醫學檢驗生物技術學系

2025

BNT162b2 mRNA vaccine elicits robust virus-specific antibodies but poor cross-protective CD8⁺ memory T cell responses in adolescents with type 1 diabetes

Shen, C. F., Chang, P. D., Chou, Y. Y., Wang, S. W., Pan, Y. W., Chen, C. A., Lin, C. W., Tsai, B. Y., Tsai, P. J., Liu, C. C., Cheng, C. M., Ko, W. C. & Shieh, C. C., 2025, (Accepted/In press) 於: Journal of Microbiology, Immunology and Infection.

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Dengue virus non-structural protein 1 binding to thrombin as a dengue severity marker: Comprehensive patient analysis in south Taiwan

Nanda, J. D., Yeh, T. M., Satria, R. D., Jhan, M. K., Wang, Y. T., Lin, Y. L., Sufriyana, H., Su, E. C. Y., Lin, C. F. & Ho, T. S., 2025 4月, 於: Journal of Microbiology, Immunology and Infection. 58, 2, p. 198-208 11 p.

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O-antigen of uropathogenic Escherichia coli is required for induction of neutrophil extracellular traps

Lin, W. H., Sheu, S. M., Wu, C. F., Huang, W. C., Hsu, L. J., Yu, K. C., Cheng, H. C., Kao, C. Y., Wu, J. J., Wang, M. C. & Teng, C. H., 2025 4月, 於: Journal of Microbiology, Immunology and Infection. 58, 2, p. 209-218 10 p.

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2024

A pilot study on the detection of microsatellite instability using long mononucleotide repeats in solid tumors

Liu, T., Ho, C. L., Chen, Y. J., Chen, P. J., Chen, W. L., Lee, C. T., Chow, N. H., Huang, W. & Chen, Y. L., 2024 9月, 於: Oncology Letters. 28, 3, 445.

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Asymptomatic enteric pathogen carriage and its association with proton pump inhibitors use in men who have sex with men in Taiwan, 2019-2022

Tsai, C. S., Lee, N. Y., Chen, P. L., Chen, S. Y., Lin, Y. J., Tsai, P. F., Tsai, H. P., Wang, J. L. & Ko, W. C., 2024 12月, 於: International Journal of Infectious Diseases. 149, 107273.

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A transcription-independent role for HIF-1α in modulating microprocessor assembly

Li, J. N., Wang, M. Y., Ruan, J. W., Lyu, Y. J., Weng, Y. H., Brindangnanam, P., Coumar, M. S. & Chen, P. S., 2024 10月 28, 於: Nucleic acids research. 52, 19, p. 11806-11821 16 p.

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Benign polymorphisms in the BRCA genes with linkage disequilibrium is associated with cancer characteristics

Lee, K. T., Chen, D. P., Loh, Z. J., Chung, W. P., Wang, C. Y., Chen, P. S., Cheung, C. H. A., Chang, C. P. & Hsu, H. P., 2024 12月, 於: Cancer Science. 115, 12, p. 3973-3985 13 p.

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Characterization of integrated hepatitis B virus DNA harboring pre-S mutations in hepatocellular carcinoma patients with ground glass hepatocytes

Su, Y. P., Lin, S. Y., Su, I. J., Kao, Y. L., Shen, S. C., Earl, J. P., Ehrlich, G. D., Chen, C. Y., Huang, W., Su, Y. H. & Tsai, H. W., 2024 1月, 於: Journal of Medical Virology. 96, 1, e29348.

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Comprehensive analysis of bulk and single-cell RNA sequencing data reveals Schlafen-5 (SLFN5) as a novel prognosis and immunity

Wu, Y. J., Chiao, C. C., Chuang, P. K., Hsieh, C. B., Ko, C. Y., Ko, C. C., Chang, C. F., Chen, T. Y., Nguyen, N. U. N., Hsu, C. C., Chu, T. H., Fang, C. C., Tsai, H. Y., Tsai, H. C., Anuraga, G., Ta, H. D. K., Xuan, D. T. M., Kumar, S., Dey, S., Wulandari, F. S., 及其他4Manalu, R. T., Ly, N. P., Wang, C. Y. & Lee, Y. K., 2024, 於: International Journal of Medical Sciences. 21, 12, p. 2348-2364 17 p.

