微生物學科暨微生物及免疫學研究所

研究成果 1984 2020

2020

Bortezomib induces HSV-1 lethality in mice with neutrophil deficiency

Yao, H. W., Wang, L. C., Tsai, H. Y., Fang, Y. H., Zheng, C., Chen, S. H. & Hsu, S. M., 2020 一月 1, 於 : Journal of Leukocyte Biology. 107, 1, p. 105-112 8 p.

研究成果: Article

Human Herpesvirus 1
Neutrophils
Virus Diseases
Leukocytes
Drug Therapy
2019
1 引文 (Scopus)
開啟存取
Reactive Oxygen Species
Oxygen
Water
Nitric oxide
Cartilage
開啟存取
Enterovirus Infections
Minocycline
Antiviral Agents
Anti-Inflammatory Agents
Enterovirus
Escherichia coli Proteins
Organism Cloning
Recombinant Proteins
Histidine
Proteins

Combination of modified NS1 and NS3 as a novel vaccine strategy against dengue virus infection

Kao, Y. S., Yu, C. Y., Huang, H. J., Tien, S. M., Wang, W. Y., Yang, M., Anderson, R., Yeh, T. M., Lin, Y. S. & Wan, S. W., 2019 十月 1, 於 : Journal of Immunology. 203, 7, p. 1909-1917 9 p.

研究成果: Article

Dengue Virus
Virus Diseases
Vaccines
Severe Dengue
Cellular Immunity

Curcumin functions as a MEK inhibitor to induce a synthetic lethal effect on KRAS mutant colorectal cancer cells receiving targeted drug regorafenib

Wu, C. S., Wu, S. Y., Chen, H. C., Chu, C. A., Tang, H. H., Liu, H. S., Hong, Y. R., Huang, C. Y. F., Huang, G. C. & Su, C. L., 2019 十二月, 於 : Journal of Nutritional Biochemistry. 74, 108227.

研究成果: Article

Curcumin
HCT116 Cells
Mitogen-Activated Protein Kinase Kinases
Colorectal Neoplasms
Cells
4 引文 (Scopus)

Degradative autophagy selectively regulates CCND1 (cyclin D1) and MIR224, two oncogenic factors involved in hepatocellular carcinoma tumorigenesis

Wu, S. Y., Lan, S. H. & Liu, H-S., 2019 四月 3, 於 : Autophagy. 15, 4, p. 729-730 2 p.

研究成果: Comment/debate

Cyclin D1
Autophagy
Hepatocellular Carcinoma
Carcinogenesis
Cell Cycle

Expression of prothymosin α in lung cancer is associated with squamous cell carcinoma and smoking

Kuo, Y. H., Shiau, A. L., Tung, C. L., Su, Y. C., Li, C. F., Su, B. H., Tsao, C. J., Wu, C. L., Feng, Y. H. & Wu, P., 2019 六月, 於 : Oncology Letters. 17, 6, p. 5740-5746 7 p.

研究成果: Article

開啟存取
Squamous Cell Carcinoma
Lung Neoplasms
Smoking
Non-Small Cell Lung Carcinoma
Neoplasms

Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling

Ge, J., Remesh, S. G., Hammel, M., Pan, S., Mahan, A. D., Wang, S-Y. & Wang, X., 2019 八月 6, 於 : Structure. 27, 8, p. 1296-1307.e5

研究成果: Article

Interleukin-1 Receptors
Cytokines
Signal Transduction
Ligands

Group A Streptococcus Induces LAPosomes via SLO/β1 Integrin/NOX2/ROS Pathway in Endothelial Cells That Are Ineffective in Bacterial Killing and Suppress Xenophagy

Cheng, Y. L., Kuo, C. F., Lu, S. L., Hiroko, O., Wu, Y. N., Hsie, C. L., Nod, T., Wu, S. R., Anderson, R., Lin, C. F., Chen, C. L., Wu, J. J. & Lin, Y. S., 2019 一月 1, 於 : mBio. 10, 5, e02148-19.

