生物化學暨分子生物學研究所

研究成果 1973 2019

篩選
Article
2019
1 引文 (Scopus)
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Reactive Oxygen Species
Oxygen
Water
Nitric oxide
Cartilage
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Thrombomodulin
Germ Layers
Blastomeres
Organogenesis
Zebrafish

Blocking IL-19 signaling ameliorates allergen-induced airway inflammation

Weng, Y. H., Chen, W. Y., Lin, Y. L., Wang, J. Y. & Chang, M. S., 2019 一月 1, 於 : Frontiers in Immunology. 10, APR, 968.

研究成果: Article

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Allergens
Asthma
Inflammation
Cytokines
Rodentia

eRF1 mediates codon usage effects on mRNA translation efficiency through premature termination at rare codons

Yang, Q., Yu, C. H., Zhao, F., Dang, Y., Wu, C., Xie, P., Sachs, M. S. & Liu, Y., 2019 九月 26, 於 : Nucleic acids research. 47, 17, p. 9243-9258 16 p.

研究成果: Article

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Protein Biosynthesis
Codon
Ribosomes
Neurospora
Proteins

Expression of prothymosin α in lung cancer is associated with squamous cell carcinoma and smoking

Kuo, Y. H., Shiau, A. L., Tung, C. L., Su, Y. C., Li, C. F., Su, B. H., Tsao, C. J., Wu, C. L., Feng, Y. H. & Wu, P., 2019 六月, 於 : Oncology Letters. 17, 6, p. 5740-5746 7 p.

研究成果: Article

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Squamous Cell Carcinoma
Lung Neoplasms
Smoking
Non-Small Cell Lung Carcinoma
Neoplasms
1 引文 (Scopus)
Acanthamoeba
Aminopeptidases
aminopeptidases
Proteins
proteins
2 引文 (Scopus)

Nasogastric tube dislodgment detection in rehabilitation patients based on fog computing with warning sensors and fuzzy petri net

Li, C. M., Ho, Y-R., Chen, W. L., Lin, C. H., Chen, M. Y. & Chen, Y. Z., 2019 一月 1, 於 : Sensors and Materials. 31, 1, p. 117-130 14 p.

研究成果: Article

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Petri nets
fog
warning
Fog
Patient rehabilitation

Oct4 upregulates osteopontin via Egr1 and is associated with poor outcome in human lung cancer

Feng, Y. H., Su, Y. C., Lin, S. F., Lin, P. R., Wu, C. L., Tung, C. L., Li, C. F., Shieh, G. S. & Shiau, A. L., 2019 八月 9, 於 : BMC cancer. 19, 1, 791.

研究成果: Article

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Osteopontin
Lung Neoplasms
Up-Regulation
Growth
Genes

Pancreatic stellate cells activated by mutant KRAS-mediated PAI-1 upregulation foster pancreatic cancer progression via IL-8

Wang, H. C., Lin, Y. L., Hsu, C. C., Chao, Y. J., Hou, Y. C., Chiu, T. J., Huang, P. H., Tang, M. J., Chen, L. T. & Shan, Y. S., 2019 一月 1, 於 : Theranostics. 9, 24, p. 7168-7183 16 p.

研究成果: Article

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Pancreatic Stellate Cells
Plasminogen Activator Inhibitor 1
Interleukin-8
Pancreatic Neoplasms
Up-Regulation
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Phosphoric Monoester Hydrolases
Urinary Bladder Neoplasms
Nuclear Localization Signals
Proteins
Ubiquitination

Prothymosin α promotes STAT3 acetylation to induce cystogenesis in Pkd1-deficient mice

Chen, Y. C., Su, Y. C., Shieh, G. S., Su, B. H., Su, W. C., Huang, P. H., Jiang, S. T., Shiau, A. L. & Wu, C. L., 2019 十一月 1, 於 : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 11, p. 13051-13061 11 p.

