傳染性疾病及訊息研究中心

研究成果 1989 2020

2010
36 引文 (Scopus)
HT29 Cells
tanespimycin
Neoplasms
Cell Line
Down-Regulation
2009
22 引文 (Scopus)

Advances in Aurora kinase inhibitor patents

Coumar, M. S., Cheung, C-H., Chang, J-Y. & Hsieh, H. P., 2009 三月 1, 於 : Expert Opinion on Therapeutic Patents. 19, 3, p. 321-356 36 p.

研究成果: Review article

Aurora Kinases
Patents
Pharmaceutical Chemistry
Mitosis
Literature
9 引文 (Scopus)

Alpha-fetoprotein response in advanced hepatocellular carcinoma receiving cytostatic agent

Chen, L. T., Shiah, H. S., Chao, Y., Chang, J. Y., Cheng, L. T. & Whang-Peng, J., 2009 十二月 20, 於 : Journal of Clinical Oncology. 27, 36, p. e271

研究成果: Letter

alpha-Fetoproteins
Cytostatic Agents
Liver Neoplasms
Tumor Biomarkers
Hepatocellular Carcinoma
83 引文 (Scopus)

Aurora kinase inhibitors in preclinical and clinical testing

Cheung, C. H. A., Coumar, M. S., Hsieh, H. P. & Chang, J. Y., 2009 四月 1, 於 : Expert Opinion on Investigational Drugs. 18, 4, p. 379-398 20 p.

研究成果: Review article

Aurora Kinases
Mitosis
Genomic Instability
Neoplasms
Carcinogenesis
48 引文 (Scopus)

Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity

Chiang, Y. K., Kuo, C. C., Wu, Y. S., Chen, C. T., Coumar, M. S., Wu, J. S., Hsieh, H. P., Chang, C. Y., Jseng, H. Y., Wu, M. H., Leou, J. S., Song, J. S., Chang, J. Y., Lyu, P. C., Chao, Y. S. & Wu, S. Y., 2009 七月 23, 於 : Journal of Medicinal Chemistry. 52, 14, p. 4221-4233 13 p.

研究成果: Article

Tubulin Modulators
Chemical Databases
KB Cells
Computer-Aided Design
G2 Phase
37 引文 (Scopus)
Cholangiocarcinoma
Chronic Hepatitis
Incidence
Neoplasms
Chronic Hepatitis B
54 引文 (Scopus)

Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers

Cheung, C-H., Chen, H. H., Kuo, C. C., Chang, C. Y., Coumar, M. S., Hsieh, H. P. & Chang, J-Y., 2009 七月 3, 於 : Molecular cancer. 8, 43.

研究成果: Article

Therapeutic Uses
Tubulin
Microtubules
Polymers
Caspases
75 引文 (Scopus)

Synthesis and evaluation of 3-aroylindoles as anticancer agents: Metabolite approach

Wu, Y. S., Coumar, M. S., Chang, J. Y., Sun, H. Y., Kuo, F. M., Kuo, C. C., Chen, Y. J., Chang, C. Y., Hsiao, C. L., Liou, J. P., Chen, C. P., Yao, H. T., Chiang, Y. K., Tan, U. K., Chen, C. T., Chu, C. Y., Wu, S. Y., Yeh, T. K., Lin, C. Y. & Hsieh, H. P., 2009 八月 13, 於 : Journal of Medicinal Chemistry. 52, 15, p. 4941-4945 5 p.

研究成果: Article

Antineoplastic Agents
Heterografts
Neoplasms
Pharmacokinetics
Cell Line
12 引文 (Scopus)

Synthesis and structure-activity relationships of 1-benzyl-4,5,6- trimethoxyindoles as a novel class of potent antimitotic agents

Lai, M. J., Kuo, C. C., Yeh, T. K., Hsieh, H. P., Chen, L. T., Pan, W. Y., Hsu, K. Y., Chang, J-Y. & Liou, J. P., 2009 四月 17, 於 : ChemMedChem. 4, 4, p. 588-593 6 p.

