藥理學科暨藥理學研究所

研究成果

2013

Survivin - biology and potential as a therapeutic target in oncology

Antonio Cheung, C. H., Huang, C. C., Tsai, F. Y., Lee, J. Y. C., Cheng, S. M., Chang, Y. C., Huang, Y. C., Chen, S. H. & Chang, J. Y., 2013 十月 28, 於 : OncoTargets and Therapy. 6, p. 1453-1462 10 p.

研究成果: Review article

93 引文 斯高帕斯(Scopus)

The Amygdala Excitatory/Inhibitory Balance in a Valproate-Induced Rat Autism Model

Lin, H. C., Gean, P. W., Wang, C. C., Chan, Y. H. & Chen, P. S., 2013 一月 29, 於 : PloS one. 8, 1, e55248.

研究成果: Article

45 引文 斯高帕斯(Scopus)

The beneficial effects of leptin on REM sleep deprivation-induced cognitive deficits in mice

Chang, H. F., Su, C. L., Chang, C. H., Chen, Y. W. & Gean, P. W., 2013 六月, 於 : Learning and Memory. 20, 6, p. 328-335 8 p.

研究成果: Article

7 引文 斯高帕斯(Scopus)
16 引文 斯高帕斯(Scopus)

The ER Ca2+ sensor STIM1 regulates actomyosin contractility of migratory cells

Chen, Y. T., Chen, Y. F., Chiu, W. T., Wang, Y. K., Chang, H. C. & Shen, M. R., 2013 三月 1, 於 : Journal of Cell Science. 126, 5, p. 1260-1267 8 p.

研究成果: Article

40 引文 斯高帕斯(Scopus)

The SNARE proteins SNAP25 and synaptobrevin are involved in endocytosis at hippocampal synapses

Zhang, Z., Wang, D., Sun, T., Xu, J., Chiang, H. C., Shin, W. & Wu, L. G., 2013 五月 22, 於 : Journal of Neuroscience. 33, 21, p. 9169-9175 7 p.

研究成果: Article

35 引文 斯高帕斯(Scopus)

Treat cancers by targeting survivin: Just a dream or future reality?

Coumar, M. S., Tsai, F. Y., Kanwar, J. R., Sarvagalla, S. & Cheung, C. H. A., 2013 十一月 1, 於 : Cancer Treatment Reviews. 39, 7, p. 802-811 10 p.

研究成果: Review article

105 引文 斯高帕斯(Scopus)
2012
30 引文 斯高帕斯(Scopus)

Annexin A2 silencing induces G2 arrest of non-small cell lung cancer cells through p53-dependent and -independent mechanisms

Wang, C. Y., Chen, C. L., Tseng, Y. L., Fang, Y. T., Lin, Y. S., Su, W. C., Chen, C. C., Chang, K. C., Wang, Y. C. & Lin, C. F., 2012 九月 21, 於 : Journal of Biological Chemistry. 287, 39, p. 32512-32524 13 p.

研究成果: Article

45 引文 斯高帕斯(Scopus)

Cancer epigenomics

Chang, J. W. & Wang, Y-C., 2012 一月 1, Systems Biology: Applications in Cancer-Related Research. World Scientific Publishing Co., p. 129-159 31 p.

研究成果: Chapter

2 引文 斯高帕斯(Scopus)

Cancer targeted nanoparticles specifically induce apoptosis in cancer cells and spare normal cells

Kanwar, J. R., Kanwar, R. K., Mahidhara, G. & Cheung, C. H. A., 2012 二月 16, 於 : Australian Journal of Chemistry. 65, 1, p. 5-14 10 p.

研究成果: Review article

16 引文 斯高帕斯(Scopus)

Catalase prevents maternal diabetes-induced perinatal programming via the Nrf2-HO-1 defense system

Chang, S. Y., Chen, Y. W., Zhao, X. P., Chenier, I., Tran, S., Sauvé, A., Ingelfinger, J. R. & Zhang, S. L., 2012 十月 1, 於 : Diabetes. 61, 10, p. 2565-2574 10 p.

研究成果: Article

24 引文 斯高帕斯(Scopus)

Ectopic ATP synthase blockade suppresses lung adenocarcinoma growth by activating the unfolded protein response

Chang, H. Y., Huang, H. C., Huang, T. C., Yang, P. C., Wang, Y. C. & Juan, H. F., 2012 九月 15, 於 : Cancer Research. 72, 18, p. 4696-4706 11 p.