研究成果: Article

Acetylation
Polycystic Kidney Diseases
STAT3 Transcription Factor
Kidney
Cysts
5 引文 (Scopus)
Thrombomodulin
Hydrogels
Hydrogel
Hyaluronic Acid
Gelatin
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Acanthamoeba
Aminopeptidases
cultured cells
Cell Communication
keratitis

The role of vascular smooth muscle cell membrane-bound thrombomodulin in neointima formation

Wang, K. C., Chen, P. S., Chao, T. H., Luo, C. Y., Chung, H. C., Tseng, S. Y., Huang, T. Y., Lin, Y. L., Shi, G. Y., Wu, H. L. & Li, Y. H., 2019 八月, 於 : Atherosclerosis. 287, p. 54-63 10 p.

研究成果: Article

Thrombomodulin
Neointima
Vascular Smooth Muscle
Smooth Muscle Myocytes
Cell Membrane

Tumor Endothelial Marker 1 (TEM1/Endosialin/CD248) Enhances Wound Healing by Interacting with Platelet-Derived Growth Factor Receptors

Hong, Y. K., Lee, Y. C., Cheng, T. L., Lai, C. H., Hsu, C. K., Kuo, C. H., Hsu, Y. Y., Li, J. T., Chang, B. I., Ma, C. Y., Lin, S. W., Wang, K. C., Shi, G. Y. & Wu, H. L., 2019 十月, 於 : Journal of Investigative Dermatology. 139, 10, p. 2204-2214.e7

研究成果: Article

Platelet-Derived Growth Factor Receptors
Tumor Biomarkers
Wound Healing
Tumors
Fibroblasts
2018
2 引文 (Scopus)

A multi-omic analysis reveals the role of fumarate in regulating the virulence of enterohemorrhagic Escherichia coli

Kuo, C. J., Wang, S. T., Lin, C. M., Chiu, H. C., Huang, C. R., Lee, D. Y., Chang, G. D., Chou, T. C., Chen, J. W. & Chen, C. S., 2018 三月 1, 於 : Cell Death and Disease. 9, 3, 381.

研究成果: Article

Enterohemorrhagic Escherichia coli
Fumarates
Virulence
Caenorhabditis elegans
Escherichia coli Infections
4 引文 (Scopus)

Astrocytic CCAAT/Enhancer-binding protein delta contributes to reactive oxygen species formation in neuroinflammation

Wang, S. M., Lim, S. W., Wang, Y. H., Lin, H. Y., Lai, M. D., Ko, C. Y. & Wang, Y-M., 2018 六月, 於 : Redox Biology. 16, p. 104-112 9 p.

研究成果: Article

CCAAT-Enhancer-Binding Protein-delta
Oxidative stress
Reactive Oxygen Species
Astrocytes
Oxidative Stress
8 引文 (Scopus)

Decreased succinate dehydrogenase B in human hepatocellular carcinoma accelerates tumor malignancy by inducing the Warburg effect

Tseng, P. L., Wu, W. H., Hu, T. H., Chen, C. W., Cheng, H. C., Li, C. F., Tsai, W. H., Tsai, H. J., Hsieh, M. C., Chuang, J. H. & Chang, W. T., 2018 十二月 1, 於 : Scientific reports. 8, 1, 3081.

研究成果: Article

Succinate Dehydrogenase
Hepatocellular Carcinoma
Neoplasms
Glycolysis
Energy Metabolism
1 引文 (Scopus)

Design and synthesis of malonamide derivatives as antibiotics against methicillin-resistant staphylococcus aureus

Su, J. C., Huang, Y. T., Chen, C. S., Chiu, H. C. & Shiau, C. W., 2018 一月 1, 於 : Molecules. 23, 1, 27.

研究成果: Article

Methicillin
staphylococcus
antibiotics
Methicillin-Resistant Staphylococcus aureus
Anti-Bacterial Agents
Bioluminescence
Enterohemorrhagic Escherichia coli
Escherichia coli
Animals
Hemolytic-Uremic Syndrome
4 引文 (Scopus)

Elovl6 is a negative clinical predictor for liver cancer and knockdown of Elovl6 reduces murine liver cancer progression

Su, Y. C., Feng, Y. H., Wu, H. T., Huang, Y. S., Tung, C. L., Wu, P., Chang, C. J., Shiau, A. L. & Wu, C. L., 2018 十二月 1, 於 : Scientific reports. 8, 1, 6586.

