如果您對這些純文本內容做了任何改變,很快就會看到。

研究成果 2005 2019

篩選
Article
2019
1 引文 (Scopus)
Fibroblast Growth Factor 9
Corpus Striatum
Huntington Disease
Oxidative stress
Oxidative Stress

Lactoferrin Protects Hyperoxia-Induced Lung and Kidney Systemic Inflammation in an In Vivo Imaging Model of NF-κB/Luciferase Transgenic Mice

Yen, C. C., Chang, W. H., Tung, M. C., Chen, H. L., Liu, H. C., Liao, C. H., Lan, Y. W., Chong, K. Y., Yang, S-H. & Chen, C. M., 2019 一月 1, 於 : Molecular Imaging and Biology.

研究成果: Article

Hyperoxia
Lactoferrin
Luciferases
Transgenic Mice
Inflammation
2018
5 引文 (Scopus)

FGF9/FGFR2 increase cell proliferation by activating ERK1/2, Rb/E2F1, and cell cycle pathways in mouse Leydig tumor cells

Chang, M. M., Lai, M. S., Hong, S. Y., Pan, B. S., Huang, H., Yang, S-H., Wu, C-C., Sun, H-F., Chuang, J-I., Wang, C-Y. & Huang, B-M., 2018 十一月 1, 於 : Cancer Science. 109, 11, p. 3503-3518 16 p.

研究成果: Article

Fibroblast Growth Factor 9
Leydig Cell Tumor
Fibroblast Growth Factor Receptors
Retinoblastoma
Fibroblast Growth Factor 2
3 引文 (Scopus)

Fibroblast Growth Factor 9 Suppresses Striatal Cell Death Dominantly Through ERK Signaling in Huntington's Disease

Yusuf, I. O., Cheng, P. H., Chen, H. M., Chang, Y. F., Chang, C. Y., Yang, H. I., Lin, C. W., Tsai, S-J., Chuang, J-I., Wu, C-C., Huang, B-M., Sun, H-F. & Yang, S-H., 2018 八月 1, 於 : Cellular Physiology and Biochemistry. 48, 2, p. 605-617 13 p.

研究成果: Article

Fibroblast Growth Factor 9
Corpus Striatum
Huntington Disease
Cell Death
MAP Kinase Signaling System
2017
3 引文 (Scopus)

A novel osteoporosis model with ascorbic acid deficiency in Akr1A1 gene knockout mice

Lai, C. W., Chen, H. L., Tu, M. Y., Lin, W. Y., Röhrig, T., Yang, S-H., Lan, Y. W., Chong, K. Y. & Chen, C. M., 2017 一月 1, 於 : Oncotarget. 8, 5, p. 7357-7369 13 p.

研究成果: Article

Ascorbic Acid Deficiency
Gene Knockout Techniques
Knockout Mice
Ascorbic Acid
Osteoporosis
4 引文 (Scopus)
CCAAT-Enhancer-Binding Protein-delta
Blood Vessels
Macrophages
Lipids
Apolipoproteins E
3 引文 (Scopus)

miR-196a enhances neuronal morphology through suppressing RANBP10 to provide neuroprotection in Huntington's disease

Her, L-S., Mao, S. H., Chang, C. Y., Cheng, P. H., Chang, Y. F., Yang, H. I., Chen, C. M. & Yang, S-H., 2017 一月 1, 於 : Theranostics. 7, 9, p. 2452-2462 11 p.

研究成果: Article

Huntington Disease
Carrier Proteins
Aptitude
MicroRNAs
Neuronal Plasticity
10 引文 (Scopus)

The truncated C-terminal fragment of mutant ATXN3 disrupts mitochondria dynamics in spinocerebellar ataxia type 3 models

Hsu, J. Y., Jhang, Y. L., Cheng, P. H., Chang, Y. F., Mao, S. H., Yang, H. I., Lin, C. W., Chen, C. M. & Yang, S. H., 2017 六月 20, 於 : Frontiers in Molecular Neuroscience. 10, 196.

研究成果: Article

Machado-Joseph Disease
Mitochondria
Mitochondrial Dynamics
Transgenic Mice
Cell Death
2016
3 引文 (Scopus)

Lentiviral transgenesis in mice via a simple method of viral concentration

Cheng, P. H., Chang, Y. F., Mao, S. H., Lin, H. L., Chen, C. M. & Yang, S-H., 2016 三月 31, 於 : Theriogenology. 86, 6, p. 1427-1435 9 p.

