Hung-Tsung Wu

2024

Consumption of the nonnutritive sweetener acesulfame potassium increases central precocious puberty risk

Wu, H. T., Chiang, C. C., Wang, C. T., Chen, Y. H., Hsu, S. Y. & Chen, Y. C., 2024 1月 5, 於: Journal of Hazardous Materials. 461, 132529.

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2023

Aspartame consumption during pregnancy impairs placenta growth in mice through sweet taste receptor-reactive oxygen species-dependent pathway

Huang, S. Y., Sun, R., Chen, Y. C., Kang, L., Wang, C. T., Chiu, C. F. & Wu, H. T., 2023 3月, 於: Journal of Nutritional Biochemistry. 113, 109228.

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3 引文斯高帕斯（Scopus）

Effects of Nonnutritive Sweeteners on Body Composition Changes during Pubertal Growth

Chien, Y. H., Lin, C. Y., Hsu, S. Y., Chen, Y. H., Wu, H. T., Huang, S. W. & Chen, Y. C., 2023 5月, 於: Nutrients. 15, 10, 2319.

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Evodiamine Exhibits Anti-Bladder Cancer Activity by Suppression of Glutathione Peroxidase 4 and Induction of Ferroptosis

Hu, C. Y., Wu, H. T., Shan, Y. S., Wang, C. T., Shieh, G. S., Wu, C. L. & Ou, H. Y., 2023 4月, 於: International journal of molecular sciences. 24, 7, 6021.

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3 引文斯高帕斯（Scopus）

Growth differentiation factor-15 is independently associated with metabolic syndrome and hyperglycemia in non-elderly subjects

Ho, L. C., Wu, H. T., Hung, H. C., Chou, H. W., Cheng, K. P., Lin, C. H., Wang, C. C. & Ou, H. Y., 2023 1月 1, 於: BioFactors. 49, 1, p. 119-126 8 p.

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2 引文斯高帕斯（Scopus）

Hepatic arterial infusion chemotherapy and immune checkpoint inhibitors, alone or in combination, in advanced hepatocellular carcinoma with macrovascular invasion: a single-centre experience in Taiwan

Wu, J. S., Hong, T. C., Wu, H-T., Lin, Y. J., Chang, T. T., Wang, C. T., Liu, W-C., Hsieh, M. T., Wu, I-C., Chen, P. J., Chen, C. Y., Lin, S-H., Chuang, C. H., Han, M. Z., Chen, H. P., Tsai, H-M. & Kuo, H. Y., 2023 4月 29, 於: Journal of Gastrointestinal Oncology. 14, 2, p. 849-862 14 p.

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2 引文斯高帕斯（Scopus）

Long-Term Consumption of Sucralose Induces Hepatic Insulin Resistance through an Extracellular Signal-Regulated Kinase 1/2-Dependent Pathway

Tsai, M. J., Li, C. H., Wu, H-T., Kuo, H. Y., Wang, C. T., Pai, H. L., Chang, C. J. & Ou, H-Y., 2023 6月, 於: Nutrients. 15, 12, 2814.

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1 引文斯高帕斯（Scopus）

Real-World Effectiveness of Sorafenib versus Lenvatinib Combined with PD-1 Inhibitors in Unresectable Hepatocellular Carcinoma

Chiang, H. C., Lee, Y. C., Chang, T. T., Lin, Y. J., Wu, H. T., Wang, C. T., Chen, C. Y., Chen, P. J., Hsieh, M. T., Lin, S. H., Chen, S. H., Chuang, C. H., Wu, I. C., Hong, T. C., Wu, J. S., Han, M. Z., Chen, W. T., Chiang, C. M., Hung, K. K. & Kuo, H. Y., 2023 2月, 於: Cancers. 15, 3, 854.

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Secretory autophagy promotes RAB37-mediated insulin secretion under glucose stimulation both in vitro and in vivo

Wu, S. Y., Wu, H. T., Wang, Y. C., Chang, C. J., Shan, Y. S., Wu, S. R., Chiu, Y. C., Hsu, C. L., Juan, H. F., Lan, K. Y., Chu, C. W., Lee, Y. R., Lan, S. H. & Liu, H. S., 2023, 於: Autophagy. 19, 4, p. 1239-1257 19 p.

