Po-See Chen

2025

Developing a risk assessment model for treatment-resistant schizophrenia: The role of niacin receptor GPR109A and prostaglandin receptors DP₁, EP₂, and EP₄ in the niacin-induced flushing pathway

Chiu, C. W., Chen, B. Y., Lin, J. J., Tseng, H. H., Huang, C. C., Wang, T. Y., Jang, F. L., Yao, C. Y., Chang, W. H., Chen, P. S. & Lin, S. H., 2025 6月, 於: Schizophrenia Research. 280, p. 30-38 9 p.

研究成果: Article › 同行評審

Dopamine D1 receptor agonist alleviates post-weaning isolation-induced neuroinflammation and depression-like behaviors in female mice

Zhao, Z. W., Wang, Y. C., Chen, P. C., Tzeng, S. F., Chen, P. S. & Kuo, Y. M., 2025 12月, 於: Behavioral and Brain Functions. 21, 1, 6.

研究成果: Article › 同行評審

Evaluation of alpha neurofeedback training to enhance sleep in remitted depression and anxiety sufferers with persistent insomnia

Lu, T. H., Hsieh, T. H., Wang, Y. H., Shaw, F. Z., Chen, P. S. & Liang, S. F., 2025 4月, 於: Psychiatry Research. 346, 116401.

研究成果: Article › 同行評審

Exploring the interplay between mitochondrial dysfunction, early life adversity and bipolar disorder

Wu, C. Y., Chang, C. C., Lin, T. T., Liu, C. S. & Chen, P. S., 2025, 於: International Journal of Psychiatry in Clinical Practice. 29, 1, p. 25-31 7 p.

研究成果: Article › 同行評審

Exploring the reduction in aquaporin-4 and increased expression of ciliary neurotrophic factor with the frontal–striatal gliosis induced by chronic high-fat dietary stress

Fu, J. T., Huang, H. T., Chen, P. C., Kuo, Y. M., Chen, P. S. & Tzeng, S. F., 2025 1月, 於: Journal of Neurochemistry. 169, 1, e16236.

研究成果: Article › 同行評審

Long-Term Moderating Effect of Resilience Capacity on the Impact of Stressful Life Events on Depressive Symptoms After 6 Years in Outpatients With Depression and/or Anxiety

Chen, Y. X., Lin, S. H., Chen, P. S., Lu, T. H., Huang, H. L. & Lee, I. H., 2025 1月 1, 於: Journal of Nervous and Mental Disease. 213, 1, p. 22-27 6 p.

研究成果: Article › 同行評審

Mitochondrial DNA copy number as a mediator of the relationship between insulin resistance and cognitive function in patients with euthymic bipolar disorder

Tsai, T. H., Wu, C. Y., Chang, C. C., Lin, T. T., Liu, C. S. & Chen, P. S., 2025 1月, 於: Kaohsiung Journal of Medical Sciences. 41, 1, e12914.

研究成果: Article › 同行評審

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Role of the insula in rTMS response for depression

Wu, C. L., Lu, T. H., Chang, W. H., Wang, T. Y., Tseng, H. H., Yang, Y. K. & Chen, P. S., 2025 2月 1, 於: Journal of Affective Disorders. 370, p. 538-546 9 p.

研究成果: Article › 同行評審

Soluble epoxide hydrolase deletion rescues behavioral and synaptic deficits by AMPK-mTOR pathway in autism animals

Chu, M. C., Wu, H. F., Lee, C. W., Wu, C. C., Chi, H., Ko, C. Y., Lee, Y. C., Tang, C. W., Chen, P. S. & Lin, H. C., 2025 1月 10, 於: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 136, 111190.

研究成果: Article › 同行評審

The Association between Childhood Trauma on Executive Functioning and Treatment Outcomes among Individuals with Methamphetamine Use Disorder

Lin, C. T., Wang, T. Y., Tsai, T. Y., Tseng, H. H., Chen, K. C., Lee, I. H., Chen, P. S., Yang, Y. K. & Lu, R. B., 2025, 於: Clinical Psychopharmacology and Neuroscience. 23, 2, p. 300-311 12 p.

