傳染性疾病及訊息研究中心

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Article

Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents

Liou, J. P., Chang, Y. L., Kuo, F. M., Chang, C. W., Tseng, H. Y., Wang, C. C., Yang, Y. N., Chang, J. Y., Lee, S. J. & Hsieh, H. P., 2004 八月 12, 於 : Journal of Medicinal Chemistry. 47, 17, p. 4247-4257 11 p.

研究成果: Article

163 引文 斯高帕斯(Scopus)

Cytotoxic and novel skeleton compounds from the heartwood of Chamaecyparis obtusa var. formosana

Chien, S. C., Chang, J. Y., Kuo, C. C., Hsieh, C. C., Yang, N. S. & Kuo, Y. H., 2007 二月 26, 於 : Tetrahedron Letters. 48, 9, p. 1567-1569 3 p.

研究成果: Article

26 引文 斯高帕斯(Scopus)

Cytotoxic C35 terpenoid cryptotrione from the bark of cryptomeria japonica

Chen, C. C., Wu, J. H., Yang, N. S., Chang, J. Y., Kuo, C. C., Wang, S. Y. & Kuo, Y. H., 2010 六月 18, 於 : Organic Letters. 12, 12, p. 2786-2789 4 p.

研究成果: Article

19 引文 斯高帕斯(Scopus)

Cytotoxic triterpenes from the aerial roots of Ficus microcarpa

Chiang, Y. M., Chang, J-Y., Kuo, C. C., Chang, C. Y. & Kuo, Y. H., 2005 一月 1, 於 : Phytochemistry. 66, 4, p. 495-501 7 p.

研究成果: Article

109 引文 斯高帕斯(Scopus)

D-501036, a novel selenophene-based triheterocycle derivative, exhibits potent in vitro and in vivo antitumoral activity which involves DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation

Juang, S. H., Lung, C. C., Hsu, P. C., Hsu, K. S., Li, Y. C., Hong, P. C., Shiah, H. S., Kuo, C. C., Huang, C. W., Wang, Y. C., Huang, L., Chen, T. S., Chen, S. F., Fu, K. C., Hsu, C. L., Lin, M. J., Chang, C. J., Ashendel, C. L., Chan, T. C. K., Chou, K. M. 及其他1, Chang, J. C., 2007 一月 1, 於 : Molecular Cancer Therapeutics. 6, 1, p. 193-202 10 p.

研究成果: Article

42 引文 斯高帕斯(Scopus)
4 引文 斯高帕斯(Scopus)

Design and synthesis of α-ketoamides as cathepsin s inhibitors with potential applications against tumor invasion and angiogenesis

Chen, J. C., Uang, B. J., Lyu, P. C., Chang, J. Y., Liu, K. J., Kuo, C. C., Hsieh, H. P., Wang, H. C., Cheng, C. S., Chang, Y. H., Chang, M. D. T., Chang, W. S. W. & Lin, C. C., 2010 六月 10, 於 : Journal of Medicinal Chemistry. 53, 11, p. 4545-4549 5 p.

研究成果: Article

32 引文 斯高帕斯(Scopus)
4 引文 斯高帕斯(Scopus)

Differences in the frequencies of K-ras c12-13 genotypes by gender and pathologic phenotypes in colorectal tumors measured using the allele discrimination method

Chow, L., Lin, P-C., Chang, J. S., Chu, P. Y., Lee, P. K., Chen, S. N., Cheng, Y. M., Lee, J-C., Chang, J-Y. & Liu, T. W., 2012 一月 1, 於 : Environmental and Molecular Mutagenesis. 53, 1, p. 22-31 10 p.

研究成果: Article

7 引文 斯高帕斯(Scopus)

Differential expression of the human metastasis adhesion molecule CD44V in normal and carcinomatous stomach mucosa of chinese subjects

Harn, HJ. J., Ho, LI. I., Chang, JY. Y., Wu, CW. W., Jiang, SY. Y., Lee, HS. S. & Lee, WH. H., 1995 三月 1, 於 : Cancer. 75, 5, p. 1065-1071 7 p.

