藥理學科暨藥理學研究所

研究成果

2009

Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons

Lin, Y. C., Chou, L. C., Chen, S. C., Kuo, S. C., Huang, L. J. & Gean, P. W., 2009 六月 15, 於 : Bioorganic and Medicinal Chemistry Letters. 19, 12, p. 3225-3228 4 p.

研究成果: Article

7 引文 斯高帕斯(Scopus)

Neuroprotective Effects of Ugonin K on Hydrogen Peroxide-Induced Cell Death in Human Neuroblastoma SH-SY5Y Cells

Lin, Y. C., Huang, Y. C., Chen, S. C., Liaw, C. C., Kuo, S. C., Huang, L. J. & Gean, P-W., 2009 五月 1, 於 : Neurochemical Research. 34, 5, p. 923-930 8 p.

研究成果: Article

30 引文 斯高帕斯(Scopus)

Reduced axin protein expression is associated with a poor prognosis in patients with squamous cell carcinoma of esophagus

Li, A. F. Y., Hsu, P. K., Tzao, C., Wang, Y-C., Hung, I. C., Huang, M. H. & Hsu, H. S., 2009 九月 1, 於 : Annals of Surgical Oncology. 16, 9, p. 2486-2493 8 p.

研究成果: Article

13 引文 斯高帕斯(Scopus)

Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers

Cheung, C. H. A., Chen, H. H., Kuo, C. C., Chang, C. Y., Coumar, M. S., Hsieh, H. P. & Chang, J. Y., 2009 七月 3, 於 : Molecular cancer. 8, 43.

研究成果: Article

56 引文 斯高帕斯(Scopus)

The role of prefrontal cortex CB1 receptors in the modulation of fear memory

Lin, H. C., Mao, S. C., Su, C. L. & Gean, P. W., 2009 一月 1, 於 : Cerebral Cortex. 19, 1, p. 165-175 11 p.

研究成果: Article

80 引文 斯高帕斯(Scopus)
2008

A triantennary dendritic galactoside-capped nanohybrid with a ZnS/CdSe nanoparticle core as a hydrophilic, fluorescent, multivalent probe for metastatic lung cancer cells

Chen, C. T., Munot, Y. S., Salunke, S. B., Wang, Y-C., Lin, R. K., Lin, C. C., Chen, C. C. & Liu, Y. H., 2008 二月 22, 於 : Advanced Functional Materials. 18, 4, p. 527-540 14 p.

研究成果: Article

44 引文 斯高帕斯(Scopus)
11 引文 斯高帕斯(Scopus)

Augmentation of fear extinction by D-cycloserine is blocked by proteasome inhibitors

Mao, S. C., Lin, H. C. & Gean, P-W., 2008 十二月 1, 於 : Neuropsychopharmacology. 33, 13, p. 3085-3095 11 p.

研究成果: Article

43 引文 斯高帕斯(Scopus)

Aβ42 mutants with different aggregation profiles induce distinct pathologies in Drosophila

Iijima, K., Chiang, H. C., Hearn, S. A., Hakker, I., Gatt, A., Shenton, C., Granger, L., Leung, A., Iijima-Ando, K. & Zhong, Y., 2008 二月 27, 於 : PloS one. 3, 2, e1703.

研究成果: Article

114 引文 斯高帕斯(Scopus)

Calcineurin-mediated dephosphorylation of c-Jun Ser-243 is required for c-Jun protein stability and cell transformation

Huang, C. C., Wang, J. M., Kikkawa, U., Mukai, H., Shen, M. R., Morita, I., Chen, B. K. & Chang, W. C., 2008 四月 10, 於 : Oncogene. 27, 17, p. 2422-2429 8 p.

研究成果: Article

20 引文 斯高帕斯(Scopus)

Chronic cannabinoid administration in vivo compromises extinction of fear memory

Lin, H. C., Mao, S. C., Chen, P-S. & Gean, P-W., 2008 十二月 1, 於 : Learning and Memory. 15, 12, p. 876-884 9 p.