研究成果: Article

Liver Neoplasms
Hepatocellular Carcinoma
Neoplasms
Fatty Acids
Monounsaturated Fatty Acids

Estrogen and mechanical loading-related regulation of estrogen receptor-β and apoptosis in tendinopathy

Hsieh, J. L., Jou, I. M., Wu, C. L., Wu, P. T., Shiau, A. L., Chong, H. E., Lo, Y. T., Shen, P. C. & Chen, S. Y., 2018 十月, 於 : PloS one. 13, 10, e0204603.

研究成果: Article

Tendinopathy
Estrogen Receptors
estrogens
Tendons
Estrogens
Aeromonas
Caenorhabditis elegans
Toxicity
Virulence
Poisons
1 引文 (Scopus)
Mutation
Neoplasms
B-Lymphocytes
Lung
Cytokines
1 引文 (Scopus)

Plasminogen/thrombomodulin signaling enhances VEGF expression to promote cutaneous wound healing

Cheng, T. L., Chen, P. K., Huang, W. K., Kuo, C. H., Cho, C. F., Wang, K. C., Shi, G. Y., Wu, H. L. & Lai, C. H., 2018 十二月 1, 於 : Journal of Molecular Medicine. 96, 12, p. 1333-1344 12 p.

研究成果: Article

Thrombomodulin
Plasminogen
Wound Healing
Vascular Endothelial Growth Factor A
Skin
1 引文 (Scopus)

Rationally designed divalent caffeic amides inhibit amyloid-β fibrillization, induce fibril dissociation, and ameliorate cytotoxicity

Tu, L. H., Tseng, N. H., Tsai, Y. R., Lin, T. W., Lo, Y. W., Charng, J. L., Hsu, H. T., Chen, Y. S., Chen, R. J., Wu, Y. T., Chan, Y. T., Chen, C. S., Fang, J. M. & Chen, Y. R., 2018 十月 5, 於 : European Journal of Medicinal Chemistry. 158, p. 393-404 12 p.

研究成果: Article

Dissociative Disorders
Cytotoxicity
Amyloid
Amides
Alzheimer Disease
1 引文 (Scopus)
Caenorhabditis elegans
p38 Mitogen-Activated Protein Kinases
Infection
Genetic Epistasis
Aeromonas
6 引文 (Scopus)

Single-cell RNA sequencing reveals gene expression signatures of breast cancer-associated endothelial cells

Sun, Z., Wang, C. Y., Lawson, D. A., Kwek, S., Velozo, H. G., Owyong, M., Lai, M. D., Fong, L., Wilson, M., Su, H., Werb, Z. & Cooke, D. L., 2018 一月 1, 於 : Oncotarget. 9, 13, p. 10945-10961 17 p.

研究成果: Article

RNA Sequence Analysis
Transcriptome
Endothelial Cells
Breast Neoplasms
Genes
1 引文 (Scopus)

The chondroitin sulfate moiety mediates thrombomodulin-enhanced adhesion and migration of vascular smooth muscle cells

Pai, V. C., Lo, I. C., Huang, Y. W., Tsai, I. C., Cheng, H. P., Shi, G. Y., Wu, H-L. & Jiang, M-J., 2018 二月 13, 於 : Journal of biomedical science. 25, 1, 306361.

研究成果: Article

Thrombomodulin
Chondroitin Sulfates
Vascular Smooth Muscle
Smooth Muscle Myocytes
Muscle
1 引文 (Scopus)

The decrease of glycolytic enzyme hexokinase 1 accelerates tumor malignancy via deregulating energy metabolism but sensitizes cancer cells to 2-deoxyglucose inhibition

Tseng, P. L., Chen, C. W., Hu, K. H., Cheng, H. C., Lin, Y. H., Tsai, W. H., Cheng, T. J., Wu, W. H., Yeh, C. W., Lin, C. C., Tsai, H. J., Chang, H. C., Chuang, J. H., Shan, Y. S. & Chang, W. T., 2018 四月 10, 於 : Oncotarget. 9, 27, p. 18949-18969 21 p.

