• 5943 引文
  • 46 h-指數
1989 …2020

Research output per year

如果您對這些純文本內容做了任何改變,很快就會看到。

研究成果

2012

Targeting cathepsin S induces tumor cell autophagy via the EGFR-ERK signaling pathway

Chen, K. L., Chang, W. S. W., Cheung, C. H. A., Lin, C. C., Huang, C. C., Yang, Y. N., Kuo, C. P., Kuo, C. C., Chang, Y. H., Liu, K. J., Wu, C. M. & Chang, J. Y., 2012 四月 1, 於 : Cancer Letters. 317, 1, p. 89-98 10 p.

研究成果: Article

42 引文 斯高帕斯(Scopus)
2011

2-Amino-3,4,5-Trimethoxybenzophenones as Potent Tubulin Polymerization Inhibitors

Chuang, H. Y., Chang, J-Y., Lai, M. J., Kuo, C. C., Lee, H. Y., Hsieh, H. P., Chen, Y. J., Chen, L. T., Pan, W. Y. & Liou, J. P., 2011 三月 7, 於 : ChemMedChem. 6, 3, p. 450-456 7 p.

研究成果: Article

12 引文 斯高帕斯(Scopus)

5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. Part 2. The impact of bridging groups at position C-2

Lee, H. Y., Chang, J. Y., Nien, C. Y., Kuo, C. C., Shih, K. H., Wu, C. H., Chang, C. Y., Lai, W. Y. & Liou, J. P., 2011 十二月 22, 於 : Journal of Medicinal Chemistry. 54, 24, p. 8517-8525 9 p.

研究成果: Article

42 引文 斯高帕斯(Scopus)

Antimutagenic constituents of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) with potential cancer chemopreventive activity

Chen, H. H., Chiang, W., Chang, J. Y., Chien, Y. L., Lee, C. K., Liu, K. J., Cheng, Y. T., Chen, T. F., Kuo, Y. H. & Kuo, C. C., 2011 六月 22, 於 : Journal of Agricultural and Food Chemistry. 59, 12, p. 6444-6452 9 p.

研究成果: Article

37 引文 斯高帕斯(Scopus)

Aurora kinase inhibitor patents and agents in clinical testing: An update (2009 - 10)

Cheung, C. H. A., Coumar, M. S., Chang, J. Y. & Hsieh, H. P., 2011 六月 1, 於 : Expert Opinion on Therapeutic Patents. 21, 6, p. 857-884 28 p.

研究成果: Review article

34 引文 斯高帕斯(Scopus)

BPR0C261 is a novel orally active antitumor agent with antimitotic and anti-angiogenic activities

Hu, C. B., Chen, C. P., Yeh, T. K., Song, J. S., Chang, C. Y., Chuu, J. J., Tung, F. F., Ho, P. Y., Chen, T. W., Lin, C. H., Wang, M. H., Chang, K. Y., Huang, C. L., Lin, H. L., Li, W. T., Hwang, D. R., Chern, J. H., Hwang, L. L., Chang, J. Y., Chao, Y. S. 及其他1, Chen, C. T., 2011 一月 1, 於 : Cancer Science. 102, 1, p. 182-191 10 p.

研究成果: Article

8 引文 斯高帕斯(Scopus)

BPR1K653, a novel aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells

Cheung, C. H. A., Lin, W. H., HsuJohn, J. T. A., Hour, T. C., Yeh, T. K., Ko, S., Lien, T. W., Coumar, M. S., Liu, J. F., Lai, W. Y., Shiao, H. Y., Lee, T. R., Hsieh, H. P. & Chang, J. Y., 2011 八月 24, 於 : PloS one. 6, 8, e23485.

研究成果: Article

13 引文 斯高帕斯(Scopus)

Combination of arsenic trioxide and BCNU synergistically triggers redox-mediated autophagic cell death in human solid tumors

Kuo, C. C., Wu, T., Chen, L. T., Shiah, H. S., Wu, C. M., Cheng, Y. T., Pan, W. Y., Liu, J. F., Chen, K. L., Yang, Y. N., Chen, S. N. & Chang, J. Y., 2011 十二月 15, 於 : Free Radical Biology and Medicine. 51, 12, p. 2195-2209 15 p.

