傳染性疾病及訊息研究中心

研究成果

2006

2-Amino and 2′-aminocombretastatin derivatives as potent antimitotic agents

Chang, J. Y., Yang, M. F., Chang, C. Y., Chen, C. M., Kuo, C. C. & Liou, J. P., 2006 十月 1, 於 : Journal of Medicinal Chemistry. 49, 21, p. 6412-6415 4 p.

研究成果: Article

43 引文 斯高帕斯(Scopus)

7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents

Chang, J. Y., Hsieh, H. P., Chang, C. Y., Hsu, K. S., Chiang, Y. F., Chen, C. M., Kuo, C. C. & Liou, J. P., 2006 十一月 16, 於 : Journal of Medicinal Chemistry. 49, 23, p. 6656-6659 4 p.

研究成果: Article

61 引文 斯高帕斯(Scopus)

Antitubulin agents for the treatment of cancer - A medicinal chemistry update

Mahindroo, N., Liou, J. P., Chang, J. Y. & Hsieh, H. P., 2006 五月 1, 於 : Expert Opinion on Therapeutic Patents. 16, 5, p. 647-691 45 p.

研究成果: Review article

65 引文 斯高帕斯(Scopus)

C 35 terpenoids from the bark of Calocedrus macrolepis var. formosana with activity against human cancer cell lines

Hsieh, C. L., Tseng, M. H., Shao, Y. Y., Chang, J-Y., Kuo, C. C., Chang, C. Y. & Kuo, Y. H., 2006 十一月 1, 於 : Journal of Natural Products. 69, 11, p. 1611-1613 3 p.

研究成果: Article

14 引文 斯高帕斯(Scopus)
22 引文 斯高帕斯(Scopus)

In vitro and in vivo studies of a novel potential anticancer agent of isochaihulactone on human lung cancer A549 cells

Chen, Y. L., Lin, S. Z., Chang, J. Y., Cheng, Y. L., Tsai, N. M., Chen, S. P., Chang, W. L. & Harn, H. J., 2006 七月 28, 於 : Biochemical Pharmacology. 72, 3, p. 308-319 12 p.

研究成果: Article

70 引文 斯高帕斯(Scopus)

Phase I and pharmacokinetic study of oral thalidomide in patients with advanced hepatocellular carcinoma

Shiah, H. S., Chao, Y., Chen, L. T., Yao, T. J., Huang, J. D., Chang, J. Y., Chen, P. J., Chuang, T. R., Chin, Y. H., Whang-Peng, J. & Liu, T. W., 2006 十一月, 於 : Cancer Chemotherapy and Pharmacology. 58, 5, p. 654-664 11 p.

研究成果: Article

11 引文 斯高帕斯(Scopus)

Phase I-II trial of weekly gemcitabine plus high-dose 5-fluorouracil and leucovorin in advanced pancreatic cancer

Shiah, H. S., Cheng, A. L., Hsu, C., Hsu, C. H., Liu, T. W., Chang, J. Y., Jan, C. M., Chao, Y., Yu, W. L., Chuang, T. R., Whang-Peng, J. & Chen, L. T., 2006 三月, 於 : Journal of Gastroenterology and Hepatology (Australia). 21, 3, p. 531-536 6 p.

研究成果: Article

5 引文 斯高帕斯(Scopus)

Phase II study of gemcitabine plus vinorelbine in the treatment of cisplatin-resistant nasopharyngeal carcinoma

Wang, C. C., Chang, J. Y., Liu, T. W., Lin, C. Y., Yu, Y. C. & Hong, R. L., 2006 一月 1, 於 : Head and Neck. 28, 1, p. 74-80 7 p.

研究成果: Article

42 引文 斯高帕斯(Scopus)

Phase I study of biweekly gemcitabine followed by oxaliplatin and simplified 48-h infusion of fluorouracil/leucovorin for advanced pancreatic cancer

Ch'ang, H. J., Wang, C. C., Cheng, A. L., Hsu, C., Lu, Y. S., Chang, M. C., Lin, J. T., Wang, H. P., Shiah, H. S., Liu, T. W., Chang, J-Y., Whang-Peng, J. & Chen, L. T., 2006 一月 1, 於 : Journal of Gastroenterology and Hepatology (Australia). 21, 5, p. 874-879 6 p.

