• 5943 引文
  • 46 h-指數
1989 …2020

Research output per year

如果您對這些純文本內容做了任何改變,很快就會看到。

研究成果

2007

D-501036, a novel selenophene-based triheterocycle derivative, exhibits potent in vitro and in vivo antitumoral activity which involves DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation

Juang, S. H., Lung, C. C., Hsu, P. C., Hsu, K. S., Li, Y. C., Hong, P. C., Shiah, H. S., Kuo, C. C., Huang, C. W., Wang, Y. C., Huang, L., Chen, T. S., Chen, S. F., Fu, K. C., Hsu, C. L., Lin, M. J., Chang, C. J., Ashendel, C. L., Chan, T. C. K., Chou, K. M. 及其他1, Chang, J. C., 2007 一月 1, 於 : Molecular Cancer Therapeutics. 6, 1, p. 193-202 10 p.

研究成果: Article

42 引文 斯高帕斯(Scopus)

Human tissue kallikreins as prognostic biomarkers and as potential targets for anticancer therapy

Chang, W. S. W., Chou, R. H., Wu, C. W. & Chang, J. Y., 2007 十月 1, 於 : Expert Opinion on Therapeutic Patents. 17, 10, p. 1227-1240 14 p.

研究成果: Review article

1 引文 斯高帕斯(Scopus)

Mitochondria-mediated and p53-associated apoptosis induced in human cancer cells by a novel selenophene derivative, D-501036

Shiah, H. S., Lee, W. S., Juang, S. H., Hong, P. C., Lung, C. C., Chang, C. J., Chou, K. M. & Chang, J. Y., 2007 三月 1, 於 : Biochemical Pharmacology. 73, 5, p. 610-619 10 p.

研究成果: Article

48 引文 斯高帕斯(Scopus)

Tamoxifen accelerates proteasomal degradation of O6- methylguanine DNA methyltransferase in human cancer cells

Kuo, C. C., Liu, J. F., Shiah, H. S., Li-Chen, M. & Chang, J. Y., 2007 十一月 15, 於 : International Journal of Cancer. 121, 10, p. 2293-2300 8 p.

研究成果: Article

19 引文 斯高帕斯(Scopus)
2006

2-Amino and 2′-aminocombretastatin derivatives as potent antimitotic agents

Chang, J. Y., Yang, M. F., Chang, C. Y., Chen, C. M., Kuo, C. C. & Liou, J. P., 2006 十月 1, 於 : Journal of Medicinal Chemistry. 49, 21, p. 6412-6415 4 p.

研究成果: Article

43 引文 斯高帕斯(Scopus)

7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents

Chang, J. Y., Hsieh, H. P., Chang, C. Y., Hsu, K. S., Chiang, Y. F., Chen, C. M., Kuo, C. C. & Liou, J. P., 2006 十一月 16, 於 : Journal of Medicinal Chemistry. 49, 23, p. 6656-6659 4 p.

研究成果: Article

61 引文 斯高帕斯(Scopus)

Antitubulin agents for the treatment of cancer - A medicinal chemistry update

Mahindroo, N., Liou, J. P., Chang, J. Y. & Hsieh, H. P., 2006 五月 1, 於 : Expert Opinion on Therapeutic Patents. 16, 5, p. 647-691 45 p.

研究成果: Review article

65 引文 斯高帕斯(Scopus)

C 35 terpenoids from the bark of Calocedrus macrolepis var. formosana with activity against human cancer cell lines

Hsieh, C. L., Tseng, M. H., Shao, Y. Y., Chang, J-Y., Kuo, C. C., Chang, C. Y. & Kuo, Y. H., 2006 十一月 1, 於 : Journal of Natural Products. 69, 11, p. 1611-1613 3 p.

研究成果: Article

14 引文 斯高帕斯(Scopus)
22 引文 斯高帕斯(Scopus)

In vitro and in vivo studies of a novel potential anticancer agent of isochaihulactone on human lung cancer A549 cells

Chen, Y. L., Lin, S. Z., Chang, J. Y., Cheng, Y. L., Tsai, N. M., Chen, S. P., Chang, W. L. & Harn, H. J., 2006 七月 28, 於 : Biochemical Pharmacology. 72, 3, p. 308-319 12 p.

