• 2754 引文
  • 30 h-指數
1990 …2020
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研究成果 1990 2019

  • 2754 引文
  • 30 h-指數
  • 87 Article
  • 4 Review article
  • 1 Patent
篩選
Article
2019
開啟存取
Colorectal Neoplasms
Neoplasms
Therapeutics
Genome
Mutation

Lysosomal cysteine protease cathepsin S is involved in cancer cell motility by regulating store-operated Ca2+ entry

Lin, H. H., Chen, S-J., Shen, M-R., Huang, Y. T., Hsieh, H. P., Lin, S. Y., Lin, C. C., Chang, W. S. W. & Chang, J-Y., 2019 十二月 1, 於 : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 12, 118517.

研究成果: Article

cathepsin S
Cysteine Proteases
Cell Movement
Neoplasms
protease S
2 引文 (Scopus)

The distinct role of STIM1 and STIM2 in the regulation of store-operated Ca2+ entry and cellular function

Chen, Y. F., Chen, L. H. & Shen, M-R., 2019 六月 1, 於 : Journal of Cellular Physiology. 234, 6, p. 8727-8739 13 p.

研究成果: Article

Uterine Cervical Neoplasms
Endoplasmic Reticulum
Sensors
Microtubules
Tissue
2018

Bcl-2 regulates store-operated Ca2+ entry to modulate ER stress-induced apoptosis

Chiu, W., Chang, H., Lin, Y., Lin, Y., Chang, H., Lin, H., Huang, S., Tang, M. & Shen, M., 2018 十二月 1, 於 : Cell Death Discovery. 4, 1

研究成果: Article

8 引文 (Scopus)

Bcl-2 regulates store-operated Ca2+ entry to modulate ER stress-induced apoptosis

Chiu, W-T., Chang, H. A., Lin, Y. H., Lin, Y. S., Chang, H. T., Lin, H. H., Huang, S. C., Tang, M-J. & Shen, M-R., 2018 十二月 1, 於 : Cell Death Discovery. 4, 1, 37.

研究成果: Article

開啟存取
Apoptosis
Tunicamycin
Thapsigargin
Mitochondria
Death Domain Receptors
2017
2 引文 (Scopus)

Differential Ca2+ mobilization and mast cell degranulation by FcεRI- and GPCR-mediated signaling

Chen, Y. C., Chang, Y. C., Chang, H. A., Lin, Y. S., Tsao, C. W., Shen, M-R. & Chiu, W-T., 2017 十一月 1, 於 : Cell Calcium. 67, p. 31-39 9 p.

研究成果: Article

Cell Degranulation
Mast Cells
Histamine
Histamine Release
G-Protein-Coupled Receptors
5 引文 (Scopus)

Minoxidil is a potential neuroprotective drug for paclitaxel-induced peripheral neuropathy

Chen, Y. F., Chen, L. H., Yeh, Y-M., Wu, P-Y., Chen, Y. F., Chang, L. Y., Chang, J-Y. & Shen, M-R., 2017 三月 28, 於 : Scientific reports. 7, 45366.

研究成果: Article

Minoxidil
Neuroprotective Agents
Peripheral Nervous System Diseases
Paclitaxel
Hair
3 引文 (Scopus)
Fluoxetine
Serotonin Uptake Inhibitors
Insulin-Secreting Cells
Cadherins
Cell Adhesion
4 引文 (Scopus)
Neoplasms
Cell Surface Extensions
Rosette Formation
Podosomes
Extracellular Matrix
2 引文 (Scopus)
Macrophage Colony-Stimulating Factor
Colony-Stimulating Factor Receptors
Immunity
Macrophages
Genes
2016
8 引文 (Scopus)

Hepatitis B virus preS2-mutant large surface antigen activates store-operated calcium entry and promotes chromosome instability

Yen, T. T. C., Yang, A., Chiu, W-T., Li, T. N., Wang, L. H., Wu, Y. H., Wang, H. C., Chen, L., Wang, W. C., Huang, W-Y., Chang, C. W., Chang, M. D. T., Shen, M-R., Su, I. J. & Wang, L. H. C., 2016 四月 26, 於 : Oncotarget. 7, 17, p. 23346-23360 15 p.