研究成果: Article

Antimitotic Agents
Colchicine
Structure-Activity Relationship
Inhibitory Concentration 50
Tubulin
2008
6 引文 (Scopus)

A novel peroxisome proliferator-activated receptor α/γ agonist, BPR1H0101, inhibits topoisomerase II catalytic activity in human cancer cells

Kao, Y. H., Hsieh, H. P., Chitlimalla, S. K., Pan, W. Y., Kuo, C. C., Tsai, Y. C., Lin, W. H., Chuang, S. E. & Chang, J. Y., 2008 二月 1, 於 : Anti-Cancer Drugs. 19, 2, p. 151-158 8 p.

研究成果: Article

Type II DNA Topoisomerase
Peroxisome Proliferator-Activated Receptors
Human Activities
KB Cells
Neoplasms
57 引文 (Scopus)

Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors

Liou, J. P., Wu, Z. Y., Kuo, C. C., Chang, C. Y., Lu, P. Y., Chen, C. M., Hsieh, H. P. & Chang, J. Y., 2008 七月 24, 於 : Journal of Medicinal Chemistry. 51, 14, p. 4351-4355 5 p.

研究成果: Article

Tubulin Modulators
Inhibitory Concentration 50
Colchicine
Cell Line
Neoplasms
46 引文 (Scopus)

Human DNA polymerase η activity and translocation is regulated by phosphorylation

Chen, Y. W., Cleaver, J. E., Hatahet, Z., Honkanen, R. E., Chang, J. Y., Yen, Y. & Chou, K. M., 2008 十月 28, 於 : Proceedings of the National Academy of Sciences of the United States of America. 105, 43, p. 16578-16583 6 p.

研究成果: Article

gemcitabine
DNA-Directed DNA Polymerase
Phosphorylation
Cisplatin
Protein Interaction Domains and Motifs
2 引文 (Scopus)

Modern staging and utility of PET imaging in esophageal cancer management

Chang, K. Y., Chang, J. Y., Chao, J. & Yen, Y., 2008 十月, 於 : JNCCN Journal of the National Comprehensive Cancer Network. 6, 9, p. 862-869 8 p.

研究成果: Article

Esophageal Neoplasms
Neoadjuvant Therapy
Fluorodeoxyglucose F18
Positron-Emission Tomography
Neoplasms
24 引文 (Scopus)

Synthesis and structure-activity relationships of 2-amino-1- aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents

Reddy, G. R., Kuo, C. C., Tan, U. K., Coumar, M. S., Chang, C. Y., Chiang, Y. K., Lai, M. J., Yeh, J. Y., Wu, S. Y., Chang, J-Y., Liou, J. P. & Hsieh, H. P., 2008 十二月 25, 於 : Journal of Medicinal Chemistry. 51, 24, p. 8163-8167 5 p.

研究成果: Article

Structure-Activity Relationship
Cell Line
Colchicine
Tubulin
Pharmaceutical Preparations
4 引文 (Scopus)
Camptothecin
Methyltransferases
Carmustine
Methyl-CpG-Binding Protein 2
DNA
2007
57 引文 (Scopus)

4- And 5-aroylindoles as novel classes of potent antitubulin agents

Liou, J. P., Wu, C. Y., Hsieh, H. P., Chang, C. Y., Chen, C. M., Kuo, C. C. & Chang, J. Y., 2007 九月 6, 於 : Journal of Medicinal Chemistry. 50, 18, p. 4548-4552 5 p.

研究成果: Article

Inhibitory Concentration 50
Tubulin Modulators
Colchicine
Tubulin
Polymerization
58 引文 (Scopus)
Sulfonamides
Human Activities
Microtubules
Phosphorylation
Multidrug Resistance-Associated Proteins
32 引文 (Scopus)

Combined modalities of resistance in an oxaliplatin-resistant human gastric cancer cell line with enhanced sensitivity to 5-fluorouracil

Chen, C. C., Chen, L. T., Tsou, T. C., Pan, W. Y., Kuo, C. C., Liu, J. F., Yeh, S. C., Tsai, F. Y., Hsieh, H. P. & Chang, J-Y., 2007 七月 31, 於 : British Journal of Cancer. 97, 3, p. 334-344 11 p.