研究成果: Article

Gene Transfer Techniques
Lentivirus
Genetically Modified Animals
genetically modified organisms
mice
5 引文 (Scopus)

Myostatin propeptide gene delivery by gene gun ameliorates muscle atrophy in a rat model of botulinum toxin-induced nerve denervation

Tsai, S. W., Tung, Y. T., Chen, H. L., Yang, S-H., Liu, C. Y., Lu, M., Pai, H. J., Lin, C. C. & Chen, C. M., 2016 二月 1, 於 : Life Sciences. 146, p. 15-23 9 p.

研究成果: Article

Myostatin
Muscular Atrophy
Botulinum Toxins
Firearms
Denervation
4 引文 (Scopus)

Sexually Dimorphic Expression of eGFP Transgene in the Akr1A1 Locus of Mouse Liver Regulated by Sex Hormone-Related Epigenetic Remodeling

Lai, C. W., Chen, H. L., Tsai, T. C., Chu, T. W., Yang, S-H., Chong, K. Y. & Chen, C. M., 2016 四月 18, 於 : Scientific reports. 6, 24023.

研究成果: Article

Gonadal Steroid Hormones
Transgenes
Epigenomics
Liver
Gene Expression
3 引文 (Scopus)
Fibroblast Growth Factor 9
Fibroblasts
Testis
Spermatids
Leydig Cells
8 引文 (Scopus)

Using Dual Fluorescence Reporting Genes to Establish an In Vivo Imaging Model of Orthotopic Lung Adenocarcinoma in Mice

Lai, C. W., Chen, H. L., Yen, C. C., Wang, J. L., Yang, S-H. & Chen, C. M., 2016 十二月 1, 於 : Molecular Imaging and Biology. 18, 6, p. 849-859 11 p.

研究成果: Article

Fluorescence
Lung
Genes
Lung Neoplasms
Neoplasms
2015
20 引文 (Scopus)
Methyltransferases
Endometriosis
MicroRNAs
Messenger RNA
DNA
34 引文 (Scopus)

Early Parkinson's disease symptoms in α-synuclein transgenic monkeys

Niu, Y., Guo, X., Chen, Y., Wang, C. E., Gao, J., Yang, W., Kang, Y., Si, W., Wang, H., Yang, S-H., Li, S., Ji, W. & Li, X. J., 2015 四月 15, 於 : Human Molecular Genetics. 24, 8, p. 2308-2317 10 p., ddu748.

研究成果: Article

Synucleins
Haplorhini
Parkinson Disease
Dopaminergic Neurons
Anxiety
21 引文 (Scopus)

Extracellular superoxide dismutase ameliorates streptozotocin-induced rat diabetic nephropathy via inhibiting the ROS/ERK1/2 signaling

Kuo, C. W., Shen, C. J., Tung, Y. T., Chen, H. L., Chen, Y. H., Chang, W. H., Cheng, K. C., Yang, S-H. & Chen, C. M., 2015 六月 22, 於 : Life Sciences. 135, p. 77-86 10 p.

研究成果: Article

Diabetic Nephropathies
Streptozocin
Mitogen-Activated Protein Kinases
Transforming Growth Factor beta
Superoxide Dismutase
15 引文 (Scopus)
Fibroblast Growth Factor 9
Fibroblast Growth Factor Receptors
Cyclic AMP Response Element-Binding Protein
Heme Oxygenase-1
Oxidation-Reduction
91 引文 (Scopus)

Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9

Chen, Y., Zheng, Y., Kang, Y., Yang, W., Niu, Y., Guo, X., Tu, Z., Si, C., Wang, H., Xing, R., Pu, X., Yang, S-H., Li, S., Ji, W. & Li, X. J., 2015 七月 1, 於 : Human Molecular Genetics. 24, 13, p. 3764-3774 11 p., ddv120.

研究成果: Article

Clustered Regularly Interspaced Short Palindromic Repeats
Dystrophin
Macaca mulatta
Haplorhini
Mutation
48 引文 (Scopus)

MicroRNA-145 as one negative regulator of astrogliosis

Wang, C. Y., Yang, S-H. & Tzeng, S-F., 2015 二月 1, 於 : GLIA. 63, 2, p. 194-205 12 p.