研究成果: Article › 同行評審

Transdiagnostic features of inflammatory markers and executive function across psychiatric disorders

Wang, T. Y., Chang, Y. H., Lee, S. Y., Chang, H. H., Tsai, T. Y., Tseng, H. H., Wang, S. M., Chen, P. S., Chen, K. C., Lee, I. H., Yang, Y. K., Hong, J. S. & Lu, R. B., 2025 1月, 於: Journal of Psychiatric Research. 181, p. 160-168 9 p.

研究成果: Article › 同行評審

2 引文斯高帕斯（Scopus）

2024

Cognitive Effect of Transcranial Direct Current Stimulation on Left Dorsolateral Prefrontal Cortex in Mild Alzheimer's Disease: A Randomized, Double-Blind, Cross-Over Small-Scale Exploratory Study

Wang, C. S. M., Chen, P. S., Tsai, T. Y., Hou, N. T., Tang, C. H., Chen, P. L., Huang, Y. C. & Cheng, K. S., 2024 3月 19, 於: Journal of Alzheimer's Disease. 98, 2, p. 563-577 15 p.

研究成果: Article › 同行評審

3 引文斯高帕斯（Scopus）

Digital Phenotyping-Based Bipolar Disorder Assessment Using Multiple Correlation Data Imputation and Lasso-MLP

Hsu, J. H., Wu, C. H., Wang, W. K., Su, H. Y., Lin, E. C. L. & Chen, P. S., 2024, 於: IEEE Transactions on Affective Computing. 15, 3, p. 885-897 13 p.

研究成果: Article › 同行評審

3 引文斯高帕斯（Scopus）

Fat loss and muscle gain: The possible role of cortical glutamate in determining the efficacy of physical exercise

Abdullah, M., Lin, S. H., Huang, L. C., Chen, P. S., Tseng, H. H. & Yang, Y. K., 2024 5月 1, 於: Obesity Research and Clinical Practice. 18, 3, p. 163-170 8 p.

研究成果: Article › 同行評審

2 引文斯高帕斯（Scopus）

Machine learning for prediction of schizophrenia based on identifying the primary and interaction effects of minor physical anomalies

Jeng, S. L., Tu, M. J., Lin, C. W., Lin, J. J., Tseng, H. H., Jang, F. L., Lu, M. K., Chen, P. S., Huang, C. C., Chang, W. H., Tan, H. P. & Lin, S. H., 2024 4月, 於: Journal of Psychiatric Research. 172, p. 108-118 11 p.

研究成果: Article › 同行評審

3 引文斯高帕斯（Scopus）

MoodSensing: A Smartphone APP for Digital Phenotyping and Assessment of Bipolar Disorder

Hsu, J-H., Wu, C-H., Lin, E. C-L. & Chen, P-S., 2024 2月 1, 於: Psychiatry Research. p. 115790

研究成果: Article › 同行評審

1 引文斯高帕斯（Scopus）

Peripheral inflammation is associated with impaired sadness recognition in euthymic bipolar patients

Chang, C. Y., Chang, H. H., Wu, C. Y., Tsai, Y. T., Lu, T. H., Chang, W. H., Hsu, C. F., Chen, P. S. & Tseng, H. H., 2024 5月, 於: Journal of Psychiatric Research. 173, p. 333-339 7 p.

研究成果: Article › 同行評審

Physical function as a predictor of chemotherapy-induced peripheral neuropathy in patients with pancreatic cancer

Lin, K. Y., Chen, P. S. & Lin, C. F., 2024 12月, 於: BMC Gastroenterology. 24, 1, 154.

研究成果: Article › 同行評審

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Posterior cingulate and medial prefrontal excitation-inhibition balance in euthymic bipolar disorder

Tseng, H. H., Wu, C. Y., Chang, H. H., Lu, T. H., Chang, W. H., Hsu, C. F., Lin, R. Y., Yeh, D. R., Shaw, F. Z., Yang, Y. K. & Chen, P. S., 2024, (Accepted/In press) 於: Psychological Medicine.