研究成果: Article

Chromosomal Instability
Surface Antigens
Hepatitis B virus
Calcium
Endoplasmic Reticulum
2 引文 (Scopus)
Peripheral Nervous System
Peripheral Nerves
Action Potentials
potassium-chloride symporters
Microvilli
2 引文 (Scopus)

Mechanistic Study of Tetrahydrofuran-acetogenins In Triggering Endoplasmic Reticulum Stress Response-apotoposis in Human Nasopharyngeal Carcinoma

Juang, S. H., Chiang, C. Y., Liang, F. P., Chan, H. H., Yang, J. S., Wang, S. H., Lin, Y. C., Kuo, P-C., Shen, M-R., Thang, T. D., Nguyet, B. T. M., Kuo, S. C. & Wu, T-S., 2016 十二月 21, 於 : Scientific reports. 6, 39251.

研究成果: Article

Acetogenins
Endoplasmic Reticulum Stress
Gene Knockdown Techniques
tetrahydrofuran
Nasopharyngeal carcinoma
6 引文 (Scopus)

Phosphorylation of E-cadherin at threonine 790 by protein kinase Cδ reduces β-catenin binding and suppresses the function of E-cadherin

Chen, C. L., Wang, S. H., Chan, P. C., Shen, M-R. & Chen, H. C., 2016 一月 1, 於 : Oncotarget. 7, 24, p. 37260-37276 17 p.

研究成果: Article

Catenins
Threonine
Cadherins
Protein Kinase C
Phosphorylation
5 引文 (Scopus)
Surgical Mesh
Confidence Intervals
Hysterectomy
Hematoma
Multivariate Analysis
24 引文 (Scopus)
G1 Phase Cell Cycle Checkpoints
Cell Cycle
Down-Regulation
Cell Membrane Structures
Phosphorylation
20 引文 (Scopus)
Neoplasms
Cell Movement
Focal Adhesions
Traction
Proteins
2015
8 引文 (Scopus)
Neuroprotective Agents
Paclitaxel
Ligands
Neurons
Drug Therapy
49 引文 (Scopus)

Mechanical phenotype of cancer cells: Cell softening and loss of stiffness sensing

Lin, H. H., Lin, H. K., Lin, I. H., Chiou, Y. W., Chen, H. W., Liu, C. Y., Harn, H. I. C., Chiu, W-T., Wang, Y-G., Shen, M-R. & Tang, M-J., 2015 一月 1, 於 : Oncotarget. 6, 25, p. 20946-20958 13 p.

研究成果: Article

Phenotype
Caveolin 1
Neoplasms
Fibroblasts
Elasticity
17 引文 (Scopus)

Mechanosensitive store-operated calcium entry regulates the formation of cell polarity

Huang, Y. W., Chang, S. J., I-Chen Harn, H., Huang, H. T., Lin, H. H., Shen, M-R., Tang, M-J. & Chiu, W-T., 2015 九月 1, 於 : Journal of Cellular Physiology. 230, 9, p. 2086-2097 12 p.

研究成果: Article

Cell Polarity
Caveolin 1
Cells
Calcium
Polarization
36 引文 (Scopus)
RNA-Binding Proteins
Ovarian Neoplasms
Platinum
Carcinoma
Inosine Monophosphate
2014
6 引文 (Scopus)

SPAK mediates KCC3-enhanced cervical cancer tumorigenesis

Chiu, M. H., Liu, H-S., Wu, Y. H., Shen, M-R. & Chou, C-Y., 2014 一月 1, 於 : FEBS Journal. 281, 10, p. 2353-2365 13 p.

研究成果: Article

Symporters
Uterine Cervical Neoplasms
Carcinogenesis
Matrix Metalloproteinase 2
p38 Mitogen-Activated Protein Kinases
2013
16 引文 (Scopus)
Glycosylation
Membranes
Polysaccharides
Mutation
Protein Folding
30 引文 (Scopus)

Microtubule-associated histone deacetylase 6 supports the calcium store sensor STIM1 in mediating malignant cell behaviors

Chen, Y. T., Chen, Y. F., Chiu, W-T., Liu, K. Y., Liu, Y. L., Chang, J-Y., Chang, H-C. & Shen, M-R., 2013 七月 15, 於 : Cancer Research. 73, 14, p. 4500-4509 10 p.

