高 宏穎

Visiting Professor

  • 5272 引文
  • 29 h-指數
1992 …2019
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研究成果 1992 2019

2019
開啟存取
CC Chemokines
Head and Neck Neoplasms
Interleukin-1
Ligands
Mouth Neoplasms
2018
5 引文 (Scopus)

ACTN4 regulates the stability of RIPK1 in melanoma

Zhang, Y. Y., Tabataba, H., Liu, X. Y., Wang, J. Y., Yan, X. G., Farrelly, M., Jiang, C. C., Guo, S. T., Liu, T., Kao, H-Y., Thorne, R. F., Zhang, X. D. & Jin, L., 2018 七月 19, 於 : Oncogene. 37, 29, p. 4033-4045 13 p.

研究成果: Article

Receptor-Interacting Protein Serine-Threonine Kinases
Actinin
Protein Kinases
Melanoma
Inhibitor of Apoptosis Proteins
開啟存取
Publications
Tumors
Neoplasms
7 引文 (Scopus)

Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains

Huang, W., Peng, Y., Kiselar, J., Zhao, X., Albaqami, A., Mendez, D., Chen, Y., Chakravarthy, S., Gupta, S., Ralston, C., Kao, H. Y., Chance, M. R. & Yang, S., 2018 十二月 1, 於 : Nature communications. 9, 1, 3520.

研究成果: Article

開啟存取
estrogens
Estrogen Receptors
deoxyribonucleic acid
Ligands
ligands
9 引文 (Scopus)

PML: Regulation and multifaceted function beyond tumor suppression

Hsu, K. S. & Kao, H. Y., 2018 一月 25, 於 : Cell and Bioscience. 8, 1, 5.

研究成果: Review article

開啟存取
Tumors
Neoplasms
Proteins
Nuclear Proteins
Cell Aging
3 引文 (Scopus)

The p53-S100A2 Positive Feedback Loop Negatively Regulates Epithelialization in Cutaneous Wound Healing

Pan, S. C., Li, C. Y., Kuo, C. Y., Kuo, Y. Z., Fang, W. Y., Huang, Y. H., Hsieh, T. C., Kao, H. Y., Kuo, Y., Kang, Y. R., Tsai, W. C., Tsai, S. T. & Wu, L. W., 2018 十二月 1, 於 : Scientific reports. 8, 1, 5458.

研究成果: Article

Wound Healing
Skin
Wounds and Injuries
Keratinocytes
Re-Epithelialization
2017
5 引文 (Scopus)

Dual regulation of Stat1 and Stat3 by the tumor suppressor protein PML contributes to interferon α-mediated inhibition of angiogenesis

Hsu, K. S., Zhao, X., Cheng, X., Guan, D., Mahabeleshwar, G. H., Liu, Y., Borden, E., Jain, M. K. & Kao, H-Y., 2017 六月 16, 於 : Journal of Biological Chemistry. 292, 24, p. 10048-10060 13 p.

研究成果: Article

開啟存取
Tumor Suppressor Proteins
Endothelial cells
Interferons
Endothelial Cells
Ubiquitination
11 引文 (Scopus)

α actinin 4 (ACTN4) regulates glucocorticoid receptor-mediated transactivation and transrepression in podocytes

Zhao, X., Khurana, S., Charkraborty, S., Tian, Y., Sedor, J. R., Bruggman, L. A. & Kao, H. Y., 2017 二月 3, 於 : Journal of Biological Chemistry. 292, 5, p. 1637-1647 11 p.

研究成果: Article

開啟存取
Actinin
Podocytes
Glucocorticoid Receptors
Transcriptional Activation
Glucocorticoids
2016
9 引文 (Scopus)

A signaling network controlling androgenic repression of c-Fos protein in prostate adenocarcinoma cells

Shankar, E., Song, K., Corum, S. L., Bane, K. L., Wang, H., Kao, H. Y. & Danielpour, D., 2016 三月 11, 於 : Journal of Biological Chemistry. 291, 11, p. 5512-5526 15 p.