研究成果: Article

開啟存取
Streptococcus
Integrins
Reactive Oxygen Species
Endothelial Cells
Phagocytosis

HECT E3 Ubiquitin Ligase-Regulated Txnip Degradation Facilitates TLR2-Mediated Inflammation During Group A Streptococcal Infection

Tseng, P. C., Kuo, C. F., Cheng, M. H., Wan, S. W., Lin, C. F., Chang, C. P., Lin, Y. S., Wu, J. J., Huang, C. C. & Chen, C. L., 2019 九月 18, 於 : Frontiers in Immunology. 10, 2147.

研究成果: Article

開啟存取
Toll-Like Receptor 2
Streptococcal Infections
Thioredoxins
Ubiquitin-Protein Ligases
Proteolysis

Implantable microneedles with an immune-boosting function for effective intradermal influenza vaccination

Chen, Y. H., Lai, K. Y., Chiu, Y. H., Wu, Y. W., Shiau, A-L. & Chen, M-C., 2019 十月 1, 於 : Acta Biomaterialia. 97, p. 230-238 9 p.

研究成果: Article

Vaccines
Chitosan
Human Influenza
Vaccination
Influenza Vaccines

Interleukin-6 from Adipose-Derived Stem Cells Promotes Tissue Repair by the Increase of Cell Proliferation and Hair Follicles in Ischemia/Reperfusion-Treated Skin Flaps

Pu, C. M., Chen, Y. C., Chen, Y. C., Lee, T. L., Peng, Y. S., Chen, S. H., Yen, Y. H., Chien, C. L., Hsieh, J. H. & Chen, Y. L., 2019 一月 1, 於 : Mediators of Inflammation. 2019, 2343867.

研究成果: Article

開啟存取
Hair Follicle
Reperfusion
Interleukin-6
Stem Cells
Ischemia
開啟存取
Enterovirus Infections
Enterovirus
Immune system
Immune System
Inflammasomes

Melatonin MT2 receptor agonist IIK-7 produces antinociception by modulation of ROS and suppression of spinal microglial activation in neuropathic pain rats

Kuthati, Y., Davuluri, V. N. G., Yang, C. P., Chang, H. C., Chang, C. P. & Wong, C. S., 2019 一月 1, 於 : Journal of Pain Research. 12, p. 2473-2485 13 p.

研究成果: Article

開啟存取
Melatonin MT2 Receptor
Neuralgia
Reactive Oxygen Species
Melatonin Receptors
Neuroglia
2 引文 (Scopus)
arsenopyrite
Arsenic
mobilization
arsenic
colonization
3 引文 (Scopus)
開啟存取
Class III Phosphatidylinositol 3-Kinases
Autophagy
Tumors
Colorectal Neoplasms
Genes

MST3 is involved in ENaC-mediated hypertension

Lu, T. J., Kan, W. C., Yang, S. S., Jiang, S. T., Wu, S. N., Ling, P., Bao, B. Y., Lin, C. Y., Yang, Z. Y., Weng, Y. P., Chan, C. H. & Lu, T. L., 2019 一月 1, 於 : American Journal of Physiology - Renal Physiology. 317, 7, p. F30-F42

研究成果: Article

Epithelial Sodium Channels
Phosphotransferases
Hypertension
Hypernatremia
Hypokalemia
開啟存取
Breast Neoplasms
Recurrence
Mutation
Genes
Computational Biology

Oct4 upregulates osteopontin via Egr1 and is associated with poor outcome in human lung cancer

Feng, Y. H., Su, Y. C., Lin, S. F., Lin, P. R., Wu, C. L., Tung, C. L., Li, C. F., Shieh, G. S. & Shiau, A. L., 2019 八月 9, 於 : BMC cancer. 19, 1, 791.