研究成果: Article

Histone Deacetylases
Microtubules
Calcium
Uterine Cervical Neoplasms
Epithelial Cells
10 引文 (Scopus)
Self assembled monolayers
Stromal Cells
Functional groups
Cell Movement
Surface chemistry
39 引文 (Scopus)

The ER Ca2+ sensor STIM1 regulates actomyosin contractility of migratory cells

Chen, Y. T., Chen, Y. F., Chiu, W-T., Wang, Y-G., Chang, H-C. & Shen, M-R., 2013 三月 1, 於 : Journal of Cell Science. 126, 5, p. 1260-1267 8 p.

研究成果: Article

Actomyosin
Endoplasmic Reticulum
Cell Movement
Uterine Cervical Neoplasms
Myosin Type II
2012
15 引文 (Scopus)
NADP
Oxidoreductases
Neutrophils
Phagosomes
Phagocytosis
10 引文 (Scopus)
Transforming Growth Factor beta1
Keloid
Fibroblasts
Mechanics
Rigidity
2011
21 引文 (Scopus)

Aberrantly expressed AURKC enhances the transformation and tumourigenicity of epithelial cells

Tsou, J. H., Chang, K-C., Chang-Liao, P. Y., Yang, S. T., Lee, C-T., Chen, Y-P., Lee, Y. C., Lin, P-W., Lee, J-C., Shen, M-R., Chuang, C. K., Chang, W. C., Wang, J-M. & Hung, L-Y., 2011 十月 1, 於 : Journal of Pathology. 225, 2, p. 243-254 12 p.

研究成果: Article

Epithelial Cells
Neoplasms
Colorectal Neoplasms
Thyroid Neoplasms
Uterine Cervical Neoplasms
7 引文 (Scopus)
Self assembled monolayers
attachment
proteins
Vitronectin
cells
196 引文 (Scopus)
Uterine Cervical Neoplasms
Calcium
Growth
Neoplasms
Epidermal Growth Factor
24 引文 (Scopus)

The potassium-chloride cotransporter 2 promotes cervical cancer cell migration and invasion by an ion transport-independent mechanism

Wei, W. C., Akerman, C. J., Newey, S. E., Pan, J., Clinch, N. W. V., Jacob, Y., Shen, M-R., Wilkins, R. J. & Ellory, J. C., 2011 十一月 1, 於 : Journal of Physiology. 589, 22, p. 5349-5359 11 p.

研究成果: Article

Ion Transport
Uterine Cervical Neoplasms
Cell Movement
Somatomedins
Biotinylation
2010
16 引文 (Scopus)
Peripheral Nerves
Neural Conduction
Schwann Cells
Action Potentials
Axons
43 引文 (Scopus)

ZBRK1 acts as a metastatic suppressor by directly regulating MMP9 in cervical cancer

Lin, L. F., Chuang, C. H., Li, C. F., Liao, C. C., Cheng, C. P., Cheng, T. L., Shen, M-R., Tseng, T-C., Chang, W., Lee, W. H. & Wang, J-M., 2010 一月 1, 於 : Cancer Research. 70, 1, p. 192-201 10 p.

研究成果: Article

Uterine Cervical Neoplasms
Neoplasm Metastasis
Neoplasms
Carcinoma
Matrix Metalloproteinase 9
2009
19 引文 (Scopus)
Aryl Hydrocarbon Receptor Nuclear Translocator
Hypoxia-Inducible Factor 1
Cyclooxygenase 2
Epidermal Growth Factor
Gene expression
27 引文 (Scopus)

Motor protein-dependent membrane trafficking of KCl cotransporter-4 is important for cancer cell invasion

Chen, Y. F., Chou, C-Y., Wilkins, R. J., Ellory, J. C., Mount, D. B. & Shen, M-R., 2009 十一月 15, 於 : Cancer Research. 69, 22, p. 8585-8593 9 p.

研究成果: Article

Insulin-Like Growth Factor I
Membrane Proteins
Epidermal Growth Factor
Neoplasms
Microdissection
2008
20 引文 (Scopus)

Calcineurin-mediated dephosphorylation of c-Jun Ser-243 is required for c-Jun protein stability and cell transformation

Huang, C. C., Wang, J-M., Kikkawa, U., Mukai, H., Shen, M-R., Morita, I., Chen, B-K. & Chang, W. C., 2008 四月 10, 於 : Oncogene. 27, 17, p. 2422-2429 8 p.