研究成果: Article

MicroRNAs
Astrocytes
Spinal Cord Injuries
Spinal Cord
Down-Regulation
6 引文 (Scopus)

SMN is required for the maintenance of embryonic stem cells and neuronal differentiation in mice

Chang, W. F., Xu, J., Chang, C. C., Yang, S-H., Li, H. Y., Hsieh-Li, H. M., Tsai, M. H., Wu, S. C., Cheng, W. T. K., Liu, J. L. & Sung, L. Y., 2015 五月 1, 於 : Brain Structure and Function. 220, 3, p. 1539-1553 15 p.

研究成果: Article

Motor Neurons
Embryonic Stem Cells
Cell Differentiation
Maintenance
Spinal Muscular Atrophy
13 引文 (Scopus)

Synergy of endothelial and neural progenitor cells from adipose-derived stem cells to preserve neurovascular structures in rat hypoxic-ischemic brain injury

Hsueh, Y-Y., Chang, Y. J., Huang, C. W., Handayani, F., Chiang, Y. L., Fan, S. C., Ho, C. J., Kuo, Y-M., Yang, S-H., Chen, Y-L., Lin, S. C., Huang, C-C. & Wu, C-C., 2015 十月 8, 於 : Scientific reports. 5, 14985.

研究成果: Article

Brain Injuries
Stem Cells
Neuropilin-1
Receptor, Fibroblast Growth Factor, Type 1
CXC Chemokines
2 引文 (Scopus)

The Differential Profiling of Ubiquitin-Proteasome and Autophagy Systems in Different Tissues before the Onset of Huntington's Disease Models

Her, L-S., Lin, J. Y., Fu, M. H., Chang, Y. F., Li, C. L., Tang, T. Y., Jhang, Y. L., Chang, C. Y., Shih, M. C., Cheng, P. H. & Yang, S-H., 2015 七月 1, 於 : Brain Pathology. 25, 4, p. 481-490 10 p.

研究成果: Article

Huntington Disease
Autophagy
Proteasome Endopeptidase Complex
Ubiquitin
Inborn Genetic Diseases
12 引文 (Scopus)

The potential regulatory mechanisms of MIR-196a in huntington's disease through bioinformatic analyses

Fu, M. H., Li, C. L., Lin, H. L., Tsai, S. J., Lai, Y. Y., Chang, Y. F., Cheng, P. H., Chen, C. M. & Yang, S. H., 2015 九月 16, 於 : PloS one. 10, 9, A1247.

研究成果: Article

Huntington Disease
Bioinformatics
cytoskeleton
Computational Biology
Cytoskeleton
2014
9 引文 (Scopus)

Lactoferrin protects against chemical-induced rat liver fibrosis by inhibiting stellate cell activation

Tung, Y. T., Tang, T. Y., Chen, H. L., Yang, S-H., Chong, K. Y., Cheng, W. T. K. & Chen, C. M., 2014 一月 1, 於 : Journal of Dairy Science. 97, 6, p. 3281-3291 11 p.

研究成果: Article

liver cirrhosis
Lactoferrin
lactoferrin
Liver Cirrhosis
Dimethylnitrosamine
2 引文 (Scopus)

Recombinant derp5 allergen with αS1-casein signal peptide secreted in murine milk protects against dust mite allergen-induced airway inflammation

Liu, H. C., Pai, S. Y., Chen, H. L., Lai, C. W., Tsai, T. C., Cheng, W. T. K., Yang, S-H. & Chen, C. M., 2014 十一月 1, 於 : Journal of Dairy Science. 97, 11, p. 6792-6803 12 p.

研究成果: Article

dust mites
Mites
Protein Sorting Signals
Caseins
allergens
2013
8 引文 (Scopus)

Ingestion of milk containing the Dp2 peptide, a dust mite allergen, protects mice from allergic airway inflammation and hyper-responsiveness

Liu, H. C., Pai, S. Y., Cheng, W. T. K., Chen, H. L., Tsai, T. C., Yang, S-H. & Chen, C. M., 2013 六月 13, 於 : Allergy, Asthma and Clinical Immunology. 9, 1, 21.

研究成果: Article

Respiratory Hypersensitivity
Mites
Dust
Allergens
Milk
10 引文 (Scopus)

Longitudinal transcriptomic dysregulation in the peripheral blood of transgenic Huntington's disease monkeys

Kocerha, J., Liu, Y., Willoughby, D., Chidamparam, K., Benito, J., Nelson, K., Xu, Y., Chi, T., Engelhardt, H., Moran, S., Yang, S-H., Li, S. H., Li, X. J., Larkin, K., Neumann, A., Banta, H., Yang, J. J. & Chan, A. W. S., 2013 八月 17, 於 : BMC Neuroscience. 14, 88.