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4 引文斯高帕斯（Scopus）

Serum Cardiotrophin-1 Concentration Is Negatively Associated with Controlled Attenuation Parameters in Subjects with Non-Alcoholic Fatty Liver Disease

Liao, Y. C., Wu, J. S., Chou, H. W., Kuo, H. Y., Lee, C. T., Wu, H. T., Li, C. H. & Ou, H. Y., 2023 4月, 於: Journal of Clinical Medicine. 12, 7, 2741.

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2022

Associations between GDF15 Levels and Pre-Diabetes in Non-Obese Subjects

Hung, H. C., Wu, H. T., Lin, C. H., Chou, H. W., Ou, H. Y. & Chang, C. J., 2022 1月, 於: Journal of Investigative Medicine. 70, 1, p. 79-84 6 p.

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1 引文斯高帕斯（Scopus）

Coral Hydrate, a Novel Antioxidant, Improves Alcohol Intoxication in Mice

Wu, H. T., Chao, T. H., Ou, H. Y. & Tsai, L-M., 2022 7月, 於: Antioxidants. 11, 7, 1290.

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1 引文斯高帕斯（Scopus）

Development and Validation of the Chinese Version Non-Nutritive Sweetener Food Frequency Questionnaire with Urinary Biomarker in Children and Adolescents

Chu, Y. Y., Chen, Y. H., Hsieh, R. H., Hsia, S. M., Wu, H. T. & Chen, Y. C., 2022, (Accepted/In press) 於: Public Health Nutrition.

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3 引文斯高帕斯（Scopus）

Long-term consumption of the sugar substitute sorbitol alters gut microbiome and induces glucose intolerance in mice

Li, C. H., Wang, C. T., Lin, Y. J., Kuo, H. Y., Wu, J. S., Hong, T. C., Chang, C. J. & Wu, H. T., 2022 9月 15, 於: Life Sciences. 305, 120770.

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11 引文斯高帕斯（Scopus）

Real-World Comparative Effectiveness of Nivolumab versus Pembrolizumab in Patients with Unresectable Hepatocellular Carcinoma

Kuo, H. Y., Han, M. Z., Liao, C. H., Lin, Y. J., Wang, C. T., Chen, S. H., Chang, T. T., Chen, P. J., Lin, S. H., Chen, C. Y., Chuang, C. H., Wu, I. C., Wu, J. S., Hong, T. C., Hsieh, M. T., Lee, Y. C., Wu, H. T. & Tsai, H. M., 2022 11月, 於: Pharmaceutics. 14, 11, 2263.

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3 引文斯高帕斯（Scopus）

Real-World Comparative Evaluation of Add-On Glucagon-like Peptide 1 Receptor Agonist in Type 2 Diabetes Treated with or without Insulin

Chou, H. W., Cheng, K. P., Lin, A. C., Hung, H. C., Lin, C. H., Wang, C. C., Wu, H. T. & Ou, H. Y., 2022 12月, 於: Pharmaceuticals. 15, 12, 1569.

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Sucralose, a Non-nutritive Artificial Sweetener Exacerbates High Fat Diet-Induced Hepatic Steatosis Through Taste Receptor Type 1 Member 3

Wu, H. T., Lin, C. H., Pai, H. L., Chen, Y. C., Cheng, K. P., Kuo, H. Y., Li, C. H. & Ou, H. Y., 2022 5月 23, 於: Frontiers in Nutrition. 9, 823723.

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7 引文斯高帕斯（Scopus）

2021

Consumption of non-nutritive sweetener, acesulfame potassium exacerbates atherosclerosis through dysregulation of lipid metabolism in apoe^−/− mice

Lin, C. H., Li, H. Y., Wang, S. H., Chen, Y. H., Chen, Y. C. & Wu, H. T., 2021 11月, 於: Nutrients. 13, 11, 3984.

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7 引文斯高帕斯（Scopus）

Eicosapentaenoic acid inhibits kras mutant pancreatic cancer cell growth by suppressing hepassocin expression and stat3 phosphorylation

Chiu, C. F., Hsu, M. I., Yeh, H. Y., Park, J. M., Shen, Y. S., Tung, T. H., Huang, J. J., Wu, H. T. & Huang, S. Y., 2021 3月, 於: Biomolecules. 11, 3, p. 1-17 17 p., 370.

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9 引文斯高帕斯（Scopus）

Life course body mass index through childhood and young adulthood and risks of asthma and pulmonary function impairment

Chen, Y. C., Kuo, H. P., Hsia, S. M., Wu, H. T., Pan, W. H. & Lee, Y. L., 2021 5月, 於: Pediatric Pulmonology. 56, 5, p. 849-857 9 p.

