臨床醫學研究所

研究成果 1986 2020

2020

A multicenter, phase I/II trial of biweekly S-1, leucovorin, oxaliplatin and gemcitabine in metastatic pancreatic adenocarcinoma–TCOG T1211 study

Chiang, N. J., Tsai, K. K., Hsiao, C. F., Yang, S. H., Hsiao, H. H., Shen, W. C., Hsu, C., Lin, Y. L., Chen, J. S., Shan, Y. S. & Chen, L. T., 2020 一月, 於 : European Journal of Cancer. 124, p. 123-130 8 p.

研究成果: Article

oxaliplatin
gemcitabine
Leucovorin
Adenocarcinoma
irinotecan
2019
1 引文 (Scopus)

4(1H)-quinolone derivatives overcome acquired resistance to anti-microtubule agents by targeting the colchicine site of β-tubulin

Lin, M. S., Hong, T. M., Chou, T. H., Yang, S. C., Chung, W. C., Weng, C. W., Tsai, M. L., Cheng, T. J. R., Chen, J. J. W., Lee, T. C., Wong, C. H., Chein, R. J. & Yang, P. C., 2019 十一月 1, 於 : European Journal of Medicinal Chemistry. 181, 111584.

研究成果: Article

4-Quinolones
Quinolones
Colchicine
Tubulin
Microtubules

A DNA Aptamer Targeting Galectin-1 as a Novel Immunotherapeutic Strategy for Lung Cancer

Tsai, Y. T., Liang, C. H., Yu, J. H., Huang, K. C., Tung, C. H., Wu, J. E., Wu, Y. Y., Chang, C. H., Hong, T. M. & Chen, Y. L., 2019 十二月 6, 於 : Molecular Therapy - Nucleic Acids. 18, p. 991-998 8 p.

研究成果: Article

開啟存取
Galectin 1
Nucleotide Aptamers
Lung Neoplasms
T-Lymphocytes
Neoplasms
Adrenergic alpha-1 Receptor Antagonists
Adrenergic Antagonists
Sleep Apnea Syndromes
Cohort Studies
Hypertension
1 引文 (Scopus)
Systemic Lupus Erythematosus
Non-Hodgkin's Lymphoma
Population
Incidence
Taiwan
開啟存取
Bronchoscopy
Asthma
Epithelium
Biological Products
Biological Factors
1 引文 (Scopus)
開啟存取
Photosensitizing Agents
Membranes
Lighting
verteporfin
Dithiothreitol
1 引文 (Scopus)

Comparison of Home and Ambulatory Blood Pressure Measurements in Association With Preclinical Hypertensive Cardiovascular Damage

Lin, T. T., Juang, J. J. M., Lee, J. K., Tsai, C. T., Chen, C. H., Yu, W. C., Cheng, H. M., Wu, Y. W., Chiu, Y. W., Kuo, C. T., Chen, J. J., Chen, Z. C., Chang, W. T., Liu, P-Y., Chen, P-W., Yen, H. W., Chen, Y. C., Tseng, W. K., Chiang, F. T. & Wu, C. K., 2019 三月 1, 於 : Journal of Cardiovascular Nursing. 34, 2, p. 106-114 9 p.

研究成果: Article

Ambulatory Blood Pressure Monitoring
Blood Pressure
Pulse Wave Analysis
Hypertension
Prehypertension
5 引文 (Scopus)
ivabradine
Neurons
linopirdine
Endocrine Cells
Reducing Agents
開啟存取
Inflammasomes
Clostridium difficile
Adenosine Triphosphate
Medicine
corrigendum
Postal Service
Taiwan
Nursing
Medicine
Neoplasms
開啟存取
Ovarian Neoplasms
Phosphotransferases
Down-Regulation
Salts
ATP Binding Cassette Transporter, Sub-Family G, Member 2
1 引文 (Scopus)
開啟存取
pioglitazone
Diet
Hepatic Stellate Cells
Insulin Resistance
Autophagy
開啟存取
Galectin 3
rho-Associated Kinases
Medical problems
Platelets
Protein Kinases

Erythropoietin prevents dementia in hemodialysis patients: A nationwide population-based study

Hung, P. H., Yeh, C. C., Sung, F. C., Hsiao, C. Y., Muo, C. H., Hung, K. Y. & Tsai, K. J., 2019 九月 1, 於 : Aging. 11, 17, p. 6941-6950 10 p.