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2 引文斯高帕斯（Scopus）

Shortening of telomere length may be associated with inflammatory cytokine levels in patients with bipolar disorder

Wang, S. M., Chang, H. H., Chang, Y. H., Tsai, T. Y., Chen, P. S., Lu, R. B. & Wang, T. Y., 2024 11月 15, 於: Journal of Affective Disorders. 365, p. 155-161 7 p.

研究成果: Article › 同行評審

2 引文斯高帕斯（Scopus）

The Association between Default-mode Network Functional Connectivity and Childhood Trauma on the Symptom Load in Male Adults with Methamphetamine Use Disorder

Wei, S. Y., Tsai, T. H., Tsai, T. Y., Chen, P. S., Tseng, H. H., Yang, Y. K., Zhai, T., Yang, Y. & Wang, T. Y., 2024 2月, 於: Clinical Psychopharmacology and Neuroscience. 22, 1, p. 105-117 13 p.

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2 引文斯高帕斯（Scopus）

2023

Association Between Inflammatory Cytokines, Executive Function, and Substance Use in Patients With Opioid Use Disorder and Amphetamine-Type Stimulants Use Disorder

Wang, T. Y., Lu, R. B., Lee, S. Y., Chang, Y. H., Chen, S. L., Tsai, T. Y., Tseng, H. H., Chen, P. S., Chen, K. C., Yang, Y. K. & Hong, J. S., 2023 1月 1, 於: International Journal of Neuropsychopharmacology. 26, 1, p. 42-51 10 p.

研究成果: Article › 同行評審

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9 引文斯高帕斯（Scopus）

Automatic Bipolar Disorder Assessment Using Machine Learning With Smartphone-Based Digital Phenotyping

Wu, C. H., Hsu, J. H., Liou, C. R., Su, H. Y., Lin, E. C. L. & Chen, P. S., 2023, 於: IEEE Access. 11, p. 121845-121858 14 p.

研究成果: Article › 同行評審

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5 引文斯高帕斯（Scopus）

Comparison of health resource usage and costs associated with first-generation and second-generation long-acting injectable antipsychotics for patients with schizophrenia: A nationwide population-based cohort study

Yang, C. P., Wu, P. N., Liao, L. T., Lin, T. Y. & Chen, P. S., 2023 11月, 於: Asian Journal of Psychiatry. 89, 103789.

研究成果: Article › 同行評審

3 引文斯高帕斯（Scopus）

Disrupted white matter network of brain structural connectomes in bipolar disorder patients revealed by q-ball imaging

Tseng, H. H., Hsu, C. F., Lu, T. H., Yang, Y. K., Chen, P. S., Lin, P. T., Chang, Y. P. E. & Weng, J. C., 2023 6月 1, 於: Journal of Affective Disorders. 330, p. 239-244 6 p.

研究成果: Article › 同行評審

2 引文斯高帕斯（Scopus）

DNA methylation signature aberration as potential biomarkers in treatment-resistant schizophrenia: Constructing a methylation risk score using a machine learning method

Lu, A. K. M., Lin, J. J., Tseng, H. H., Wang, X. Y., Jang, F. L., Chen, P. S., Huang, C. C., Hsieh, S. & Lin, S. H., 2023 1月, 於: Journal of Psychiatric Research. 157, p. 57-65 9 p.

研究成果: Article › 同行評審

11 引文斯高帕斯（Scopus）

Effects of comorbid alcohol use disorder on bipolar disorder: Focusing on neurocognitive function and inflammatory markers

Liou, Y. J., Wang, T. Y., Lee, S. Y., Chang, Y. H., Tsai, T. Y., Chen, P. S., Huang, S. Y., Tzeng, N. S., Lee, I. H., Chen, K. C., Yang, Y. K., Hong, J. S. & Lu, R. B., 2023 6月, 於: Psychoneuroendocrinology. 152, 106083.

研究成果: Article › 同行評審

4 引文斯高帕斯（Scopus）

Glibenclamide promotes FGF21 secretion in interscapular BAT and attenuates depression-like behaviors in male mice with HFD-induced obesity

Kuo, Y. Y., Tsai, H. Y., Kuo, Y. M., Tzeng, S. F., Chen, P. S., Hsu, P. H., Lin, Y. T. & Chen, P. C., 2023 9月 1, 於: Life Sciences. 328, 121900.