研究成果: Article

開啟存取
Proto-Oncogene Proteins c-fos
Tetradecanoylphorbol Acetate
Androgens
Prostate
Adenocarcinoma
14 引文 (Scopus)

Translational control of PML contributes to TNFα-induced apoptosis of MCF7 breast cancer cells and decreased angiogenesis in HUVECs

Hsu, K. S., Guan, B. J., Cheng, X., Guan, D., Lam, M., Hatzoglou, M. & Kao, H. Y., 2016 三月 1, 於 : Cell Death and Differentiation. 23, 3, p. 469-483 15 p.

研究成果: Article

開啟存取
Leukemia
Tumor Necrosis Factor-alpha
Apoptosis
Breast Neoplasms
90-kDa Ribosomal Protein S6 Kinases
6 引文 (Scopus)

Novel vitamin D receptor mutations in hereditary vitamin D resistant rickets in Chinese

Lim, L. M., Zhao, X., Chao, M. C., Chang, J. M., Chang, W. C., Kao, H-Y., Hwang, D. Y. & Chen, H. C., 2015 九月 30, 於 : PloS one. 10, 9, e0138152.

研究成果: Article

開啟存取
Familial Hypophosphatemic Rickets
rickets
Rickets
Calcitriol Receptors
vitamin D
4 引文 (Scopus)
開啟存取
27 引文 (Scopus)
開啟存取
Tumor Suppressor Proteins
Proteins
Cells
Therapeutics
Acute Promyelocytic Leukemia
18 引文 (Scopus)
開啟存取
Actinin
Podocytes
Actins
B-Lymphocytes
Cells
2014
10 引文 (Scopus)

Control of antioxidative response by the tumor suppressor protein PML through regulating Nrf2 activity

Guo, S., Cheng, X., Lim, J. H., Liu, Y. & Kao, H. Y., 2014 一月 1, 於 : Molecular Biology of the Cell. 25, 16, p. 2485-2498 14 p.

研究成果: Article

Tumor Suppressor Proteins
Reactive Oxygen Species
Oxidants
Promyelocytic Leukemia Protein
Oxidative Stress
18 引文 (Scopus)

Deacetylation of the tumor suppressor protein PML regulates hydrogen peroxide-Induced cell death

Guan, D., Lim, J. H., Peng, L., Liu, Y., Lam, M., Seto, E. & Kao, H. Y., 2014 七月, 於 : Cell Death and Disease. 5, 7, e1340.

研究成果: Article

開啟存取
Tumor Suppressor Proteins
Hydrogen Peroxide
Cell Death
Acetylation
HeLa Cells
2013
14 引文 (Scopus)

Ablation of promyelocytic leukemia protein (PML) re-patterns energy balance and protects mice from obesity induced by a western diet

Cheng, X., Guo, S., Liu, Y., Chu, H., Hakimi, P., Berger, N. A., Hanson, R. W. & Kao, H. Y., 2013 十月 11, 於 : Journal of Biological Chemistry. 288, 41, p. 29746-29759 14 p.

研究成果: Article

開啟存取
Nutrition
Ablation
Energy balance
Metabolism
Obesity
24 引文 (Scopus)

Alpha-Actinin 4 and Tumorigenesis of Breast Cancer

Hsu, K. S. & Kao, H. Y., 2013, Vitamins and Hormones. Academic Press Inc., p. 323-351 29 p. (Vitamins and Hormones; 卷 93).

研究成果: Chapter

Actinin
Carcinogenesis
Breast Neoplasms
Mechanical Stress
Chromatin Assembly and Disassembly
3 引文 (Scopus)

Correction: Microarray analyses of glucocorticoid and vitamin D3 target genes in differentiating cultured human podocytes (PLoS ONE)

Cheng, X., Zhao, X., Khurana, S., Bruggeman, L. A. & Kao, H. Y., 2013 六月 21, 於 : PloS one. 8, 6

研究成果: Comment/debate

開啟存取
8 引文 (Scopus)

Microarray Analyses of Glucocorticoid and Vitamin D3 Target Genes in Differentiating Cultured Human Podocytes

Cheng, X., Zhao, X., Khurana, S., Bruggeman, L. A. & Kao, H. Y., 2013 四月 4, 於 : PloS one. 8, 4, e60213.