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7 引文斯高帕斯（Scopus）

Maternal Plasma Lipids during Pregnancy, Insulin-like Growth Factor-1, and Excess Fetal Growth

Chen, K. Y., Lin, S. Y., Lee, C. N., Wu, H. T., Kuo, C. H., Kuo, H. C., Chuang, C. C., Kuo, C. H., Chen, S. C., Fan, K. C., Lin, M. W., Fang, C. T. & Li, H. Y., 2021 9月 1, 於: Journal of Clinical Endocrinology and Metabolism. 106, 9, p. E3461-E3472

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8 引文斯高帕斯（Scopus）

The serum concentrations of hedgehog-interacting protein, a novel biomarker, were decreased in overweight or obese subjects

Chou, H. W., Hung, H. C., Lin, C. H., Lin, A. C., Du, Y. F., Cheng, K. P., Li, C. H., Chang, C. J., Wu, H. T. & Ou, H. Y., 2021 2月 2, 於: Journal of Clinical Medicine. 10, 4, p. 1-8 8 p., 742.

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4 引文斯高帕斯（Scopus）

2020

Discovery of a role of the novel hepatokine, hepassocin, in obesity

Huang, R. L., Li, C. H., Du, Y. F., Cheng, K. P., Lin, C. H., Hu, C. Y., Wu, J. S., Chang, C-J., Wu, H. T. & Ou, H. Y., 2020 1月 1, 於: BioFactors. 46, 1, p. 100-105 6 p.

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10 引文斯高帕斯（Scopus）

n-3 PUFA and caloric restriction diet alters lipidomic profiles in obese men with metabolic syndrome: a preliminary open study

Shabrina, A., Tung, T. H., Nguyen, N. T. K., Lee, H. C., Wu, H. T., Wang, W. & Huang, S. Y., 2020 10月 1, 於: European Journal of Nutrition. 59, 7, p. 3103-3112 10 p.

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9 引文斯高帕斯（Scopus）

Prothymosin α activates type i collagen to develop a fibrotic placenta in gestational diabetes

Wu, H. T., Kang, L., Su, Y. C., Ou, H. Y., Chan, F. Y., Chen, Y-C., Su, B. H., Wang, Y. S., Wu, C. L., Shiau, A. L. & Wu, P., 2020 9月, 於: Clinical Science. 134, 18, p. 2435-2445 11 p.

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Role of placental fibrinogen-like protein 1 in gestational diabetes

Kang, L., Li, H. Y., Ou, H. Y., Wu, P., Wang, S. H., Chang, C-J., Lin, S. Y., Wu, C. L. & Wu, H. T., 2020 4月, 於: Translational Research. 218, p. 73-80 8 p.

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18 引文斯高帕斯（Scopus）

Serum Angiopoietin-like Protein 6, Risk of Type 2 Diabetes, and Response to Hyperglycemia: A prospective cohort study

Fan, K. C., Wu, H. T., Wei, J. N., Chuang, L. M., Hsu, C. Y., Yen, I. W., Lin, C. H., Lin, M. S., Shih, S. R., Wang, S. H., Chang, T. J. & Li, H. Y., 2020 5月 1, 於: Journal of Clinical Endocrinology and Metabolism. 105, 5, dgaa103.

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7 引文斯高帕斯（Scopus）

Targeting fibrinogen-like protein 1 is a novel therapeutic strategy to combat obesity

Wu, H. T., Chen, S. C., Fan, K. C., Kuo, C. H., Lin, S. Y., Wang, S. H., Chang, C. J. & Li, H. Y., 2020 2月 1, 於: FASEB Journal. 34, 2, p. 2958-2967 10 p.

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23 引文斯高帕斯（Scopus）

2019

Chronic exposure to high fat diet triggers myelin disruption and interleukin-33 upregulation in hypothalamus

Huang, H. T., Tsai, S. F., Wu, H. T., Huang, H. Y., Hsieh, H. H., Kuo, Y. M., Chen, P. S., Yang, C. S. & Tzeng, S. F., 2019 7月 10, 於: BMC Neuroscience. 20, 1, 33.