研究成果: Article

開啟存取
Osteopontin
Lung Neoplasms
Up-Regulation
Growth
Genes
開啟存取
Phosphoric Monoester Hydrolases
Urinary Bladder Neoplasms
Nuclear Localization Signals
Proteins
Ubiquitination

Prothymosin α promotes STAT3 acetylation to induce cystogenesis in Pkd1-deficient mice

Chen, Y. C., Su, Y. C., Shieh, G. S., Su, B. H., Su, W. C., Huang, P. H., Jiang, S. T., Shiau, A. L. & Wu, C. L., 2019 十一月 1, 於 : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 11, p. 13051-13061 11 p.

研究成果: Article

Acetylation
Polycystic Kidney Diseases
STAT3 Transcription Factor
Kidney
Cysts
1 引文 (Scopus)
Glycogen Synthase Kinase 3
Streptococcus pyogenes
Streptococcus
Macrophages
Infection

Swimming pool-associated Vittaforma-like microsporidia linked to microsporidial keratoconjunctivitis outbreak, Taiwan

Chen, J. S., Hsu, T. K., Hsu, B. M., Chao, S. C., Huang, T. Y., Ji, D. D., Yang, P. Y. & Huang, I. H., 2019 一月 1, 於 : Emerging infectious diseases. 25, 11, p. 2100-2103 4 p.

研究成果: Article

開啟存取
Vittaforma
Microsporidia
Swimming Pools
Keratoconjunctivitis
Taiwan
開啟存取
Leucine-Responsive Regulatory Protein
Clostridium difficile
Genome
Gram-Positive Bacteria
Virulence Factors
2018
2 引文 (Scopus)

A multi-omic analysis reveals the role of fumarate in regulating the virulence of enterohemorrhagic Escherichia coli

Kuo, C. J., Wang, S. T., Lin, C. M., Chiu, H. C., Huang, C. R., Lee, D. Y., Chang, G. D., Chou, T. C., Chen, J. W. & Chen, C. S., 2018 三月 1, 於 : Cell Death and Disease. 9, 3, 381.

研究成果: Article

Enterohemorrhagic Escherichia coli
Fumarates
Virulence
Caenorhabditis elegans
Escherichia coli Infections
1 引文 (Scopus)
開啟存取
Autophagy
Antioxidant Response Elements
Apoptosis
Drug Therapy
Physiological Stress
1 引文 (Scopus)
Genomics
Plasmids
Clone Cells
Escherichia coli
Cefixime
1 引文 (Scopus)

Correlation of severity of human tick-borne encephalitis virus disease and pathogenicity in mice

Kurhade, C., Schreier, S., Lee, Y. P., Zegenhagen, L., Hjertqvist, M., Dobler, G., Kröger, A. & Överby, A. K., 2018 九月, 於 : Emerging infectious diseases. 24, 9, p. 1709-1712 4 p.

研究成果: Article

開啟存取
Tick-Borne Encephalitis Viruses
Tick-Borne Encephalitis
Virus Diseases
Nervous System
Virulence
18 引文 (Scopus)

Dengue virus-induced ER stress is required for autophagy activation, viral replication, and pathogenesis both in vitro and in vivo

Lee, Y. R., Kuo, S. H., Lin, C. Y., Fu, P. J., Lin, Y. S., Yeh, T. M. & Liu, H. S., 2018 十二月 1, 於 : Scientific reports. 8, 1, 489.

研究成果: Article

Virus Activation
Dengue Virus
Endoplasmic Reticulum Stress
Autophagy
Virus Diseases
4 引文 (Scopus)

Dextromethorphan attenuates NADPH oxidase-regulated glycogen synthase kinase 3 and NF-B activation and reduces nitric oxide production in group a streptococcal infection

Chen, C. L., Cheng, M. H., Kuo, C. F., Cheng, Y. L., Li, M. H., Chang, C. P., Wu, J. J., Anderson, R., Wang, S., Tsai, P-J., Liu, C. C. & Linc, Y. S., 2018 六月, 於 : Antimicrobial agents and chemotherapy. 62, 6, e02045-17.