研究成果: Article

Proto-Oncogene Proteins c-jun
jun Genes
Protein Stability
Calcineurin
Fluorescence Resonance Energy Transfer
36 引文 (Scopus)
Somatomedins
IGF Type 1 Receptor
Uterine Cervical Neoplasms
Insulin-Like Growth Factor Binding Protein 3
Recurrence
16 引文 (Scopus)

Conditionally replicating E1B-deleted adenovirus driven by the squamous cell carcinoma antigen 2 promoter for uterine cervical cancer therapy

Hsu, K-F., Wu, C-L., Huang, S. C., Hsieh, J. L., Huang, Y. S., Chen, Y. F., Shen, M-R., Chung, W. J., Chou, C-Y. & Shiau, A-L., 2008 八月 18, 於 : Cancer Gene Therapy. 15, 8, p. 526-534 9 p.

研究成果: Article

Adenoviridae
Uterine Cervical Neoplasms
Neoplasms
Therapeutics
SCID Mice
69 引文 (Scopus)
Sodium-Hydrogen Antiporter
Epidermal Growth Factor
Uterine Cervical Neoplasms
Up-Regulation
Cells
54 引文 (Scopus)

Epigenetic silencing of CCAAT/enhancer-binding protein δ activity by YY1/polycomb group/DNA methyltransferase complex

Ko, C. Y., Hsu, H. C., Shen, M-R., Chang, W. C. & Wang, J-M., 2008 十一月 7, 於 : Journal of Biological Chemistry. 283, 45, p. 30919-30932 14 p.

研究成果: Article

Yin-Yang
CCAAT-Enhancer-Binding Proteins
Methyltransferases
Epigenomics
Gene expression
186 引文 (Scopus)
Epithelial-Mesenchymal Transition
Snails
Epidermal Growth Factor Receptor
Uterine Cervical Neoplasms
Up-Regulation
31 引文 (Scopus)

Eps8 decreases chemosensitivity and affects survival of cervical cancer patients

Chen, Y. J., Shen, M-R., Chen, Y. J., Maa, M. C. & Leu, T-H., 2008 十月 15, 於 : Molecular Cancer Therapeutics. 7, 6, p. 1376-1385 10 p.

研究成果: Article

Uterine Cervical Neoplasms
HeLa Cells
Survival
Cyclin D3
Cyclin E
7 引文 (Scopus)

Low substratum rigidity of collagen gel promotes ERK phosphorylation via lipid raft to augment cell migration

Wei, W. C., Hsu, Y. C., Chiu, W-T., Wang, C. Z., Wu, C. M., Wang, Y-G., Shen, M-R. & Tang, M-J., 2008 三月 1, 於 : Journal of Cellular Biochemistry. 103, 4, p. 1111-1124 14 p.

研究成果: Article

Phosphorylation
Rigidity
Cell Movement
Collagen
Gels
44 引文 (Scopus)
Integrins
Cluster Analysis
Focal Adhesion Kinase 1
Collagen
Phosphorylation
30 引文 (Scopus)
Calpain
Up-Regulation
Epithelial Cells
Apoptosis
Homeostasis
63 引文 (Scopus)
Sumoylation
SUMO-1 Protein
Proteins
Proteolysis
Ubiquitination
2007
30 引文 (Scopus)
STAT3 Transcription Factor
Domes
Chemical activation
Madin Darby Canine Kidney Cells
sodium-hydrogen exchanger 3
31 引文 (Scopus)

IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness

Hsu, Y. M., Chou, C-Y., Chen, H. H. W., Lee, W. Y., Chen, Y. F., Lin, P. W., Alper, S. L., Ellory, J. C. & Shen, M-R., 2007 三月 1, 於 : Journal of Cellular Physiology. 210, 3, p. 626-636 11 p.

研究成果: Article

Cell proliferation
Somatomedins
Up-Regulation
Cell Proliferation
Breast Neoplasms
27 引文 (Scopus)
Uterine Cervical Neoplasms
Messenger RNA
Carcinogenesis
Epithelium
Genes