• 2311 引文
  • 26 h-指數
19962019
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研究成果 1996 2019

2019
開啟存取
Fluorodeoxyglucose F18
Non-Small Cell Lung Carcinoma
Glycolysis
Radiotherapy
Tumor Burden
2018
3 引文 (Scopus)

Adjuvant radiotherapy after curative surgery for oral cavity squamous cell carcinoma and treatment effect of timing and duration on outcome—A Taiwan Cancer Registry national database analysis

Cheng, Y-J., Tsai, M-H., Chiang, C. J., Tsai, S-T., Liu, T. W., Lou, P. J., Liao, C. T., Lin, J. C., Chang, J. T. C., Tsai, M. H., Chu, P. Y., Leu, Y. S., Tsai, K. Y., Terng, S. D., Chien, C. Y., Yang, M. H., Hao, S. P., Wang, C. C., Tsai, M. H., Chen, H. H. W. 及其他2, Kuo, C. & Wu, Y-H., 2018 七月 1, 於 : Cancer medicine. 7, 7, p. 3073-3083 11 p.

研究成果: Article

Adjuvant Radiotherapy
Taiwan
Registries
Mouth
Squamous Cell Carcinoma
7 引文 (Scopus)
homeostasis
Drug and Narcotic Control
Platinum
Antineoplastic Agents
Tumors
2017
5 引文 (Scopus)

Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy

Long, Y., Tsai, W. B., Wang, D., Hawke, D. H., Savaraj, N., Feun, L. G., Hung, M. C., Chen, H. H. W. & Kuo, M. T., 2017 三月 1, 於 : Cancer Letters. 388, p. 54-63 10 p.

研究成果: Article

Argininosuccinate Synthase
Starvation
Glutamine
Arginine
Therapeutics
1 引文 (Scopus)

Chromatin remodeling system p300-HDAC2-Sin3A is involved in Arginine Starvation-Induced HIF-1α Degradation at the ASS1 promoter for ASS1 Derepression

Tsai, W. B., Long, Y., Chang, J. T., Savaraj, N., Feun, L. G., Jung, M., Chen, H. H. W. & Kuo, M. T., 2017 十二月 1, 於 : Scientific reports. 7, 1, 10814.

研究成果: Article

Argininosuccinate Synthase
Chromatin Assembly and Disassembly
Starvation
Arginine
Histones
22 引文 (Scopus)

Improving radiotherapy in cancer treatment: Promises and challenges

Chen, H. H. W. & Kuo, M. T., 2017 九月 1, 於 : Oncotarget. 8, 37, p. 62742-62758 17 p.

研究成果: Review article

Radiotherapy
Neoplasms
Tumor Microenvironment
Radiation Tolerance
Therapeutics
3 引文 (Scopus)
Wheat Germ Agglutinins
Autophagy
Cell Death
HeLa Cells
Unfolded Protein Response
2016
8 引文 (Scopus)

Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1α, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation

Long, Y., Tsai, W. B., Chang, J. T., Estecio, M., Wangpaichitr, M., Savaraj, N., Feun, L. G., Chen, H. W. & Kuo, M. T., 2016 一月 1, 於 : Oncotarget. 7, 50, p. 82658-82670 13 p.

研究成果: Article

Argininosuccinate Synthase
DNA Methylation
Starvation
Cisplatin
Arginine
5 引文 (Scopus)
Taiwan
Cost-Benefit Analysis
Quality-Adjusted Life Years
Gross Domestic Product
Neoplasms
4 引文 (Scopus)
DNA-Binding Proteins
Platinum
Cisplatin
Copper
Homeostasis
2015
5 引文 (Scopus)
Life Expectancy
Quality of Life
Incidence
Health
Neoplasms
19 引文 (Scopus)

Targeting drug transport mechanisms for improving platinum-based cancer chemotherapy

Chen, H. H. W., Chen, W. C., Liang, Z. D., Tsai, W. B., Long, Y., Aiba, I., Fu, S., Broaddus, R., Liu, J., Feun, L. G., Savaraj, N. & Kuo, M. T., 2015 十月 3, 於 : Expert Opinion on Therapeutic Targets. 19, 10, p. 1307-1317 11 p.

研究成果: Review article

Chemotherapy
Drug Delivery Systems
Platinum
Drug Therapy
Copper
2014
9 引文 (Scopus)
Life Expectancy
Lung Neoplasms
Quality of Life
Non-Small Cell Lung Carcinoma
Quality-Adjusted Life Years
7 引文 (Scopus)

Inhibiting glucosylceramide synthase facilitates the radiosensitizing effects of vinorelbine in lung adenocarcinoma cells

Chiu, W-H., Chen, H. H. W., Chang, J-Y., Luo, S. J., Li, C. L., Chen, C. L., Su, W-C. & Lin, C. F., 2014 七月 28, 於 : Cancer Letters. 349, 2, p. 144-151 8 p.