研究成果: Article

oxaliplatin
Fluorouracil
Stomach Neoplasms
Cell Line
Thymidylate Synthase
26 引文 (Scopus)

Cytotoxic and novel skeleton compounds from the heartwood of Chamaecyparis obtusa var. formosana

Chien, S. C., Chang, J. Y., Kuo, C. C., Hsieh, C. C., Yang, N. S. & Kuo, Y. H., 2007 二月 26, 於 : Tetrahedron Letters. 48, 9, p. 1567-1569 3 p.

研究成果: Article

Chamaecyparis
Monoterpenes
Skeleton
Cells
Inhibitory Concentration 50
41 引文 (Scopus)

D-501036, a novel selenophene-based triheterocycle derivative, exhibits potent in vitro and in vivo antitumoral activity which involves DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation

Juang, S. H., Lung, C. C., Hsu, P. C., Hsu, K. S., Li, Y. C., Hong, P. C., Shiah, H. S., Kuo, C. C., Huang, C. W., Wang, Y. C., Huang, L., Chen, T. S., Chen, S. F., Fu, K. C., Hsu, C. L., Lin, M. J., Chang, C. J., Ashendel, C. L., Chan, T. C. K., Chou, K. M. 及其他1, Chang, J. C., 2007 一月 1, 於 : Molecular Cancer Therapeutics. 6, 1, p. 193-202 10 p.

研究成果: Article

Ataxia Telangiectasia Mutated Proteins
Nuclear Proteins
Protein Kinases
DNA Damage
DNA Breaks
1 引文 (Scopus)

Human tissue kallikreins as prognostic biomarkers and as potential targets for anticancer therapy

Chang, W. S. W., Chou, R. H., Wu, C. W. & Chang, J. Y., 2007 十月 1, 於 : Expert Opinion on Therapeutic Patents. 17, 10, p. 1227-1240 14 p.

研究成果: Review article

Tissue Kallikreins
Biomarkers
Physiological Phenomena
Patents
Alternative Splicing
48 引文 (Scopus)

Mitochondria-mediated and p53-associated apoptosis induced in human cancer cells by a novel selenophene derivative, D-501036

Shiah, H. S., Lee, W. S., Juang, S. H., Hong, P. C., Lung, C. C., Chang, C. J., Chou, K. M. & Chang, J. Y., 2007 三月 1, 於 : Biochemical Pharmacology. 73, 5, p. 610-619 10 p.

研究成果: Article

Mitochondria
Cells
Apoptosis
Derivatives
Apoptosis Regulatory Proteins
19 引文 (Scopus)

Tamoxifen accelerates proteasomal degradation of O6- methylguanine DNA methyltransferase in human cancer cells

Kuo, C. C., Liu, J. F., Shiah, H. S., Li-Chen, M. & Chang, J. Y., 2007 十一月 15, 於 : International Journal of Cancer. 121, 10, p. 2293-2300 8 p.

研究成果: Article

Methyltransferases
Tamoxifen
Protein Methyltransferases
DNA
Neoplasms
2006
42 引文 (Scopus)

2-Amino and 2′-aminocombretastatin derivatives as potent antimitotic agents

Chang, J. Y., Yang, M. F., Chang, C. Y., Chen, C. M., Kuo, C. C. & Liou, J. P., 2006 十月 1, 於 : Journal of Medicinal Chemistry. 49, 21, p. 6412-6415 4 p.

研究成果: Article

Antimitotic Agents
Inhibitory Concentration 50
Tubulin Modulators
Colchicine
Structure-Activity Relationship
61 引文 (Scopus)

7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents

Chang, J. Y., Hsieh, H. P., Chang, C. Y., Hsu, K. S., Chiang, Y. F., Chen, C. M., Kuo, C. C. & Liou, J. P., 2006 十一月 16, 於 : Journal of Medicinal Chemistry. 49, 23, p. 6656-6659 4 p.

研究成果: Article

Sulfonamides
Tubulin Modulators
KB Cells
Colchicine
Microtubules
65 引文 (Scopus)

Antitubulin agents for the treatment of cancer - A medicinal chemistry update

Mahindroo, N., Liou, J. P., Chang, J. Y. & Hsieh, H. P., 2006 五月 1, 於 : Expert Opinion on Therapeutic Patents. 16, 5, p. 647-691 45 p.