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Detection of toxigenic M1_UK lineage group A Streptococcus clones in Taiwan

Chiang-Ni, C., Hsu, C. Y., Yeh, Y. H., Chi, C. Y., Wang, S., Tsai, P. J. & Chiu, C. H., 2024 4月, 於: Journal of Microbiology, Immunology and Infection. 57, 2, p. 269-277 9 p.

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7 引文斯高帕斯（Scopus）

Distinct protective effects of a novel Akkermansia sp. BCRC 18949 against DSS-Induced colitis in mice

Huang, C. H., Huang, C. T., Tsai, H. Y., Liao, Y. C., Lin, C. M., Chen, P. C., Liou, J. S., Hsu, C. L., Chiu, S. H., Chen, C. C., Hsieh, S. Y., Zou, H. B., Hsu, C. C., Chen, P. S., Kao, C. Y. & Ruan, J. W., 2024 4月, 於: Journal of Functional Foods. 115, 106110.

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6 引文斯高帕斯（Scopus）

Disturbed intracellular folate homeostasis impairs autophagic flux and increases hepatocytic lipid accumulation

Chi, W. Y., Lee, G. H., Tang, M. J., Chen, B. H., Lin, W. L. & Fu, T. F., 2024 12月, 於: BMC Biology. 22, 1, 146.

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3 引文斯高帕斯（Scopus）

Enhanced production of recombinant coxsackievirus A16 using a serum-free HEK293A suspension culture system for bivalent enterovirus vaccine development

Chen, Y. A., Shen, Y. S., Fang, C. Y., Chan, T. T., Wu, S. R., Wang, J. R., Wu, S. C. & Liu, C. C., 2024 10月, 於: Vaccine: X. 20, 100559.

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Enhancement of NETosis by ACE2-cross-reactive anti-SARS-CoV-2 RBD antibodies in patients with COVID-19

Hsieh, K. H., Chao, C. H., Cheng, Y. L., Lai, Y. C., Chuang, Y. C., Wang, J. R., Chang, S. Y., Hung, Y. P., Chen, Y. M. A., Liu, W. L., Chuang, W. J. & Yeh, T. M., 2024 12月, 於: Journal of biomedical science. 31, 1, 39.

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2 引文斯高帕斯（Scopus）

Focused ion beam-fabricated nanorod substrate for label-free surface-enhanced Raman spectroscopy and enabling dual virus detection

Lee, H., Liao, J. D., Tsai, H-P., Wang, H. & Sitjar, J., 2024 10月 1, 於: Talanta. 278, 126466.

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Haemolysin Ahh1 secreted from Aeromonas dhakensis activates the NLRP3 inflammasome in macrophages and mediates severe soft tissue infection

Su, Y. C., Wang, C. C., Chen, Y. W., Wang, S. T., Shu, C. Y., Tsai, P. J., Ko, W. C., Chen, C. S. & Chen, P. L., 2024 2月 15, 於: International Immunopharmacology. 128, 111478.

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4 引文斯高帕斯（Scopus）

Intestinal dual-specificity phosphatase 6 regulates the cold-induced gut microbiota remodeling to promote white adipose browning

Chen, P. C., Tsai, T. P., Liao, Y. C., Liao, Y. C., Cheng, H. W., Weng, Y. H., Lin, C. M., Kao, C. Y., Tai, C. C. & Ruan, J. W., 2024 12月, 於: npj Biofilms and Microbiomes. 10, 1, 22.

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1 引文斯高帕斯（Scopus）

Label-free SERS method with size-matched selectivity for analytes of varying sizes

Lee, H., Liao, J. D., Tsai, H. P., Chen, C. H., Sitjar, J., Fu, W. E. & Lin, F. H., 2024 1月, 於: Surfaces and Interfaces. 44, 103821.

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7 引文斯高帕斯（Scopus）

Phage transcriptional regulator X (PtrX)-mediated augmentation of toxin production and virulence in Clostridioides difficile strain R20291

Gong, J. J., Huang, I. H., Su, M. S. W., Xie, S. X., Liu, W. Y., Huang, C. R., Hung, YP. P., Wu, S. R., Tsai, PJ. J., Ko, WC. C. & Chen, J. W., 2024 3月, 於: Microbiological Research. 280, 127576.

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Phosphorylation of TG-interacting factor 1 at carboxyl-terminal sites in response to insulin regulates adipocyte differentiation

Chang, Y. H., Tseng, Y. H., Wang, J. M., Tsai, Y. S., Liu, X. L. & Huang, H. S., 2024 4月, 於: FEBS Letters. 598, 8, p. 945-955 11 p.