研究成果: Article

5 引文 斯高帕斯(Scopus)

Statistical quality control process for traditional Chinese medicine

Tse, S. K., Chang, J. Y., Su, W. L., Chow, S. C., Hsiung, C. & Lu, Q., 2006 十二月 1, 於 : Journal of Biopharmaceutical Statistics. 16, 6, p. 861-874 14 p.

研究成果: Article

16 引文 斯高帕斯(Scopus)

Structure-activity relationship studies of 3-aroylindoles as potent antimitotic agents

Liou, J. P., Mahindroo, N., Chang, C. W., Guo, F. M., Lee, S. W. H., Tan, U. K., Yeh, T. K., Kuo, C. C., Chang, Y. W., Lu, P. H., Tung, Y. S., Lin, K. T., Chang, J-Y. & Hsieh, H. P., 2006 十月 1, 於 : ChemMedChem. 1, 10, p. 1106-1118 13 p.

研究成果: Article

37 引文 斯高帕斯(Scopus)

Synthesis of new camptothecin analogues with the E-lactone ring replaced by α,β-cyclohexenone

Bacherikov, V. A., Tsai, T. J., Chang, J-Y., Chou, T. C., Lee, R. Z. & Su, T. L., 2006 九月 25, 於 : European Journal of Organic Chemistry. 19, p. 4490-4499 10 p.

研究成果: Article

7 引文 斯高帕斯(Scopus)
2007

4- And 5-aroylindoles as novel classes of potent antitubulin agents

Liou, J. P., Wu, C. Y., Hsieh, H. P., Chang, C. Y., Chen, C. M., Kuo, C. C. & Chang, J. Y., 2007 九月 6, 於 : Journal of Medicinal Chemistry. 50, 18, p. 4548-4552 5 p.

研究成果: Article

57 引文 斯高帕斯(Scopus)
58 引文 斯高帕斯(Scopus)

Combined modalities of resistance in an oxaliplatin-resistant human gastric cancer cell line with enhanced sensitivity to 5-fluorouracil

Chen, C. C., Chen, L. T., Tsou, T. C., Pan, W. Y., Kuo, C. C., Liu, J. F., Yeh, S. C., Tsai, F. Y., Hsieh, H. P. & Chang, J-Y., 2007 七月 31, 於 : British Journal of Cancer. 97, 3, p. 334-344 11 p.

研究成果: Article

33 引文 斯高帕斯(Scopus)

Cytotoxic and novel skeleton compounds from the heartwood of Chamaecyparis obtusa var. formosana

Chien, S. C., Chang, J. Y., Kuo, C. C., Hsieh, C. C., Yang, N. S. & Kuo, Y. H., 2007 二月 26, 於 : Tetrahedron Letters. 48, 9, p. 1567-1569 3 p.

研究成果: Article

26 引文 斯高帕斯(Scopus)

D-501036, a novel selenophene-based triheterocycle derivative, exhibits potent in vitro and in vivo antitumoral activity which involves DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation

Juang, S. H., Lung, C. C., Hsu, P. C., Hsu, K. S., Li, Y. C., Hong, P. C., Shiah, H. S., Kuo, C. C., Huang, C. W., Wang, Y. C., Huang, L., Chen, T. S., Chen, S. F., Fu, K. C., Hsu, C. L., Lin, M. J., Chang, C. J., Ashendel, C. L., Chan, T. C. K., Chou, K. M. 及其他1, Chang, J. C., 2007 一月 1, 於 : Molecular Cancer Therapeutics. 6, 1, p. 193-202 10 p.

研究成果: Article

42 引文 斯高帕斯(Scopus)

Human tissue kallikreins as prognostic biomarkers and as potential targets for anticancer therapy

Chang, W. S. W., Chou, R. H., Wu, C. W. & Chang, J. Y., 2007 十月 1, 於 : Expert Opinion on Therapeutic Patents. 17, 10, p. 1227-1240 14 p.