研究成果: Article

35 引文 斯高帕斯(Scopus)
38 引文 斯高帕斯(Scopus)
16 引文 斯高帕斯(Scopus)

Cytotoxicity and proteomics analyses of OSU03013 in lung cancer

Tan, Y. H., Lee, K. H., Lin, T., Sun, Y. C., Hsieh-Li, H. M., Juan, H. F. & Wang, Y. C., 2008 三月 15, 於 : Clinical Cancer Research. 14, 6, p. 1823-1830 8 p.

研究成果: Article

12 引文 斯高帕斯(Scopus)

Deficiency of intrarenal angiotensin II type 2 receptor impairs paired homeo box-2 and N-myc expression during nephrogenesis

Chen, Y-W., Tran, S., Chenier, I., Chan, J. S. D., Ingelfinger, J. R., Inagami, T. & Zhang, S. L., 2008 七月 9, 於 : Pediatric Nephrology. 23, 10, p. 1769-1777 9 p.

研究成果: Article

10 引文 斯高帕斯(Scopus)
72 引文 斯高帕斯(Scopus)

Emerging methods for analysis of the cancer methylome

Chang, J. W., Huang, T. H. M. & Wang, Y-C., 2008 十二月 1, 於 : Pharmacogenomics. 9, 12, p. 1869-1878 10 p.

研究成果: Review article

11 引文 斯高帕斯(Scopus)

Epigenetic silencing of AXIN2/betaTrCP and deregulation of p53-mediated control lead to wild-type β-catenin nuclear accumulation in lung tumorigenesis

Tseng, R. C., Lin, R. K., Wen, C. K., Tseng, C., Hsu, H. S., Hsu, W. H. & Wang, Y. C., 2008 七月 24, 於 : Oncogene. 27, 32, p. 4488-4496 9 p.

研究成果: Article

32 引文 斯高帕斯(Scopus)

Epigenetic silencing of CCAAT/enhancer-binding protein δ activity by YY1/polycomb group/DNA methyltransferase complex

Ko, C. Y., Hsu, H. C., Shen, M. R., Chang, W. C. & Wang, J. M., 2008 十一月 7, 於 : Journal of Biological Chemistry. 283, 45, p. 30919-30932 14 p.

研究成果: Article

56 引文 斯高帕斯(Scopus)
201 引文 斯高帕斯(Scopus)

Eps8 decreases chemosensitivity and affects survival of cervical cancer patients

Chen, Y. J., Shen, M. R., Chen, Y. J., Maa, M. C. & Leu, T. H., 2008 十月 15, 於 : Molecular Cancer Therapeutics. 7, 6, p. 1376-1385 10 p.

研究成果: Article

32 引文 斯高帕斯(Scopus)
50 引文 斯高帕斯(Scopus)
22 引文 斯高帕斯(Scopus)

Low substratum rigidity of collagen gel promotes ERK phosphorylation via lipid raft to augment cell migration

Wei, W. C., Hsu, Y. C., Chiu, W. T., Wang, C. Z., Wu, C. M., Wang, Y. K., Shen, M. R. & Tang, M. J., 2008 三月 1, 於 : Journal of Cellular Biochemistry. 103, 4, p. 1111-1124 14 p.

研究成果: Article

7 引文 斯高帕斯(Scopus)

Maternal diabetes modulates renal morphogenesis in offspring

Tran, S., Chen, Y. W., Chenier, I., Chan, J. S. D., Quaggin, S., Hébert, M. J., Ingelfinger, J. R. & Zhang, S. L., 2008 五月 1, 於 : Journal of the American Society of Nephrology. 19, 5, p. 943-952 10 p.

