每年研究成果
研究成果
2020
Bortezomib induces HSV-1 lethality in mice with neutrophil deficiency
Yao, H. W., Wang, L. C., Tsai, H. Y., Fang, Y. H., Zheng, C., Chen, S. H. & Hsu, S. M., 2020 一月 1, 於 : Journal of Leukocyte Biology. 107, 1, p. 105-112 8 p.研究成果: Article
Functional analysis of Clostridium difficile sortase B reveals key residues for catalytic activity and substrate specificity
Kang, C. Y., Huang, I. H., Chou, C. C., Wu, T. Y., Chang, J. C., Hsiao, Y. Y., Cheng, C. H., Tsai, W. J., Hsu, K. C. & Wang, S., 2020 三月 13, 於 : Journal of Biological Chemistry. 295, 11, p. 3734-3745 12 p.研究成果: Article
Hepatocellular carcinoma-derived high mobility group box 1 triggers M2 macrophage polarization via a TLR2/NOX2/autophagy axis
Shiau, D. J., Kuo, W. T., Davuluri, G. V. N., Shieh, C. C., Tsai, P. J., Chen, C. C., Lin, Y. S., Wu, Y. Z., Hsiao, Y. P. & Chang, C. P., 2020 十二月 1, 於 : Scientific reports. 10, 1, 13582.研究成果: Article
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Loss of EGR-1 uncouples compensatory responses of pancreatic β cells
Leu, S. Y., Kuo, L. H., Weng, W. T., Lien, I. C., Yang, C. C., Hsieh, T. T., Cheng, Y. N., Chien, P. H., Ho, L. C., Chen, S. H., Shan, Y. S., Chen, Y. W., Tsai, P. J., Sung, J. M. & Tsai, Y. S., 2020, 於 : Theranostics. 10, 9, p. 4233-4249 17 p.研究成果: Article
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Nicotinamide Increases Intracellular NAD+ Content to Enhance Autophagy-Mediated Group A Streptococcal Clearance in Endothelial Cells
Hsieh, C. L., Hsieh, S. Y., Huang, H. M., Lu, S. L., Omori, H., Zheng, P. X., Ho, Y. N., Cheng, Y. L., Lin, Y. S., Chiang-Ni, C., Tsai, P. J., Wang, S. Y., Liu, C. C., Noda, T. & Wu, J. J., 2020 二月 11, 於 : Frontiers in Microbiology. 11, 117.研究成果: Article
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Oct4 promotes M2 macrophage polarization through upregulation of macrophage colony-stimulating factor in lung cancer
Lu, C. S., Shiau, A. L., Su, B. H., Su, B. H., Hsu, T. S., Wang, C. T., Su, Y. C., Tsai, M. S., Feng, Y. H., Tseng, Y. L., Yen, Y. T., Wu, C. L., Shieh, G. S. & Shieh, G. S., 2020 六月 1, 於 : Journal of Hematology and Oncology. 13, 1, 62.研究成果: Article
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ProT-α gene transfer attenuates cardiopulmonary remedying and mortality in a flow-induced pulmonary hypertension rat model
Roan, J. N., Hsu, C. H., Fang, S. Y., Chiu, M. S., Wu, C. L., Shiau, A. L. & Lam, C. F., 2020, (Accepted/In press) 於 : Journal of Heart and Lung Transplantation. 39, 10, p. 1126-1135 10 p.研究成果: Article
Suppression of the reactive oxygen response alleviates experimental autoimmune uveitis in mice
Hsu, S. M., Yang, C. H., Teng, Y. T., Tsai, H. Y., Lin, C. Y., Lin, C. J., Shieh, C. C. & Chen, S. H., 2020 五月 1, 於 : International journal of molecular sciences. 21, 9, 3261.研究成果: Article
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UvrY is required for the full virulence of Aeromonas dhakensis
Chen, Y. W., Yeh, W. H., Tang, H. J., Chen, J. W., Shu, H. Y., Su, Y. C., Wang, S. T., Kuo, C. J., Chuang, Y. C., Chen, C. C., Ko, W. C., Chen, C. S. & Chen, P. L., 2020 一月 1, 於 : Virulence. 11, 1, p. 502-520 19 p.研究成果: Article
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Wwox deficiency leads to neurodevelopmental and degenerative neuropathies and glycogen synthase kinase 3β-mediated epileptic seizure activity in mice
Cheng, Y. Y., Chou, Y. T., Lai, F. J., Jan, M. S., Chang, T. H., Jou, I. M., Chen, P. S., Lo, J. Y., Huang, S. S., Chang, N. S., Liou, Y. T., Hsu, P. C., Cheng, H. C., Lin, Y. S. & Hsu, L. J., 2020 一月 30, 於 : Acta Neuropathologica Communications. 8, 1, 6.研究成果: Article
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1