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21 引文斯高帕斯（Scopus）

Elevated hedgehog-interacting protein levels in subjects with prediabetes and type 2 diabetes

Lin, A. C., Hung, H. C., Chen, Y. W., Cheng, K. P., Li, C. H., Lin, C. H., Chang, C. J., Wu, H. T. & Ou, H. Y., 2019 10月, 於: Journal of Clinical Medicine. 8, 10, 1635.

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9 引文斯高帕斯（Scopus）

Serum secretogranin III concentrations were increased in subjects with metabolic syndrome and independently associated with fasting plasma glucose levels

Lin, C. C., Cheng, K. P., Hung, H. C., Li, C. H., Lin, C. H., Chang, C. J., Hu, C. Y., Wu, H. T. & Ou, H. Y., 2019 9月, 於: Journal of Clinical Medicine. 8, 9, 1436.

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2 引文斯高帕斯（Scopus）

Serum vascular adhesion protein-1 is up-regulated in hyperglycemia and is associated with incident diabetes negatively

Kuo, C. H., Wei, J. N., Yang, C. Y., Ou, H. Y., Wu, H. T., Fan, K. C., Wang, S. H., Hua, C. H., Hsiao, C. H., Lee, M. K. & Li, H. Y., 2019 3月 1, 於: International Journal of Obesity. 43, 3, p. 512-522 11 p.

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11 引文斯高帕斯（Scopus）

2018

Elovl6 is a negative clinical predictor for liver cancer and knockdown of Elovl6 reduces murine liver cancer progression

Su, Y. C., Feng, Y. H., Wu, H. T., Huang, Y. S., Tung, C. L., Wu, P., Chang, C. J., Shiau, A. L. & Wu, C. L., 2018 12月 1, 於: Scientific reports. 8, 1, 6586.

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31 引文斯高帕斯（Scopus）

High-fat diet suppresses the astrocytic process arborization and downregulates the glial glutamate transporters in the hippocampus of mice

Tsai, S. F., Wu, H. T., Chen, P. C., Chen, Y. W., Yu, M., Wang, T. F., Wu, S. Y., Tzeng, S. F. & Kuo, Y. M., 2018 12月 1, 於: Brain Research. 1700, p. 66-77 12 p.

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36 引文斯高帕斯（Scopus）

Unsaturated Fatty Acids Increase the Expression of Hepassocin through a Signal Transducer and Activator of Transcription 3-Dependent Pathway in HepG2 Cells

Cheng, K. P., Ou, H. Y., Hung, H. C., Li, C. H., Fan, K. C., Wu, J. S., Wu, H. T. & Chang, C. J., 2018 9月, 於: Lipids. 53, 9, p. 863-869 7 p.

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9 引文斯高帕斯（Scopus）

2017

Evodiamine Exerts an Anti-Hepatocellular Carcinoma Activity through a WWOX-Dependent Pathway

Hu, C. Y., Wu, H. T., Su, Y. C., Lin, C. H., Chang, C. J. & Wu, C. L., 2017 7月 14, 於: Molecules (Basel, Switzerland). 22, 7

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34 引文斯高帕斯（Scopus）

The hepatic protection effects of hepassocin in hyperglycemic crisis

Ou, H. Y., Wu, H. T., Lin, C. H., Du, Y. F., Hu, C. Y., Hung, H. C., Wu, P., Li, H. Y., Wang, S. H. & Chang, C. J., 2017 7月 1, 於: Journal of Clinical Endocrinology and Metabolism. 102, 7, p. 2407-2415 9 p.

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19 引文斯高帕斯（Scopus）

2016

A novel hepatokine, HFREP1, plays a crucial role in the development of insulin resistance and type 2 diabetes

Wu, H. T., Ou, H. Y., Hung, H. C., Su, Y. C., Lu, F. H., Wu, J. S., Yang, Y. C., Wu, C. L. & Chang, C-J., 2016 8月 1, 於: Diabetologia. 59, 8, p. 1732-1742 11 p.

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58 引文斯高帕斯（Scopus）

Fenretinide inhibits macrophage inflammatory mediators and controls hypertension in spontaneously hypertensive rats via the peroxisome proliferator-activated receptor gamma pathway

Lin, C. H., Lee, S. Y., Zhang, C. C., Du, Y. F., Hung, H. C., Wu, H. T. & Ou, H. Y., 2016 11月 1, 於: Drug Design, Development and Therapy. 10, p. 3591-3597 7 p.