研究成果: Article

49 引文 斯高帕斯(Scopus)

Direct comparisons of peripheral T-cell lymphoma with diffuse B-cell lymphoma of comparable histological grades - Should peripheral T-cell lymphoma be considered separately?

Cheng, A. L., Chen, Y. C., Wang, C. H., Su, I. J., Hsieh, H. C., Chang, J. Y., Hwang, W. S., Su, W. C., Liu, T. W., Tien, H. F., Tsai, W., Shen, M. C. & Liu, C. H., 1989 一月 1, 於 : Journal of Clinical Oncology. 7, 6, p. 725-731 7 p.

研究成果: Article

66 引文 斯高帕斯(Scopus)

Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors

Liou, J. P., Wu, Z. Y., Kuo, C. C., Chang, C. Y., Lu, P. Y., Chen, C. M., Hsieh, H. P. & Chang, J. Y., 2008 七月 24, 於 : Journal of Medicinal Chemistry. 51, 14, p. 4351-4355 5 p.

研究成果: Article

59 引文 斯高帕斯(Scopus)

Dissecting the EGFR-PI3K-AKT pathway in oral cancer highlights the role of the EGFR variant III and its clinical relevance

Chang, K. Y., Tsai, S. Y., Chen, S. H., Tsou, H. H., Yen, C. J., Liu, K. J., Fang, H. L., Wu, H. C., Chuang, B. F., Chou, S. W., Tang, C. K., Liu, S. Y., Lu, P. J., Yen, C. Y. & Chang, J. Y., 2013 七月 2, 於 : Journal of biomedical science. 20, 1, 43.

研究成果: Article

16 引文 斯高帕斯(Scopus)
22 引文 斯高帕斯(Scopus)

Down regulation of bcl-2 by p53 in nasopharyngeal carcinoma and lack of detection of its specific t(14;18) chromosomal translocation in fixed tissues

Harn, H. J., Ho, L. I., Liu, C. A., Liu, G. C., Lin, F. G., Lin, J. J., Chang, J. Y. & Lee, W. H., 1996 一月 1, 於 : Histopathology. 28, 4, p. 317-323 7 p.

研究成果: Article

42 引文 斯高帕斯(Scopus)

Dual inhibition of topoisomerase I and tubulin polymerization by BPR0Y007, a novel cytotoxic agent

Chang, J-Y., Hsieh, H. P., Pan, W. Y., Liou, J. P., Bey, S. J., Chen, L. T., Liu, J. F. & Song, J. S., 2003 六月 15, 於 : Biochemical Pharmacology. 65, 12, p. 2009-2019 11 p.

研究成果: Article

20 引文 斯高帕斯(Scopus)

Dysregulation of RUNX2/activin-A axis upon miR-376c downregulation promotes lymph node metastasis in head and neck squamous cell carcinoma

Chang, W. M., Lin, Y. F., Su, C. Y., Peng, H. Y., Chang, Y. C., Lai, T. C., Wu, G. H., Hsu, Y. M., Chi, L. H., Hsiao, J. R., Chen, C. L., Chang, J. Y., Shieh, Y. S., Hsiao, M. & Shiah, S. G., 2016 十二月 15, 於 : Cancer Research. 76, 24, p. 7140-7150 11 p.

研究成果: Article

16 引文 斯高帕斯(Scopus)

Effect of 4β-Arylamino Derivatives of 4′-O-Demethylepipodophyllotoxin on Human DNA Topoisomerase II, Tubulin Polymerization, KB Cells, and Their Resistant Variants

Chang, J. Y., Han, F. S., Liu, S. Y., Wang, Z. Q., Lee, K. H. & Cheng, Y. C., 1991 四月 1, 於 : Cancer Research. 51, 7, p. 1755-1759 5 p.

研究成果: Article

46 引文 斯高帕斯(Scopus)

Effects of indomethacin on lymphokine-activated killer cell activities in cancer patients

Chao, T. Y., Ting, C. S., Yeh, M. Y., Chang, J. Y., Wang, C. C. & Chu, T. M., 1995 一月 1, 於 : Tumor Biology. 16, 4, p. 230-242 13 p.