研究成果: Article

70 引文 斯高帕斯(Scopus)

Phase I and pharmacokinetic study of oral thalidomide in patients with advanced hepatocellular carcinoma

Shiah, H. S., Chao, Y., Chen, L. T., Yao, T. J., Huang, J. D., Chang, J. Y., Chen, P. J., Chuang, T. R., Chin, Y. H., Whang-Peng, J. & Liu, T. W., 2006 十一月, 於 : Cancer Chemotherapy and Pharmacology. 58, 5, p. 654-664 11 p.

研究成果: Article

11 引文 斯高帕斯(Scopus)

Phase I-II trial of weekly gemcitabine plus high-dose 5-fluorouracil and leucovorin in advanced pancreatic cancer

Shiah, H. S., Cheng, A. L., Hsu, C., Hsu, C. H., Liu, T. W., Chang, J. Y., Jan, C. M., Chao, Y., Yu, W. L., Chuang, T. R., Whang-Peng, J. & Chen, L. T., 2006 三月, 於 : Journal of Gastroenterology and Hepatology (Australia). 21, 3, p. 531-536 6 p.

研究成果: Article

5 引文 斯高帕斯(Scopus)

Phase II study of gemcitabine plus vinorelbine in the treatment of cisplatin-resistant nasopharyngeal carcinoma

Wang, C. C., Chang, J. Y., Liu, T. W., Lin, C. Y., Yu, Y. C. & Hong, R. L., 2006 一月 1, 於 : Head and Neck. 28, 1, p. 74-80 7 p.

研究成果: Article

42 引文 斯高帕斯(Scopus)

Phase I study of biweekly gemcitabine followed by oxaliplatin and simplified 48-h infusion of fluorouracil/leucovorin for advanced pancreatic cancer

Ch'ang, H. J., Wang, C. C., Cheng, A. L., Hsu, C., Lu, Y. S., Chang, M. C., Lin, J. T., Wang, H. P., Shiah, H. S., Liu, T. W., Chang, J-Y., Whang-Peng, J. & Chen, L. T., 2006 一月 1, 於 : Journal of Gastroenterology and Hepatology (Australia). 21, 5, p. 874-879 6 p.

研究成果: Article

5 引文 斯高帕斯(Scopus)

Statistical quality control process for traditional Chinese medicine

Tse, S. K., Chang, J. Y., Su, W. L., Chow, S. C., Hsiung, C. & Lu, Q., 2006 十二月 1, 於 : Journal of Biopharmaceutical Statistics. 16, 6, p. 861-874 14 p.

研究成果: Article

16 引文 斯高帕斯(Scopus)

Structure-activity relationship studies of 3-aroylindoles as potent antimitotic agents

Liou, J. P., Mahindroo, N., Chang, C. W., Guo, F. M., Lee, S. W. H., Tan, U. K., Yeh, T. K., Kuo, C. C., Chang, Y. W., Lu, P. H., Tung, Y. S., Lin, K. T., Chang, J-Y. & Hsieh, H. P., 2006 十月 1, 於 : ChemMedChem. 1, 10, p. 1106-1118 13 p.

研究成果: Article

37 引文 斯高帕斯(Scopus)

Synthesis of new camptothecin analogues with the E-lactone ring replaced by α,β-cyclohexenone

Bacherikov, V. A., Tsai, T. J., Chang, J-Y., Chou, T. C., Lee, R. Z. & Su, T. L., 2006 九月 25, 於 : European Journal of Organic Chemistry. 19, p. 4490-4499 10 p.

研究成果: Article

7 引文 斯高帕斯(Scopus)
2005

Cytotoxic triterpenes from the aerial roots of Ficus microcarpa

Chiang, Y. M., Chang, J-Y., Kuo, C. C., Chang, C. Y. & Kuo, Y. H., 2005 一月 1, 於 : Phytochemistry. 66, 4, p. 495-501 7 p.

研究成果: Article

109 引文 斯高帕斯(Scopus)

Four new 6-nor-5(6→7)abeo-abietane type diterpenes and antitumoral cytotoxic diterpene constituents from the bark of Taiwania cryptomerioides

Chang, C. I., Chang, J. Y., Kuo, C. C., Pan, W. Y. & Kuo, Y. H., 2005 一月 1, 於 : Planta Medica. 71, 1, p. 72-76 5 p.