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斯高帕斯（Scopus）
2019
Amelioration of experimentally induced arthritis by reducing reactive oxygen species production through the intra-articular injection of water-soluble fullerenol
Kuo, W. S., Weng, C-T., Chen, J. H., Wu, C-L., Shiau, A-L., Hsieh, J. L., So, E. C., Wu, P-T. & Chen, S. Y., 2019 六月, 於 : Nanomaterials. 9, 6, 909.研究成果: Article
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1
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斯高帕斯（Scopus）
Anti-inflammatory and antiviral effects of minocycline in enterovirus 71 infections
Liao, Y. T., Wang, S. M. & Chen, S. H., 2019 十月, 於 : Biomedicine and Pharmacotherapy. 118, 109271.研究成果: Article
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3
引文
斯高帕斯（Scopus）
Cloning, expression, and purification of the recombinant pro-apoptotic dominant-negative survivin T34A-C84A protein in Escherichia coli
Tsai, S. L., Chang, Y. C., Sarvagalla, S., Wang, S., Coumar, M. S. & Cheung, C. H. A., 2019 八月, 於 : Protein Expression and Purification. 160, p. 73-83 11 p.研究成果: Article
2
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斯高帕斯（Scopus）
Combination of modified NS1 and NS3 as a novel vaccine strategy against dengue virus infection
Kao, Y. S., Yu, C. Y., Huang, H. J., Tien, S. M., Wang, W. Y., Yang, M., Anderson, R., Yeh, T. M., Lin, Y. S. & Wan, S. W., 2019 十月 1, 於 : Journal of Immunology. 203, 7, p. 1909-1917 9 p.研究成果: Article
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斯高帕斯（Scopus）
Conditional deletion of CC2D1A reduces hippocampal synaptic plasticity and impairs cognitive function through RAC1 hyperactivation
Yang, C. Y., Yu, T. H., Wen, W. L., Ling, P. & Hsu, K. S., 2019 六月 19, 於 : Journal of Neuroscience. 39, 25, p. 4959-4975 17 p.研究成果: Article
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斯高帕斯（Scopus）
Curcumin functions as a MEK inhibitor to induce a synthetic lethal effect on KRAS mutant colorectal cancer cells receiving targeted drug regorafenib
Wu, C. S., Wu, S. Y., Chen, H. C., Chu, C. A., Tang, H. H., Liu, H. S., Hong, Y. R., Huang, C. Y. F., Huang, G. C. & Su, C. L., 2019 十二月, 於 : Journal of Nutritional Biochemistry. 74, 108227.研究成果: Article
Expression of prothymosin α in lung cancer is associated with squamous cell carcinoma and smoking
Kuo, Y. H., Shiau, A. L., Tung, C. L., Su, Y. C., Li, C. F., Su, B. H., Tsao, C. J., Wu, C. L., Feng, Y. H. & Wu, P., 2019 六月, 於 : Oncology Letters. 17, 6, p. 5740-5746 7 p.研究成果: Article
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Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling
Ge, J., Remesh, S. G., Hammel, M., Pan, S., Mahan, A. D., Wang, S. & Wang, X., 2019 八月 6, 於 : Structure. 27, 8, p. 1296-1307.e5研究成果: Article
Group A Streptococcus Induces LAPosomes via SLO/β1 Integrin/NOX2/ROS Pathway in Endothelial Cells That Are Ineffective in Bacterial Killing and Suppress Xenophagy
Cheng, Y. L., Kuo, C. F., Lu, S. L., Hiroko, O., Wu, Y. N., Hsie, C. L., Nod, T., Wu, S. R., Anderson, R., Lin, C. F., Chen, C. L., Wu, J. J. & Lin, Y. S., 2019, 於 : mBio. 10, 5, e02148-19.研究成果: Article
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3
引文
斯高帕斯（Scopus）
HECT E3 Ubiquitin Ligase-Regulated Txnip Degradation Facilitates TLR2-Mediated Inflammation During Group A Streptococcal Infection
Tseng, P. C., Kuo, C. F., Cheng, M. H., Wan, S. W., Lin, C. F., Chang, C. P., Lin, Y. S., Wu, J. J., Huang, C. C. & Chen, C. L., 2019 九月 18, 於 : Frontiers in Immunology. 10, 2147.研究成果: Article
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Implantable microneedles with an immune-boosting function for effective intradermal influenza vaccination
