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研究成果 1987 2019

2019

Combination of modified NS1 and NS3 as a novel vaccine strategy against dengue virus infection

Kao, Y. S., Yu, C. Y., Huang, H. J., Tien, S. M., Wang, W. Y., Yang, M., Anderson, R., Yeh, T. M., Lin, Y. S. & Wan, S. W., 2019 十月 1, 於 : Journal of Immunology. 203, 7, p. 1909-1917 9 p.

研究成果: Article

Dengue Virus
Virus Diseases
Vaccines
Severe Dengue
Cellular Immunity
3 引文 (Scopus)

Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage

Chao, C. H., Wu, W. C., Lai, Y. C., Tsai, P. J., Perng, G-C., Lin, Y. S. & Yeh, T-M., 2019 一月 1, 於 : PLoS pathogens. 15, 4, e1007625.

研究成果: Article

開啟存取
Dengue Virus
Toll-Like Receptor 4
Thrombocytopenia
Blood Platelets
Hemorrhage
Autophagy
Blood Vessels
Sepsis
Cytokines
Lipopolysaccharides
2018
17 引文 (Scopus)
Virus Activation
Dengue Virus
Endoplasmic Reticulum Stress
Autophagy
Virus Diseases
1 引文 (Scopus)
Viral Structural Proteins
Severe Dengue
Dengue Virus
Viruses
Vaccines
5 引文 (Scopus)

Macrophage Migration Inhibitory Factor-Induced Autophagy Contributes to Thrombin-Triggered Endothelial Hyperpermeability in Sepsis

Chao, C. H., Chen, H. R., Chuang, Y. C. & Yeh, T-M., 2018 七月 1, 於 : Shock. 50, 1, p. 103-111 9 p.

研究成果: Article

Macrophage Migration-Inhibitory Factors
Autophagy
Thrombin
Sepsis
Blood Vessels
4 引文 (Scopus)
Macrophage Migration-Inhibitory Factors
Glycocalyx
Dengue
Metalloproteases
Proteins
3 引文 (Scopus)
Macrophage Migration-Inhibitory Factors
Dengue Virus
Minocycline
Autophagy
Virus Replication

合成多肽、包含該合成多肽之疫苗組合物及其用途

Yeh, T-M. & LAI, YEN-CHUNG., 2018 八月 16, 專利號 (申請號)106136365, 2017 十月 23

研究成果: Patent

評估個體之登革熱病毒感染嚴重程度的方法

HO, TZONG. SHIANN., CHUANG, YUNG. CHUN., HSU, PO. CHIH., CHENG, YU. WEI., LIU, CHING. CHUANG. & Yeh, T-M., 2018 五月 21, 專利號 I624668, 2017 五月 12, 優先日期 2037 五月 11

研究成果: Patent

2017
7 引文 (Scopus)

Antibodies Against Modified NS1 Wing Domain Peptide Protect Against Dengue Virus Infection

Lai, Y. C., Chuang, Y. C., Liu, C-C., Ho, T-S., Lin, Y-S., Anderson, R. & Yeh, T-M., 2017 十二月 1, 於 : Scientific reports. 7, 1, 6975.

研究成果: Article

Dengue Virus
Virus Diseases
Antibodies
Proteins
Dengue
4 引文 (Scopus)

Honeysuckle aqueous extract and induced let-7a suppress dengue virus type 2 replication and pathogenesis

Lee, Y. R., Yeh, S. F., Ruan, X. M., Zhang, H., Hsu, S. D., Huang, H. D., Hsieh, C. C., Lin, Y-S., Yeh, T-M., Liu, H-S. & Gan, D. D., 2017 二月 23, 於 : Journal of Ethnopharmacology. 198, p. 109-121 13 p.

研究成果: Article

Lonicera
Dengue Virus
Virus Replication
MicroRNAs
High-Throughput Nucleotide Sequencing
8 引文 (Scopus)

Therapeutic effects of monoclonal antibody against dengue virus NS1 in a STAT1 knockout mouse model of dengue infection

Wan, S. W., Chen, P. W., Chen, C. Y., Lai, Y. C., Chu, Y. T., Hung, C. Y., Lee, H., Wu, H. F., Chuang, Y. C., Lin, J., Chang, C-P., Wang, S-Y., Liu, C-C., Ho, T-S., Lin, C. F., Lee, C. K., Wu-Hsieh, B. A., Anderson, R., Yeh, T-M. & Lin, Y-S., 2017 十月 15, 於 : Journal of Immunology. 199, 8, p. 2834-2844 11 p.

