分子醫學研究所

研究成果 1985 2020

2020
開啟存取
Escherichia coli
Peptide Hydrolases
Infection
Flagella
Gene Expression Profiling
2019
1 引文 (Scopus)

A novel proteotoxic combination therapy for EGFR+ and HER2+ cancers

Wang, M., Ferreira, R. B., Law, M. E., Davis, B. J., Yaaghubi, E., Ghilardi, A. F., Sharma, A., Avery, B. A., Rodriguez, E., Chiang, C. W., Narayan, S., Heldermon, C. D., Castellano, R. K. & Law, B. K., 2019 五月 30, 於 : Oncogene. 38, 22, p. 4264-4282 19 p.

研究成果: Article

Disulfides
Neoplasms
Cyclosporine
Protein Folding
Therapeutics
2 引文 (Scopus)
開啟存取
Brain
Agglomeration
Chemical activation
Apoptosis
Cell Movement
1 引文 (Scopus)
開啟存取
CC Chemokines
Head and Neck Neoplasms
Interleukin-1
Ligands
Mouth Neoplasms

Correlation between interleukin-6 levels and methadone maintenance therapy outcomes

Lu, R. B., Wang, T. Y., Lee, S. Y., Chen, S. L., Chang, Y. H., See Chen, P., Lin, S. H., Chu, C. H., Huang, S. Y., Tzeng, N. S., Lee, I. H., Chin Chen, K., Kuang Yang, Y., Chen, P., Chen, S. H. & Hong, J. S., 2019 十一月 1, 於 : Drug and Alcohol Dependence. 204, 107516.

研究成果: Article

Methadone
Interleukin-6
Opioid Analgesics
Brain-Derived Neurotrophic Factor
Morphine

Disulfide bond-disrupting agents activate the tumor necrosis family-related apoptosis-inducing ligand/death receptor 5 pathway

Wang, M., Law, M. E., Davis, B. J., Yaaghubi, E., Ghilardi, A. F., Ferreira, R. B., Chiang, C. W., Guryanova, O. A., Kopinke, D., Heldermon, C. D., Castellano, R. K. & Law, B. K., 2019 十二月 1, 於 : Cell Death Discovery. 5, 1, 153.

研究成果: Article

開啟存取
TNF-Related Apoptosis-Inducing Ligand Receptors
Disulfides
Necrosis
Apoptosis
Ligands
開啟存取
5 引文 (Scopus)
Fibroblast Growth Factor 9
Corpus Striatum
Huntington Disease
Oxidative stress
Oxidative Stress
2 引文 (Scopus)

Fibroblast growth factors: Potential novel targets for regenerative therapy of osteoarthritis

Chen, T. M., Chen, Y. H., Sun, H-F. & Tsai, S-J., 2019 一月 1, 於 : Chinese Journal of Physiology. 62, 1, p. 2-10 9 p.

研究成果: Review article

Fibroblast Growth Factors
Osteoarthritis
Cartilage
Therapeutics
Research

hnRNPM induces translation switch under hypoxia to promote colon cancer development

Chen, T. M., Lai, M. C., Li, Y. H., Chan, Y. L., Wu, C. H., Wang, Y. M., Chien, C. W., Huang, S. Y., Sun, H. S. & Tsai, S. J., 2019 三月, 於 : EBioMedicine. 41, p. 299-309 11 p.

研究成果: Article

開啟存取
Colonic Neoplasms
Genes
Switches
Carcinogenesis
Proteins
Mineralocorticoid Receptors
Ubiquitin
Catenins
Aldosterone
Transcriptional Activation

Immunoregulatory effects of very low density lipoprotein from healthy individuals and metabolic syndrome patients on glial cells

Li, C. L., Chu, C. H., Lee, H. C., Chou, M. C., Liu, C. K., Chen, C. H., Ke, L. Y. & Chen, S. L., 2019 九月, 於 : Immunobiology. 224, 5, p. 632-637 6 p.