研究成果: Article

13 引文 斯高帕斯(Scopus)

Concise syntheses of N-aryl-5,6,7-trimethoxyindoles as antimitotic and vascular disrupting agents: Application of the copper-mediated Ullmann-type arylation

Lee, H. Y., Chang, J. Y., Chang, L. Y., Lai, W. Y., Lai, M. J., Shih, K. H., Kuo, C. C., Chang, C. Y. & Liou, J. P., 2011 五月 7, 於 : Organic and Biomolecular Chemistry. 9, 9, p. 3154-3157 4 p.

研究成果: Article

19 引文 斯高帕斯(Scopus)

Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036

Yang, Y. N., Chou, K. M., Pan, W. Y., Chen, Y. W., Tsou, T. C., Yeh, S. C., Cheung, C. H. A., Chen, L. T. & Chang, J. Y., 2011 十月 1, 於 : Cancer Letters. 309, 1, p. 110-118 9 p.

研究成果: Article

5 引文 斯高帕斯(Scopus)

Identification of salt-inducible kinase 3 as a novel tumor antigen associated with tumorigenesis of ovarian cancer

Charoenfuprasert, S., Yang, Y. Y., Lee, Y. C., Chao, K. C., Chu, P. Y., Lai, C. R., Hsu, K. F., Chang, K. C., Chen, Y. C., Chen, L. T., Chang, J. Y., Leu, S. J. & Shih, N. Y., 2011 八月 18, 於 : Oncogene. 30, 33, p. 3570-3584 15 p.

研究成果: Article

17 引文 斯高帕斯(Scopus)

Induction chemotherapy with gemcitabine, oxaliplatin, and 5-fluorouracil/leucovorin followed by concomitant chemoradiotherapy in patients with locally advanced pancreatic cancer: A Taiwan cooperative oncology group phase II study

Ch'Ang, H. J., Lin, Y. L., Wang, H. P., Chiu, Y. F., Chang, M. C., Hsu, C. H., Tien, Y. W., Chen, J. S., Hsieh, R. K., Lin, P. W., Shan, Y-S., Cheng, A. L., Chang, J-Y., Whang-Peng, J., Hwang, T. L. & Chen, L. T., 2011 十二月 1, 於 : International Journal of Radiation Oncology Biology Physics. 81, 5

研究成果: Article

13 引文 斯高帕斯(Scopus)

Investigations of survivin: The past, present and future

Cheung, C. H. A., Cheng, L. T., Chang, K. Y., Chen, H. H. & Chang, J. Y., 2011 一月 1, 於 : Frontiers in Bioscience. 16, 3, p. 952-961 10 p.

研究成果: Article

46 引文 斯高帕斯(Scopus)

Labdanecaryophyllic acid, a novel cytotoxic C35 terpenoid from Calocedrus macrolepis var. formosana

Hsien, C. L., Tseng, M. H., Pan, R. N., Chang, J. Y., Kuo, C. C., Lee, T. H. & Kuo, Y. H., 2011 一月 26, 於 : Tetrahedron Letters. 52, 4, p. 515-517 3 p.

研究成果: Article

3 引文 斯高帕斯(Scopus)
76 引文 斯高帕斯(Scopus)

Novel terpenoids from Calocedrus macrolepis var. formosana

Hsieh, C. L., Tseng, M. H., Pan, R. N., Chang, J. Y., Kuo, C. C., Lee, T. H. & Kuo, Y. H., 2011 十月 1, 於 : Chemistry and Biodiversity. 8, 10, p. 1901-1907 7 p.

研究成果: Article

3 引文 斯高帕斯(Scopus)

Scaffold-hopping strategy: Synthesis and biological evaluation of 5,6-fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents

Tung, Y. S., Coumar, M. S., Wu, Y. S., Shiao, H. Y., Chang, J-Y., Liou, J. P., Shukla, P., Chang, C. W., Chang, C. Y., Kuo, C. C., Yeh, T. K., Lin, C. Y., Wu, J. S., Wu, S. Y., Liao, C. C. & Hsieh, H. P., 2011 四月 28, 於 : Journal of Medicinal Chemistry. 54, 8, p. 3076-3080 5 p.