研究成果: Article

40 引文 斯高帕斯(Scopus)

Epidermal growth factor receptor is a preferred target for treating Amyloid-β-induced memory loss

Wang, L., Chiang, H. C., Wu, W., Liang, B., Xie, Z., Yao, X., Ma, W., Du, S. & Zhong, Y., 2012 十月 9, 於 : Proceedings of the National Academy of Sciences of the United States of America. 109, 41, p. 16743-16748 6 p.

研究成果: Article

81 引文 斯高帕斯(Scopus)

Epithelial-mesenchymal transition in cervical carcinoma

Lee, M. Y. & Shen, M-R., 2012 二月 9, 於 : American Journal of Translational Research. 4, 1, p. 1-13 13 p.

研究成果: Review article

92 引文 斯高帕斯(Scopus)

Eps8 protein facilitates phagocytosis by increasing TLR4-MyD88 protein interaction in lipopolysaccharide-stimulated macrophages

Chen, Y. J., Hsieh, M. Y., Chang, M. Y., Chen, H. C., Jan, M. S., Maa, M. C. & Leu, T. H., 2012 五月 25, 於 : Journal of Biological Chemistry. 287, 22, p. 18806-18819 14 p.

研究成果: Article

28 引文 斯高帕斯(Scopus)

Expression of Eps8 correlates with poor survival in oral squamous cell carcinoma

Chu, P. Y., Liou, J. H., Lin, Y. M., Chen, C. J., Chen, M. K., Lin, S. H., Yeh, C. M., Wang, H. K., Maa, M. C., Leu, T. H., Chang, N. W., Hsu, N. C. & Yeh, K. T., 2012 十二月 1, 於 : Asia-Pacific Journal of Clinical Oncology. 8, 4, p. e77-e81

研究成果: Article

10 引文 斯高帕斯(Scopus)

Involvement of store-operated calcium signaling in EGF-mediated COX-2 gene activation in cancer cells

Wang, J. Y., Chen, B. K., Wang, Y. S., Tsai, Y. T., Chen, W. C., Chang, W. C., Hou, M. F., Wu, Y. C. & Chang, W. C., 2012 一月 1, 於 : Cellular Signalling. 24, 1, p. 162-169 8 p.

研究成果: Article

57 引文 斯高帕斯(Scopus)
15 引文 斯高帕斯(Scopus)

MDM2 overexpression deregulates the transcriptional control of RB/E2F leading to DNA methyltransferase 3A overexpression in lung cancer

Tang, Y. A., Lin, R. K., Tsai, Y. T., Hsu, H. S., Yang, Y. C., Chen, C. Y. & Wang, Y. C., 2012 八月 15, 於 : Clinical Cancer Research. 18, 16, p. 4325-4333 9 p.

研究成果: Article

32 引文 斯高帕斯(Scopus)

Mitochondrial apoptosis and FAK signaling disruption by a novel histone deacetylase inhibitor, HTPB, in antitumor and antimetastatic mouse models

Shieh, J. M., Wei, T. T., Tang, Y. A., Huang, S. M., Wen, W. L., Chen, M. Y., Cheng, H. C., Salunke, S. B., Chen, C. S., Lin, P., Chen, C. T. & Wang, Y. C., 2012 一月 18, 於 : PloS one. 7, 1, e30240.

研究成果: Article

17 引文 斯高帕斯(Scopus)

Modulating the interaction of CXCR4 and CXCL12 by low-molecular-weight heparin inhibits hepatic metastasis of colon cancer

Ma, L., Qiao, H., He, C., Yang, Q., Cheung, C. H. A., Kanwar, J. R. & Sun, X., 2012 四月 1, 於 : Investigational New Drugs. 30, 2, p. 508-517 10 p.

研究成果: Article

32 引文 斯高帕斯(Scopus)

Overexpression of PAFAH1B1 is associated with tumor metastasis and poor survival in non-small cell lung cancer

Lo, F. Y., Chen, H. T., Cheng, H. C., Hsu, H. S. & Wang, Y. C., 2012 九月 1, 於 : Lung Cancer. 77, 3, p. 585-592 8 p.

研究成果: Article

13 引文 斯高帕斯(Scopus)
9 引文 斯高帕斯(Scopus)

Significance of migration-related genes (S100A9, MAGED4, C8orf30A, IL-8) in esophageal squamous cell carcinoma

Huang, C. T., Huang, G. C., Wu, P. S., Wu, L. W., Lin, S. H., Lai, W. W., Wang, Y. C. & Liu, H. S., 2012 三月 1, 於 : Genomic Medicine, Biomarkers, and Health Sciences. 4, 1-2, p. 16-18 3 p.