Chen, Y. H., Lai, K. Y., Chiu, Y. H., Wu, Y. W., Shiau, A-L. & Chen, M-C., 2019 十月 1, 於 : Acta Biomaterialia. 97, p. 230-238 9 p.研究成果: Article
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斯高帕斯（Scopus）
Interleukin-6 from Adipose-Derived Stem Cells Promotes Tissue Repair by the Increase of Cell Proliferation and Hair Follicles in Ischemia/Reperfusion-Treated Skin Flaps
Pu, C. M., Chen, Y. C., Chen, Y. C., Lee, T. L., Peng, Y. S., Chen, S. H., Yen, Y. H., Chien, C. L., Hsieh, J. H. & Chen, Y. L., 2019, 於 : Mediators of Inflammation. 2019, 2343867.研究成果: Article
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Melatonin MT2 receptor agonist IIK-7 produces antinociception by modulation of ROS and suppression of spinal microglial activation in neuropathic pain rats
Kuthati, Y., Davuluri, V. N. G., Yang, C. P., Chang, H. C., Chang, C. P. & Wong, C. S., 2019, 於 : Journal of Pain Research. 12, p. 2473-2485 13 p.研究成果: Article
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1
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斯高帕斯（Scopus）
Micro-colonization of arsenic-resistant Staphylococcus sp. As-3 on arsenopyrite (FeAsS) drives arsenic mobilization under anoxic sub-surface mimicking conditions
Rathod, J., Jean, J. S., Jiang, W. T., Huang, I. H., Liu, B. H. & Lee, Y. C., 2019 六月 15, 於 : Science of the Total Environment. 669, p. 527-539 13 p.研究成果: Article
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斯高帕斯（Scopus）
MiR-338-5p promotes metastasis of colorectal cancer by inhibition of phosphatidylinositol 3-kinase, catalytic subunit type 3-mediated autophagy pathway
Chu, C. A., Lee, C. T., Lee, J. C., Wang, Y. W., Huang, C. T., Lan, S. H., Lin, P. C., Lin, B. W., Tian, Y. F., Liu, H. S. & Chow, N. H., 2019 五月, 於 : EBioMedicine. 43, p. 270-281 12 p.研究成果: Article
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7
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斯高帕斯（Scopus）
MST3 is involved in ENaC-mediated hypertension
Lu, T. J., Kan, W. C., Yang, S. S., Jiang, S. T., Wu, S. N., Ling, P., Bao, B. Y., Lin, C. Y., Yang, Z. Y., Weng, Y. P., Chan, C. H. & Lu, T. L., 2019 一月 1, 於 : American Journal of Physiology - Renal Physiology. 317, 1, p. F30-F42研究成果: Article
Mutation of the PTCH1 gene predicts recurrence of breast cancer
Wang, C. Y., Chang, Y. C., Kuo, Y. L., Lee, K. T., Chen, P. S., Cheung, C. H. A., Chang, C. P., Phan, N. N., Shen, M. R. & Hsu, H. P., 2019 十一月 8, 於 : Scientific reports. 9, 1, 1 p., 16359.研究成果: Article
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2
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斯高帕斯（Scopus）
Oct4 upregulates osteopontin via Egr1 and is associated with poor outcome in human lung cancer
Feng, Y. H., Su, Y. C., Lin, S. F., Lin, P. R., Wu, C. L., Tung, C. L., Li, C. F., Shieh, G. S. & Shiau, A. L., 2019 八月 9, 於 : BMC cancer. 19, 1, 791.研究成果: Article
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Prothymosin-α enhances phosphatase and tensin homolog expression and binds with tripartite motif-containing protein 21 to regulate Kelch-like ECH-associated protein 1/nuclear factor erythroid 2-related factor 2 signaling in human bladder cancer
Tsai, Y. S., Jou, Y. C., Tsai, H. T., Shiau, A. L., Wu, C. L. & Tzai, T. S., 2019 四月, 於 : Cancer Science. 110, 4, p. 1208-1219 12 p.研究成果: Article
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2
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斯高帕斯（Scopus）
Prothymosin α promotes STAT3 acetylation to induce cystogenesis in Pkd1-deficient mice
Chen, Y. C., Su, Y. C., Shieh, G. S., Su, B. H., Su, W. C., Huang, P. H., Jiang, S. T., Shiau, A. L. & Wu, C. L., 2019 十一月 1, 於 : FASEB Journal. 33, 11, p. 13051-13061 11 p.研究成果: Article