研究成果: Review article

1 引文 斯高帕斯(Scopus)

Mitochondria-mediated and p53-associated apoptosis induced in human cancer cells by a novel selenophene derivative, D-501036

Shiah, H. S., Lee, W. S., Juang, S. H., Hong, P. C., Lung, C. C., Chang, C. J., Chou, K. M. & Chang, J. Y., 2007 三月 1, 於 : Biochemical Pharmacology. 73, 5, p. 610-619 10 p.

研究成果: Article

48 引文 斯高帕斯(Scopus)

Tamoxifen accelerates proteasomal degradation of O6- methylguanine DNA methyltransferase in human cancer cells

Kuo, C. C., Liu, J. F., Shiah, H. S., Li-Chen, M. & Chang, J. Y., 2007 十一月 15, 於 : International Journal of Cancer. 121, 10, p. 2293-2300 8 p.

研究成果: Article

19 引文 斯高帕斯(Scopus)
2008

A novel peroxisome proliferator-activated receptor α/γ agonist, BPR1H0101, inhibits topoisomerase II catalytic activity in human cancer cells

Kao, Y. H., Hsieh, H. P., Chitlimalla, S. K., Pan, W. Y., Kuo, C. C., Tsai, Y. C., Lin, W. H., Chuang, S. E. & Chang, J. Y., 2008 二月 1, 於 : Anti-Cancer Drugs. 19, 2, p. 151-158 8 p.

研究成果: Article

6 引文 斯高帕斯(Scopus)

Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors

Liou, J. P., Wu, Z. Y., Kuo, C. C., Chang, C. Y., Lu, P. Y., Chen, C. M., Hsieh, H. P. & Chang, J. Y., 2008 七月 24, 於 : Journal of Medicinal Chemistry. 51, 14, p. 4351-4355 5 p.

研究成果: Article

59 引文 斯高帕斯(Scopus)

Human DNA polymerase η activity and translocation is regulated by phosphorylation

Chen, Y. W., Cleaver, J. E., Hatahet, Z., Honkanen, R. E., Chang, J. Y., Yen, Y. & Chou, K. M., 2008 十月 28, 於 : Proceedings of the National Academy of Sciences of the United States of America. 105, 43, p. 16578-16583 6 p.

研究成果: Article

47 引文 斯高帕斯(Scopus)

Modern staging and utility of PET imaging in esophageal cancer management

Chang, K. Y., Chang, J. Y., Chao, J. & Yen, Y., 2008 十月, 於 : JNCCN Journal of the National Comprehensive Cancer Network. 6, 9, p. 862-869 8 p.

研究成果: Article

2 引文 斯高帕斯(Scopus)

Synthesis and structure-activity relationships of 2-amino-1- aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents

Reddy, G. R., Kuo, C. C., Tan, U. K., Coumar, M. S., Chang, C. Y., Chiang, Y. K., Lai, M. J., Yeh, J. Y., Wu, S. Y., Chang, J-Y., Liou, J. P. & Hsieh, H. P., 2008 十二月 25, 於 : Journal of Medicinal Chemistry. 51, 24, p. 8163-8167 5 p.

研究成果: Article

24 引文 斯高帕斯(Scopus)
4 引文 斯高帕斯(Scopus)
2009

Advances in Aurora kinase inhibitor patents

Coumar, M. S., Cheung, C-H., Chang, J-Y. & Hsieh, H. P., 2009 三月 1, 於 : Expert Opinion on Therapeutic Patents. 19, 3, p. 321-356 36 p.

研究成果: Review article

22 引文 斯高帕斯(Scopus)

Alpha-fetoprotein response in advanced hepatocellular carcinoma receiving cytostatic agent

Chen, L. T., Shiah, H. S., Chao, Y., Chang, J. Y., Cheng, L. T. & Whang-Peng, J., 2009 十二月 20, 於 : Journal of Clinical Oncology. 27, 36, p. e271

研究成果: Letter

9 引文 斯高帕斯(Scopus)

Aurora kinase inhibitors in preclinical and clinical testing

Cheung, C. H. A., Coumar, M. S., Hsieh, H. P. & Chang, J. Y., 2009 四月 1, 於 : Expert Opinion on Investigational Drugs. 18, 4, p. 379-398 20 p.