研究成果: Article

15 引文 斯高帕斯(Scopus)

Enhanced B-Raf-mediated NRF2 gene transcription and HATs-mediated NRF2 protein acetylation contributes to ABCC1-mediated chemoresistance and glutathione-mediated survival in acquired topoisomerase II poison-resistant cancer cells

Chen, H. H., Chang, H. H., Chang, J. Y., Tang, Y. C., Cheng, Y. C., Lin, L. M., Cheng, S. Y., Huang, C. H., Sun, M. W., Chen, C. T. & Kuo, C. C., 2017 十二月, 於 : Free Radical Biology and Medicine. 113, p. 505-518 14 p.

研究成果: Article

4 引文 斯高帕斯(Scopus)

Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036

Yang, Y. N., Chou, K. M., Pan, W. Y., Chen, Y. W., Tsou, T. C., Yeh, S. C., Cheung, C. H. A., Chen, L. T. & Chang, J. Y., 2011 十月 1, 於 : Cancer Letters. 309, 1, p. 110-118 9 p.

研究成果: Article

5 引文 斯高帕斯(Scopus)
1 引文 斯高帕斯(Scopus)

Epigenetic regulation of the X-linked tumour suppressors BEX1 and LDOC1 in oral squamous cell carcinoma

Lee, C. H., Wong, T. S., Chan, J. Y. W., Lu, S. C., Lin, P., Cheng, A. J., Chen, Y. J., Chang, J. S. M., Hsiao, S. H., Leu, Y. W., Li, C. I., Hsiao, J-R. & Chang, J-Y., 2013 七月 1, 於 : Journal of Pathology. 230, 3, p. 298-309 12 p.

研究成果: Article

37 引文 斯高帕斯(Scopus)

Epstein-Barr virus-associated gastric adenocarcinoma in Taiwan

Harn, H. J., Chang, J. Y., Wang, M. W., Ho, L. I., Lee, H. S., Chiang, J. H. & Lee, W. H., 1995 三月, 於 : Human Pathology. 26, 3, p. 267-271 5 p.

研究成果: Article

90 引文 斯高帕斯(Scopus)

Examination of pericardial effusions by cytology and immunocytochemistry.

Chen, L. M., Chao, T. Y., Chiang, J. H., Nieh, S., Chang, J-Y., Hwang, S. H., Hseuh, E. J. & Wang, C. C., 1996 一月 1, 於 : Zhonghua yi xue za zhi = Chinese medical journal; Free China ed. 58, 4, p. 248-253 6 p.

研究成果: Article

1 引文 斯高帕斯(Scopus)

Expression of Epstein-Barr virus-encoded RNAs as a marker for metastatic undifferentiated nasopharyngeal carcinoma

Chao, T. Y., Chow, K. C., Chang, J-Y., Wang, C. C., Tsao, T. Y., Harn, H. J. & Chi, K. H., 1996 七月 1, 於 : Cancer. 78, 1, p. 24-29 6 p.

研究成果: Article

28 引文 斯高帕斯(Scopus)
1 引文 斯高帕斯(Scopus)

Four new 6-nor-5(6→7)abeo-abietane type diterpenes and antitumoral cytotoxic diterpene constituents from the bark of Taiwania cryptomerioides

Chang, C. I., Chang, J. Y., Kuo, C. C., Pan, W. Y. & Kuo, Y. H., 2005 一月 1, 於 : Planta Medica. 71, 1, p. 72-76 5 p.

研究成果: Article

69 引文 斯高帕斯(Scopus)

Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity

Chiang, Y. K., Kuo, C. C., Wu, Y. S., Chen, C. T., Coumar, M. S., Wu, J. S., Hsieh, H. P., Chang, C. Y., Jseng, H. Y., Wu, M. H., Leou, J. S., Song, J. S., Chang, J. Y., Lyu, P. C., Chao, Y. S. & Wu, S. Y., 2009 七月 23, 於 : Journal of Medicinal Chemistry. 52, 14, p. 4221-4233 13 p.