研究成果: Article

ceramide glucosyltransferase
Radiation-Sensitizing Agents
Chemoradiotherapy
JNK Mitogen-Activated Protein Kinases
Apoptosis
10 引文 (Scopus)

Regulation of the high-affinity copper transporter (hCtr1) expression by cisplatin and heavy metals

Liang, Z. D., Long, Y., Chen, H. H. W., Savaraj, N. & Kuo, M. T., 2014 一月 14, 於 : Journal of Biological Inorganic Chemistry. 19, 1, p. 17-27 11 p.

研究成果: Article

Heavy Metals
Cisplatin
Copper
Platinum
Pharmaceutical Preparations
2013
13 引文 (Scopus)
Lung Neoplasms
Quality of Life
Life Expectancy
Health
Health Expenditures
66 引文 (Scopus)
Tumor Microenvironment
Interleukin-17
Breast Neoplasms
Disease-Free Survival
Th17 Cells
15 引文 (Scopus)

Overcoming platinum drug resistance with copper-lowering agents

Chen, H. H. W. & Kuo, M. T., 2013 十月 1, 於 : Anticancer Research. 33, 10, p. 4157-4162 6 p.

研究成果: Article

Platinum
Drug Resistance
Copper
Drug Therapy
Carboplatin

Pharmaceutical composition for elevating radio-sensitiving of cancer cells, pharmacutical composition for detecting cancer cells with radio-sensitivity and detection mehtod thereof

貢獻的翻譯標題: 提升癌細胞之放射敏感性之醫藥組成物、檢測癌細胞是否具有放射抗性之醫藥組成物、及其檢測方法Chen, H. H. W., Shieh, D-B. & Wu, P-C., 2013 七月 4, 專利號 9121049

研究成果: Patent

5 引文 (Scopus)
Rectal Neoplasms
Neoplasms
Surgeons
Lymph Nodes
Anus Neoplasms
14 引文 (Scopus)
Fluorodeoxyglucose F18
Non-Small Cell Lung Carcinoma
Disease-Free Survival
Lung
Survival
6 引文 (Scopus)
Doppler Ultrasonography
Radiotherapy
Carcinoma
Recurrence
Biomarkers
2012
4 引文 (Scopus)

Bone marrow transplantation enhances trafficking of host-derived myelomonocytic cells that rescue intestinal mucosa after whole body radiation

Ch'Ang, H. J., Lin, L. M., Chang, P. Y., Luo, C. W., Chang, Y. H., Chou, C. K. & Chen, H. H., 2012 九月 1, 於 : Radiotherapy and Oncology. 104, 3, p. 401-407 7 p.

研究成果: Article

Whole-Body Irradiation
Intestinal Mucosa
Bone Marrow Transplantation
Intestines
Transplantation
6 引文 (Scopus)
Uterine Cervical Neoplasms
radiation therapy
Radiotherapy
cancer
activation
Skin Neoplasms
Radiotherapy
Therapeutics
13 引文 (Scopus)
Intensity-Modulated Radiotherapy
Mouth
Squamous Cell Carcinoma
Radiotherapy
Survival Rate
45 引文 (Scopus)

Mechanistic basis for overcoming platinum resistance using copper chelating agents

Liang, Z. D., Long, Y., Tsai, W. B., Fu, S., Kurzrock, R., Gagea-Iurascu, M., Zhang, F., Chen, H. H. W., Hennessy, B. T., Mills, G. B., Savaraj, N. & Kuo, M. T., 2012 十一月 1, 於 : Molecular Cancer Therapeutics. 11, 11, p. 2483-2494 12 p.

研究成果: Article

Chelating Agents
Platinum
Copper
Drug Resistance
Ovarian Neoplasms
19 引文 (Scopus)
Paclitaxel
Lung Neoplasms
Survival
Reactive Oxygen Species
Drug Therapy
51 引文 (Scopus)
Platinum
Non-Small Cell Lung Carcinoma
Drug Therapy
Disease-Free Survival
Copper
144 引文 (Scopus)
Glycolysis
Non-Small Cell Lung Carcinoma
Tumor Burden
Disease-Free Survival
Lung
54 引文 (Scopus)

Role of the human high-affinity copper transporter in copper homeostasis regulation and cisplatin sensitivity in cancer chemotherapy

Kuo, M. T., Fu, S., Savaraj, N. & Chen, H. H. W., 2012 九月 15, 於 : Cancer Research. 72, 18, p. 4616-4621 6 p.

研究成果: Review article

Cisplatin
Copper
Homeostasis
Drug Therapy
Neoplasms
2011
12 引文 (Scopus)
STAT3 Transcription Factor
Estrogen Receptors
Up-Regulation
Lung Neoplasms
Epidermal Growth Factor Receptor
2010
31 引文 (Scopus)

Hypothyroidism After Radiotherapy for Nasopharyngeal Cancer Patients

Wu, Y-H., Wang, H. M., Chen, H. H. W., Lin, C. Y., Chen, E. Y. C., Fan, K. H., Huang, S. F., Chen, I. H., Liao, C. T., Cheng, A. J. & Chang, J. T. C., 2010 三月 15, 於 : International Journal of Radiation Oncology Biology Physics. 76, 4, p. 1133-1139 7 p.