研究成果: Article

Huntington Disease
Haplorhini
Primate Diseases
Disease Progression
Neurodegenerative Diseases
47 引文 (Scopus)

MiR-196a ameliorates phenotypes of huntington disease in cell, transgenic mouse, and induced pluripotent stem cell models

Cheng, P. H., Li, C. L., Chang, Y. F., Tsai, S-J., Lai, Y. Y., Chan, A. W. S., Chen, C. M. & Yang, S-H., 2013 八月 8, 於 : American Journal of Human Genetics. 93, 2, p. 306-312 7 p.

研究成果: Article

Induced Pluripotent Stem Cells
Huntington Disease
Transgenic Mice
Phenotype
MicroRNAs
14 引文 (Scopus)

Overexpression of Smad proteins, especially Smad7, in oral epithelial dysplasias

Chen, Y. K., Huang, A. H. C., Cheng, P. H., Yang, S-H. & Lin, L. M., 2013 一月 1, 於 : Clinical Oral Investigations. 17, 3, p. 921-932 12 p.

研究成果: Article

Smad Proteins
Squamous Cell Carcinoma
Mouth Mucosa
Hyperplasia
Transforming Growth Factors
13 引文 (Scopus)
Huntington Disease
Green Fluorescent Proteins
Transgenic Mice
Brain
Exons
13 引文 (Scopus)
Andrographis
Neoplasms
Lung
Vascular Endothelial Growth Factor A
Therapeutics
2012
18 引文 (Scopus)

Differential differences in methylation status of putative imprinted genes among cloned swine genomes

Shen, C. J., Cheng, W. T. K., Wu, S. C., Chen, H. L., Tsai, T. C., Yang, S-H. & Chen, C. M., 2012 二月 29, 於 : PloS one. 7, 2, e32812.

研究成果: Article

Methylation
methylation
Swine
Epigenomics
epigenetics
72 引文 (Scopus)
Phosphorylation
Stromal Cells
MicroRNAs
Gene expression
Gene Expression
2011
8 引文 (Scopus)
Cheek
Transforming Growth Factors
Cricetinae
Carcinogenesis
Epithelial Cells
7 引文 (Scopus)

Characterization of dental pulp stem/stromal cells of Huntington monkey tooth germs

Snyder, B. R., Cheng, P. H., Yang, J., Yang, S-H., Huang, A. H. C. & Chan, A. W. S., 2011 九月 12, 於 : BMC Cell Biology. 12, 39.

研究成果: Article

Tooth Germ
Dental Pulp
Stromal Cells
Haplorhini
Stem Cells
2010
23 引文 (Scopus)

Granzyme G is expressed in the two-cell stage mouse embryo and is required for the maternal-zygotic transition

Tsai, T. C., Lin, W., Yang, S-H., Cheng, W. T. K., Cheng, E. H., Lee, M. S., Chong, K. Y. & Chen, C. M., 2010 八月 16, 於 : BMC Developmental Biology. 10, 88.

研究成果: Article

Granzymes
Embryonic Structures
Mothers
Embryonic Development
Clone Cells
13 引文 (Scopus)

Monkey hybrid stem cells develop cellular features of Huntington's disease

Laowtammathron, C., Cheng, E. C. H., Cheng, P. H., Snyder, B. R., Yang, S-H., Johnson, Z., Lorthongpanich, C., Kuo, H. C., Parnpai, R. & Chan, A. W. S., 2010 二月 5, 於 : BMC Cell Biology. 11, 12.

研究成果: Article

Hybrid Cells
Huntington Disease
Haplorhini
Stem Cells
Pluripotent Stem Cells
2009
4 引文 (Scopus)

Assisted fertilization and embryonic axis formation in higher primates

Piotrowska-Nitsche, K., Yang, S-H., Banta, H. & Chan, A. W. S., 2009 一月 1, 於 : Reproductive BioMedicine Online. 18, 3, p. 382-390 9 p.

研究成果: Article

Fertilization
Primates
Spermatozoa
Intracytoplasmic Sperm Injections
Embryonic Structures
58 引文 (Scopus)

Noninvasive monitoring of embryonic stem cells in vivo with MRI transgene reporter

Liu, J., Cheng, E. C. H., Long, R. C., Yang, S-H., Wang, L., Cheng, P. H., Yang, J., Wu, D., Mao, H. & Chan, A. W. S., 2009 十二月 1, 於 : Tissue Engineering - Part C: Methods. 15, 4, p. 739-747 9 p.