研究成果: Article

69 引文 斯高帕斯(Scopus)

Hepatocellular carcinoma associated with acquired von Willebrand disease and extreme thrombocytosis [2]

Chen, C. C., Chang, J. Y., Liu, K. J., Chan, C., Ho, C. H., Lee, S. C. & Chen, L. T., 2005 六月 1, 於 : Annals of Oncology. 16, 6, p. 988-989 2 p.

研究成果: Letter

6 引文 斯高帕斯(Scopus)
1 引文 斯高帕斯(Scopus)

Pulmonary embolism after transcatheter arterial chemoembolization

Shiah, H. S., Liu, T. W., Chen, L. T., Chang, J-Y., Liu, J. M., Chuang, T. R., Lee, W. S. & Whang-Peng, J., 2005 十二月 1, 於 : European Journal of Cancer Care. 14, 5, p. 440-442 3 p.

研究成果: Article

12 引文 斯高帕斯(Scopus)

Synthesis and antitumor activity of 5-(9-acridinylamino)anisidine derivatives

Bacherikov, V. A., Chang, J. Y., Lin, Y. W., Chen, C. H., Pan, W. Y., Dong, H., Lee, R. Z., Chou, T. C. & Su, T. L., 2005 十二月 1, 於 : Bioorganic and Medicinal Chemistry. 13, 23, p. 6513-6520 8 p.

研究成果: Article

26 引文 斯高帕斯(Scopus)

α-fetoprotein response predicts survival benefits of thalidomide in advanced hepatocellular carcinoma

Chen, L. T., Liu, T. W., Chao, Y., Shiah, H. S., Chang, J-Y., Juang, S. H., Chen, S. C., Chuang, T. R., Chin, Y. H. & Whang-Peng, J., 2005 八月 1, 於 : Alimentary Pharmacology and Therapeutics. 22, 3, p. 217-226 10 p.

研究成果: Article

31 引文 斯高帕斯(Scopus)
2004

A novel bis-benzylidenecyclopentanone derivative, BPR0Y007, inducing a rapid caspase activation involving upregulation of Fas (CD95/APO-1) and wild-type p53 in human oral epidermoid carcinoma cells

Juang, S. H., Pan, W. Y., Kuo, C. C., Liou, J. P., Hung, Y. M., Chen, L. T., Hsieh, H. P. & Chang, J-Y., 2004 七月 15, 於 : Biochemical Pharmacology. 68, 2, p. 293-303 11 p.

研究成果: Article

17 引文 斯高帕斯(Scopus)

BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo

Kuo, C. C., Hsieh, H. P., Pan, W. Y., Chen, C. P., Liou, J. P., Lee, S. J., Chang, Y. L., Chen, L. T., Chen, C. T. & Chang, J. Y., 2004 七月 1, 於 : Cancer Research. 64, 13, p. 4621-4628 8 p.

研究成果: Article

182 引文 斯高帕斯(Scopus)

Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents

Liou, J. P., Chang, Y. L., Kuo, F. M., Chang, C. W., Tseng, H. Y., Wang, C. C., Yang, Y. N., Chang, J. Y., Lee, S. J. & Hsieh, H. P., 2004 八月 12, 於 : Journal of Medicinal Chemistry. 47, 17, p. 4247-4257 11 p.

研究成果: Article

163 引文 斯高帕斯(Scopus)

Hepatocellular carcinoma with intra-atrial tumor thrombi: A report of three cases responsive to thalidomide treatment and literature review

Chang, J. Y., Ka, W. S., Chao, T. Y., Liu, T. W., Chuang, T. R. & Chen, L. T., 2004 一月 1, 於 : Oncology. 67, 3-4, p. 320-326 7 p.

研究成果: Article

53 引文 斯高帕斯(Scopus)

Phase II study of weekly oxaliplatin and 24-h infusion of high-dose 5-fluorouracil and folinic acid in the treatment of advanced gastric cancer

Chao, Y., Yeh, K. H., Chang, C. J., Chen, L. T., Chao, T. Y., Wu, M. F., Chang, C. S., Chang, J. Y., Chung, C. Y., Kao, W. Y., Hsieh, R. K. & Cheng, A. L., 2004 八月 2, 於 : British Journal of Cancer. 91, 3, p. 453-458 6 p.