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1 引文斯高帕斯（Scopus）

Potential effectiveness of parenteral nemonoxacin in the treatment of Clostridioides difficile infections: in vitro, ex vivo, and mouse studies

Lee, C. C., Yan, X. Z., Wu, H. T., Ko, W. C., Tsai, P. J. & Hung, Y. P., 2024, 於: Frontiers in Microbiology. 15, 1418817.

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Simultaneous detection of SARS-CoV-2 and influenza A/B viruses on an electromagnetically-driven, integrated microfluidic system

Chiu, C. H., Wang, C. H., Lin, Y. J., Tang, C. C., Peng, W. J., Huang, W. Y., Shan, Y. S., Tsai, H. P. & Lee, G. B., 2024 7月, 於: Sensors and Actuators B: Chemical. 410, 135647.

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2 引文斯高帕斯（Scopus）

SnoRNA U50A mediates everolimus resistance in breast cancer through mTOR downregulation

Li, J. N., Loh, Z. J., Chen, H. W., Lee, I. Y., Tsai, J. H. & Chen, P. S., 2024 10月, 於: Translational Oncology. 48, 102062.

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1 引文斯高帕斯（Scopus）

TG-interacting factor 1 regulates mitotic clonal expansion during adipocyte differentiation

Chang, Y. H., Tseng, Y. H., Wang, J. M., Tsai, Y. S. & Huang, H. S., 2024 6月, 於: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1869, 5, 159492.

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1 引文斯高帕斯（Scopus）

The Aloe vera acemannan polysaccharides inhibit phthalate-induced cell viability, metastasis, and stemness in colorectal cancer cells

Shih, P. C., Lin, C. H., Chokkalingam, U., Prakash, E., Kao, C. N., Chang, C. F. & Lin, W. L., 2024 12月, 於: Ecotoxicology and Environmental Safety. 288, 117351.

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2 引文斯高帕斯（Scopus）

The molecular epidemiology of a dengue virus outbreak in Taiwan: population wide versus infrapopulation mutation analysis

Tsai, Y. Y., Cheng, D., Huang, S. W., Hung, S. J., Wang, Y. F., Lin, Y. J., Tsai, H. P., Chu, J. J. H. & Wang, J. R., 2024 6月, 於: PLoS neglected tropical diseases. 18, 6, e0012268.

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1 引文斯高帕斯（Scopus）

Using a 3D Silicon Micro-Channel Device and Raman Spectroscopy for the Analysis of Whole Blood and Abnormal Blood

Chiang, C. C., Huang, S. J., Immanuel, P. N., Lan, J. H., Lo, F. Y. & Young, K. C., 2024 1月, 於: Micromachines. 15, 1, 21.

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1 引文斯高帕斯（Scopus）

VP1 codon deoptimization and high-fidelity substitutions in 3D polymerase as potential vaccine strategies for eliciting immune responses against enterovirus A71

Hsieh, W. S., Chao, C. H., Shen, C. Y., Cheng, D., Huang, S. W., Wang, Y. F., Chen, C. C., Chen, S. H., Hsu, L. J. & Wang, J. R., 2024 1月, 於: Journal of Virology. 98, 1

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2023

Acyclovir-resistant HSV-1 isolates among immunocompromised patients in southern Taiwan: Low prevalence and novel mutations

Kuo, J. Y., Yeh, C. S., Wang, S. M., Chen, S. H., Wang, J. R., Chen, T. Y. & Tsai, H. P., 2023 8月, 於: Journal of Medical Virology. 95, 8, e28985.

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6 引文斯高帕斯（Scopus）

Age and prior vaccination determine the antibody level in children with primary SARS-CoV-2 Omicron infection

Taiwan Pediatric Infectious Disease Alliance (TPIDA), 2023 12月, 於: Journal of Microbiology, Immunology and Infection. 56, 6, p. 1187-1197 11 p.

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3 引文斯高帕斯（Scopus）

Antagonizing apolipoprotein J chaperone promotes proteasomal degradation of mTOR and relieves hepatic lipid deposition

Duan, S., Qin, N., Pi, J., Sun, P., Gao, Y., Liu, L., Li, Z., Li, Y., Shi, L., Gao, Q., Qiu, Y., Tang, S., Wang, C. H., Chen, T. Y., Wang, S. T., Young, K. C. & Sun, H. Y., 2023 10月, 於: Hepatology. 78, 4, p. 1182-1199 18 p.