研究成果: Article › 同行評審

3 引文斯高帕斯（Scopus）

Social cognitive deficit is associated with visuomotor coordination impairment and dopamine transporter availability in euthymic bipolar disorder

Tsai, Y. T., Chang, C. Y., Wu, C. Y., Huang, Y. L., Chang, H. H., Lu, T-H., Chang, W. H., Chiu, N. T., Hsu, C. F., Yang, Y-K., Chen, P. S. & Tseng, H-H., 2023 9月, 於: Journal of Psychiatric Research. 165, p. 158-164 7 p.

研究成果: Article › 同行評審

1 引文斯高帕斯（Scopus）

The relationship between peripheral insulin resistance and social cognitive deficits among euthymic patients with bipolar disorder

Tsai, T. H., Lu, T. H., Tseng, H. H., Chang, W. H., Wang, T. Y., Yang, Y. K., Chang, H. H. & Chen, P. S., 2023 12月 1, 於: Journal of Affective Disorders. 342, p. 121-126 6 p.

研究成果: Article › 同行評審

1 引文斯高帕斯（Scopus）

Which Severe Mental Illnesses Most Increase the Risk of Developing Dementia? Comparing the Risk of Dementia in Patients with Schizophrenia, Major Depressive Disorder and Bipolar Disorder

Chang, W. H., Su, C. C., Chen, K. C., Hsiao, Y. Y., Chen, P. S. & Yang, Y. K., 2023 8月, 於: Clinical Psychopharmacology and Neuroscience. 21, 3, p. 478-487 10 p.

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8 引文斯高帕斯（Scopus）

2022

Associations among smartphone app-based measurements of mood, sleep and activity in bipolar disorder

Tseng, Y. C., Lin, E. C. L., Wu, C. H., Huang, H. L. & Chen, P. S., 2022 4月, 於: Psychiatry Research. 310, 114425.

研究成果: Article › 同行評審

11 引文斯高帕斯（Scopus）

Associations of emotion recognition, loneliness, and social functioning in euthymic patients with bipolar disorder

Lee, C. N., Huang, Y. L., Chang, H. H., Kuo, C. Y., Lu, T. H., Hsieh, Y. T., Chang, W. H., Yang, Y. K., Chen, P. S. & Tseng, H. H., 2022 7月, 於: Kaohsiung Journal of Medical Sciences. 38, 7, p. 703-711 9 p.

研究成果: Article › 同行評審

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12 引文斯高帕斯（Scopus）

Associations of leptin and corticostriatal connectivity in bipolar disorder

Wei, S. Y., Tseng, H. H., Chang, H. H., Chang, W. H., Yang, Y. K. & Chen, P. S., 2022 12月, 於: Scientific reports. 12, 1, 21898.

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1 引文斯高帕斯（Scopus）

Correlation between loneliness, personality traits, and treatment outcomes in patients with methamphetamine use disorder

Tsai, T. Y., Wang, T. Y., Tseng, H. H., Chen, K. C., Chiu, C. J., Chen, P. S. & Yang, Y. K., 2022 12月, 於: Scientific reports. 12, 1, 8629.

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3 引文斯高帕斯（Scopus）

Development and validation of a web-based prediction tool on minor physical anomalies for schizophrenia

Wang, X. Y., Lin, J. J., Lu, M. K., Jang, F. L., Tseng, H. H., Chen, P. S., Chen, P. F., Chang, W. H., Huang, C. C., Lu, K. M., Tan, H. P. & Lin, S. H., 2022 12月, 於: Schizophrenia. 8, 1, 4.

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3 引文斯高帕斯（Scopus）

Generational synaptic functions of GABA_A receptor β3 subunit deteriorations in an animal model of social deficit

Chu, M. C., Wu, H. F., Lee, C. W., Chung, Y. J., Chi, H., Chen, P. S. & Lin, H. C., 2022 12月, 於: Journal of biomedical science. 29, 1, 51.