研究成果: Article

70 引文 斯高帕斯(Scopus)
84 引文 斯高帕斯(Scopus)

Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents

Liou, J. P., Chang, J. Y., Chang, C. W., Chang, C. Y., Mahindroo, N., Kuo, F. M. & Hsieh, H. P., 2004 五月 20, 於 : Journal of Medicinal Chemistry. 47, 11, p. 2897-2905 9 p.

研究成果: Article

99 引文 斯高帕斯(Scopus)
57 引文 斯高帕斯(Scopus)
2003

Dual inhibition of topoisomerase I and tubulin polymerization by BPR0Y007, a novel cytotoxic agent

Chang, J-Y., Hsieh, H. P., Pan, W. Y., Liou, J. P., Bey, S. J., Chen, L. T., Liu, J. F. & Song, J. S., 2003 六月 15, 於 : Biochemical Pharmacology. 65, 12, p. 2009-2019 11 p.

研究成果: Article

20 引文 斯高帕斯(Scopus)

Erratum: Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents (Bioorganic and Medicinal Chemistry Letters (2003) 13 (101) PII S0960894X02008508)

Hsieh, H. P., Liou, J. P., Lin, Y. T., Mahindroo, N., Chang, J. Y., Yang, Y. N., Chern, S. S., Tan, U. K., Chang, C. W., Chen, T. W., Lin, C. H., Chang, Y. Y. & Wang, C. C., 2003 三月 10, 於 : Bioorganic and Medicinal Chemistry Letters. 13, 5, 1 p.

研究成果: Comment/debate

New analogues of AHMA as potential antitumor agents: Synthesis and biological activity

Chang, J. Y., Lin, C. F., Pan, W. Y., Bacherikov, V., Chou, T. C., Chen, C. H., Dong, H., Cheng, S. Y., Tasi, T. J., Lin, Y. W., Chen, K. T., Chen, L. T. & Su, T. L., 2003 十一月 17, 於 : Bioorganic and Medicinal Chemistry. 11, 23, p. 4959-4969 11 p.

研究成果: Article

25 引文 斯高帕斯(Scopus)

Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents

Hsieh, H. P., Liou, J. P., Lin, Y. T., Mahindroo, N., Chang, J. Y., Yang, Y. N., Chern, S. S., Tan, U. K., Chang, C. W., Chen, T. W., Lin, C. H., Chang, Y. Y. & Wang, C. C., 2003 一月 6, 於 : Bioorganic and Medicinal Chemistry Letters. 13, 1, p. 101-105 5 p.

研究成果: Article

72 引文 斯高帕斯(Scopus)
2002

2,2′-Diphenyl-1-picrylhydrazyl radical-scavenging active components from adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) hulls

Kuo, C. C., Chiang, W., Liu, G. P., Chien, Y. L., Chang, J-Y., Lee, C. K., Lo, J. M., Huang, S. L., Shih, M. C. & Kuo, Y. H., 2002 十月 9, 於 : Journal of Agricultural and Food Chemistry. 50, 21, p. 5850-5855 6 p.

研究成果: Article

69 引文 斯高帕斯(Scopus)

Antitumor AHMA linked to DNA minor groove binding agents: Synthesis and biological evaluation

Rastogi, K., Chang, J. Y., Pan, W. Y., Chen, C. H., Chou, T. C., Chen, L. T. & Su, T. L., 2002 九月 26, 於 : Journal of Medicinal Chemistry. 45, 20, p. 4485-4493 9 p.

研究成果: Article

30 引文 斯高帕斯(Scopus)

A phase I study of weekly docetaxel, 24-hour infusion of high-dose fluorouracil/leucovorin and cisplatin in patients with advanced gastric cancer

Chen, L. T., Liu, T. W., Wu, C. W., Chung, T. R., Shiah, H. S., Jan, C. M., Ming Liu, J., Whang-Peng, J. & Chang, J-Y., 2002 十二月 1, 於 : Oncology. 63, 3, p. 239-247 9 p.