研究成果: Article

1 引文 斯高帕斯(Scopus)

Synthesis and Biological Evaluation of ortho-Aryl N-Hydroxycinnamides as Potent Histone Deacetylase (HDAC) 8 Isoform-Selective Inhibitors

Huang, W. J., Wang, Y. C., Chao, S. W., Yang, C. Y., Chen, L. C., Lin, M. H., Hou, W. C., Chen, M. Y., Lee, T. L., Yang, P. & Chang, C. I., 2012 十月 1, 於 : ChemMedChem. 7, 10, p. 1815-1824 10 p.

研究成果: Article

40 引文 斯高帕斯(Scopus)

Targeting cathepsin S induces tumor cell autophagy via the EGFR-ERK signaling pathway

Chen, K. L., Chang, W. S. W., Cheung, C. H. A., Lin, C. C., Huang, C. C., Yang, Y. N., Kuo, C. P., Kuo, C. C., Chang, Y. H., Liu, K. J., Wu, C. M. & Chang, J. Y., 2012 四月 1, 於 : Cancer Letters. 317, 1, p. 89-98 10 p.

研究成果: Article

45 引文 斯高帕斯(Scopus)
11 引文 斯高帕斯(Scopus)

The database of chromosome imbalance regions and genes resided in lung cancer from Asian and Caucasian identified by array-comparative genomic hybridization

Lo, F. Y., Chang, J. W., Chang, I. S., Chen, Y. J., Hsu, H. S., Huang, S. F. K., Tsai, F. Y., Jiang, S. S., Kanteti, R., Nandi, S., Salgia, R. & Wang, Y. C., 2012 六月 12, 於 : BMC cancer. 12, 235.

研究成果: Article

25 引文 斯高帕斯(Scopus)

The novel indole compound SK228 induces apoptosis and FAK/Paxillin disruption in tumor cell lines and inhibits growth of tumor graft in the nude mouse

Huang, S. M., Hsu, P. C., Chen, M. Y., Li, W. S., More, S. V., Lu, K. T. & Wang, Y-C., 2012 八月 1, 於 : International Journal of Cancer. 131, 3, p. 722-732 11 p.

研究成果: Article

18 引文 斯高帕斯(Scopus)

The role of mitochondria-mediated intrinsic death pathway in gingerdione derivative I6-induced neuronal apoptosis

Lin, C. H., Chen, P. S., Kuo, S. C., Huang, L. J., Gean, P. W. & Chiu, T. H., 2012 三月 1, 於 : Food and Chemical Toxicology. 50, 3-4, p. 1073-1081 9 p.

研究成果: Article

7 引文 斯高帕斯(Scopus)
51 引文 斯高帕斯(Scopus)
24 引文 斯高帕斯(Scopus)
2011

Aberrantly expressed AURKC enhances the transformation and tumourigenicity of epithelial cells

Tsou, J. H., Chang, K. C., Chang-Liao, P. Y., Yang, S. T., Lee, C. T., Chen, Y. P., Lee, Y. C., Lin, B. W., Lee, J. C., Shen, M. R., Chuang, C. K., Chang, W. C., Wang, J. M. & Hung, L. Y., 2011 十月, 於 : Journal of Pathology. 225, 2, p. 243-254 12 p.

研究成果: Article

22 引文 斯高帕斯(Scopus)

Activation of Toll-like receptors induces macrophage migration via the iNOS/Src/FAK pathway

Maa, M. C. & Leu, T. H., 2011 十二月, 於 : BioMedicine (Netherlands). 1, 1, p. 11-15 5 p.

研究成果: Review article

11 引文 斯高帕斯(Scopus)

An E3 ubiquitin ligase: C-Cbl: A new therapeutic target of lung cancer

Lo, F. Y., Tan, Y. H. C., Cheng, H. C., Salgia, R. & Wang, Y. C., 2011 十二月 1, 於 : Cancer. 117, 23, p. 5344-5350 7 p.

研究成果: Article

23 引文 斯高帕斯(Scopus)

Angiotensin II type II receptor deficiency accelerates the development of nephropathy in type i diabetes via oxidative stress and ACE2

Chang, S. Y., Chen, Y. W., Chenier, I., Tran, S. L. M. & Zhang, S. L., 2011 十二月 1, 於 : Experimental Diabetes Research. 2011, 521076.