研究成果: Article

Dengue Virus
Dengue
Therapeutic Uses
Knockout Mice
Monoclonal Antibodies
2016
8 引文 (Scopus)

Anti-dengue virus nonstructural protein 1 antibodies contribute to platelet phagocytosis by macrophages

Wan, S. W., Yang, Y. W., Chu, Y. T., Lin, C. F., Chang, C-P., Yeh, T-M., Anderson, R. & Lin, Y-S., 2016 一月 1, 於 : Thrombosis and Haemostasis. 115, 3, p. 646-656 11 p.

研究成果: Article

Dengue Virus
Phagocytosis
Blood Platelets
Macrophages
Antibodies
15 引文 (Scopus)
Severe Dengue
Dengue Virus
Plasminogen
Antibodies
Proteins
30 引文 (Scopus)
Macrophage Migration-Inhibitory Factors
Dengue Virus
Severe Dengue
Autophagy
Blood Vessels

SYNTHETIC POLYPEPTIDE, VACCINE COMPOSITION COMPRISING THE SAME, AND USES THEREOF

Yeh, T-M. & 賴彥仲, 2016 十月 21, 專利號 (美國臨時專利)62411493

研究成果: Patent

2015
6 引文 (Scopus)
Dengue Virus
Dengue
Autoantigens
Protein Disulfide-Isomerases
Immunoglobulin M
5 引文 (Scopus)
Macrophage Migration-Inhibitory Factors
Autophagy
Concanavalin A
Hepatocellular Carcinoma
Cell Death
22 引文 (Scopus)

Macrophage migration inhibitory factor induces vascular leakage via autophagy

Chen, H. R., Chuang, Y. C., Chao, C. H. & Yeh, T-M., 2015 二月 15, 於 : Biology Open. 4, 2, p. 244-252 9 p.

研究成果: Article

Macrophage Migration-Inhibitory Factors
autophagy
Autophagy
blood vessels
Blood Vessels
17 引文 (Scopus)

Pathogenic roles of macrophage migration inhibitory factor during dengue virus infection

Chuang, Y. C., Chen, H. R. & Yeh, T-M., 2015 一月 1, 於 : Mediators of Inflammation. 2015, 547094.

研究成果: Review article

Macrophage Migration-Inhibitory Factors
Severe Dengue
Dengue Virus
Virus Diseases
Viral Hemorrhagic Fevers

抗登革熱病毒非結構性蛋白1之單株抗體及其用途

Lin, Y-S. & Yeh, T-M., 2015 十二月 11, 專利號 I511977, 2014 二月 27, 優先日期 2034 二月 26

研究成果: Patent

2014

Lessons learned from dengue: Focus on Taiwan

Ho, T-S., Lin, C. F., Liu, C-C., Yeh, T-M., Anderson, R. & Lin, Y-S., 2014 二月 1, Clinical Insights: Dengue: Transmission, Diagnosis & Surveillance. Future Medicine Ltd., p. 49-64 16 p.

研究成果: Chapter

Dengue Vaccines
Dengue
Taiwan
Epidemiology
Viruses
13 引文 (Scopus)

Macrophage migration inhibitory factor triggers chemotaxis of CD74+CXCR2+NKT cells in chemically induced IFN-γ-Mediated skin inflammation

Hsieh, C. Y., Chen, C. L., Lin, Y-S., Yeh, T-M., Tsai, T. T., Hong, M-Y. & Lin, C. F., 2014 十月 1, 於 : Journal of Immunology. 193, 7, p. 3693-3703 11 p.

研究成果: Article

Macrophage Migration-Inhibitory Factors
Natural Killer T-Cells
Chemotaxis
Inflammation
Skin
14 引文 (Scopus)
molecular mimicry
Molecular Mimicry
fibrinolysis
Dengue virus
Dengue Virus

MONOCLONAL ANTIBODY ACTIVATING PLASMINOGEN AND METHOD FOR PRODUCING THE SAME TO TREAT STROKE, MYOCARDIAL INFARCTION OR OTHER SYNDROMES CAUSED BY BLOOD CLOT

貢獻的翻譯標題: 活化纖維蛋白溶?原之抗體、其用途與製備方法以及含有其之製劑Yeh, T-M. & CHUANG, YUNG. CHUN., 2014 七月 22, 專利號 100-294AP

研究成果: Patent

23 引文 (Scopus)

Protection against dengue virus infection in mice by administration of antibodies against modified nonstructural protein 1

Wan, S. W., Lu, Y. T., Huang, C. H., Lin, C. F., Anderson, R., Liu, H-S., Yeh, T-M., Yen, Y. T., Wu-Hsieh, B. A. & Lin, Y-S., 2014 三月 21, 於 : PloS one. 9, 3, e92495.

研究成果: Article

Dengue virus
Dengue Virus
Virus Diseases
Viruses
antibodies
3 引文 (Scopus)

Ripple structure-generated hybrid electrokinetics for on-chip mixing and separating of functionalized beads

Cheng, I. F., Chiang, S. C., Chung, C. C., Yeh, T-M. & Chang, H-C., 2014 十二月 30, 於 : Biomicrofluidics. 8, 6, 066501.