研究成果: Article

開啟存取
Podocytes
cholecalciferol
Cholecalciferol
dexamethasone
Microarray Analysis
8 引文 (Scopus)

Monoubiquitination of filamin B regulates vascular endothelial growth factor-mediated trafficking of histone deacetylase 7

Su, Y. T., Gao, C., Liu, Y., Guo, S., Wang, A., Wang, B., Erdjument-Bromage, H., Miyagi, M., Tempst, P. & Kao, H. Y., 2013 四月 1, 於 : Molecular and Cellular Biology. 33, 8, p. 1546-1560 15 p.

研究成果: Article

Filamins
Histone Deacetylases
Vascular Endothelial Growth Factor A
Ubiquitination
Protein Kinase C
29 引文 (Scopus)

Post-translational modifications of PML: Consequences and implications

Cheng, X. & Kao, H. Y., 2013 十二月 24, 於 : Frontiers in Oncology. 2 JAN, Article 00210.

研究成果: Review article

開啟存取
Post Translational Protein Processing
Sumoylation
Tumor Suppressor Proteins
Ubiquitination
Acetylation
40 引文 (Scopus)

The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein

Guan, D., Factor, D., Liu, Y., Wang, Z. & Kao, H-Y., 2013 八月 15, 於 : Oncogene. 32, 33, p. 3819-3828 10 p.

研究成果: Article

開啟存取
Tumor Suppressor Proteins
Ubiquitination
Epigenomics
Leukemia
Neoplasms
4 引文 (Scopus)
開啟存取
Nuclear Receptor Co-Repressor 2
Transducin
Gene expression
Proteolysis
Tumor Necrosis Factor-alpha
2012
70 引文 (Scopus)

Acetylation of retinal histones in diabetes increases inflammatory proteins: Effects of minocycline and manipulation of histone acetyltransferase (HAT) and histone deacetylase (HDAC)

Kadiyala, C. S. R., Zheng, L., Du, Y., Yohannes, E., Kao, H-Y., Miyagi, M. & Kern, T. S., 2012 七月 27, 於 : Journal of Biological Chemistry. 287, 31, p. 25869-25880 12 p.

研究成果: Article

開啟存取
Histone Acetyltransferases
Acetylation
Minocycline
Histone Deacetylases
Medical problems
25 引文 (Scopus)

Familial focal segmental glomerulosclerosis (FSGS)-linked α-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors

Khurana, S., Chakraborty, S., Lam, M., Liu, Y., Su, Y. T., Zhao, X., Saleem, M. A., Mathieson, P. W., Bruggeman, L. A. & Kao, H. Y., 2012 四月 6, 於 : Journal of Biological Chemistry. 287, 15, p. 12027-12035 9 p.

研究成果: Article

開啟存取
Actinin
Focal Segmental Glomerulosclerosis
Mutant Proteins
Transcription
Cytoplasmic and Nuclear Receptors
17 引文 (Scopus)

Identification of a novel LXXLL motif in α-actinin 4-spliced isoform that is critical for its interaction with estrogen receptor α and co-activators

Khurana, S., Chakraborty, S., Zhao, X., Liu, Y., Guan, D., Lam, M., Huang, W., Yang, S. & Kao, H. Y., 2012 十月 12, 於 : Journal of Biological Chemistry. 287, 42, p. 35418-35429 12 p.

研究成果: Article

開啟存取
Actinin
Estrogen Receptors
Protein Isoforms
Cytoplasmic and Nuclear Receptors
Ligands
15 引文 (Scopus)
開啟存取
Microarray Analysis
Endothelial Cells
Tumor Necrosis Factor-alpha
Promyelocytic Leukemia Protein
Biological Phenomena
10 引文 (Scopus)

Nuclear hormone receptors in podocytes

Khurana, S., Bruggeman, L. A. & Kao, H-Y., 2012 九月 20, 於 : Cell and Bioscience. 2, 1, 33.