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21 引文斯高帕斯（Scopus）

2015

Both diabetes and fetuin-A are independently associated with increased risk of arterial stiffness

Ou, H. Y., Lu, F. H., Wu, H. T., Hung, H. C., Wu, J. S., Yang, Y. C. & Chang, C-J., 2015 5月 1, 於: Clinica Chimica Acta. 445, p. 133-138 6 p.

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4 引文斯高帕斯（Scopus）

Cardiotrophin-1 is associated with increased risk of arterial stiffness

Hung, H. C., Lu, F. H., Ou, H. Y., Wu, H. T., Wu, J. S., Yang, Y. C. & Chang, C-J., 2015 2月 1, 於: Biomarkers in Medicine. 9, 2, p. 123-130 8 p.

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4 引文斯高帕斯（Scopus）

Cardiotrophin-1 is inversely associated with obesity in non-diabetic individuals

Hung, H. C., Lu, F. H., Wu, H. T., Ou, H. Y., Yang, Y. C., Wu, J. S. & Chang, C. J., 2015 12月 1, 於: Scientific reports. 5, 17438.

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13 引文斯高帕斯（Scopus）

Prothymosin-α overexpression contributes to the development of insulin resistance

Su, Y. C., Ou, H. Y., Wu, H. T., Wu, P., Chen, Y. C., Su, B. H., Shiau, A. L., Chang, C. J. & Wu, C. L., 2015 11月, 於: Journal of Clinical Endocrinology and Metabolism. 100, 11, p. 4114-4123 10 p.

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10 引文斯高帕斯（Scopus）

2014

Activation of free fatty acid receptor 1 improves hepatic steatosis through a p38-dependent pathway

Ou, H. Y., Wu, H. T., Lu, F. H., Su, Y. C., Hung, H. C., Wu, J. S., Yang, Y. C., Wu, C. L. & Chang, C. J., 2014 7月 9, 於: Journal of Molecular Endocrinology. 53, 2, p. 165-174 10 p.

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12 引文斯高帕斯（Scopus）

In vivo and in vitro anti-tumor effects of fungal extracts

Wu, H. T., Lu, F. H., Su, Y. C., Ou, H. Y., Hung, H. C., Wu, J. S., Yang, Y. C. & Chang, C. J., 2014 2月, 於: Molecules. 19, 2, p. 2546-2556 11 p.

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42 引文斯高帕斯（Scopus）

2013

Increased cardiotrophin-1 in subjects with impaired glucose tolerance and newly diagnosed diabetes

Hung, H. C., Lu, F. H., Ou, H. Y., Wu, H. T., Wu, J. S., Yang, Y. C. & Chang, C-J., 2013 11月 5, 於: International Journal of Cardiology. 169, 3, p. e33-e34

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14 引文斯高帕斯（Scopus）

Multiple mechanisms of GW-9508, a selective G protein-coupled receptor 40 agonist, in the regulation of glucose homeostasis and insulin sensitivity

Ou, H. Y., Wu, H. T., Hung, H. C., Yang, Y. C., Wu, J. S. & Chang, C. J., 2013, 於: American Journal of Physiology - Endocrinology and Metabolism. 304, 6, p. E668-E676

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33 引文斯高帕斯（Scopus）

The role of Hepassocin in the development of non-alcoholic fatty liver disease

Wu, H. T., Lu, F. H., Ou, H. Y., Su, Y. C., Hung, H. C., Wu, J. S., Yang, Y. C., Wu, C. L. & Chang, C-J., 2013 11月, 於: Journal of Hepatology. 59, 5, p. 1065-1072 8 p.

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62 引文斯高帕斯（Scopus）

2012

Endoplasmic reticulum stress induces the expression of fetuin-A to develop insulin resistance

Ou, H. Y., Wu, H. T., Hung, H. C., Yang, Y. C., Wu, J. S. & Chang, C-J., 2012 7月, 於: Endocrinology. 153, 7, p. 2974-2984 11 p.

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55 引文斯高帕斯（Scopus）

Glycogen synthase kinase-3β is critical for Interferon-α-induced serotonin uptake in human Jurkat T cells

Tsao, C. W., Lin, C. F., Wu, H. T., Ma, C. T., Huang, W. C., Hsieh, C. Y., Choi, P. C. & Young, K. C., 2012 6月, 於: Journal of Cellular Physiology. 227, 6, p. 2556-2566 11 p.

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8 引文斯高帕斯（Scopus）

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吳泓璁