研究成果: Article

Dextromethorphan
Glycogen Synthase Kinase 3
Streptococcal Infections
NADPH Oxidase
Streptococcus
4 引文 (Scopus)

Elovl6 is a negative clinical predictor for liver cancer and knockdown of Elovl6 reduces murine liver cancer progression

Su, Y. C., Feng, Y. H., Wu, H. T., Huang, Y. S., Tung, C. L., Wu, P., Chang, C. J., Shiau, A. L. & Wu, C. L., 2018 十二月 1, 於 : Scientific reports. 8, 1, 6586.

研究成果: Article

Liver Neoplasms
Hepatocellular Carcinoma
Neoplasms
Fatty Acids
Monounsaturated Fatty Acids
1 引文 (Scopus)

Estrogen and mechanical loading-related regulation of estrogen receptor-β and apoptosis in tendinopathy

Hsieh, J. L., Jou, I. M., Wu, C. L., Wu, P. T., Shiau, A. L., Chong, H. E., Lo, Y. T., Shen, P. C. & Chen, S. Y., 2018 十月, 於 : PloS one. 13, 10, e0204603.

研究成果: Article

Tendinopathy
Estrogen Receptors
estrogens
Tendons
Estrogens
Enterovirus
B-Lymphocytes
Enterovirus Infections
Viral Load
Therapeutics
3 引文 (Scopus)

Genetic relationships among multidrug-resistant salmonella enterica serovar typhimurium strains from humans and animals

Hong, Y. P., Wang, Y. W., Huang, I. H., Liao, Y. C., Kuo, H. C., Liu, Y. Y., Tu, Y. H., Chen, B. H., Liao, Y. S. & Chiou, C. S., 2018 五月, 於 : Antimicrobial agents and chemotherapy. 62, 5, e00213.

研究成果: Article

Azithromycin
Salmonella enterica
Salmonella
Cefoxitin
Trimethoprim
16 引文 (Scopus)

Hepatocellular carcinoma–related cyclin D1 is selectively regulated by autophagy degradation system

Wu, S. Y., Lan, S. H., Wu, S-R., Chiu, Y. C., Lin, X-Z., Su, I. J., Tsai, T. F., Yen, C-J., Lu, T-H., Liang, F. W., Li, C-Y., Su, H-J., Su, C. L. & Liu, H-S., 2018 七月 1, 於 : Hepatology. 68, 1, p. 141-154 14 p.

研究成果: Article

Cyclin D1
Autophagy
Hepatocellular Carcinoma
Neoplasms
Carcinogenesis
17 引文 (Scopus)

Herpes simplex virus 1 tegument protein VP22 abrogates cGAS/ STING-mediated antiviral innate immunity

Huang, J., You, H., Su, C., Li, Y., Chen, S. & Zheng, C., 2018 八月 1, 於 : Journal of Virology. 92, 15, e00841-18.

研究成果: Article

GMP synthase (glutamine-hydrolyzing)
cyclic GMP
Human herpesvirus 1
interferons
Innate Immunity
2 引文 (Scopus)

In vitro reconstitution of sortase-catalyzed pilus polymerization reveals structural elements involved in pilin cross-linking

Chang, C., Amer, B. R., Osipiuk, J., McConnell, S. A., Huang, I. H., Hsieh, V., Fu, J., Nguyen, H. H., Muroski, J., Flores, E., Loo, R. R. O., Loo, J. A., Putkey, J. A., Joachimiak, A., Das, A., Clubb, R. T. & Ton-That, H., 2018 六月 12, 於 : Proceedings of the National Academy of Sciences of the United States of America. 115, 24, p. E5477-E5486

研究成果: Article

Fimbriae Proteins
Polymerization
Protein Subunits
Ligation
Enzymes
10 引文 (Scopus)
lauric acid
Clostridium difficile
Inflammation
Clostridium Infections
Growth
7 引文 (Scopus)
Macrophage Migration-Inhibitory Factors
Glycocalyx
Dengue
Metalloproteases
Proteins
4 引文 (Scopus)
Macrophage Migration-Inhibitory Factors
Dengue Virus
Minocycline
Autophagy
Virus Replication
1 引文 (Scopus)

MST3 (mammalian Ste20-like protein kinase 3), a novel gene involved in ion homeostasis and renal regulation of blood pressure in spontaneous hypertensive rats

Lu, T. J., Chan, C. H., Ling, P., Chao, Y. M., Bao, B. Y., Chiang, C. Y., Lee, T. H., Weng, Y. P., Kan, W. C. & Lu, T. L., 2018 十二月 1, 於 : International Urology and Nephrology. 50, 12, p. 2299-2307 9 p.