研究成果: Review article

Pharmaceutical Chemistry
Microtubules
patent
cancer
chemistry
14 引文 (Scopus)

C 35 terpenoids from the bark of Calocedrus macrolepis var. formosana with activity against human cancer cell lines

Hsieh, C. L., Tseng, M. H., Shao, Y. Y., Chang, J-Y., Kuo, C. C., Chang, C. Y. & Kuo, Y. H., 2006 十一月 1, 於 : Journal of Natural Products. 69, 11, p. 1611-1613 3 p.

研究成果: Article

Cupressaceae
Terpenes
Human Activities
Cells
KB Cells
22 引文 (Scopus)
Topoisomerase I Inhibitors
DNA Repair Enzymes
Camptothecin
Methyltransferases
DNA
69 引文 (Scopus)

In vitro and in vivo studies of a novel potential anticancer agent of isochaihulactone on human lung cancer A549 cells

Chen, Y. L., Lin, S. Z., Chang, J. Y., Cheng, Y. L., Tsai, N. M., Chen, S. P., Chang, W. L. & Harn, H. J., 2006 七月 28, 於 : Biochemical Pharmacology. 72, 3, p. 308-319 12 p.

研究成果: Article

Antineoplastic Agents
Lung Neoplasms
Cells
Non-Small Cell Lung Carcinoma
Bupleurum
11 引文 (Scopus)

Phase I and pharmacokinetic study of oral thalidomide in patients with advanced hepatocellular carcinoma

Shiah, H. S., Chao, Y., Chen, L. T., Yao, T. J., Huang, J. D., Chang, J. Y., Chen, P. J., Chuang, T. R., Chin, Y. H., Whang-Peng, J. & Liu, T. W., 2006 十一月, 於 : Cancer Chemotherapy and Pharmacology. 58, 5, p. 654-664 11 p.

研究成果: Article

Thalidomide
Pharmacokinetics
Hepatocellular Carcinoma
Toxicity
Maximum Tolerated Dose
5 引文 (Scopus)

Phase I-II trial of weekly gemcitabine plus high-dose 5-fluorouracil and leucovorin in advanced pancreatic cancer

Shiah, H. S., Cheng, A. L., Hsu, C., Hsu, C. H., Liu, T. W., Chang, J. Y., Jan, C. M., Chao, Y., Yu, W. L., Chuang, T. R., Whang-Peng, J. & Chen, L. T., 2006 三月, 於 : Journal of Gastroenterology and Hepatology (Australia). 21, 3, p. 531-536 6 p.

研究成果: Article

gemcitabine
Leucovorin
Pancreatic Neoplasms
Fluorouracil
Maximum Tolerated Dose
41 引文 (Scopus)

Phase II study of gemcitabine plus vinorelbine in the treatment of cisplatin-resistant nasopharyngeal carcinoma

Wang, C. C., Chang, J. Y., Liu, T. W., Lin, C. Y., Yu, Y. C. & Hong, R. L., 2006 一月 1, 於 : Head and Neck. 28, 1, p. 74-80 7 p.

研究成果: Article

gemcitabine
Cisplatin
Febrile Neutropenia
Therapeutics
Neutropenia
5 引文 (Scopus)

Phase I study of biweekly gemcitabine followed by oxaliplatin and simplified 48-h infusion of fluorouracil/leucovorin for advanced pancreatic cancer

Ch'ang, H. J., Wang, C. C., Cheng, A. L., Hsu, C., Lu, Y. S., Chang, M. C., Lin, J. T., Wang, H. P., Shiah, H. S., Liu, T. W., Chang, J-Y., Whang-Peng, J. & Chen, L. T., 2006 一月 1, 於 : Journal of Gastroenterology and Hepatology (Australia). 21, 5, p. 874-879 6 p.

研究成果: Article

oxaliplatin
gemcitabine
Leucovorin
Pancreatic Neoplasms
Fluorouracil
16 引文 (Scopus)

Statistical quality control process for traditional Chinese medicine

Tse, S. K., Chang, J. Y., Su, W. L., Chow, S. C., Hsiung, C. & Lu, Q., 2006 十二月 1, 於 : Journal of Biopharmaceutical Statistics. 16, 6, p. 861-874 14 p.