研究成果: Article

VLDL Lipoproteins
Microglia
Neuroglia
Astrocytes
Dinoprostone

Nuclear KIT induces a NFKBIB-RELA-KIT autoregulatory loop in imatinib-resistant gastrointestinal stromal tumors

Hsueh, Y. S., Chang, H. H., Shan, Y. S., Sun, H. S., Fletcher, J. A., Li, C. F. & Chen, L. T., 2019 九月 19, 於 : Oncogene. 38, 38, p. 6550-6565 16 p.

研究成果: Article

開啟存取
Gastrointestinal Stromal Tumors
Stromal Cells
Chromatin Immunoprecipitation
Valproic Acid
Carcinogenesis
1 引文 (Scopus)

Regulation of septin phosphorylation: SEPT12 phosphorylation in sperm septin assembly

Lin, C. H., Shen, Y. R., Wang, H. Y., Chiang, C. W., Wang, C. Y. & Kuo, P. L., 2019 一月, 於 : Cytoskeleton. 76, 1, p. 137-142 6 p.

研究成果: Review article

Septins
Spermatozoa
Phosphorylation
Sumoylation
Sperm Motility
3 引文 (Scopus)

Strategies by which WWOX-deficient metastatic cancer cells utilize to survive via dodging, compromising, and causing damage to WWOX-positive normal microenvironment

Chou, P. Y., Lai, F. J., Chen, Y. A., Sie, Y. D., Kuo, H. L., Su, W. P., Wu, C. Y., Liu, T. Y., Wen, K. Y., Hsu, L-J., Sze, C-I. & Chang, N-S., 2019 十二月 1, 於 : Cell Death Discovery. 5, 1, 97.

研究成果: Article

開啟存取
Neoplasms
Cellular Microenvironment
Hyaluronoglucosaminidase
Growth
Neoplasm Metastasis

Subunit composition of ribosome in the yqgf mutant is deficient in pre-16S rRNA processing of Escherichia coli

Kurata, T., Nakanishi, S., Hashimoto, M., Taoka, M., Isobe, T. & Kato, J. I., 2019 一月 1, 於 : Journal of Molecular Microbiology and Biotechnology. 28, 4, p. 179-182 4 p.

研究成果: Article

Ribosome Subunits
RNA Precursors
Ribosomes
Escherichia coli
Ribonucleases
7 引文 (Scopus)

WW domain-containing proteins YAP and TAZ in the hippo pathway as key regulators in stemness maintenance, tissue homeostasis, and tumorigenesis

Chen, Y. A., Lu, C. Y., Cheng, T. Y., Pan, S. H., Chen, H. F. & Chang, N. S., 2019 一月 1, 於 : Frontiers in Oncology. 9, FEB, 60.

研究成果: Review article

開啟存取
Carcinogenesis
Homeostasis
Stem Cells
Maintenance
Regeneration

Wwox possesses n-terminal cell surface-exposed epitopes wwox7-21 and wwox7-11 for signaling cancer growth suppression and prevention in vivo

Wang, W. J., Ho, P. C., Nagarajan, G., Chen, Y. A., Kuo, H. L., Subhan, D., Su, W. P., Chang, J. Y., Lu, C. Y., Chang, K. T., Lin, S. R., Lee, M. H. & Chang, N. S., 2019 十一月, 於 : Cancers. 11, 11, 1818.

研究成果: Article

開啟存取
Epitopes
Growth
Neoplasms
Peptides
Antibodies
2018
5 引文 (Scopus)

ACTN4 regulates the stability of RIPK1 in melanoma

Zhang, Y. Y., Tabataba, H., Liu, X. Y., Wang, J. Y., Yan, X. G., Farrelly, M., Jiang, C. C., Guo, S. T., Liu, T., Kao, H. Y., Thorne, R. F., Zhang, X. D. & Jin, L., 2018 七月 19, 於 : Oncogene. 37, 29, p. 4033-4045 13 p.

研究成果: Article

Receptor-Interacting Protein Serine-Threonine Kinases
Actinin
Protein Kinases
Melanoma
Inhibitor of Apoptosis Proteins
Fibroblast Growth Factors
Transforming Growth Factors
Cicatrix
Fibroblasts
angiogenin
1 引文 (Scopus)

A Non-Enzymatic Pathway with Superoxide in Intracellular Terpenoid Synthesis

Ueda, D., Matsugane, S., Okamoto, W., Hashimoto, M. & Sato, T., 2018 八月 6, 於 : Angewandte Chemie - International Edition. 57, 32, p. 10347-10351 5 p.