研究成果: Article

Hexokinase
Deoxyglucose
Energy Metabolism
Enzymes
Neoplasms

The establishment of a lung colonization assay for circulating tumor cell visualization in lung tissues

Lin, T. C., Liao, Y. C., Chang, W. T., Yang, C. H., Cheng, L. H., Cheng, M. & Cheng, H. C., 2018 六月 18, 於 : Journal of Visualized Experiments. 2018, 136, e56761.

研究成果: Article

Circulating Neoplastic Cells
Tumors
Assays
Visualization
Cells
1 引文 (Scopus)

VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function

Wang, Y., Tzeng, H., Tsai, C., Cheng, H., Lai, W., Liu, H. & Wang, Y., 2018 十一月 1, 於 : Cancer Letters. 437, p. 79-88

研究成果: Article

2017
6 引文 (Scopus)
Aeromonas
Caenorhabditis elegans
Necrosis
Muscles
RNA Interference
5 引文 (Scopus)

Anti-IL-20 monoclonal antibody inhibited inflammation and protected against cartilage destruction in murine models of osteoarthritis

Hsu, Y. H., Yang, Y. Y., Huwang, M. H., Weng, Y. H., Jou, I. M., Wu, P. T., Lin, T. Y., Wu, L. W. & Chang, M. S., 2017 四月, 於 : PloS one. 12, 4, e0175802.

研究成果: Article

osteoarthritis
Cartilage
interleukins
cartilage
Osteoarthritis

Anti-IL-20 monoclonal antibody inhibited tumor growth in hepatocellular carcinoma

Chiu, Y. S., Hsing, C. H., Li, C. F., Lee, C. Y., Hsu, Y. H. & Chang, M. S., 2017 十二月 1, 於 : Scientific reports. 7, 1, 17609.

研究成果: Article

Hepatocellular Carcinoma
Monoclonal Antibodies
Growth
Cyclin D1
Neoplasms
7 引文 (Scopus)

Argininosuccinate lyase interacts with cyclin A2 in cytoplasm and modulates growth of liver tumor cells

Hung, Y. H., Huang, H. L., Chen, W. C., Yen, M. C., Cho, C. Y., Weng, T. Y., Wang, C. Y., Chen, Y. L., Chen, L. T. & Lai, M. D., 2017 二月, 於 : Oncology Reports. 37, 2, p. 969-978 10 p.

研究成果: Article

Cyclin A2
Argininosuccinate Lyase
Cytoplasm
Liver
Growth
13 引文 (Scopus)

Chemotherapeutics-induced Oct4 expression contributes to drug resistance and tumor recurrence in bladder cancer

Lu, C. S., Shieh, G. S., Wang, C. T., Su, B. H., Su, Y. C., Chen, Y. C., Su, W. C., Wu, P., Yang, W. H., Shiau, A. L. & Wu, C. L., 2017 一月 1, 於 : Oncotarget. 8, 19, p. 30844-30858 15 p.

研究成果: Article

Drug Resistance
Urinary Bladder Neoplasms
Cisplatin
Recurrence
Neoplasms
15 引文 (Scopus)
Codon
Drosophila
Proteins
Protein Biosynthesis
Cell-Free System
14 引文 (Scopus)

Cyclin D1 overexpression correlates with poor tumor differentiation and prognosis in gastric cancer

Shan, Y. S., Hsu, H. P., Lai, M. D., Hung, Y. H., Wang, C. Y., Yen, M. C. & Chen, Y. L., 2017 一月 1, 於 : Oncology Letters. 14, 4, p. 4517-4526 10 p.

研究成果: Article

Cyclin D1
Stomach Neoplasms
Cyclin D2
Stomach
Cyclin D
6 引文 (Scopus)
Neuroprotective Agents
Stroke
Tumor Necrosis Factor-alpha
Middle Cerebral Artery Infarction
Interleukin-10
1 引文 (Scopus)
Tendinopathy
Weight-Bearing
Hindlimb
Collagenases
Achilles Tendon
2 引文 (Scopus)

Effects of the RGD loop and C-terminus of rhodostomin on regulating integrin αIIbβ3 recognition

Chang, Y. T., Shiu, J. H., Huang, C. H., Chen, Y. C., Chen, C. Y., Chang, Y. S. & Chuang, W. J., 2017 四月, 於 : PloS one. 12, 4, e0175321.