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6 引文斯高帕斯（Scopus）

High-fat diet induces depression-like phenotype via astrocyte-mediated hyperactivation of ventral hippocampal glutamatergic afferents to the nucleus accumbens

Tsai, S. F., Hsu, P. L., Chen, Y. W., Hossain, M. S., Chen, P. C., Tzeng, S. F., Chen, P. S. & Kuo, Y. M., 2022 11月, 於: Molecular Psychiatry. 27, 11, p. 4372-4384 13 p.

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28 引文斯高帕斯（Scopus）

Loneliness and isolated living status in middle-aged and older adults in Taiwan: exploration on stress-related biomarkers, depressive symptoms, and disability

Tsai, T. Y., Chiu, C. J., Wang, T. Y., Tseng, H. H., Chen, K. C., Chen, P. S. & Yang, Y. K., 2022 12月, 於: BMC Psychiatry. 22, 1, 177.

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11 引文斯高帕斯（Scopus）

Mitochondrial DNA Copy Number Is Associated With Treatment Response and Cognitive Function in Euthymic Bipolar Patients Receiving Valproate

Chang, C. C., Chen, P. S., Lin, J. R., Chen, Y. A., Liu, C. S., Lin, T. T. & Chang, H. H., 2022 7月 1, 於: International Journal of Neuropsychopharmacology. 25, 7, p. 525-533 9 p.

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7 引文斯高帕斯（Scopus）

Peripheral insulin sensitivity predicting cognitive function in euthymic bipolar disorder patients

Chang, H. H., Tseng, H. H., Chang, W. H., Huang, K. C., Lu, T. H., Yang, Y. K. & Chen, P. S., 2022 10月 11, 於: CNS Spectrums. 27, 5, p. 598-603 6 p.

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6 引文斯高帕斯（Scopus）

Predicting the Treatment Outcomes of Antidepressants Using a Deep Neural Network of Deep Learning in Drug-Naïve Major Depressive Patients

Tsai, P. L., Chang, H. H. & Chen, P. S., 2022 5月, 於: Journal of Personalized Medicine. 12, 5, 693.

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3 引文斯高帕斯（Scopus）

Profiling antibody signature of schizophrenia by Escherichia coli proteome microarrays

Chen, B. Y., Hsu, C. C., Chen, Y. Z., Lin, J. J., Tseng, H. H., Jang, F. L., Chen, P. S., Chen, W. N., Chen, C. S. & Lin, S. H., 2022 11月, 於: Brain, Behavior, and Immunity. 106, p. 11-20 10 p.

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8 引文斯高帕斯（Scopus）

Roles of C-reactive protein polymorphisms and life event changes on cognitive function in bipolar patients receiving valproate

Chen, P. S., Tang, L. Y. & Chang, H. H., 2022 3月 8, 於: International Journal of Immunopathology and Pharmacology. 36

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3 引文斯高帕斯（Scopus）

Serotonin Modulates the Correlations between Obsessive-compulsive Trait and Heart Rate Variability in Normal Healthy Subjects: A SPECT Study with [¹²³I]ADAM and Heart Rate Variability Measurement

Kuo, C. Y., Chen, K. C., Hui Lee, I., Tseng, H. H., Chiu, N. T., Chen, P. S., Yang, Y. K. & Chang, W. H., 2022 5月, 於: Clinical Psychopharmacology and Neuroscience. 20, 2, p. 271-278 8 p.

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3 引文斯高帕斯（Scopus）

Sex differences in the diagnosis of autism spectrum disorder and effects of comorbid mental retardation and attention-deficit hyperactivity disorder

Tang, C. H., Chi, M. H., Hsieh, Y. T., Lee, T. I., Tai, Y. C., Lien, Y. J., Yang, Y. K. & Chen, P. S., 2022 1月, 於: Journal of the Formosan Medical Association. 121, 1, p. 210-217 8 p.

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5 引文斯高帕斯（Scopus）

Striatal dopamine D 2/3 receptors in medication-naïve schizophrenia: an [¹²³I] IBZM SPECT study

Chen, K. C., Yang, Y. K., Howes, O. D., Lee, I. H., Yeh, T. L., Chiu, N. T., Chen, P. S., David, A. S. & Bramon, E., 2022 10月 8, 於: Psychological Medicine. 52, 14, p. 3251-3259 9 p.

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