研究成果: Article

56 引文 斯高帕斯(Scopus)

Synthesis and biological evaluation of 1-(4′-Indolyl and 6′-Quinolinyl) indoles as a new class of potent anticancer agents

Lai, M. J., Chang, J. Y., Lee, H. Y., Kuo, C. C., Lin, M. H., Hsieh, H. P., Chang, C. Y., Wu, J. S., Wu, S. Y., Shey, K. S. & Liou, J. P., 2011 九月 1, 於 : European Journal of Medicinal Chemistry. 46, 9, p. 3623-3629 7 p.

研究成果: Article

27 引文 斯高帕斯(Scopus)

Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents

Hsieh, C. C., Lee, H. Y., Nien, C. Y., Kuo, C. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., 2011 三月 1, 於 : Molecules. 16, 3, p. 2274-2284 11 p.

研究成果: Article

2 引文 斯高帕斯(Scopus)
2010

5-Amino-2-Aroylquinolines as highly potent tubulin polymerization inhibitors

Nien, C. Y., Chen, Y. C., Kuo, C. C., Hsieh, H. P., Chang, C. Y., Wu, J. S., Wu, S. Y., Liou, J. P. & Chang, J-Y., 2010 三月 11, 於 : Journal of Medicinal Chemistry. 53, 5, p. 2309-2313 5 p.

研究成果: Article

63 引文 斯高帕斯(Scopus)

Antitumor activities and pharmacokinetics of silatecans DB-67 and DB-91

Yeh, T. K., Li, C. M., Chen, C. P., Chuu, J. J., Huang, C. L., Wang, H. S., Shen, C. C., Lee, T. Y., Chang, C. Y., Chang, C. M., Chao, Y. S., Lin, C. T., Chang, J. Y. & Chen, C. T., 2010 二月 1, 於 : Pharmacological Research. 61, 2, p. 108-115 8 p.

研究成果: Article

11 引文 斯高帕斯(Scopus)

Arecoline arrests cells at prometaphase by deregulating mitotic spindle assembly and spindle assembly checkpoint: Implication for carcinogenesis

Wang, Y. C., Tsai, Y. S., Huang, J. L., Lee, K. W., Kuo, C. C., Wang, C. S., Huang, A. M., Chang, J. Y., Jong, Y. J. & Lin, C. S., 2010 四月 1, 於 : Oral Oncology. 46, 4, p. 255-262 8 p.

研究成果: Article

21 引文 斯高帕斯(Scopus)

Cancer cells acquire mitotic drug resistance properties through beta i-tubulin mutations and alterations in the expression of beta-tubulin isotypes

Cheung, C. H. A., Wu, S. Y., Lee, T. R., Chang, C. Y., Wu, J. S., Hsieh, H. P. & Chang, J. Y., 2010 十一月 1, 於 : PloS one. 5, 9, p. 1-11 11 p., e12564.

研究成果: Article

29 引文 斯高帕斯(Scopus)

Chamaecypanone C, a novel skeleton microtubule inhibitor, with anticancer activity by trigger caspase 8-Fas/FasL dependent apoptotic pathway in human cancer cells

Hsieh, C. C., Kuo, Y. H., Kuo, C. C., Chen, L. T., Cheung, C-H., Chao, T. Y., Lin, C. H., Pan, W. Y., Chang, C. Y., Chien, S. C., Chen, T. W., Lung, C. C. & Chang, J-Y., 2010 五月 1, 於 : Biochemical Pharmacology. 79, 9, p. 1261-1271 11 p.

研究成果: Article

24 引文 斯高帕斯(Scopus)

Cytotoxic C35 terpenoid cryptotrione from the bark of cryptomeria japonica

Chen, C. C., Wu, J. H., Yang, N. S., Chang, J. Y., Kuo, C. C., Wang, S. Y. & Kuo, Y. H., 2010 六月 18, 於 : Organic Letters. 12, 12, p. 2786-2789 4 p.

研究成果: Article

19 引文 斯高帕斯(Scopus)

Design and synthesis of α-ketoamides as cathepsin s inhibitors with potential applications against tumor invasion and angiogenesis

Chen, J. C., Uang, B. J., Lyu, P. C., Chang, J. Y., Liu, K. J., Kuo, C. C., Hsieh, H. P., Wang, H. C., Cheng, C. S., Chang, Y. H., Chang, M. D. T., Chang, W. S. W. & Lin, C. C., 2010 六月 10, 於 : Journal of Medicinal Chemistry. 53, 11, p. 4545-4549 5 p.