研究成果: Review article

開啟存取
Podocytes
Cytoplasmic and Nuclear Receptors
Ligands
Kidney
DNA sequences
24 引文 (Scopus)
開啟存取
Endothelial cells
Interferons
Endothelial Cells
Tumor Necrosis Factor-alpha
STAT1 Transcription Factor
2011
23 引文 (Scopus)
開啟存取
Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinases
Leukemia
Degradation
Phosphorylation
46 引文 (Scopus)

The actin-binding protein, actinin alpha 4 (ACTN4), is a nuclear receptor coactivator that promotes proliferation of MCF-7 breast cancer cells

Khurana, S., Chakraborty, S., Cheng, X., Su, Y. T. & Kao, H. Y., 2011 一月 21, 於 : Journal of Biological Chemistry. 286, 3, p. 1850-1859 10 p.

研究成果: Article

開啟存取
Nuclear Receptor Coactivators
Actinin
Microfilament Proteins
Cells
Breast Neoplasms
2010
175 引文 (Scopus)

DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination

Du, Z., Song, J., Wang, Y., Zhao, Y., Guda, K., Yang, S., Kao, H. Y., Xu, Y., Willis, J., Markowitz, S. D., Sedwick, D., Ewing, R. M. & Wang, Z., 2010 十一月 2, 於 : Science Signaling. 3, 146, ra80.

研究成果: Article

開啟存取
Acetylation
Ubiquitination
Methyltransferases
Ubiquitin-Specific Proteases
DNA
8 引文 (Scopus)

Histone deacetylase 7 (HDAC7) regulates myocyte migration and differentiation

Gao, C., Liu, Y., Lam, M. & Kao, H-Y., 2010 十月 1, 於 : Biochimica et Biophysica Acta - Molecular Cell Research. 1803, 10, p. 1186-1197 12 p.

研究成果: Article

開啟存取
Histone Deacetylases
Muscle Cells
Muscle Development
Actin Cytoskeleton
Myoblasts
47 引文 (Scopus)

Membrane permeable cyclic peptidyl inhibitors against human peptidylprolyl isomer ase pin1

Liu, T., Liu, Y., Kao, H. Y. & Pei, D., 2010 三月 25, 於 : Journal of Medicinal Chemistry. 53, 6, p. 2494-2501 8 p.

研究成果: Article

Cyclic Peptides
Membranes
Peptide Library
Calorimetry
Phosphoproteins
28 引文 (Scopus)
開啟存取
Somatomedins
Hydrogen Peroxide
Cell Movement
Insulin-Like Growth Factor I
Proteins
2009
21 引文 (Scopus)
開啟存取
Co-Repressor Proteins
GTP-Binding Proteins
Estrogen Receptors
Nuclear Receptor Co-Repressor 2
Genes
26 引文 (Scopus)
開啟存取
Co-Repressor Proteins
Thyroid Hormone Receptors
Estrogen Receptor Modulators
Retinoids
Cytoplasmic and Nuclear Receptors
16 引文 (Scopus)

PML: An emerging tumor suppressor and a target with therapeutic potential

Reineke, E. L. & Kao, H. Y., 2009 一月 1, 於 : Cancer Therapy. 7, ISSUE A, p. 219-226 8 p.

研究成果: Review article

Neoplasms
Therapeutics
Carcinogenesis
Acute Promyelocytic Leukemia
Cell Cycle Checkpoints
32 引文 (Scopus)
開啟存取
nuclear proteins
Staphylococcal Protein A
leukemia
targeting
protein
2008
43 引文 (Scopus)

Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT

Stanya, K. J., Liu, Y., Means, A. R. & Kao, H. Y., 2008 十月 6, 於 : Journal of Cell Biology. 183, 1, p. 49-61 13 p.