研究成果: Article

Nasopharyngeal Neoplasms
Hypothyroidism
radiation therapy
Radiotherapy
cancer
10 引文 (Scopus)

Isolated osteoradionecrosis of the dens mimicking metastasis of nasopharyngeal carcinoma after radiotherapy

Lee, J-S., Huang, C. M., Yeh, I. C., Chen, H. H. W., Lin, J. C. & Chen, H. H., 2010 八月 1, 於 : Journal of Clinical Neuroscience. 17, 8, p. 1064-1066 3 p.

研究成果: Article

Osteoradionecrosis
Radiotherapy
Neoplasm Metastasis
Spine
Nasopharynx
108 引文 (Scopus)

Role of glutathione in the regulation of cisplatin resistance in cancer chemotherapy

Kuo, M. T. & Chen, H. H. W., 2010 十月 20, 於 : Metal-Based Drugs. 2010, 430939.

研究成果: Review article

Chemotherapy
Cisplatin
Glutathione
Cells
Drug Therapy
7 引文 (Scopus)
Lung Neoplasms
Flow Cytometry
Neoplasms
Malignant Pleural Effusion
Cisplatin
2009
7 引文 (Scopus)
Cauda Equina
Fibrosis
Radiation
Somatosensory Evoked Potentials
Radiotherapy
2008
52 引文 (Scopus)

Elevated glutathione levels confer cellular sensitization to cisplatin toxicity by up-regulation of copper transporter hCtr1

Chen, H. H. W., Song, I. S., Hossain, A., Choi, M. K., Yamane, Y., Liang, Z. D., Lu, J., Wu, L. Y. H., Siddik, Z. H., Klomp, L. W. J., Savaraj, N. & Kuo, M. T., 2008 九月 1, 於 : Molecular Pharmacology. 74, 3, p. 697-704 8 p.

研究成果: Article

Cisplatin
Glutathione
Copper
Up-Regulation
Glutamate-Cysteine Ligase
169 引文 (Scopus)
Gold
Nanoparticles
Electrons
Neoplasms
Melanoma
52 引文 (Scopus)

Transcription factor Sp1 plays an important role in the regulation of copper homeostasis in mammalian cells

Song, I. S., Chen, H. H. W., Aiba, I., Hossain, A., Liang, Z. D., Klomp, L. W. J. & Kuo, M. T., 2008 九月 1, 於 : Molecular Pharmacology. 74, 3, p. 705-713 9 p.

研究成果: Article

Sp1 Transcription Factor
Copper
Homeostasis
Messenger RNA
Poisons
2007
49 引文 (Scopus)
Hypoxia-Inducible Factor 1
Breast Neoplasms
Neoplasm Metastasis
Disease-Free Survival
Survival Rate
31 引文 (Scopus)

IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness

Hsu, Y. M., Chou, C-Y., Chen, H. H. W., Lee, W. Y., Chen, Y. F., Lin, P. W., Alper, S. L., Ellory, J. C. & Shen, M-R., 2007 三月 1, 於 : Journal of Cellular Physiology. 210, 3, p. 626-636 11 p.

研究成果: Article

Cell proliferation
Somatomedins
Up-Regulation
Cell Proliferation
Breast Neoplasms

In Reply to Dr. Lee

Chen, H. H. W. & Lin, J. C., 2007 八月 1, 於 : International Journal of Radiation Oncology Biology Physics. 68, 5, 1 p.

研究成果: Letter

185 引文 (Scopus)

The roles of copper transporters in cisplatin resistance

Kuo, M. T., Chen, H. H. W., Song, I. S., Savaraj, N. & Ishikawa, T., 2007 三月 1, 於 : Cancer and Metastasis Reviews. 26, 1, p. 71-83 13 p.

研究成果: Review article

Platinum
Cisplatin
Copper
Pharmaceutical Preparations
oxaliplatin
2006
153 引文 (Scopus)
Malignant Pleural Effusion
Interleukin-6
Vascular Endothelial Growth Factor A
Lung Neoplasms
Adenocarcinoma of lung
15 引文 (Scopus)
Genetic Promoter Regions
Single Nucleotide Polymorphism
Tumor Necrosis Factor-alpha
Genes
Alleles
25 引文 (Scopus)
acceleration (physics)
radiation therapy
Radiotherapy
cancer
Neck
9 引文 (Scopus)
peritoneum
Doppler Ultrasonography
Papillary Carcinoma
Peritoneum
tumors
2005
10 引文 (Scopus)
Loss of Heterozygosity
Carcinoma
Neoplasms
Microsatellite Repeats
Stomach Neoplasms