研究成果: Article

Norisoprenoids
Terpenes
Bacilli
Superoxides
Vitamin K 2
4 引文 (Scopus)
CRISPR-Cas Systems
Klebsiella pneumoniae
Anti-Bacterial Agents
Genome
Microbial Drug Resistance
3 引文 (Scopus)

Chasing the signaling run by tri-molecular time-lapse FRET microscopy

Kuo, H. L., Ho, P. C., Huang, S. S. & Chang, N. S., 2018 十二月 1, 於 : Cell Death Discovery. 4, 1, 45.

研究成果: Article

開啟存取
Energy Transfer
Microscopy
Signal Transduction
Proteins
Cell Death
開啟存取
Publications
Tumors
Neoplasms
1 引文 (Scopus)

Correlation of cytokines, BDNF levels, and memory function in patients with opioid use disorder undergoing methadone maintenance treatment

Wang, T-Y., Lee, S. Y., Chang, Y. H., Chen, S. L., Chen, P-S., Chu, C-H., Huang, S. Y., Tzeng, N. S., Lee, I-H., Chen, K-C., Yang, Y-K., Chen, S. H., Hong, J. S. & Lu, R-B., 2018 十月 1, 於 : Drug and Alcohol Dependence. 191, p. 6-13 8 p.

研究成果: Article

Methadone
Brain-Derived Neurotrophic Factor
Opioid Analgesics
Cytokines
Data storage equipment
1 引文 (Scopus)

Digestion of peptidoglycan near the cross-link is necessary for the growth of bacillus subtilis

Hashimoto, M., Matsushima, H., Putu Suparthana, I., Ogasawara, H., Yamamoto, H., Teng, C. & Sekiguchi, J., 2018 三月, 於 : Microbiology (United Kingdom). 164, 3, p. 299-307 9 p., 000614.

研究成果: Article

Peptidoglycan
Bacillus subtilis
Digestion
Cell Separation
Growth
Digital devices
Holography
holography
Microscopic examination
microscopy
9 引文 (Scopus)
Fibroblast Growth Factor 9
Leydig Cell Tumor
Fibroblast Growth Factor Receptors
Retinoblastoma
Fibroblast Growth Factor 2
3 引文 (Scopus)

Fibroblast Growth Factor 9 Suppresses Striatal Cell Death Dominantly Through ERK Signaling in Huntington's Disease

Yusuf, I. O., Cheng, P. H., Chen, H. M., Chang, Y. F., Chang, C. Y., Yang, H. I., Lin, C. W., Tsai, S. J., Chuang, J. I., Wu, C. C., Huang, B. M., Sun, H. S. & Yang, S. H., 2018 八月 1, 於 : Cellular Physiology and Biochemistry. 48, 2, p. 605-617 13 p.

研究成果: Article

Fibroblast Growth Factor 9
Corpus Striatum
Huntington Disease
Cell Death
MAP Kinase Signaling System
8 引文 (Scopus)

Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains

Huang, W., Peng, Y., Kiselar, J., Zhao, X., Albaqami, A., Mendez, D., Chen, Y., Chakravarthy, S., Gupta, S., Ralston, C., Kao, H. Y., Chance, M. R. & Yang, S., 2018 十二月 1, 於 : Nature communications. 9, 1, 3520.

研究成果: Article

開啟存取
estrogens
Estrogen Receptors
deoxyribonucleic acid
Ligands
ligands
4 引文 (Scopus)

Natural zeolite for adsorbing and release of functional materials

Hovhannisyan, V. A., Dong, C. Y., Lai, F. J., Chang, N. S. & Chen, S. J., 2018 九月 1, 於 : Journal of Biomedical Optics. 23, 9, 091411.

研究成果: Article

Zeolites
Functional materials
Spectrometry
Microscopic examination
drugs
4 引文 (Scopus)

NTF3 Is a Novel Target Gene of the Transcription Factor POU3F2 and Is Required for Neuronal Differentiation

Lin, Y. M. J., Hsin, I. L., Sun, H. S., Lin, S., Lai, Y. L., Chen, H. Y., Chen, T. Y., Chen, Y. P., Shen, Y. T. & Wu, H. M., 2018 十一月 1, 於 : Molecular Neurobiology. 55, 11, p. 8403-8413 11 p.