研究成果: Article

Erythropoietin
Dementia
Renal Dialysis
Population
Vascular Dementia

Exercise alleviates osteoporosis in rats with mild chronic kidney disease by decreasing sclerostin production

Liao, H. W., Huang, T. H., Chang, Y. H., Liou, H. H., Chou, Y. H., Sue, Y. M., Hung, P. H., Chang, Y. T., Ho, P. C. & Tsai, K. J., 2019 四月 2, 於 : International journal of molecular sciences. 20, 8, 2044.

研究成果: Article

開啟存取
kidney diseases
osteoporosis
physical exercise
Chronic Renal Insufficiency
bones
開啟存取
Chemotherapy
Teratoma
Surgery
surgery
Drug Therapy
1 引文 (Scopus)

Gastroesophageal reflux disease and atrial fibrillation: Insight from autonomic cardiogastric neural interaction

Huang, T. C., Lo, L. W., Yamada, S., Chou, Y. H., Lin, W. L., Chang, S. L., Lin, Y. J., Liu, S. H., Cheng, W. H., Tsai, T. Y., Liu, P. Y. & Chen, S. A., 2019 十一月 1, 於 : Journal of Cardiovascular Electrophysiology. 30, 11, p. 2262-2270 9 p.

研究成果: Article

Gastroesophageal Reflux
Atrial Fibrillation
Electrophysiology
Acids
Muscarinic Antagonists

High-CLDN4 ESCC cells harbor stem-like properties and indicate for poor concurrent chemoradiation therapy response in esophageal squamous cell carcinoma

Lin, C. H., Li, H. Y., Liu, Y. P., Kuo, P. F., Wang, W. C., Lin, F. C., Chang, W. L., Sheu, B. S., Wang, Y. C., Hung, W. C., Cheng, H. C., Yao, Y. C., Calkins, M. J., Hsiao, M. & Lu, P. J., 2019 一月 1, 於 : Therapeutic Advances in Medical Oncology. 11

研究成果: Article

開啟存取
Stem Cells
Fursultiamin
Neoplasms
Therapeutics
Neoplastic Stem Cells
開啟存取
Action Potentials
Vascular Smooth Muscle
Smooth Muscle Myocytes
Neuroendocrine Cells
Proteasome Inhibitors
3 引文 (Scopus)

Hypoxia-induced Slug SUMOylation enhances lung cancer metastasis 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis 06 Biological Sciences 0601 Biochemistry and Cell Biology

Hung, P. F., Hong, T. M., Chang, C. C., Hung, C. L., Hsu, Y. L., Chang, Y. L., Wu, C. T., Chang, G. C., Chan, N. L., Yu, S. L., Yang, P. C. & Pan, S. H., 2019 一月 6, 於 : Journal of Experimental and Clinical Cancer Research. 38, 1, 5.

研究成果: Article

開啟存取
Sumoylation
Gastropoda
Biological Science Disciplines
Biochemistry
Cell Biology

IL-29 promoted obesity-induced inflammation and insulin resistance

Lin, T. Y., Chiu, C. J., Kuan, C. H., Chen, F. H., Shen, Y. C., Wu, C-H. & Hsu, Y-H., 2019 一月 1, 於 : Cellular and Molecular Immunology.

研究成果: Article

Interleukins
Insulin Resistance
Obesity
Inflammation
Macrophages
Mean Platelet Volume
Acute Coronary Syndrome
Blood Platelets
clopidogrel
Platelet Aggregation Inhibitors
開啟存取
cardiac arrest
rating scales
Heart Arrest
Retrospective Studies
Emergency rooms
1 引文 (Scopus)
Aplastic Anemia
Databases
Incidence
Population
Survival

Increased ILC3s associated with higher levels of IL‐1β aggravates inflammatory arthritis in mice lacking phagocytic NADPH oxidase

Chan, T., Yen, C., Huang, Y., Lo, P., Nigrovic, P. A., Cheng, C., Wang, W., Wu, S. & Shieh, C-C., 2019 七月 26, 於 : European Journal of Immunology.

研究成果: Article

1 引文 (Scopus)

Loss of the transcriptional repressor TGIF1 results in enhanced Kras-driven development of pancreatic cancer

Weng, C. C., Hsieh, M. J., Wu, C. C., Lin, Y. C., Shan, Y-S., Hung, W. C., Chen, L. T. & Cheng, K. H., 2019 五月 20, 於 : Molecular cancer. 18, 1, 96.