研究成果: Article

Magnetic resonance
Embryonic Stem Cells
Stem cells
Transgenes
Magnetic Resonance Imaging
18 引文 (Scopus)

Production of germline transgenic prairie voles (Microtus ochrogaster) using lentiviral vectors

Donaldson, Z. R., Yang, S-H., Chan, A. W. S. & Young, L. J., 2009 十二月 1, 於 : Biology of Reproduction. 81, 6, p. 1189-1195 7 p.

研究成果: Article

Arvicolinae
Green Fluorescent Proteins
Transgenes
Rodentia
Ubiquitin C
2008
96 引文 (Scopus)

Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease

Wang, C. E., Tydlacka, S., Orr, A. L., Yang, S-H., Graham, R. K., Hayden, M. R., Li, S., Chan, A. W. S. & Li, X. J., 2008 八月 22, 於 : Human Molecular Genetics. 17, 17, p. 2738-2751 14 p.

研究成果: Article

Huntington Disease
Haplorhini
Phenotype
Neurological Models
Neuropil
7 引文 (Scopus)

Chemical enhancement in embryo development and stem cell derivation from single blastomeres

Lorthongpanich, C., Yang, S-H., Piotrowska-Nitsche, K., Parnpai, R. & Chan, A. W. S., 2008 十二月 1, 於 : Cloning and Stem Cells. 10, 4, p. 503-512 10 p.

研究成果: Article

Blastomeres
Embryonic Development
Stem Cells
Mitogen-Activated Protein Kinase 14
Adrenocorticotropic Hormone
30 引文 (Scopus)

Development of single mouse blastomeres into blastocysts, outgrowths and the establishment of embryonic stem cells

Lorthongpanich, C., Yang, S-H., Piotrowska-Nitsche, K., Parnpai, R. & Chan, A. W. S., 2008 六月 1, 於 : Reproduction. 135, 6, p. 805-813 9 p.

研究成果: Article

Blastomeres
Blastocyst
Embryonic Stem Cells
Embryonic Structures
Cell Line
12 引文 (Scopus)

Lentiviral integration preferences in transgenic mice

Yang, S-H., Cheng, P. H., Sulivan, R. T., Thomas, J. W. & Chan, A. W. S., 2008 十二月 1, 於 : Genesis. 46, 12, p. 711-718 8 p.

研究成果: Article

Lentivirus
Transgenic Mice
Genome
CpG Islands
Transcription Initiation Site
295 引文 (Scopus)

Towards a transgenic model of Huntington's disease in a non-human primate

Yang, S-H., Cheng, P. H., Banta, H., Piotrowska-Nitsche, K., Yang, J. J., Cheng, E. C. H., Snyder, B., Larkin, K., Liu, J., Orkin, J., Fang, Z. H., Smith, Y., Bachevalier, J., Zola, S. M., Li, S. H., Li, X. J. & Chan, A. W. S., 2008 六月 12, 於 : Nature. 453, 7197, p. 921-924 4 p.

研究成果: Article

Huntington Disease
Primates
Haplorhini
Brain
Trinucleotide Repeats
2007
11 引文 (Scopus)

Enhanced transgenesis by intracytoplasmic injection of envelope-free lentivirus

Yang, S-H., Agca, Y., Cheng, P. H., Yang, J. J., Agca, C. & Chan, A. W. S., 2007 四月 1, 於 : Genesis. 45, 4, p. 177-183 7 p.

研究成果: Article

Gene Transfer Techniques
Lentivirus
Green Fluorescent Proteins
Injections
Zygote
2005
23 引文 (Scopus)

Production of recombinant porcine lactoferrin exhibiting antibacterial activity in methylotrophic yeast, Pichia pastoris

Chen, H. L., Lai, Y. W., Yen, C. C., Lin, Y. Y., Lu, C. Y., Yang, S-H., Tsai, T. C., Lin, Y. J., Lin, C. W. & Chen, C. M., 2005 七月 1, 於 : Journal of Molecular Microbiology and Biotechnology. 8, 3, p. 141-149 9 p.

研究成果: Article

Lactoferrin
Pichia
Swine
Yeasts
Mating Factor