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1 引文斯高帕斯（Scopus）

Antigenic mapping of enterovirus A71 from Taiwan and Southeast Asia

Cheng, D., Huang, S. W., Tsai, Y. H., Lien, Y. Y. & Wang, J. R., 2023 4月, 於: Antiviral Research. 212, 105569.

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Antiviral and immunoregulatory effects of curcumin on coxsackievirus B3-infected hepatitis

Lin, Y. J., Wang, L. C., Tsai, H. P., Chi, C. Y., Chang, C. P., Chen, S. H. & Wang, S. M., 2023 10月 15, 於: Virus Research. 336, 199203.

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2 引文斯高帕斯（Scopus）

Association of Single Nucleotide Polymorphisms in Nucleotide-Binding Domain Leucine-Rich Repeat Protein 1 with Clostridioides difficile Colonization or Infection

Tsai, B. Y., Tsai, P. J., Lee, C. C., Chiu, C. W., Lai, Y. H., Lee, J. C., Ko, W. C. & Hung, Y. P., 2023, 於: Infection and Drug Resistance. 16, p. 413-421 9 p.

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CDCP1 (CUB domain containing protein 1) is a potential urine-based biomarker in the diagnosis of low-grade urothelial carcinoma

Liu, C. L., Tsai, H. W., Peng, S. L., Chang, C. P., Chang, Y. H. & Huang, H. S., 2023 3月, 於: PloS one. 18, 3 March, e0281873.

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1 引文斯高帕斯（Scopus）

Characteristics of rectal chlamydia among men who have sex with men in southern Taiwan, 2020–2022: An emerging threat of rectal lymphogranuloma venereum L2b

Tsai, C. S., Chen, P. L., Lee, N. Y., Tsai, H. P., Huang, S. H., Chen, S. Y., Tang, Y. W., Lin, Y. C., Tsai, P. F., Mao, L. W., Su, S. L., Wang, J. L. & Ko, W. C., 2023 4月, 於: Journal of Microbiology, Immunology and Infection. 56, 2, p. 408-415 8 p.

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10 引文斯高帕斯（Scopus）

Clinical implications of PNA-sequencing as a complementary test for EGFR mutation analysis in human lung cancer

Chen, Y. L., Lin, C. C., Yu, Y. T., Chen, W. L., Yang, S. C., Huang, W., Su, W. C., Chow, N. H. & Ho, C. L., 2023, 於: Oncology Letters. 26, 6, 539.

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1 引文斯高帕斯（Scopus）

Detection of live SARS-CoV-2 virus and its variants by specially designed SERS-active substrates and spectroscopic analyses

Sitjar, J., Liao, J. D., Lee, H., Tsai, H. P., Wang, J. R., Chen, C. H., Wang, H. & Liu, B. H., 2023 5月 22, 於: Analytica Chimica Acta. 1256, 341151.

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9 引文斯高帕斯（Scopus）

Establishment of quantitative and recovery method for detection of dengue virus in wastewater with noncognate spike control

Chen, K. W., Chen, T. Y., Wang, S. T., Hou, T. Y., Wang, S. W. & Young, K. C., 2023 4月, 於: Journal of Virological Methods. 314, 114687.

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6 引文斯高帕斯（Scopus）

Experimental study on construction vibration during different phases of diaphragm wall-supported deep excavation and its influence on indoor sensitive receivers

Ko, Y. Y., Lai, L. Y., Lee, G. H., Wang, Y. F., Jao, S. W. & Fu, T. F., 2023 9月, 於: JVC/Journal of Vibration and Control. 29, 17-18, p. 3925-3941 17 p.

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4 引文斯高帕斯（Scopus）

High concordance rate of capillary electrophoresis workflow for microsatellite instability analysis and mismatch repair (MMR) immunostaining in colorectal carcinoma

Huang, W., Ho, C. L., Lee, C. T., Chen, W. L., Yang, S. C., Chow, N. H. & Chen, Y. L., 2023 4月, 於: PloS one. 18, 4 April, e0284227.

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1 引文斯高帕斯（Scopus）

Highly-specific aptamer targeting SARS-CoV-2 S1 protein screened on an automatic integrated microfluidic system for COVID-19 diagnosis

Wu, H. B., Wang, C. H., Chung, Y. D., Shan, Y. S., Lin, Y. J., Tsai, H. P. & Lee, G. B., 2023 9月 15, 於: Analytica Chimica Acta. 1274, 341531.