Streptolysin S induces mitochondrial damage and macrophage death through inhibiting degradation of glycogen synthase kinase-3β in Streptococcus pyogenes infection
Tsao, N., Kuo, C. F., Cheng, M. H., Lin, W. C., Lin, C. F. & Lin, Y. S., 2019 十二月 1, 於 : Scientific reports. 9, 1, 5371.研究成果: Article
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斯高帕斯（Scopus）
Swimming pool-associated Vittaforma-like microsporidia linked to microsporidial keratoconjunctivitis outbreak, Taiwan
Chen, J. S., Hsu, T. K., Hsu, B. M., Chao, S. C., Huang, T. Y., Ji, D. D., Yang, P. Y. & Huang, I. H., 2019, 於 : Emerging infectious diseases. 25, 11, p. 2100-2103 4 p.研究成果: Article
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The Transcriptional Regulator Lrp Contributes to Toxin Expression, Sporulation, and Swimming Motility in Clostridium difficile
Chen, K. Y., Rathod, J., Chiu, Y. C., Chen, J. W., Tsai, P. J. & Huang, I. H., 2019 一月 1, 於 : Frontiers in Cellular and Infection Microbiology. 9, 1 p.研究成果: Article
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2018
A multi-omic analysis reveals the role of fumarate in regulating the virulence of enterohemorrhagic Escherichia coli
Kuo, C. J., Wang, S. T., Lin, C. M., Chiu, H. C., Huang, C. R., Lee, D. Y., Chang, G. D., Chou, T. C., Chen, J. W. & Chen, C. S., 2018 三月 1, 於 : Cell Death and Disease. 9, 3, 381.研究成果: Article
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斯高帕斯（Scopus）
Autophagy regulates vinorelbine sensitivity due to continued Keap1-mediated ROS generation in lung adenocarcinoma cells
Wu, Y. W., Lin, C. F., Lin, Y. S., Su, W. C. & Chiu, W. H., 2018 十二月 1, 於 : Cell Death Discovery. 4, 1, 96.研究成果: Article
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1
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斯高帕斯（Scopus）
Comparative genomics of Escherichia coli sequence type 219 clones from the same patient: Evolution of the IncI1 blaCMY-carrying plasmid in vivo
Kao, C. Y., Chen, J. W., Liu, T. L., Yan, J. J. & Wu, J. J., 2018 七月 9, 於 : Frontiers in Microbiology. 9, JUL, 1518.研究成果: Article
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斯高帕斯（Scopus）
Correlation of severity of human tick-borne encephalitis virus disease and pathogenicity in mice
Kurhade, C., Schreier, S., Lee, Y. P., Zegenhagen, L., Hjertqvist, M., Dobler, G., Kröger, A. & Överby, A. K., 2018 九月, 於 : Emerging infectious diseases. 24, 9, p. 1709-1712 4 p.研究成果: Article
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2
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斯高帕斯（Scopus）
Dengue virus-induced ER stress is required for autophagy activation, viral replication, and pathogenesis both in vitro and in vivo
Lee, Y. R., Kuo, S. H., Lin, C. Y., Fu, P. J., Lin, Y. S., Yeh, T. M. & Liu, H. S., 2018 十二月 1, 於 : Scientific reports. 8, 1, 489.研究成果: Article
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斯高帕斯（Scopus）
Dextromethorphan attenuates NADPH oxidase-regulated glycogen synthase kinase 3 and NF-B activation and reduces nitric oxide production in group a streptococcal infection
Chen, C. L., Cheng, M. H., Kuo, C. F., Cheng, Y. L., Li, M. H., Chang, C. P., Wu, J. J., Anderson, R., Wang, S., Tsai, P-J., Liu, C. C. & Linc, Y. S., 2018 六月, 於 : Antimicrobial agents and chemotherapy. 62, 6, e02045-17.研究成果: Article
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斯高帕斯（Scopus）
Elovl6 is a negative clinical predictor for liver cancer and knockdown of Elovl6 reduces murine liver cancer progression
Su, Y. C., Feng, Y. H., Wu, H. T., Huang, Y. S., Tung, C. L., Wu, P., Chang, C. J., Shiau, A. L. & Wu, C. L., 2018 十二月 1, 於 : Scientific reports. 8, 1, 6586.研究成果: Article
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斯高帕斯（Scopus）