研究成果: Article

Electroosmosis
Convection
Microfluidics
electrokinetics
ripples

活化纖維蛋白溶酶原之抗體、其用途以及含有其之製劑

貢獻的翻譯標題: 活化纖維蛋白溶?原之抗體、其用途以及含有其之製劑Yeh, T-M. & CHUANG, YUNG. CHUN., 2014 二月 21, 專利號 I427085, 2011 十二月 28, 優先日期 2031 十二月 27

研究成果: Patent

黃病毒科病毒感染之檢測方法

貢獻的翻譯標題: 黃病毒科病毒感染之檢測方法Yeh, T-M., CHUANG, YUNG. CHUN. & LIN, SHI. WEI., 2014 三月 1, 專利號 I428598, 2011 十一月 23, 優先日期 2031 十一月 22

研究成果: Patent

2013
17 引文 (Scopus)
Herpetic Keratitis
keratitis
Keratitis
neutrophils
cornea
12 引文 (Scopus)
Dengue
Thrombin
Antibodies
Severe Dengue
Dengue Virus
21 引文 (Scopus)

Anti-dengue virus nonstructural protein 1 antibodies cause NO-mediated endothelial cell apoptosis via ceramide-regulated glycogen synthase kinase-3β and NF-κB activation

Chen, C. L., Lin, C. F., Wan, S. W., Wei, L. S., Chen, M. C., Yeh, T-M., Liu, H-S., Anderson, R. & Lin, Y-S., 2013 八月 15, 於 : Journal of Immunology. 191, 4, p. 1744-1752 9 p.

研究成果: Article

Glycogen Synthase Kinase 3
Dengue Virus
Ceramides
Endothelial Cells
Apoptosis
41 引文 (Scopus)

Autoimmunity in dengue pathogenesis

Wan, S. W., Lin, C. F., Yeh, T-M., Liu, C-C., Liu, H-S., Wang, S-Y., Ling, P., Anderson, R., Lei, H. Y. & Lin, Y-S., 2013 一月 1, 於 : Journal of the Formosan Medical Association. 112, 1, p. 3-11 9 p.

研究成果: Review article

Dengue Virus
Dengue
Severe Dengue
Autoimmunity
Virus Diseases
48 引文 (Scopus)

Current progress in dengue vaccines

Wan, S. W., Lin, C. F., Wang, S-Y., Chen, Y-H., Yeh, T-M., Liu, H-S., Anderson, R. & Lin, Y-S., 2013 六月 17, 於 : Journal of biomedical science. 20, 1, 37.

研究成果: Review article

Dengue Vaccines
Viruses
Severe Dengue
Attenuated Vaccines
Dengue
19 引文 (Scopus)

Dengue Virus Enhances Thrombomodulin and ICAM-1 Expression through the Macrophage Migration Inhibitory Factor Induction of the MAPK and PI3K Signaling Pathways

Yeh, T-M., Liu, S. H., Lin, K. C., Kuo, C., Kuo, S. Y., Huang, T. Y., Yen, Y. R., Wen, R. K., Chen, L. C. & Fu, T. F., 2013 一月 28, 於 : PloS one. 8, 1, e55018.

研究成果: Article

Macrophage Migration-Inhibitory Factors
Thrombomodulin
Dengue virus
Dengue Virus
phosphatidylinositol 3-kinase
47 引文 (Scopus)

Dengue virus infection induces autophagy: An in vivo study

Lee, Y. R., Hu, H. Y., Kuo, S. H., Lei, H. Y., Lin, Y-S., Yeh, T-M., Liu, C-C. & Liu, H-S., 2013 九月 11, 於 : Journal of biomedical science. 20, 1, 65.

研究成果: Article

Dengue Virus
Autophagy
Virus Diseases
Viruses
Virus Replication
17 引文 (Scopus)

Factors contributing to the disturbance of coagulation and fibrinolysis in dengue virus infection

Chuang, Y. C., Lin, Y-S., Liu, C-C., Liu, H-S., Liao, S. H., Shi, M. D., Lei, H. Y. & Yeh, T-M., 2013 一月 1, 於 : Journal of the Formosan Medical Association. 112, 1, p. 12-17 6 p.

研究成果: Review article

Dengue Virus
Fibrinolysis
Virus Diseases
Hemorrhage
Severe Dengue
22 引文 (Scopus)
Propolis
Alveolar Epithelial Cells
Epithelial-Mesenchymal Transition
PPAR gamma
Transforming Growth Factors
17 引文 (Scopus)
Severe Dengue
Dengue Virus
Virus Diseases
Viruses
Antibodies
2012
45 引文 (Scopus)

Dengue virus nonstructural protein NS1 binds to prothrombin/thrombin and inhibits prothrombin activation

Lin, S. W., Chuang, Y. C., Lin, Y-S., Lei, H. Y., Liu, H-S. & Yeh, T-M., 2012 三月 1, 於 : Journal of Infection. 64, 3, p. 325-334 10 p.