研究成果: Article

開啟存取
Pancreatic Neoplasms
Adenocarcinoma
Epithelial-Mesenchymal Transition
Neoplasm Metastasis
Epigenomics
4 引文 (Scopus)
開啟存取
Death Domain Receptors
Neoplastic Stem Cells
Pancreatic Neoplasms
Ligands
T-Lymphocytes

Male patients on peritoneal dialysis have a higher risk of sleep apnea

Lee, Y. C., Hung, S. Y., Wang, H. K., Lin, C. W., Wang, H. H., Chang, M. Y., Wu, C. F., Sung, J-M., Chiou, Y-Y. & Lin, S-H., 2019 一月 1, 於 : Journal of Clinical Sleep Medicine. 15, 7, p. 937-945 9 p.

研究成果: Article

Sleep Apnea Syndromes
Peritoneal Dialysis
Renal Dialysis
Uremia
Databases

Nuclear KIT induces a NFKBIB-RELA-KIT autoregulatory loop in imatinib-resistant gastrointestinal stromal tumors

Hsueh, Y. S., Chang, H. H., Shan, Y. S., Sun, H. S., Fletcher, J. A., Li, C. F. & Chen, L. T., 2019 九月 19, 於 : Oncogene. 38, 38, p. 6550-6565 16 p.

研究成果: Article

開啟存取
Gastrointestinal Stromal Tumors
Stromal Cells
Chromatin Immunoprecipitation
Valproic Acid
Carcinogenesis

Pancreatic stellate cells activated by mutant KRAS-mediated PAI-1 upregulation foster pancreatic cancer progression via IL-8

Wang, H. C., Lin, Y. L., Hsu, C. C., Chao, Y. J., Hou, Y. C., Chiu, T. J., Huang, P. H., Tang, M. J., Chen, L. T. & Shan, Y. S., 2019 一月 1, 於 : Theranostics. 9, 24, p. 7168-7183 16 p.

研究成果: Article

開啟存取
Pancreatic Stellate Cells
Plasminogen Activator Inhibitor 1
Interleukin-8
Pancreatic Neoplasms
Up-Regulation

Postoperative Mycobacteroides abscessus subsp. abscessus endophthalmitis: Clinical analysis of 12 clustered adults and a proposed therapeutic algorithm

Hung, J-H., Ko, W-C., Chen, C. Y., Lin, S-H., Wu, C. L., Hsu, S-M., Teng, Y. T., Wang, S. H., Tseng, S. H., Huang, F-C., Lai, C. C., Chen, C. L., Lai, C. H., Chen, P-L. & Jou-Chen Huang, E., 2019 一月 1, (Accepted/In press) 於 : Journal of Microbiology, Immunology and Infection.

研究成果: Article

Endophthalmitis
Temazepam
Vitrectomy
Taiwan
Nontuberculous Mycobacteria
開啟存取
Venous Thrombosis
Postpartum Period
Catheters
Iliac Vein
Femoral Vein
4 引文 (Scopus)

Protein arginine methyltransferase 3 enhances chemoresistance in pancreatic cancer by methylating hnRNPA1 to increase ABCG2 expression

Hsu, M. C., Pan, M. R., Chu, P. Y., Tsai, Y. L., Tsai, C. H., Shan, Y. S., Chen, L. T. & Hung, W. C., 2019 一月 1, 於 : Cancers. 11, 1, 8.

研究成果: Article

開啟存取
Protein-Arginine N-Methyltransferases
Pancreatic Neoplasms
gemcitabine
Adenosine Triphosphate
Drug Resistance

Protein arginine methyltransferase 3-induced metabolic reprogramming is a vulnerable target of pancreatic cancer

Hsu, M. C., Tsai, Y. L., Lin, C. H., Pan, M. R., Shan, Y-S., Cheng, T. Y., Cheng, S. H. C., Chen, L. T. & Hung, W. C., 2019 七月 19, 於 : Journal of Hematology and Oncology. 12, 1, 79.

研究成果: Article

開啟存取
Protein-Arginine N-Methyltransferases
Glyceraldehyde-3-Phosphate Dehydrogenases
Pancreatic Neoplasms
Respiration
Oxidative Phosphorylation

Regeneration of rete ridges in Lanyu pig (Sus scrofa): Insights for human skin wound healing

Lin, C. H., Chiu, P. Y., Hsueh, Y-Y., Shieh, S-J., Wu, C-C., Wong, T-W., Chuong, C. M. & Hughes, M. W., 2019 四月 1, 於 : Experimental Dermatology. 28, 4, p. 472-479 8 p.