研究成果: Article

32 引文 斯高帕斯(Scopus)

MBP-1 is efficiently encoded by an alternative transcript of the ENO1 gene but post-translationally regulated by proteasome-dependent protein turnover

Lung, J., Liu, K. J., Chang, J-Y., Leu, S. J. & Shih, N. Y., 2010 一月 1, 於 : FEBS Journal. 277, 20, p. 4308-4321 14 p.

研究成果: Article

17 引文 斯高帕斯(Scopus)
6 引文 斯高帕斯(Scopus)

Recent advances in anti-survivin treatments for cancer

Kanwar, R. K., Cheung, C-H., Chang, J-Y. & Kanwar, J. R., 2010 六月 18, 於 : Current Medicinal Chemistry. 17, 15, p. 1509-1515 7 p.

研究成果: Article

69 引文 斯高帕斯(Scopus)

Synthesis and biological evaluation of 7-arylindoline-1-benzenesulfonamides as a novel class of potent anticancer agents

Chang, J. Y., Lai, M. J., Chang, Y. T., Lee, H. Y., Cheng, Y. C., Kuo, C. C., Su, M. C., Chang, C. Y. & Liou, J. P., 2010 八月 1, 於 : MedChemComm. 1, 2, p. 152-155 4 p.

研究成果: Article

19 引文 斯高帕斯(Scopus)
36 引文 斯高帕斯(Scopus)
2009

Advances in Aurora kinase inhibitor patents

Coumar, M. S., Cheung, C-H., Chang, J-Y. & Hsieh, H. P., 2009 三月 1, 於 : Expert Opinion on Therapeutic Patents. 19, 3, p. 321-356 36 p.

研究成果: Review article

22 引文 斯高帕斯(Scopus)

Alpha-fetoprotein response in advanced hepatocellular carcinoma receiving cytostatic agent

Chen, L. T., Shiah, H. S., Chao, Y., Chang, J. Y., Cheng, L. T. & Whang-Peng, J., 2009 十二月 20, 於 : Journal of Clinical Oncology. 27, 36, p. e271

研究成果: Letter

9 引文 斯高帕斯(Scopus)

Aurora kinase inhibitors in preclinical and clinical testing

Cheung, C. H. A., Coumar, M. S., Hsieh, H. P. & Chang, J. Y., 2009 四月 1, 於 : Expert Opinion on Investigational Drugs. 18, 4, p. 379-398 20 p.

研究成果: Review article

83 引文 斯高帕斯(Scopus)

Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity

Chiang, Y. K., Kuo, C. C., Wu, Y. S., Chen, C. T., Coumar, M. S., Wu, J. S., Hsieh, H. P., Chang, C. Y., Jseng, H. Y., Wu, M. H., Leou, J. S., Song, J. S., Chang, J. Y., Lyu, P. C., Chao, Y. S. & Wu, S. Y., 2009 七月 23, 於 : Journal of Medicinal Chemistry. 52, 14, p. 4221-4233 13 p.

研究成果: Article

48 引文 斯高帕斯(Scopus)
37 引文 斯高帕斯(Scopus)

Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers

Cheung, C. H. A., Chen, H. H., Kuo, C. C., Chang, C. Y., Coumar, M. S., Hsieh, H. P. & Chang, J. Y., 2009 七月 3, 於 : Molecular cancer. 8, 43.

研究成果: Article

55 引文 斯高帕斯(Scopus)

Synthesis and evaluation of 3-aroylindoles as anticancer agents: Metabolite approach

Wu, Y. S., Coumar, M. S., Chang, J. Y., Sun, H. Y., Kuo, F. M., Kuo, C. C., Chen, Y. J., Chang, C. Y., Hsiao, C. L., Liou, J. P., Chen, C. P., Yao, H. T., Chiang, Y. K., Tan, U. K., Chen, C. T., Chu, C. Y., Wu, S. Y., Yeh, T. K., Lin, C. Y. & Hsieh, H. P., 2009 八月 13, 於 : Journal of Medicinal Chemistry. 52, 15, p. 4941-4945 5 p.