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13 引文斯高帕斯（Scopus）

Inguinal Fat Compensates Whole Body Metabolic Functionality in Partially Lipodystrophic Mice with Reduced PPARγ Expression

Chang, C. S., Yu, S. S., Ho, L. C., Chao, S. H., Chou, T. Y., Shao, A. N., Kao, L. Z., Chang, C. Y., Chen, Y. H., Wu, M. S., Tsai, P. J., Maeda, N. & Tsai, Y. S., 2023 2月, 於: International journal of molecular sciences. 24, 4, 3904.

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2 引文斯高帕斯（Scopus）

Interdependence of glycemic and lipid modulation in cured chronic hepatitis C patients by direct-acting antiviral agents

Cheng, P. N., Sun, H. Y., Feng, I. C., Chiu, Y. C., Wang, S. T., Tan, D. C., Chiu, H. C., Chien, S. C. & Young, K. C., 2023 2月, 於: Journal of Microbiology, Immunology and Infection. 56, 1, p. 20-30 11 p.

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1 引文斯高帕斯（Scopus）

Long-term DEHP/MEHP exposure promotes colorectal cancer stemness associated with glycosylation alterations

Shih, P. C., Chen, H. P., Hsu, C. C., Lin, C. H., Ko, C. Y., Hsueh, C. W., Huang, C. Y., Chu, T. H., Wu, C. C., Ho, Y. C., Nguyen, N. U. N., Huang, S. C., Fang, C. C., Tzou, S. J., Wu, Y. J., Chen, T. Y., Chang, C. F. & Lee, Y. K., 2023 6月 15, 於: Environmental Pollution. 327, 121476.

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10 引文斯高帕斯（Scopus）

Loss of fragile WWOX gene leads to senescence escape and genome instability

Cheng, H. C., Huang, P. H., Lai, F. J., Jan, M. S., Chen, Y. L., Chen, S. Y., Chen, W. L., Hsu, C. K., Huang, W. & Hsu, L. J., 2023 11月, 於: Cellular and Molecular Life Sciences. 80, 11, 338.

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2 引文斯高帕斯（Scopus）

Negative regulation of type I interferon signaling by integrin-linked kinase permits dengue virus replication

Kao, Y. S., Wang, L. C., Chang, P. C., Lin, H. M., Lin, Y. S., Yu, C. Y., Chen, C. C., Lin, C. F., Yeh, T. M., Wan, S. W., Wang, J. R., Ho, T. S., Chu, C. C., Zhang, B. C. & Chang, C. P., 2023 3月, 於: PLoS pathogens. 19, 3 March, e1011241.

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4 引文斯高帕斯（Scopus）

Novel antibacterial activity of silver nanoparticles combined with pterostilbene against Staphylococcus aureus via induction of apoptosis-like cell death and downregulation of ribosomal gene expression

Shih, Y. H., Pranata, R., Chen, Y. C., Liao, M. Y., Cheng, Y. H., Chen, Y. Y., Lai, Y. H., Tsai, P. J. & Chen, R. J., 2023 6月 13, 於: Environmental Science: Nano. 10, 8, p. 2115-2131 17 p.

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5 引文斯高帕斯（Scopus）

Novel metal peroxide nanoboxes restrain Clostridioides difficile infection beyond the bactericidal and sporicidal activity

Yang, L. X., Lai, Y. H., Cheung, C. I., Ye, Z., Huang, T. C., Wang, Y. C., Chin, Y. C., Chia, Z. C., Chen, Y. J., Li, M. J., Tseng, H. Y., Tsai, Y. T., Zhang, Z. B., Chen, K. H., Tsai, B. Y., Shieh, D. B., Lee, N. Y., Tsai, P. J. & Huang, C. C., 2023 11月, 於: Bioengineering and Translational Medicine. 8, 6, e10593.

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1 引文斯高帕斯（Scopus）

Novel Software for High-level Virological Testing: Self-Designed Immersive Virtual Reality Training Approach

Tsai, H. P., Lin, C. W., Lin, Y. J., Yeh, C. S. & Shan, Y. S., 2023, 於: Journal of medical Internet research. 25, e44538.

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4 引文斯高帕斯（Scopus）

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