研究成果: Article

integrins
Integrins
Platelets
Disintegrins
mutants
8 引文 (Scopus)
Hepatocellular Carcinoma
cancer
mice
Bearings (structural)
Catenins
12 引文 (Scopus)

GATA3 targets semaphorin 3B in mammary epithelial cells to suppress breast cancer progression and metastasis

Shahi, P., Wang, C. Y., Chou, J., Hagerling, C., Gonzalez Velozo, H., Ruderisch, A., Yu, Y., Lai, M. D. & Werb, Z., 2017 十月 5, 於 : Oncogene. 36, 40, p. 5567-5575 9 p.

研究成果: Article

Semaphorins
Breast
Epithelial Cells
Breast Neoplasms
Neoplasm Metastasis
24 引文 (Scopus)

HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium

Wu, D., Huang, R. T., Hamanaka, R. B., Krause, M., Oh, M. J., Kuo, C-H., Nigdelioglu, R., Meliton, A. Y., Witt, L., Dai, G., Civelek, M., Prabhakar, N. R., Fang, Y. & Mutlu, G. M., 2017 五月 30, 於 : eLife. 6, e25217.

研究成果: Article

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Hypoxia-Inducible Factor 1
Endothelial cells
Vascular Endothelium
Swine
Endothelial Cells
10 引文 (Scopus)

HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans

Chen, H. D., Kao, C. Y., Liu, B. Y., Huang, S. W., Kuo, C. J., Ruan, J. W., Lin, Y. H., Huang, C. R., Chen, Y. H., Wang, H. D., Aroian, R. V. & Chen, C. S., 2017 二月 1, 於 : Autophagy. 13, 2, p. 371-385 15 p.

研究成果: Article

Autophagy
Epithelium
Caenorhabditis elegans
Immunotoxins
Recycling
14 引文 (Scopus)

IL-6 ameliorates acute lung injury in influenza virus infection

Yang, M. L., Wang, C. T., Yang, S. J., Leu, C. H., Chen, S. H., Wu, C. L. & Shiau, A. L., 2017 三月 6, 於 : Scientific reports. 7, 43829.

研究成果: Article

Acute Lung Injury
Virus Diseases
Orthomyxoviridae
Interleukin-6
Lung
5 引文 (Scopus)

Increased risk of brain cancer incidence in stroke patients: A clinical case series, population-based and longitudinal follow-up study

Chen, C. W., Cheng, T. J., Ho, C. H., Wang, J. J., Weng, S. F., Hou, Y. C., Cheng, H. C., Chio, C. C., Shan, Y. S. & Chang, W. T., 2017 一月 1, 於 : Oncotarget. 8, 65, p. 108989-108999 11 p.

研究成果: Article

Brain Neoplasms
Stroke
Incidence
Population
Confidence Intervals
5 引文 (Scopus)

Inhibition of osteoporosis by the αvβ3 integrin antagonist of rhodostomin variants

Lin, T. H., Yang, R. S., Tu, H. J., Liou, H. C., Lin, Y. M., Chuang, W-J. & Fu, W. M., 2017 一月 1, 於 : European Journal of Pharmacology. 804, p. 94-101 8 p.

研究成果: Article

Osteoclasts
Integrins
Osteoporosis
Bone Resorption
Osteogenesis
2 引文 (Scopus)

Interleukin-20 targets podocytes and is upregulated in experimental murine diabetic nephropathy

Hsu, Y. H., Li, H. H., Sung, J. M., Chen, W. Y., Hou, Y. C., Weng, Y. H., Lai, W. T., Wu, C. H. & Chang, M. S., 2017 三月 3, 於 : Experimental and Molecular Medicine. 49, 3, e310.

研究成果: Article

Podocytes
Diabetic Nephropathies
Interleukins
Medical problems
Blood Glucose