研究成果: Article

48 引文 斯高帕斯(Scopus)
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2 引文 斯高帕斯(Scopus)

Hepatocellular carcinoma with intra-atrial tumor thrombi: A report of three cases responsive to thalidomide treatment and literature review

Chang, J. Y., Ka, W. S., Chao, T. Y., Liu, T. W., Chuang, T. R. & Chen, L. T., 2004 一月 1, 於 : Oncology. 67, 3-4, p. 320-326 7 p.

研究成果: Article

53 引文 斯高帕斯(Scopus)
3 引文 斯高帕斯(Scopus)

Human DNA polymerase η activity and translocation is regulated by phosphorylation

Chen, Y. W., Cleaver, J. E., Hatahet, Z., Honkanen, R. E., Chang, J. Y., Yen, Y. & Chou, K. M., 2008 十月 28, 於 : Proceedings of the National Academy of Sciences of the United States of America. 105, 43, p. 16578-16583 6 p.

研究成果: Article

47 引文 斯高帕斯(Scopus)

Hypoxia-induced downregulation of DUSP-2 phosphatase drives colon cancer stemness

Hou, P. C., Li, Y. H., Lin, S. C., Lin, S. C., Lee, J. C., Lin, B. W., Liou, J. P., Chang, J. Y., Kuo, C. C., Liu, Y. M., Sun, H. S. & Tsai, S. J., 2017 八月 15, 於 : Cancer Research. 77, 16, p. 4305-4316 12 p.

研究成果: Article

23 引文 斯高帕斯(Scopus)

Identification of salt-inducible kinase 3 as a novel tumor antigen associated with tumorigenesis of ovarian cancer

Charoenfuprasert, S., Yang, Y. Y., Lee, Y. C., Chao, K. C., Chu, P. Y., Lai, C. R., Hsu, K. F., Chang, K. C., Chen, Y. C., Chen, L. T., Chang, J. Y., Leu, S. J. & Shih, N. Y., 2011 八月 18, 於 : Oncogene. 30, 33, p. 3570-3584 15 p.

研究成果: Article

17 引文 斯高帕斯(Scopus)

IL-8 induces miR-424-5p expression and modulates SOCS2/STAT5 signaling pathway in oral squamous cell carcinoma

Peng, H. Y., Jiang, S. S., Hsiao, J. R., Hsiao, M., Hsu, Y. M., Wu, G. H., Chang, W. M., Chang, J. Y., Jin, S. L. C. & Shiah, S. G., 2016 六月 1, 於 : Molecular Oncology. 10, 6, p. 895-909 15 p.

研究成果: Article

22 引文 斯高帕斯(Scopus)

Immunohistochemical studies of Na + /I - symporter in human thyroid tissues - A correlation with clinical thyroid scintigraphy

Lee, C. H., Yang, A. H., Chang, J-Y., Huang, C. L. & Chi, C. W., 2001 七月 12, 於 : Chinese Medical Journal (Taipei). 64, 3, p. 141-146 6 p.

研究成果: Article

37 引文 斯高帕斯(Scopus)

Induction chemotherapy with gemcitabine, oxaliplatin, and 5-fluorouracil/leucovorin followed by concomitant chemoradiotherapy in patients with locally advanced pancreatic cancer: A Taiwan cooperative oncology group phase II study

Ch'Ang, H. J., Lin, Y. L., Wang, H. P., Chiu, Y. F., Chang, M. C., Hsu, C. H., Tien, Y. W., Chen, J. S., Hsieh, R. K., Lin, P. W., Shan, Y-S., Cheng, A. L., Chang, J-Y., Whang-Peng, J., Hwang, T. L. & Chen, L. T., 2011 十二月 1, 於 : International Journal of Radiation Oncology Biology Physics. 81, 5

研究成果: Article

13 引文 斯高帕斯(Scopus)
10 引文 斯高帕斯(Scopus)

Intrathecal ketamine reduces morphine requirements in patients with terminal cancer pain

Yang, C. Y., Wong, C. S., Chang, J. Y. & Ho, S. T., 1996 四月, 於 : Canadian Journal of Anaesthesia. 43, 4, p. 379-383 5 p.