研究成果: Article

Statistical Quality Control
Traditional Chinese Medicine
Chinese Traditional Medicine
Quality Control
Confidence
36 引文 (Scopus)

Structure-activity relationship studies of 3-aroylindoles as potent antimitotic agents

Liou, J. P., Mahindroo, N., Chang, C. W., Guo, F. M., Lee, S. W. H., Tan, U. K., Yeh, T. K., Kuo, C. C., Chang, Y. W., Lu, P. H., Tung, Y. S., Lin, K. T., Chang, J-Y. & Hsieh, H. P., 2006 十月 1, 於 : ChemMedChem. 1, 10, p. 1106-1118 13 p.

研究成果: Article

Oxygen Compounds
Antimitotic Agents
Carbamates
Sulfides
Structure-Activity Relationship
7 引文 (Scopus)

Synthesis of new camptothecin analogues with the E-lactone ring replaced by α,β-cyclohexenone

Bacherikov, V. A., Tsai, T. J., Chang, J-Y., Chou, T. C., Lee, R. Z. & Su, T. L., 2006 九月 25, 於 : European Journal of Organic Chemistry. 19, p. 4490-4499 10 p.

研究成果: Article

Osmium
Camptothecin
Type I DNA Topoisomerase
Cell growth
Lactones
2005
109 引文 (Scopus)

Cytotoxic triterpenes from the aerial roots of Ficus microcarpa

Chiang, Y. M., Chang, J-Y., Kuo, C. C., Chang, C. Y. & Kuo, Y. H., 2005 一月 1, 於 : Phytochemistry. 66, 4, p. 495-501 7 p.

研究成果: Article

Ficus microcarpa
Ficus
Triterpenes
triterpenoids
Antennas
69 引文 (Scopus)

Four new 6-nor-5(6→7)abeo-abietane type diterpenes and antitumoral cytotoxic diterpene constituents from the bark of Taiwania cryptomerioides

Chang, C. I., Chang, J. Y., Kuo, C. C., Pan, W. Y. & Kuo, Y. H., 2005 一月 1, 於 : Planta Medica. 71, 1, p. 72-76 5 p.

研究成果: Article

Abietane Diterpenes
Diterpenes
Bearings (structural)
Aldehydes
Inhibitory Concentration 50
6 引文 (Scopus)

Hepatocellular carcinoma associated with acquired von Willebrand disease and extreme thrombocytosis [2]

Chen, C. C., Chang, J. Y., Liu, K. J., Chan, C., Ho, C. H., Lee, S. C. & Chen, L. T., 2005 六月 1, 於 : Annals of Oncology. 16, 6, p. 988-989 2 p.

研究成果: Letter

Paraneoplastic Syndromes
Thrombocytosis
von Willebrand Diseases
Liver Neoplasms
Hepatocellular Carcinoma
1 引文 (Scopus)
docetaxel
Digestive System Surgical Procedures
Retroperitoneal Neoplasms
Antineoplastic Combined Chemotherapy Protocols
Remission Induction
11 引文 (Scopus)

Pulmonary embolism after transcatheter arterial chemoembolization

Shiah, H. S., Liu, T. W., Chen, L. T., Chang, J-Y., Liu, J. M., Chuang, T. R., Lee, W. S. & Whang-Peng, J., 2005 十二月 1, 於 : European Journal of Cancer Care. 14, 5, p. 440-442 3 p.

研究成果: Article

Pulmonary Embolism
Liver
Hepatic Insufficiency
Renal Cell Carcinoma
Fever
26 引文 (Scopus)

Synthesis and antitumor activity of 5-(9-acridinylamino)anisidine derivatives

Bacherikov, V. A., Chang, J. Y., Lin, Y. W., Chen, C. H., Pan, W. Y., Dong, H., Lee, R. Z., Chou, T. C. & Su, T. L., 2005 十二月 1, 於 : Bioorganic and Medicinal Chemistry. 13, 23, p. 6513-6520 8 p.