研究成果: Article

Sus scrofa
Proliferating Cell Nuclear Antigen
Wound Healing
Alkaline Phosphatase
Regeneration
1 引文 (Scopus)
Metaplasia
Helicobacter pylori
Stomach Neoplasms
MicroRNAs
spasmolytic polypeptide

Subsequent thyroid disorders associated with treatment strategy in head and neck cancer patients: A nationwide cohort study

Lin, C. L., Wu, S. Y., Huang, W. T., Feng, Y. H., Yiu, C. Y., Chiang, W. F., Ho, S. Y. & Lin, S. H., 2019 五月 16, 於 : BMC cancer. 19, 1, 461.

研究成果: Article

開啟存取
Head and Neck Neoplasms
Thyroid Gland
Cohort Studies
Radiotherapy
Neoplasms
開啟存取
Severe Acute Respiratory Syndrome
Adult Respiratory Distress Syndrome
Bronchoscopy
Extracorporeal Membrane Oxygenation
Hyperkalemia

Targeted delivery of curcumin rescues endoplasmic reticulum-retained mutant Nox2 protein and avoids leukocyte apoptosis

Yen, C. L., Liao, Y. C., Chen, R. F., Huang, Y. F., Chung, W. C., Lo, P. C., Chang, C. F., Wu, P. C., Shieh, D. B., Jiang, S. T. & Shieh, C. C., 2019 六月 15, 於 : Journal of Immunology. 202, 12, p. 3394-3403 10 p.

研究成果: Article

Curcumin
Mutant Proteins
Endoplasmic Reticulum
Leukocytes
Apoptosis
2 引文 (Scopus)
開啟存取
Amniotic Fluid
Stem Cells
Cardiac Myocytes
Action Potentials
Myosin Light Chains
1 引文 (Scopus)

The differential distributions of ASPM isoforms and their roles in Wnt signaling, cell cycle progression, and pancreatic cancer prognosis

Hsu, C. C., Liao, W. Y., Chan, T. S., Chen, W. Y., Lee, C. T., Shan, Y. S., Huang, P. J., Hou, Y. C., Li, C. R. & Tsai, K. K., 2019 十二月 1, 於 : Journal of Pathology. 249, 4, p. 498-508 11 p.

研究成果: Article

開啟存取
Microcephaly
Pancreatic Neoplasms
Cell Cycle
Protein Isoforms
Adenocarcinoma
2 引文 (Scopus)
開啟存取
1-Phosphatidylinositol 4-Kinase
Sirolimus
Epidermal Growth Factor Receptor
Lung Neoplasms
Non-Small Cell Lung Carcinoma

The Epidemiology of Gastric Cancers in the Era of Helicobacter pylori Eradication: A nationwide cancer registry-based study in Taiwan

Chang, J. S., Kuo, S. H., Chu, P. Y., Shan, Y. S., Tsai, C. R., Tsai, H. J. & Chen, L. T., 2019 一月 1, 於 : Cancer Epidemiology Biomarkers and Prevention. 28, 10, p. 1694-1703 10 p.

研究成果: Article

Taiwan
Helicobacter pylori
Stomach Neoplasms
Registries
Epidemiology
2 引文 (Scopus)

Therapeutic targeting of aldolase a interactions inhibits lung cancer metastasis and prolongs survival

Chang, Y. C., Chiou, J., Yang, Y. F., Su, C. Y., Lin, Y. F., Yang, C. N., Lu, P. J., Huang, M. S., Yang, C. J. & Hsiao, M., 2019 九月 15, 於 : Cancer Research. 79, 18, p. 4754-4766 13 p.

研究成果: Article

Fructose-Bisphosphate Aldolase
Lung Neoplasms
Neoplasm Metastasis
Actins
Therapeutics
Nucleic Acids
Alzheimer Disease
Biomarkers
Amyloid
Relapsing-Remitting Multiple Sclerosis
5 引文 (Scopus)

The tension biology of wound healing

Harn, H. I. C., Ogawa, R., Hsu, C. K., Hughes, M. W., Tang, M. J. & Chuong, C. M., 2019 四月, 於 : Experimental Dermatology. 28, 4, p. 464-471 8 p.

研究成果: Review article

開啟存取
Wound Healing
Cicatrix
Skin
Keloid
Regeneration