研究成果: Article

69 引文 斯高帕斯(Scopus)
47 引文 斯高帕斯(Scopus)
21 引文 斯高帕斯(Scopus)
16 引文 斯高帕斯(Scopus)

Novel 2-step synthetic indole compound 1,1,3-tri(3-indolyl)cyclohexane inhibits cancer cell growth in lung cancer cells and xenograft models

Lee, C. H., Yao, C. F., Huang, S. M., Ko, S., Tan, Y. H., Lee-Chen, G. J. & Wang, Y. C., 2008 八月 15, 於 : Cancer. 113, 4, p. 815-825 11 p.

研究成果: Article

21 引文 斯高帕斯(Scopus)
34 引文 斯高帕斯(Scopus)
64 引文 斯高帕斯(Scopus)

Paxillin is a target for somatic mutations in lung cancer: Implications for cell growth and invasion

Jagadeeswaran, R., Surawska, H., Krishnaswamy, S., Janamanchi, V., Mackinnon, A. C., Seiwert, T. Y., Loganathan, S., Kanteti, R., Reichman, T., Nallasura, V., Schwartz, S., Faoro, L., Wang, Y. C., Girard, L., Tretiakova, M. S., Ahmed, S., Zumba, O., Soulii, L., Bindokas, V. P., Szeto, L. L. 及其他13, Gordon, G. J., Bueno, R., Sugarbaker, D., Lingen, M. W., Sattler, M., Krausz, T., Vigneswaran, W., Natarajan, V., Minna, J., Vokes, E. E., Ferguson, M. K., Husain, A. N. & Salgia, R., 2008 一月 1, 於 : Cancer Research. 68, 1, p. 132-142 11 p.

研究成果: Article

89 引文 斯高帕斯(Scopus)

Reduced membranous β-catenin protein expression is associated with metastasis and poor prognosis in squamous cell carcinoma of the esophagus

Hsu, P. K., Li, A. F. Y., Wang, Y. C., Hsieh, C. C., Huang, M. H., Hsu, W. H. & Hsu, H. S., 2008 五月 1, 於 : Journal of Thoracic and Cardiovascular Surgery. 135, 5, p. 1029-1035 7 p.

研究成果: Article

26 引文 斯高帕斯(Scopus)

Requirement of inducible nitric-oxide synthase in lipopolysaccharide- mediated Src induction and macrophage migration

Maa, M. C., Miao, Y. C., Chen, Y. J., Lin, C. H., Chih, J. Y., Yi, L. Y., Li, J., Chen, P. R., Tang, C. H., Lei, H. Y. & Leu, T-H., 2008 十一月 14, 於 : Journal of Biological Chemistry. 283, 46, p. 31408-31416 9 p.

研究成果: Article

34 引文 斯高帕斯(Scopus)
30 引文 斯高帕斯(Scopus)
63 引文 斯高帕斯(Scopus)

Synthesis of 2-[4-(imidazolin-2-ylideneamino)benzyl]-Indan-1-ones as novel potent prostacyclin antagonists

Chern, C. Y., Yek, Y. L., Chen, Y. L. & Kan, W. M., 2008 一月 1, 於 : Journal of the Chinese Chemical Society. 55, 4, p. 846-853 8 p.

研究成果: Article

1 引文 斯高帕斯(Scopus)
2007

Alteration of DNA methyltransferases contributes to 5′CpG methylation and poor prognosis in lung cancer

Lin, R. K., Hsu, H. S., Chang, J. W., Chen, C. Y., Chen, J. T. & Wang, Y. C., 2007 二月 1, 於 : Lung Cancer. 55, 2, p. 205-213 9 p.

研究成果: Article

172 引文 斯高帕斯(Scopus)
35 引文 斯高帕斯(Scopus)

Characterization of a multiple epigenetic marker panel for lung cancer detection and risk assessment in plasma

Hsu, H. S., Chen, T. P., Hung, C. H., Wen, C. K., Lin, R. K., Lee, H. C. & Wang, Y-C., 2007 十一月 1, 於 : Cancer. 110, 9, p. 2019-2026 8 p.