研究成果: Review article

83 引文 斯高帕斯(Scopus)

Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity

Chiang, Y. K., Kuo, C. C., Wu, Y. S., Chen, C. T., Coumar, M. S., Wu, J. S., Hsieh, H. P., Chang, C. Y., Jseng, H. Y., Wu, M. H., Leou, J. S., Song, J. S., Chang, J. Y., Lyu, P. C., Chao, Y. S. & Wu, S. Y., 2009 七月 23, 於 : Journal of Medicinal Chemistry. 52, 14, p. 4221-4233 13 p.

研究成果: Article

48 引文 斯高帕斯(Scopus)
37 引文 斯高帕斯(Scopus)

Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers

Cheung, C. H. A., Chen, H. H., Kuo, C. C., Chang, C. Y., Coumar, M. S., Hsieh, H. P. & Chang, J. Y., 2009 七月 3, 於 : Molecular cancer. 8, 43.

研究成果: Article

55 引文 斯高帕斯(Scopus)

Synthesis and evaluation of 3-aroylindoles as anticancer agents: Metabolite approach

Wu, Y. S., Coumar, M. S., Chang, J. Y., Sun, H. Y., Kuo, F. M., Kuo, C. C., Chen, Y. J., Chang, C. Y., Hsiao, C. L., Liou, J. P., Chen, C. P., Yao, H. T., Chiang, Y. K., Tan, U. K., Chen, C. T., Chu, C. Y., Wu, S. Y., Yeh, T. K., Lin, C. Y. & Hsieh, H. P., 2009 八月 13, 於 : Journal of Medicinal Chemistry. 52, 15, p. 4941-4945 5 p.

研究成果: Article

76 引文 斯高帕斯(Scopus)

Synthesis and structure-activity relationships of 1-benzyl-4,5,6- trimethoxyindoles as a novel class of potent antimitotic agents

Lai, M. J., Kuo, C. C., Yeh, T. K., Hsieh, H. P., Chen, L. T., Pan, W. Y., Hsu, K. Y., Chang, J-Y. & Liou, J. P., 2009 四月 17, 於 : ChemMedChem. 4, 4, p. 588-593 6 p.

研究成果: Article

13 引文 斯高帕斯(Scopus)
2010

5-Amino-2-Aroylquinolines as highly potent tubulin polymerization inhibitors

Nien, C. Y., Chen, Y. C., Kuo, C. C., Hsieh, H. P., Chang, C. Y., Wu, J. S., Wu, S. Y., Liou, J. P. & Chang, J-Y., 2010 三月 11, 於 : Journal of Medicinal Chemistry. 53, 5, p. 2309-2313 5 p.

研究成果: Article

63 引文 斯高帕斯(Scopus)

Antitumor activities and pharmacokinetics of silatecans DB-67 and DB-91

Yeh, T. K., Li, C. M., Chen, C. P., Chuu, J. J., Huang, C. L., Wang, H. S., Shen, C. C., Lee, T. Y., Chang, C. Y., Chang, C. M., Chao, Y. S., Lin, C. T., Chang, J. Y. & Chen, C. T., 2010 二月 1, 於 : Pharmacological Research. 61, 2, p. 108-115 8 p.

研究成果: Article

11 引文 斯高帕斯(Scopus)

Arecoline arrests cells at prometaphase by deregulating mitotic spindle assembly and spindle assembly checkpoint: Implication for carcinogenesis

Wang, Y. C., Tsai, Y. S., Huang, J. L., Lee, K. W., Kuo, C. C., Wang, C. S., Huang, A. M., Chang, J. Y., Jong, Y. J. & Lin, C. S., 2010 四月 1, 於 : Oral Oncology. 46, 4, p. 255-262 8 p.

研究成果: Article

21 引文 斯高帕斯(Scopus)

Cancer cells acquire mitotic drug resistance properties through beta i-tubulin mutations and alterations in the expression of beta-tubulin isotypes

Cheung, C. H. A., Wu, S. Y., Lee, T. R., Chang, C. Y., Wu, J. S., Hsieh, H. P. & Chang, J. Y., 2010 十一月 1, 於 : PloS one. 5, 9, p. 1-11 11 p., e12564.