研究成果: Article

Protein Kinases
Homeostasis
Ions
Blood Pressure
Hypertension
1 引文 (Scopus)
NAD+ Nucleosidase
Streptococcus
NAD
Endothelial Cells
Vacuoles
4 引文 (Scopus)
Indocyanine Green
Methicillin-Resistant Staphylococcus aureus
Light
Photochemotherapy
Singlet Oxygen
28 引文 (Scopus)

PM2.5-induced oxidative stress increases intercellular adhesion molecule-1 expression in lung epithelial cells through the IL-6/AKT/STAT3/NF-ΚB-dependent pathway

Liu, C. W., Lee, T. L., Chen, Y. C., Liang, C. J., Wang, S. H., Lue, J. H., Tsai, J. S., Lee, S. W., Chen, S. H., Yang, Y. F., Chuang, T. Y. & Chen, Y. L., 2018 一月 12, 於 : Particle and Fibre Toxicology. 15, 1, 4.

研究成果: Article

Oxidative stress
Particulate Matter
Intercellular Adhesion Molecule-1
Interleukin-6
Oxidative Stress

Sera of patients with systemic lupus erythematosus cross-neutralizes dengue viruses

Zainal, N., Tan, K. K., Johari, J., Hussein, H., Wan Musa, W. R., Hassan, J., Lin, Y. S. & AbuBakar, S., 2018 十月, 於 : Microbiology and Immunology. 62, 10, p. 659-672 14 p.

研究成果: Article

Dengue Virus
Systemic Lupus Erythematosus
Serum
Dengue
Immunoglobulin G
9 引文 (Scopus)

Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein

Zhang, S., Zhou, P., Wang, P., Li, Y., Jiang, L., Jia, W., Wang, H., Fan, A., Wang, D., Shi, X., Fang, X., Hammel, M., Wang, S., Wang, X. & Zhang, L., 2018 七月 10, 於 : Cell Reports. 24, 2, p. 441-452 12 p.

研究成果: Article

Functional analysis
Neutralizing Antibodies
Structural analysis
Epitopes
Glycoproteins

Structural insights into the duplex DNA processing of TREX2

Cheng, H. L., Lin, C. T., Huang, K. W., Wang, S., Lin, Y. T., Toh, S. I. & Hsiao, Y. Y., 2018 一月 1, 於 : Nucleic acids research. 46, 22, p. 12166-12176 11 p.

研究成果: Article

開啟存取
Exonucleases
DNA
Skin
Genomic Instability
Psoriasis
3 引文 (Scopus)

The monocyte-macrophage-mast cell axis in dengue pathogenesis

Wan, S. W., Wu-Hsieh, B. A., Lin, Y-S., Chen, W. Y., Huang, Y. & Anderson, R., 2018 十一月 8, 於 : Journal of biomedical science. 25, 1, 77.

研究成果: Review article

Dengue Virus
Dengue
Macrophages
Viruses
Mast Cells
3 引文 (Scopus)

Toll-like receptor 3 is involved in detection of enterovirus a71 infection and targeted by viral 2a protease

Chen, K. R., Yu, C. K., Kung, S. H., Chen, S. H., Chang, C. F., Ho, T. C., Lee, Y. P., Chang, H. C., Huang, L. Y., Lo, S. Y., Chang, J. C. & Ling, P., 2018 十二月, 於 : Viruses. 10, 12, 689.

研究成果: Article

Toll-Like Receptor 3
Enterovirus Infections
Peptide Hydrolases
Antiviral Agents
Enterovirus