研究成果: Article

35 引文 斯高帕斯(Scopus)

A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways

Chen, J. Y., Tang, Y. A., Huang, S. M., Juan, H. F., Wu, L. W., Sun, Y. C., Wang, S. C., Wu, K. W., Balraj, G., Chang, T. T., Li, W. S., Cheng, H. C. & Wang, Y. C., 2011 一月 15, 於 : Cancer Research. 71, 2, p. 473-483 11 p.

研究成果: Article

72 引文 斯高帕斯(Scopus)

ATM/ATR and SMAD3 pathways contribute to 3-indole-induced G1 arrest in cancer cells and xenograft models

Huang, S. M., Lu, K. T. & Wang, Y. I. C., 2011 一月 1, 於 : Anticancer research. 31, 1, p. 203-208 6 p.

研究成果: Article

10 引文 斯高帕斯(Scopus)
7 引文 斯高帕斯(Scopus)

Aurora kinase inhibitor patents and agents in clinical testing: An update (2009 - 10)

Cheung, C. H. A., Coumar, M. S., Chang, J. Y. & Hsieh, H. P., 2011 六月 1, 於 : Expert Opinion on Therapeutic Patents. 21, 6, p. 857-884 28 p.

研究成果: Review article

34 引文 斯高帕斯(Scopus)

BPR1K653, a novel aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells

Cheung, C. H. A., Lin, W. H., HsuJohn, J. T. A., Hour, T. C., Yeh, T. K., Ko, S., Lien, T. W., Coumar, M. S., Liu, J. F., Lai, W. Y., Shiao, H. Y., Lee, T. R., Hsieh, H. P. & Chang, J. Y., 2011 八月 24, 於 : PloS one. 6, 8, e23485.

研究成果: Article

14 引文 斯高帕斯(Scopus)
215 引文 斯高帕斯(Scopus)

Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036

Yang, Y. N., Chou, K. M., Pan, W. Y., Chen, Y. W., Tsou, T. C., Yeh, S. C., Cheung, C. H. A., Chen, L. T. & Chang, J. Y., 2011 十月 1, 於 : Cancer Letters. 309, 1, p. 110-118 9 p.

研究成果: Article

5 引文 斯高帕斯(Scopus)

Functional EGFR germline polymorphisms may confer risk for EGFR somatic mutations in non-small cell lung cancer, with a predominant effect on exon 19 microdeletions

Liu, W., He, L., Ramírez, J., Krishnaswamy, S., Kanteti, R., Wang, Y. C., Salgia, R. & Ratain, M. J., 2011 四月 1, 於 : Cancer Research. 71, 7, p. 2423-2427 5 p.

研究成果: Article

35 引文 斯高帕斯(Scopus)
29 引文 斯高帕斯(Scopus)

High glucose promotes nascent nephron apoptosis via NF-κB and p53 pathways

Chen, Y-W., Chenier, I., Chang, S. Y., Tran, S., Ingelfinger, J. R. & Zhang, S. L., 2011 一月 1, 於 : American Journal of Physiology - Renal Physiology. 300, 1

研究成果: Article

18 引文 斯高帕斯(Scopus)

Investigations of survivin: The past, present and future

Cheung, C. H. A., Cheng, L. T., Chang, K. Y., Chen, H. H. & Chang, J. Y., 2011 一月 1, 於 : Frontiers in Bioscience. 16, 3, p. 952-961 10 p.

研究成果: Article

46 引文 斯高帕斯(Scopus)

Mechanisms underlying Benzyl alcohol cytotoxicity (triamcinolone acetonide preservative) in human retinal pigment epithelial cells

Chang, Y-S., Lin, C. F., Wu, C-L., Kuo, P. Y., Wu, F. S., Shieh, C-C., Gean, P-W., Chen, S. T., Chen, M. S., Wu, W. C., Tai, M. H. & Tseng, S. H., 2011 六月 1, 於 : Investigative Ophthalmology and Visual Science. 52, 7, p. 4214-4222 9 p.

研究成果: Article

13 引文 斯高帕斯(Scopus)

Minocycline inhibits the growth of glioma by inducing autophagy

Liu, W. T., Lin, C. H., Hsiao, M. & Gean, P. W., 2011 二月, 於 : Autophagy. 7, 2, p. 166-175 10 p.

研究成果: Article

50 引文 斯高帕斯(Scopus)