研究成果: Article

165 引文 斯高帕斯(Scopus)
12 引文 斯高帕斯(Scopus)

Investigating the association between diet and risk of head and neck cancer in Taiwan

Chang, C. C., Lee, W. T., Lee, Y. C., Huang, C. C., Ou, C. Y., Lin, Y. H., Huang, J. S., Wong, T. Y., Chen, K. C., Hsiao, J. R., Lu, Y. C., Tsai, S. T., Lai, Y. H., Wu, Y. H., Hsueh, W. T., Yen, C. J., Wu, S. Y., Chang, J. Y., Fang, S. Y., Wu, J. L. 及其他5, Lin, C. L., Weng, Y. L., Yang, H. C., Chen, Y. S. & Chang, J. S., 2017 一月 1, 於 : Oncotarget. 8, 58, p. 98865-98875 11 p.

研究成果: Article

5 引文 斯高帕斯(Scopus)

Investigations of survivin: The past, present and future

Cheung, C. H. A., Cheng, L. T., Chang, K. Y., Chen, H. H. & Chang, J. Y., 2011 一月 1, 於 : Frontiers in Bioscience. 16, 3, p. 952-961 10 p.

研究成果: Article

46 引文 斯高帕斯(Scopus)

In vitro and in vivo studies of a novel potential anticancer agent of isochaihulactone on human lung cancer A549 cells

Chen, Y. L., Lin, S. Z., Chang, J. Y., Cheng, Y. L., Tsai, N. M., Chen, S. P., Chang, W. L. & Harn, H. J., 2006 七月 28, 於 : Biochemical Pharmacology. 72, 3, p. 308-319 12 p.

研究成果: Article

70 引文 斯高帕斯(Scopus)

Labdanecaryophyllic acid, a novel cytotoxic C35 terpenoid from Calocedrus macrolepis var. formosana

Hsien, C. L., Tseng, M. H., Pan, R. N., Chang, J. Y., Kuo, C. C., Lee, T. H. & Kuo, Y. H., 2011 一月 26, 於 : Tetrahedron Letters. 52, 4, p. 515-517 3 p.

研究成果: Article

3 引文 斯高帕斯(Scopus)

Laminin γ2-enriched extracellular vesicles of oral squamous cell carcinoma cells enhance in vitro lymphangiogenesis via integrin α3-dependent uptake by lymphatic endothelial cells

Wang, S. H., Liou, G. G., Liu, S. H., Chang, J. S., Hsiao, J. R., Yen, Y. C., Chen, Y. L., Wu, W. L., Chang, J. Y. & Chen, Y. W., 2019 六月 1, 於 : International Journal of Cancer. 144, 11, p. 2795-2810 16 p.

研究成果: Article

2 引文 斯高帕斯(Scopus)

Loss of GDF10/BMP3b as a prognostic marker collaborates with TGFBR3 to enhance chemotherapy resistance and epithelial-mesenchymal transition in oral squamous cell carcinoma

Cheng, C. W., Hsiao, J. R., Fan, C. C., Lo, Y. K., Tzen, C. Y., Wu, L. W., Fang, W. Y., Cheng, A. J., Chen, C. H., Chang, I. S., Jiang, S. S., Chang, J. Y. & Lee, A. Y. L., 2016 五月 1, 於 : Molecular Carcinogenesis. 55, 5, p. 499-513 15 p.

研究成果: Article

7 引文 斯高帕斯(Scopus)

Lysosomal cysteine protease cathepsin S is involved in cancer cell motility by regulating store-operated Ca2+ entry

Lin, H. H., Chen, S. J., Shen, M. R., Huang, Y. T., Hsieh, H. P., Lin, S. Y., Lin, C. C., Chang, W. S. W. & Chang, J. Y., 2019 十二月, 於 : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 12, 118517.

研究成果: Article