研究成果: Article

Dengue Virus
Prothrombin
Thrombin
Dengue
Hemorrhage
41 引文 (Scopus)

Macrophage migration inhibitory factor induces autophagy via reactive oxygen species generation

Chuang, Y. C., Su, W. H., Lei, H. Y., Lin, Y-S., Liu, H-S., Chang, C-P. & Yeh, T-M., 2012 五月 22, 於 : PloS one. 7, 5, e37613.

研究成果: Article

Macrophage Migration-Inhibitory Factors
autophagy
Autophagy
reactive oxygen species
Reactive Oxygen Species
8 引文 (Scopus)

Macrophage migration inhibitory factor induces ICAM-1and thrombomobulin expression in vitro

Shyu, L. Y., Yeh, T-M., Chang, H. H., Lin, D. P. C., Teng, Y. H., Chen, L. C. & Lee, H. H., 2012 一月 1, 於 : Thrombosis Research. 129, 1, p. 43-49 7 p.

研究成果: Article

Macrophage Migration-Inhibitory Factors
Thrombomodulin
Intercellular Adhesion Molecule-1
Human Migration
Blood Coagulation Factors
2011
27 引文 (Scopus)

Dengue virus-induced autoantibodies bind to plasminogen and enhance its activation

Chuang, Y. C., Lei, H. Y., Lin, Y. S., Liu, H. S., Wu, H. L. & Yeh, T. M., 2011 十二月 15, 於 : Journal of Immunology. 187, 12, p. 6483-6490 8 p.

研究成果: Article

Severe Dengue
Dengue Virus
Plasminogen
Autoantibodies
Fibrinolysin
46 引文 (Scopus)

Macrophage migration inhibitory factor induced by dengue virus infection increases vascular permeability

Chuang, Y. C., Lei, H. Y., Liu, H-S., Lin, Y-S., Fu, T-F. & Yeh, T-M., 2011 五月 1, 於 : Cytokine. 54, 2, p. 222-231 10 p.

研究成果: Article

Macrophage Migration-Inhibitory Factors
Dengue Virus
Capillary Permeability
Virus Diseases
Viruses
64 引文 (Scopus)

Molecular mimicry between virus and host and its implications for dengue disease pathogenesis

Lin, Y. S., Yeh, T. M., Lin, C. F., Wan, S. W., Chuang, Y. C., Hsu, T. K., Liu, H. S., Liu, C. C., Anderson, R. & Lei, H. Y., 2011 五月 1, 於 : Experimental Biology and Medicine. 236, 5, p. 515-523 9 p.

研究成果: Review article

Molecular Mimicry
Dengue
Dengue Virus
Viruses
Proteins
4 引文 (Scopus)

Zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1

Lin, C. J., Hsiao, T. H., Chung, Y. S., Chang, W. N., Yeh, T-M., Chen, B. H. & Fu, T-F., 2011 三月 1, 於 : Protein Expression and Purification. 76, 1, p. 36-43 8 p.

研究成果: Article

Zebrafish
Zebrafish Proteins
Recombinant Proteins
Proteins
Sp1 Transcription Factor
2010
10 引文 (Scopus)
Annexin A2
Severe Acute Respiratory Syndrome
Coronavirus
Epithelial Cells
Lung
50 引文 (Scopus)

Characteristic of dengue disease in Taiwan: 2002-2007

Lin, C. C., Huang, Y. H., Shu, P. Y., Wu, H. S., Lin, Y-S., Yeh, T-M., Liu, H-S., Liu, C-C. & Lei, H. Y., 2010 四月 1, 於 : American Journal of Tropical Medicine and Hygiene. 82, 4, p. 731-739 9 p.

研究成果: Article

Dengue
Taiwan
Dengue Virus
Infection
Severe Dengue
8 引文 (Scopus)

The dengue virus envelope protein induced PAI-1 gene expression via MEK/ERK pathways

Shyu, H. W., Lin, Y. Y., Chen, L. C., Wang, Y. F., Yeh, T-M., Su, S. J., Cheng, W. C., Chen, C. Y., Lin, K. H. & Chou, M. C., 2010 十二月 1, 於 : Thrombosis and Haemostasis. 104, 6, p. 1219-1227 9 p.

研究成果: Article

Viral Envelope Proteins
Dengue Virus
Plasminogen Activator Inhibitor 1
Mitogen-Activated Protein Kinase Kinases
Extracellular Signal-Regulated MAP Kinases