Estrogen and mechanical loading-related regulation of estrogen receptor-β and apoptosis in tendinopathy
Hsieh, J. L., Jou, I. M., Wu, C. L., Wu, P. T., Shiau, A. L., Chong, H. E., Lo, Y. T., Shen, P. C. & Chen, S. Y., 2018 十月, 於 : PloS one. 13, 10, e0204603.研究成果: Article
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斯高帕斯（Scopus）
Flt3 ligand treatment reduces enterovirus A71 lethality in mice with enhanced B cell responses
Lin, Y. W., Wang, L. C., Lee, C. K. & Chen, S. H., 2018 十二月 1, 於 : Scientific reports. 8, 1, 12184.研究成果: Article
Genetic relationships among multidrug-resistant salmonella enterica serovar typhimurium strains from humans and animals
Hong, Y. P., Wang, Y. W., Huang, I. H., Liao, Y. C., Kuo, H. C., Liu, Y. Y., Tu, Y. H., Chen, B. H., Liao, Y. S. & Chiou, C. S., 2018 五月, 於 : Antimicrobial agents and chemotherapy. 62, 5, e00213.研究成果: Article
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斯高帕斯（Scopus）
Hepatocellular carcinoma–related cyclin D1 is selectively regulated by autophagy degradation system
Wu, S. Y., Lan, S. H., Wu, S. R., Chiu, Y. C., Lin, X. Z., Su, I. J., Tsai, T. F., Yen, C. J., Lu, T. H., Liang, F. W., Li, C. Y., Su, H. J., Su, C. L. & Liu, H. S., 2018 七月, 於 : Hepatology. 68, 1, p. 141-154 14 p.研究成果: Article
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斯高帕斯（Scopus）
Herpes simplex virus 1 tegument protein VP22 abrogates cGAS/ STING-mediated antiviral innate immunity
Huang, J., You, H., Su, C., Li, Y., Chen, S. & Zheng, C., 2018 八月 1, 於 : Journal of Virology. 92, 15, e00841-18.研究成果: Article
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斯高帕斯（Scopus）
In vitro reconstitution of sortase-catalyzed pilus polymerization reveals structural elements involved in pilin cross-linking
Chang, C., Amer, B. R., Osipiuk, J., McConnell, S. A., Huang, I. H., Hsieh, V., Fu, J., Nguyen, H. H., Muroski, J., Flores, E., Loo, R. R. O., Loo, J. A., Putkey, J. A., Joachimiak, A., Das, A., Clubb, R. T. & Ton-That, H., 2018 六月 12, 於 : Proceedings of the National Academy of Sciences of the United States of America. 115, 24, p. E5477-E5486研究成果: Article
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斯高帕斯（Scopus）
Lauric acid is an inhibitor of Clostridium difficile growth in vitro and reduces inflammation in a mouse infection model
Yang, H. T., Chen, J. W., Rathod, J., Jiang, Y. Z., Tsai, P. J., Hung, Y. P., Ko, W. C., Paredes-Sabja, D. & Huang, I. H., 2018 一月 17, 於 : Frontiers in Microbiology. 8, JAN, 2635.研究成果: Article
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斯高帕斯（Scopus）
Macrophage migration inhibitory factor is critical for dengue NS1-induced endothelial glycocalyx degradation and hyperpermeability
Chen, H. R., Chao, C. H., Liu, C. C., Ho, T. S., Tsai, H. P., Perng, G. C., Lin, Y. S., Wang, J. R. & Yeh, T. M., 2018 四月, 於 : PLoS pathogens. 14, 4, e1007033.研究成果: Article
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斯高帕斯（Scopus）
Minocycline suppresses dengue virus replication by down-regulation of macrophage migration inhibitory factor-induced autophagy
Lai, Y. C., Chuang, Y. C., Chang, C. P., Lin, Y. S., Perng, G. C., Wu, H. C., Hsieh, S. L. & Yeh, T. M., 2018 七月, 於 : Antiviral Research. 155, p. 28-38 11 p.研究成果: Article
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斯高帕斯（Scopus）
MST3 (mammalian Ste20-like protein kinase 3), a novel gene involved in ion homeostasis and renal regulation of blood pressure in spontaneous hypertensive rats
Lu, T. J., Chan, C. H., Ling, P., Chao, Y. M., Bao, B. Y., Chiang, C. Y., Lee, T. H., Weng, Y. P., Kan, W. C. & Lu, T. L., 2018 十二月 1, 於 : International Urology and Nephrology. 50, 12, p. 2299-2307 9 p.研究成果: Article
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斯高帕斯（Scopus）