研究成果: Article

118 引文 斯高帕斯(Scopus)

Elevated p53 and p21waf1 mRNA expression in blood lymphocytes from lung cancer patients with chemoresistance

Shih, C. M., Chen, K., Wang, Y. C., Lee, P. J. & Wang, Y-C., 2007 十二月 4, 於 : Cancer Detection and Prevention. 31, 5, p. 366-370 5 p.

研究成果: Article

7 引文 斯高帕斯(Scopus)

Epigenetic inactivation of the chromosomal stability control genes BRCA1 BRCA2, and XRCC5 in non-small cell lung cancer

Lee, M. N., Tseng, R. C., Hsu, H. S., Chen, J. Y., Tzao, C., Ho, W. L. & Wang, Y. C., 2007 二月 1, 於 : Clinical Cancer Research. 13, 3, p. 832-838 7 p.

研究成果: Article

86 引文 斯高帕斯(Scopus)

EPS8 facilitates cellular growth and motility of colon cancer cells by increasing the expression and activity of focal adhesion kinase

Maa, M. C., Lee, J-C., Chen, Y. J., Chen, Y. J., Lee, Y. C., Wang, S-T., Huang, C. C., Chow, N-H. & Leu, T-H., 2007 七月 6, 於 : Journal of Biological Chemistry. 282, 27, p. 19399-19409 11 p.

研究成果: Article

55 引文 斯高帕斯(Scopus)

IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness

Hsu, Y. M., Chou, C-Y., Chen, H. H. W., Lee, W. Y., Chen, Y. F., Lin, P. W., Alper, S. L., Ellory, J. C. & Shen, M-R., 2007 三月 1, 於 : Journal of Cellular Physiology. 210, 3, p. 626-636 11 p.

研究成果: Article

31 引文 斯高帕斯(Scopus)
27 引文 斯高帕斯(Scopus)

KCl cotransporter-3 down-regulates E-cadherin/β-catenin complex to promote epithelial-mesenchymal transition

Hsu, Y. M., Chen, Y. F., Chou, C. Y., Tang, M. J., Chen, J. H., Wilkins, R. J., Clive Ellory, J. & Shen, M. R., 2007 十一月 15, 於 : Cancer Research. 67, 22, p. 11064-11073 10 p.

研究成果: Article

52 引文 斯高帕斯(Scopus)

Mithramycin A inhibits DNA methyltransferase and metastasis potential of lung cancer cells

Lin, R. K., Hsu, C. H. & Wang, Y-C., 2007 十一月 1, 於 : Anti-Cancer Drugs. 18, 10, p. 1157-1164 8 p.

研究成果: Article

44 引文 斯高帕斯(Scopus)

Multiple genetic and epigenetic biomarkers for lung cancer detection in cytologically negative sputum and a nested case-control study for risk assessment

Hsu, H. S., Chen, T. P., Wen, C. K., Hung, C. H., Chen, C. Y., Chen, J. T. & Wang, Y. C., 2007 十二月 1, 於 : Journal of Pathology. 213, 4, p. 412-419 8 p.

研究成果: Article

39 引文 斯高帕斯(Scopus)

Pax-2 and N-myc regulate epithelial cell proliferation and apoptosis in a positive autocrine feedback loop

Zhang, S. L., Chen, Y-W., Tran, S., Liu, F., Nestoridi, E., Hébert, M. J. & Ingelfinger, J. R., 2007 六月 1, 於 : Pediatric Nephrology. 22, 6, p. 813-824 12 p.

研究成果: Article

12 引文 斯高帕斯(Scopus)

Polymorphism in the hMSH2 gene (gISV12-6T > C) is a prognostic factor in non-small cell lung cancer

Hsu, H. S., Lee, I. H., Hsu, W. H., Kao, W. T. & Wang, Y. C., 2007 十月 1, 於 : Lung Cancer. 58, 1, p. 123-130 8 p.

研究成果: Article

18 引文 斯高帕斯(Scopus)