研究成果: Article

Cell Differentiation
Transcription Factors
POU Domain Factors
Genome
Neurotrophin 3
8 引文 (Scopus)
Phosphorylation
Tumors
Disease Progression
Neoplasms
Alzheimer Disease

Physiological Concentration of Prostaglandin E 2 Exerts Anti-inflammatory Effects by Inhibiting Microglial Production of Superoxide Through a Novel Pathway

Chen, S. H., Sung, Y. F., Oyarzabal, E. A., Tan, Y. M., Leonard, J., Guo, M., Li, S., Wang, Q., Chu, C-H., Chen, S. L., Lu, R-B. & Hong, J. S., 2018 十月 1, 於 : Molecular Neurobiology. 55, 10, p. 8001-8013 13 p.

研究成果: Article

Prostaglandins E
Dinoprostone
Superoxides
Anti-Inflammatory Agents
Neuroprotective Agents
11 引文 (Scopus)

PML: Regulation and multifaceted function beyond tumor suppression

Hsu, K. S. & Kao, H. Y., 2018 一月 25, 於 : Cell and Bioscience. 8, 1, 5.

研究成果: Review article

開啟存取
Tumors
Neoplasms
Proteins
Nuclear Proteins
Cell Aging

Predominance of CD14+ Cells in Burn Blister Fluids

Chen, S. H., Wong, T. W., Lee, C. H., Chen, C. L., Wu, L. W. & Pan, S. C., 2018 二月 1, 於 : Annals of plastic surgery. 80, 2S Suppl 1, p. S70-S74

研究成果: Article

Blister
Wounds and Injuries
Angiogenesis Inducing Agents
Vascular Endothelial Growth Factor Receptor-2
Informed Consent
1 引文 (Scopus)
Escherichia coli Infections
Cytokines
Kidney
Urinary Bladder
Infection
3 引文 (Scopus)

The p53-S100A2 Positive Feedback Loop Negatively Regulates Epithelialization in Cutaneous Wound Healing

Pan, S. C., Li, C. Y., Kuo, C. Y., Kuo, Y. Z., Fang, W. Y., Huang, Y. H., Hsieh, T. C., Kao, H. Y., Kuo, Y., Kang, Y. R., Tsai, W. C., Tsai, S. T. & Wu, L. W., 2018 十二月 1, 於 : Scientific reports. 8, 1, 5458.

研究成果: Article

Wound Healing
Skin
Wounds and Injuries
Keratinocytes
Re-Epithelialization
9 引文 (Scopus)

The role of HGF-MET pathway and CCDC66 cirRNA expression in EGFR resistance and epithelial-to-mesenchymal transition of lung adenocarcinoma cells

Joseph, N. A., Chiou, S. H., Lung, Z., Yang, C. L., Lin, T. Y., Chang, H. W., Sun, H-F., Gupta, S. K., Yen, L., Wang, S. D. & Chow, K. C., 2018 五月 31, 於 : Journal of Hematology and Oncology. 11, 1, 74.

研究成果: Article

Epithelial-Mesenchymal Transition
Drug Resistance
Proteins
Western Blotting
Immunohistochemistry
1 引文 (Scopus)

The transmembrane segment of TagH is required for wall teichoic acid transport under heat stress in Bacillus subtilis

Yamada, T., Miyashita, M., Kasahara, J., Tanaka, T., Hashimoto, M. & Yamamoto, H., 2018 七月, 於 : Microbiology (United Kingdom). 164, 7, p. 935-945 11 p.

研究成果: Article

Teichoic Acids
Bacillus subtilis
Hot Temperature
Temperature
Fluorescence Microscopy
Postoperative Nausea and Vomiting
Taiwan
Antiemetics
Emetics
6 引文 (Scopus)

WWOX phosphorylation, signaling, and role in neurodegeneration

Liu, C. C., Ho, P. C., Lee, I. T., Chen, Y. A., Chu, C. H., Teng, C. C., Wu, S. N., Sze, C. I., Chiang, M. F. & Chang, N. S., 2018 八月 15, 於 : Frontiers in Neuroscience. 12, AUG, 563.