研究成果: Article

17 引文 斯高帕斯(Scopus)
5 引文 斯高帕斯(Scopus)

Novel mutation of topoisomerase I in rendering cells resistant to camptothecin

Chang, J. Y., Liu, J. F., Juang, S. H., Liu, T. W. & Chen, L. T., 2002 七月 1, 於 : Cancer Research. 62, 13, p. 3716-3721 6 p.

研究成果: Article

49 引文 斯高帕斯(Scopus)

Phase II and pharmacokinetic study of GL331 in previously treated Chinese gastric cancer patients

Liu, J., Chen, L., Chao, Y., Li, A., Wu, C., Liu, T. S., Shiah, H., Chang, J., Chen, J., Wu, H., Lin, W., Lan, C. & Whang-Peng, J., 2002 五月 6, 於 : Cancer Chemotherapy and Pharmacology. 49, 5, p. 425-428 4 p.

研究成果: Article

12 引文 斯高帕斯(Scopus)
2001

Immunohistochemical studies of Na + /I - symporter in human thyroid tissues - A correlation with clinical thyroid scintigraphy

Lee, C. H., Yang, A. H., Chang, J-Y., Huang, C. L. & Chi, C. W., 2001 七月 12, 於 : Chinese Medical Journal (Taipei). 64, 3, p. 141-146 6 p.

研究成果: Article

The p38 mitogen-activated protein kinase pathway regulates interleukin-6 synthesis in response to tumor necrosis factor in osteoblasts

Chae, H. J., Chae, S. W., Chin, H. Y., Bang, B. G., Cho, S. B., Han, K. S., Kim, S. C., Tae, K. C., Lee, K. H., Kim, D. E., Im, M. K., Lee, S. J., Chang, J. Y., Lee, Y. M., Kim, H. M., Kim, H. H., Lee, Z. H. & Kim, H. R., 2001 二月 13, 於 : Bone. 28, 1, p. 45-53 9 p.

研究成果: Article

35 引文 斯高帕斯(Scopus)
2000

Unique biochemical, cytotoxic, and antitumor activity of camptothecin and 4β-amino-4'-O-demethylepipodophyllotoxin conjugates

Chang, J-Y., Guo, X., Chen, H. X., Jiang, Z., Fu, Q., Wang, H. K., Bastow, K. F., Zhu, X. K., Guan, J., Lee, K. H. & Cheng, Y. C., 2000 三月 1, 於 : Biochemical Pharmacology. 59, 5, p. 497-508 12 p.

研究成果: Article

30 引文 斯高帕斯(Scopus)
1998

Acquired hemophilia A: Report of two cases

Chen, Y. C., Chang, J. Y., Hsueh, E. J., Wan, H. L. & Chao, T. Y., 1998 九月 1, 於 : Chinese Medical Journal (Taipei). 61, 9, p. 538-544 7 p.

研究成果: Article

2 引文 斯高帕斯(Scopus)
1996

Allogeneic bone marrow transplantation for fourteen patients with severe aplastic anemia

Hsueh, E. J., Hwang, W. S., Huang, S. H., Chao, T. Y., Chang, J-Y. & Wang, C. C., 1996 四月 1, 於 : Chinese Medical Journal (Taipei). 57, 4, p. 247-253 7 p.

研究成果: Article

51 引文 斯高帕斯(Scopus)

Down regulation of bcl-2 by p53 in nasopharyngeal carcinoma and lack of detection of its specific t(14;18) chromosomal translocation in fixed tissues

Harn, H. J., Ho, L. I., Liu, C. A., Liu, G. C., Lin, F. G., Lin, J. J., Chang, J. Y. & Lee, W. H., 1996 一月 1, 於 : Histopathology. 28, 4, p. 317-323 7 p.

研究成果: Article

42 引文 斯高帕斯(Scopus)

Examination of pericardial effusions by cytology and immunocytochemistry.

Chen, L. M., Chao, T. Y., Chiang, J. H., Nieh, S., Chang, J-Y., Hwang, S. H., Hseuh, E. J. & Wang, C. C., 1996 一月 1, 於 : Zhonghua yi xue za zhi = Chinese medical journal; Free China ed. 58, 4, p. 248-253 6 p.

研究成果: Article

1 引文 斯高帕斯(Scopus)