研究成果: Article

Bearings (structural)
Tumors
Derivatives
Acridines
Type II DNA Topoisomerase
31 引文 (Scopus)

α-fetoprotein response predicts survival benefits of thalidomide in advanced hepatocellular carcinoma

Chen, L. T., Liu, T. W., Chao, Y., Shiah, H. S., Chang, J-Y., Juang, S. H., Chen, S. C., Chuang, T. R., Chin, Y. H. & Whang-Peng, J., 2005 八月 1, 於 : Alimentary Pharmacology and Therapeutics. 22, 3, p. 217-226 10 p.

研究成果: Article

Fetal Proteins
Thalidomide
Hepatocellular Carcinoma
Survival
Intention to Treat Analysis
2004
17 引文 (Scopus)

A novel bis-benzylidenecyclopentanone derivative, BPR0Y007, inducing a rapid caspase activation involving upregulation of Fas (CD95/APO-1) and wild-type p53 in human oral epidermoid carcinoma cells

Juang, S. H., Pan, W. Y., Kuo, C. C., Liou, J. P., Hung, Y. M., Chen, L. T., Hsieh, H. P. & Chang, J-Y., 2004 七月 15, 於 : Biochemical Pharmacology. 68, 2, p. 293-303 11 p.

研究成果: Article

Caspases
Squamous Cell Carcinoma
Up-Regulation
Chemical activation
Cells
181 引文 (Scopus)

BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo

Kuo, C. C., Hsieh, H. P., Pan, W. Y., Chen, C. P., Liou, J. P., Lee, S. J., Chang, Y. L., Chen, L. T., Chen, C. T. & Chang, J. Y., 2004 七月 1, 於 : Cancer Research. 64, 13, p. 4621-4628 8 p.

研究成果: Article

Antimitotic Agents
Human Activities
KB Cells
Neoplasms
Colchicine
161 引文 (Scopus)

Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents

Liou, J. P., Chang, Y. L., Kuo, F. M., Chang, C. W., Tseng, H. Y., Wang, C. C., Yang, Y. N., Chang, J. Y., Lee, S. J. & Hsieh, H. P., 2004 八月 12, 於 : Journal of Medicinal Chemistry. 47, 17, p. 4247-4257 11 p.

研究成果: Article

Structure-Activity Relationship
Stomach
Substitution reactions
Skeleton
Polymerization
53 引文 (Scopus)

Hepatocellular carcinoma with intra-atrial tumor thrombi: A report of three cases responsive to thalidomide treatment and literature review

Chang, J. Y., Ka, W. S., Chao, T. Y., Liu, T. W., Chuang, T. R. & Chen, L. T., 2004 一月 1, 於 : Oncology. 67, 3-4, p. 320-326 7 p.

研究成果: Article

Thalidomide
Hepatocellular Carcinoma
Thrombosis
Inferior Vena Cava
Neoplasms
70 引文 (Scopus)

Phase II study of weekly oxaliplatin and 24-h infusion of high-dose 5-fluorouracil and folinic acid in the treatment of advanced gastric cancer

Chao, Y., Yeh, K. H., Chang, C. J., Chen, L. T., Chao, T. Y., Wu, M. F., Chang, C. S., Chang, J-Y., Chung, C. Y., Kao, W. Y., Hsieh, R. K. & Cheng, A. L., 2004 八月 2, 於 : British Journal of Cancer. 91, 3, p. 453-458 6 p.

研究成果: Article

oxaliplatin
Leucovorin
Fluorouracil
Stomach Neoplasms
Therapeutics
83 引文 (Scopus)
Salvia miltiorrhiza
Antimitotic Agents
Microtubules
Neoplasms
Multidrug Resistance-Associated Proteins
98 引文 (Scopus)

Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents

Liou, J. P., Chang, J. Y., Chang, C. W., Chang, C. Y., Mahindroo, N., Kuo, F. M. & Hsieh, H. P., 2004 五月 20, 於 : Journal of Medicinal Chemistry. 47, 11, p. 2897-2905 9 p.

研究成果: Article

Tubulin Modulators
Antimitotic Agents
Structure-Activity Relationship
Benzophenones
Lead compounds