研究成果: Review article

Amyloid
Phosphorylation
Genetic Suppression
Glycogen Synthase Kinase 3
Proteins
2017
5 引文 (Scopus)

Anti-IL-20 monoclonal antibody inhibited inflammation and protected against cartilage destruction in murine models of osteoarthritis

Hsu, Y. H., Yang, Y. Y., Huwang, M. H., Weng, Y. H., Jou, I. M., Wu, P. T., Lin, T. Y., Wu, L. W. & Chang, M. S., 2017 四月, 於 : PloS one. 12, 4, e0175802.

研究成果: Article

osteoarthritis
Cartilage
interleukins
cartilage
Osteoarthritis
48 引文 (Scopus)

Circular RNA – New member of noncoding RNA with novel functions

Hsiao, K. Y., Sun, H. S. & Tsai, S. J., 2017 六月 1, 於 : Experimental Biology and Medicine. 242, 11, p. 1136-1141 6 p.

研究成果: Review article

Untranslated RNA
Biosynthesis
MicroRNAs
Clustered Regularly Interspaced Short Palindromic Repeats
RNA Editing
5 引文 (Scopus)

CK1δ/GSK3β/FBXW7α axis promotes degradation of the ZNF322A oncoprotein to suppress lung cancer progression

Liao, S. Y., Chiang, C-W., Hsu, C. H., Chen, Y. T., Jen, J., Juan, H. F., Lai, W-W. & Wang, Y-C., 2017 十月 12, 於 : Oncogene. 36, 41, p. 5722-5733 12 p.

研究成果: Article

Oncogene Proteins
Zinc Fingers
Lung Neoplasms
Serine
Phosphorylation
5 引文 (Scopus)

Dual regulation of Stat1 and Stat3 by the tumor suppressor protein PML contributes to interferon α-mediated inhibition of angiogenesis

Hsu, K. S., Zhao, X., Cheng, X., Guan, D., Mahabeleshwar, G. H., Liu, Y., Borden, E., Jain, M. K. & Kao, H-Y., 2017 六月 16, 於 : Journal of Biological Chemistry. 292, 24, p. 10048-10060 13 p.

研究成果: Article

開啟存取
Tumor Suppressor Proteins
Endothelial cells
Interferons
Endothelial Cells
Ubiquitination
17 引文 (Scopus)
Thrombospondin 1
Endothelial Cells
Neoplasm Metastasis
Tumor Microenvironment
Exocytosis
10 引文 (Scopus)

Hyaluronan activates Hyal-2/WWOX/Smad4 signaling and causes bubbling cell death when the signaling complex is overexpressed

Hsu, L. J., Hong, Q., Chen, S. T., Kuo, H. L., Schultz, L., Heath, J., Lin, S. R., Lee, M. H., Li, D. Z., Li, Z. L., Cheng, H. C., Armand, G. & Chang, N. S., 2017 一月 1, 於 : Oncotarget. 8, 12, p. 19137-19155 19 p.

研究成果: Article

Hyaluronic Acid
Cell Death
Hyaluronoglucosaminidase
Transforming Growth Factor beta
Membranes
6 引文 (Scopus)
Mouth Neoplasms
Tumor Necrosis Factor-alpha
Hyaluronic Acid
Chemokine CCL2
hyaluronan synthase
23 引文 (Scopus)

Hypoxia-induced downregulation of DUSP-2 phosphatase drives colon cancer stemness

Hou, P. C., Li, Y. H., Lin, S. C., Lin, S. C., Lee, J. C., Lin, B. W., Liou, J. P., Chang, J. Y., Kuo, C. C., Liu, Y. M., Sun, H. S. & Tsai, S. J., 2017 八月 15, 於 : Cancer Research. 77, 16, p. 4305-4316 12 p.

研究成果: Article

Dual-Specificity Phosphatases
Dual Specificity Phosphatase 2
Colonic Neoplasms
Down-Regulation
Neoplasms