研究成果: Article

開啟存取
Co-Repressor Proteins
Phosphorylation
Nuclear Receptor Co-Repressor 2
ErbB-2 Receptor
Peptidylprolyl Isomerase
65 引文 (Scopus)

Degradation of the tumor suppressor PML by Pin1 contributes to the cancer phenotype of breast cancer MDA-MB-231 ce11s

Reineke, E. L., Lam, M., Liu, Q., Liu, Y., Stanya, K. J., Chang, K. S., Means, A. R. & Kao, H. Y., 2008 二月 1, 於 : Molecular and Cellular Biology. 28, 3, p. 997-1006 10 p.

研究成果: Article

開啟存取
Tumor Suppressor Proteins
Breast Neoplasms
Phenotype
Sumoylation
Promyelocytic Leukemia Protein
54 引文 (Scopus)

Histone deacetylase 7 promotes PML sumoylation and is essential for PML nuclear body formation

Gao, C., Ho, C. C., Reineke, E., Lam, M., Cheng, X., Stanya, K. J., Liu, Y., Chakraborty, S., Shih, H. M. & Kao, H. Y., 2008 九月 1, 於 : Molecular and Cellular Biology. 28, 18, p. 5658-5667 10 p.

研究成果: Article

開啟存取
Sumoylation
Histone Deacetylases
Human Umbilical Vein Endothelial Cells
Promyelocytic Leukemia Protein
Ubiquitin-Protein Ligases
28 引文 (Scopus)

Signal-dependent regulation of transcription by histone deacetylase 7 involves recruitment to promyelocytic leukemia protein nuclear bodies

Gao, C., Cheng, X., Lam, M., Liu, Y., Liu, Q., Chang, K. S. & Kao, H. Y., 2008 七月 1, 於 : Molecular Biology of the Cell. 19, 7, p. 3020-3024 5 p.

研究成果: Article

Histone Deacetylases
MEF2 Transcription Factors
Matrix Metalloproteinase 10
Tumor Necrosis Factor-alpha
Messenger RNA
19 引文 (Scopus)

The Positive Transcription Elongation Factor b Is an Essential Cofactor for the Activation of Transcription by Myocyte Enhancer Factor 2

Nojima, M., Huang, Y., Tyagi, M., Kao, H. Y. & Fujinaga, K., 2008 十月 3, 於 : Journal of Molecular Biology. 382, 2, p. 275-287 13 p.

研究成果: Article

MEF2 Transcription Factors
Peptide Elongation Factors
Transcriptional Activation
Transcription Factors
Cyclin T
63 引文 (Scopus)
開啟存取
Histone Deacetylases
Matrix Metalloproteinases
Vascular Endothelial Growth Factor A
Phosphorylation
Protein Kinases
2007
8 引文 (Scopus)
開啟存取
Retinoic Acid Receptors
Gene expression
Association reactions
Gene Expression
Proteins
2006
22 引文 (Scopus)

CRM1 mediates nuclear export of HDAC7 independently of HDAC7 phosphorylation and association with 14-3-3s

Gao, C., Li, X., Lam, M., Liu, Y., Chakraborty, S. & Kao, H-Y., 2006 九月 18, 於 : FEBS Letters. 580, 21, p. 5096-5104 9 p.

研究成果: Article

開啟存取
Phosphorylation
Cell Nucleus Active Transport
Cytoplasm
Phospho-Specific Antibodies
Association reactions
55 引文 (Scopus)

α-actinin 4 potentiates myocyte enhancer factor-2 transcription activity by antagonizing histone deacetylase 7

Chakraborty, S., Reineke, E. L., Lam, M., Li, X., Liu, Y., Gao, C., Khurana, S. & Kao, H-Y., 2006 十一月 17, 於 : Journal of Biological Chemistry. 281, 46, p. 35070-35080 11 p.

研究成果: Article

開啟存取
MEF2 Transcription Factors
Actinin
Histone Deacetylases
Transcription
Association reactions