou, J. P., Shukla, P., Chang, C. W., Chang, C. Y., Kuo, C. C., Yeh, T. K., Lin, C. Y., Wu, J. S., Wu, S. Y., Liao, C. C. & Hsieh, H. P., 2011 四月 28, 於 : Journal of Medicinal Chemistry. 54, 8, p. 3076-3080 5 p.

研究成果: Article

Antineoplastic Agents
Nitrogen
Drug Design
Biological Availability
Pharmaceutical Preparations
26 引文 (Scopus)

Synthesis and biological evaluation of 1-(4′-Indolyl and 6′-Quinolinyl) indoles as a new class of potent anticancer agents

Lai, M. J., Chang, J-Y., Lee, H. Y., Kuo, C. C., Lin, M. H., Hsieh, H. P., Chang, C. Y., Wu, J. S., Wu, S. Y., Shey, K. S. & Liou, J. P., 2011 九月 1, 於 : European Journal of Medicinal Chemistry. 46, 9, p. 3623-3629 7 p.

研究成果: Article

Indoles
Colchicine
Antineoplastic Agents
Multiple Drug Resistance
Tubulin
2 引文 (Scopus)

Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents

Hsieh, C. C., Lee, H. Y., Nien, C. Y., Kuo, C. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., 2011 三月 1, 於 : Molecules. 16, 3, p. 2274-2284 11 p.

研究成果: Article

cultured cells
Antineoplastic Agents
cancer
Cells
Cell Line
2010
63 引文 (Scopus)

5-Amino-2-Aroylquinolines as highly potent tubulin polymerization inhibitors

Nien, C. Y., Chen, Y. C., Kuo, C. C., Hsieh, H. P., Chang, C. Y., Wu, J. S., Wu, S. Y., Liou, J. P. & Chang, J-Y., 2010 三月 11, 於 : Journal of Medicinal Chemistry. 53, 5, p. 2309-2313 5 p.

研究成果: Article

Tubulin Modulators
Inhibitory Concentration 50
Cell Line
Colchicine
Tubulin
11 引文 (Scopus)

Antitumor activities and pharmacokinetics of silatecans DB-67 and DB-91

Yeh, T. K., Li, C. M., Chen, C. P., Chuu, J. J., Huang, C. L., Wang, H. S., Shen, C. C., Lee, T. Y., Chang, C. Y., Chang, C. M., Chao, Y. S., Lin, C. T., Chang, J. Y. & Chen, C. T., 2010 二月 1, 於 : Pharmacological Research. 61, 2, p. 108-115 8 p.

研究成果: Article

Pharmacokinetics
Camptothecin
Lactones
Topoisomerase I Inhibitors
Neoplasms
21 引文 (Scopus)

Arecoline arrests cells at prometaphase by deregulating mitotic spindle assembly and spindle assembly checkpoint: Implication for carcinogenesis

Wang, Y. C., Tsai, Y. S., Huang, J. L., Lee, K. W., Kuo, C. C., Wang, C. S., Huang, A. M., Chang, J. Y., Jong, Y. J. & Lin, C. S., 2010 四月 1, 於 : Oral Oncology. 46, 4, p. 255-262 8 p.

研究成果: Article

Arecoline
Prometaphase
M Phase Cell Cycle Checkpoints
Spindle Apparatus
Carcinogenesis
28 引文 (Scopus)

Cancer cells acquire mitotic drug resistance properties through beta i-tubulin mutations and alterations in the expression of beta-tubulin isotypes

Cheung, C. H. A., Wu, S. Y., Lee, T. R., Chang, C. Y., Wu, J. S., Hsieh, H. P. & Chang, J. Y., 2010 十一月 1, 於 : PloS one. 5, 9, p. 1-11 11 p., e12564.

研究成果: Article

drug resistance
Tubulin
tubulin
Drug Resistance
Microtubules
24 引文 (Scopus)

Chamaecypanone C, a novel skeleton microtubule inhibitor, with anticancer activity by trigger caspase 8-Fas/FasL dependent apoptotic pathway in human cancer cells

Hsieh, C. C., Kuo, Y. H., Kuo, C. C., Chen, L. T., Cheung, C-H., Chao, T. Y., Lin, C. H., Pan, W. Y., Chang, C. Y., Chien, S. C., Chen, T. W., Lung, C. C. & Chang, J-Y., 2010 五月 1, 於 : Biochemical Pharmacology. 79, 9, p. 1261-1271 11 p.

研究成果: Article

Caspase 8
Skeleton
Microtubules
Cells
Neoplasms
19 引文 (Scopus)

Cytotoxic C35 terpenoid cryptotrione from the bark of cryptomeria japonica

Chen, C. C., Wu, J. H., Yang, N. S., Chang, J. Y., Kuo, C. C., Wang, S. Y. & Kuo, Y. H., 2010 六月 18, 於 : Organic Letters. 12, 12, p. 2786-2789 4 p.

研究成果: Article

Cryptomeria
Sesquiterpenes
Terpenes
musculoskeletal system
Skeleton
30 引文 (Scopus)

Design and synthesis of α-ketoamides as cathepsin s inhibitors with potential applications against tumor invasion and angiogenesis

Chen, J. C., Uang, B. J., Lyu, P. C., Chang, J. Y., Liu, K. J., Kuo, C. C., Hsieh, H. P., Wang, H. C., Cheng, C. S., Chang, Y. H., Chang, M. D. T., Chang, W. S. W. & Lin, C. C., 2010 六月 10, 於 : Journal of Medicinal Chemistry. 53, 11, p. 4545-4549 5 p.

研究成果: Article

cathepsin S
Cathepsins
Neoplasms
Inhibitory Concentration 50
Cell Movement
17 引文 (Scopus)

MBP-1 is efficiently encoded by an alternative transcript of the ENO1 gene but post-translationally regulated by proteasome-dependent protein turnover

Lung, J., Liu, K. J., Chang, J-Y., Leu, S. J. & Shih, N. Y., 2010 一月 1, 於 : FEBS Journal. 277, 20, p. 4308-4321 14 p.

研究成果: Article

Proteasome Endopeptidase Complex
Carrier Proteins
Genes
Proteins
Cell Fractionation
6 引文 (Scopus)
Carboplatin
Paclitaxel
Gastrointestinal Tract
Carcinoma
Omentum
69 引文 (Scopus)

Recent advances in anti-survivin treatments for cancer

Kanwar, R. K., Cheung, C-H., Chang, J-Y. & Kanwar, J. R., 2010 六月 18, 於 : Current Medicinal Chemistry. 17, 15, p. 1509-1515 7 p.

研究成果: Article

Cells
Tumors
Apoptosis
Neoplasms
Chemotherapy
19 引文 (Scopus)

Synthesis and biological evaluation of 7-arylindoline-1-benzenesulfonamides as a novel class of potent anticancer agents

Chang, J. Y., Lai, M. J., Chang, Y. T., Lee, H. Y., Cheng, Y. C., Kuo, C. C., Su, M. C., Chang, C. Y. & Liou, J. P., 2010 八月 1, 於 : MedChemComm. 1, 2, p. 152-155 4 p.

研究成果: Article

Tubulin
Antineoplastic Agents
Inhibitory Concentration 50
Colchicine
Binding Sites