研究成果: Article

29 引文 斯高帕斯(Scopus)

Chamaecypanone C, a novel skeleton microtubule inhibitor, with anticancer activity by trigger caspase 8-Fas/FasL dependent apoptotic pathway in human cancer cells

Hsieh, C. C., Kuo, Y. H., Kuo, C. C., Chen, L. T., Cheung, C-H., Chao, T. Y., Lin, C. H., Pan, W. Y., Chang, C. Y., Chien, S. C., Chen, T. W., Lung, C. C. & Chang, J-Y., 2010 五月 1, 於 : Biochemical Pharmacology. 79, 9, p. 1261-1271 11 p.

研究成果: Article

24 引文 斯高帕斯(Scopus)

Cytotoxic C35 terpenoid cryptotrione from the bark of cryptomeria japonica

Chen, C. C., Wu, J. H., Yang, N. S., Chang, J. Y., Kuo, C. C., Wang, S. Y. & Kuo, Y. H., 2010 六月 18, 於 : Organic Letters. 12, 12, p. 2786-2789 4 p.

研究成果: Article

19 引文 斯高帕斯(Scopus)

Design and synthesis of α-ketoamides as cathepsin s inhibitors with potential applications against tumor invasion and angiogenesis

Chen, J. C., Uang, B. J., Lyu, P. C., Chang, J. Y., Liu, K. J., Kuo, C. C., Hsieh, H. P., Wang, H. C., Cheng, C. S., Chang, Y. H., Chang, M. D. T., Chang, W. S. W. & Lin, C. C., 2010 六月 10, 於 : Journal of Medicinal Chemistry. 53, 11, p. 4545-4549 5 p.

研究成果: Article

32 引文 斯高帕斯(Scopus)

MBP-1 is efficiently encoded by an alternative transcript of the ENO1 gene but post-translationally regulated by proteasome-dependent protein turnover

Lung, J., Liu, K. J., Chang, J-Y., Leu, S. J. & Shih, N. Y., 2010 一月 1, 於 : FEBS Journal. 277, 20, p. 4308-4321 14 p.

研究成果: Article

17 引文 斯高帕斯(Scopus)
6 引文 斯高帕斯(Scopus)

Recent advances in anti-survivin treatments for cancer

Kanwar, R. K., Cheung, C-H., Chang, J-Y. & Kanwar, J. R., 2010 六月 18, 於 : Current Medicinal Chemistry. 17, 15, p. 1509-1515 7 p.

研究成果: Article

69 引文 斯高帕斯(Scopus)

Synthesis and biological evaluation of 7-arylindoline-1-benzenesulfonamides as a novel class of potent anticancer agents

Chang, J. Y., Lai, M. J., Chang, Y. T., Lee, H. Y., Cheng, Y. C., Kuo, C. C., Su, M. C., Chang, C. Y. & Liou, J. P., 2010 八月 1, 於 : MedChemComm. 1, 2, p. 152-155 4 p.

研究成果: Article

19 引文 斯高帕斯(Scopus)
36 引文 斯高帕斯(Scopus)
2011

2-Amino-3,4,5-Trimethoxybenzophenones as Potent Tubulin Polymerization Inhibitors

Chuang, H. Y., Chang, J-Y., Lai, M. J., Kuo, C. C., Lee, H. Y., Hsieh, H. P., Chen, Y. J., Chen, L. T., Pan, W. Y. & Liou, J. P., 2011 三月 7, 於 : ChemMedChem. 6, 3, p. 450-456 7 p.

研究成果: Article

12 引文 斯高帕斯(Scopus)

5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. Part 2. The impact of bridging groups at position C-2

Lee, H. Y., Chang, J. Y., Nien, C. Y., Kuo, C. C., Shih, K. H., Wu, C. H., Chang, C. Y., Lai, W. Y. & Liou, J. P., 2011 十二月 22, 於 : Journal of Medicinal Chemistry. 54, 24, p. 8517-8525 9 p.

研究成果: Article

42 引文 斯高帕斯(Scopus)