研究成果: Article

76 引文 斯高帕斯(Scopus)

Synthesis and structure-activity relationships of 1-benzyl-4,5,6- trimethoxyindoles as a novel class of potent antimitotic agents

Lai, M. J., Kuo, C. C., Yeh, T. K., Hsieh, H. P., Chen, L. T., Pan, W. Y., Hsu, K. Y., Chang, J-Y. & Liou, J. P., 2009 四月 17, 於 : ChemMedChem. 4, 4, p. 588-593 6 p.

研究成果: Article

13 引文 斯高帕斯(Scopus)
2008

A novel peroxisome proliferator-activated receptor α/γ agonist, BPR1H0101, inhibits topoisomerase II catalytic activity in human cancer cells

Kao, Y. H., Hsieh, H. P., Chitlimalla, S. K., Pan, W. Y., Kuo, C. C., Tsai, Y. C., Lin, W. H., Chuang, S. E. & Chang, J. Y., 2008 二月 1, 於 : Anti-Cancer Drugs. 19, 2, p. 151-158 8 p.

研究成果: Article

6 引文 斯高帕斯(Scopus)

Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors

Liou, J. P., Wu, Z. Y., Kuo, C. C., Chang, C. Y., Lu, P. Y., Chen, C. M., Hsieh, H. P. & Chang, J. Y., 2008 七月 24, 於 : Journal of Medicinal Chemistry. 51, 14, p. 4351-4355 5 p.

研究成果: Article

59 引文 斯高帕斯(Scopus)

Human DNA polymerase η activity and translocation is regulated by phosphorylation

Chen, Y. W., Cleaver, J. E., Hatahet, Z., Honkanen, R. E., Chang, J. Y., Yen, Y. & Chou, K. M., 2008 十月 28, 於 : Proceedings of the National Academy of Sciences of the United States of America. 105, 43, p. 16578-16583 6 p.

研究成果: Article

47 引文 斯高帕斯(Scopus)

Modern staging and utility of PET imaging in esophageal cancer management

Chang, K. Y., Chang, J. Y., Chao, J. & Yen, Y., 2008 十月, 於 : JNCCN Journal of the National Comprehensive Cancer Network. 6, 9, p. 862-869 8 p.

研究成果: Article

2 引文 斯高帕斯(Scopus)

Synthesis and structure-activity relationships of 2-amino-1- aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents

Reddy, G. R., Kuo, C. C., Tan, U. K., Coumar, M. S., Chang, C. Y., Chiang, Y. K., Lai, M. J., Yeh, J. Y., Wu, S. Y., Chang, J-Y., Liou, J. P. & Hsieh, H. P., 2008 十二月 25, 於 : Journal of Medicinal Chemistry. 51, 24, p. 8163-8167 5 p.

研究成果: Article

24 引文 斯高帕斯(Scopus)
4 引文 斯高帕斯(Scopus)
2007

4- And 5-aroylindoles as novel classes of potent antitubulin agents

Liou, J. P., Wu, C. Y., Hsieh, H. P., Chang, C. Y., Chen, C. M., Kuo, C. C. & Chang, J. Y., 2007 九月 6, 於 : Journal of Medicinal Chemistry. 50, 18, p. 4548-4552 5 p.

研究成果: Article

57 引文 斯高帕斯(Scopus)
58 引文 斯高帕斯(Scopus)

Combined modalities of resistance in an oxaliplatin-resistant human gastric cancer cell line with enhanced sensitivity to 5-fluorouracil

Chen, C. C., Chen, L. T., Tsou, T. C., Pan, W. Y., Kuo, C. C., Liu, J. F., Yeh, S. C., Tsai, F. Y., Hsieh, H. P. & Chang, J-Y., 2007 七月 31, 於 : British Journal of Cancer. 97, 3, p. 334-344 11 p.

研究成果: Article

33 引文 斯高帕斯(Scopus)

Cytotoxic and novel skeleton compounds from the heartwood of Chamaecyparis obtusa var. formosana

Chien, S. C., Chang, J. Y., Kuo, C. C., Hsieh, C. C., Yang, N. S. & Kuo, Y. H., 2007 二月 26, 於 : Tetrahedron Letters. 48, 9, p. 1567-1569 3 p.

研究成果: Article

26 引文 斯高帕斯(Scopus)