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研究成果 1987 2019

篩選
Article
2019

Combination of modified NS1 and NS3 as a novel vaccine strategy against dengue virus infection

Kao, Y. S., Yu, C. Y., Huang, H. J., Tien, S. M., Wang, W. Y., Yang, M., Anderson, R., Yeh, T. M., Lin, Y. S. & Wan, S. W., 2019 十月 1, 於 : Journal of Immunology. 203, 7, p. 1909-1917 9 p.

研究成果: Article

Dengue Virus
Virus Diseases
Vaccines
Severe Dengue
Cellular Immunity
3 引文 (Scopus)

Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage

Chao, C. H., Wu, W. C., Lai, Y. C., Tsai, P. J., Perng, G-C., Lin, Y. S. & Yeh, T-M., 2019 一月 1, 於 : PLoS pathogens. 15, 4, e1007625.

研究成果: Article

開啟存取
Dengue Virus
Toll-Like Receptor 4
Thrombocytopenia
Blood Platelets
Hemorrhage
Autophagy
Blood Vessels
Sepsis
Cytokines
Lipopolysaccharides
2018
17 引文 (Scopus)
Virus Activation
Dengue Virus
Endoplasmic Reticulum Stress
Autophagy
Virus Diseases
5 引文 (Scopus)

Macrophage Migration Inhibitory Factor-Induced Autophagy Contributes to Thrombin-Triggered Endothelial Hyperpermeability in Sepsis

Chao, C. H., Chen, H. R., Chuang, Y. C. & Yeh, T-M., 2018 七月 1, 於 : Shock. 50, 1, p. 103-111 9 p.

研究成果: Article

Macrophage Migration-Inhibitory Factors
Autophagy
Thrombin
Sepsis
Blood Vessels
4 引文 (Scopus)
Macrophage Migration-Inhibitory Factors
Glycocalyx
Dengue
Metalloproteases
Proteins
3 引文 (Scopus)
Macrophage Migration-Inhibitory Factors
Dengue Virus
Minocycline
Autophagy
Virus Replication
2017
7 引文 (Scopus)

Antibodies Against Modified NS1 Wing Domain Peptide Protect Against Dengue Virus Infection

Lai, Y. C., Chuang, Y. C., Liu, C-C., Ho, T-S., Lin, Y-S., Anderson, R. & Yeh, T-M., 2017 十二月 1, 於 : Scientific reports. 7, 1, 6975.

研究成果: Article

Dengue Virus
Virus Diseases
Antibodies
Proteins
Dengue
4 引文 (Scopus)

Honeysuckle aqueous extract and induced let-7a suppress dengue virus type 2 replication and pathogenesis

Lee, Y. R., Yeh, S. F., Ruan, X. M., Zhang, H., Hsu, S. D., Huang, H. D., Hsieh, C. C., Lin, Y-S., Yeh, T-M., Liu, H-S. & Gan, D. D., 2017 二月 23, 於 : Journal of Ethnopharmacology. 198, p. 109-121 13 p.

研究成果: Article

Lonicera
Dengue Virus
Virus Replication
MicroRNAs
High-Throughput Nucleotide Sequencing
8 引文 (Scopus)

Therapeutic effects of monoclonal antibody against dengue virus NS1 in a STAT1 knockout mouse model of dengue infection

Wan, S. W., Chen, P. W., Chen, C. Y., Lai, Y. C., Chu, Y. T., Hung, C. Y., Lee, H., Wu, H. F., Chuang, Y. C., Lin, J., Chang, C-P., Wang, S-Y., Liu, C-C., Ho, T-S., Lin, C. F., Lee, C. K., Wu-Hsieh, B. A., Anderson, R., Yeh, T-M. & Lin, Y-S., 2017 十月 15, 於 : Journal of Immunology. 199, 8, p. 2834-2844 11 p.

研究成果: Article

Dengue Virus
Dengue
Therapeutic Uses
Knockout Mice
Monoclonal Antibodies
2016
8 引文 (Scopus)

Anti-dengue virus nonstructural protein 1 antibodies contribute to platelet phagocytosis by macrophages

Wan, S. W., Yang, Y. W., Chu, Y. T., Lin, C. F., Chang, C-P., Yeh, T-M., Anderson, R. & Lin, Y-S., 2016 一月 1, 於 : Thrombosis and Haemostasis. 115, 3, p. 646-656 11 p.

研究成果: Article

Dengue Virus
Phagocytosis
Blood Platelets
Macrophages
Antibodies
15 引文 (Scopus)
Severe Dengue
Dengue Virus
Plasminogen
Antibodies
Proteins
30 引文 (Scopus)
Macrophage Migration-Inhibitory Factors
Dengue Virus
Severe Dengue
Autophagy
Blood Vessels
2015
6 引文 (Scopus)
Dengue Virus
Dengue
Autoantigens
Protein Disulfide-Isomerases
Immunoglobulin M
5 引文 (Scopus)
Macrophage Migration-Inhibitory Factors
Autophagy
Concanavalin A
Hepatocellular Carcinoma
Cell Death
22 引文 (Scopus)

Macrophage migration inhibitory factor induces vascular leakage via autophagy

Chen, H. R., Chuang, Y. C., Chao, C. H. & Yeh, T-M., 2015 二月 15, 於 : Biology Open. 4, 2, p. 244-252 9 p.

研究成果: Article

Macrophage Migration-Inhibitory Factors
autophagy
Autophagy
blood vessels
Blood Vessels
2014
13 引文 (Scopus)

Macrophage migration inhibitory factor triggers chemotaxis of CD74+CXCR2+NKT cells in chemically induced IFN-γ-Mediated skin inflammation

Hsieh, C. Y., Chen, C. L., Lin, Y-S., Yeh, T-M., Tsai, T. T., Hong, M-Y. & Lin, C. F., 2014 十月 1, 於 : Journal of Immunology. 193, 7, p. 3693-3703 11 p.

研究成果: Article

Macrophage Migration-Inhibitory Factors
Natural Killer T-Cells
Chemotaxis
Inflammation
Skin
14 引文 (Scopus)
molecular mimicry
Molecular Mimicry
fibrinolysis
Dengue virus
Dengue Virus
23 引文 (Scopus)

Protection against dengue virus infection in mice by administration of antibodies against modified nonstructural protein 1

Wan, S. W., Lu, Y. T., Huang, C. H., Lin, C. F., Anderson, R., Liu, H-S., Yeh, T-M., Yen, Y. T., Wu-Hsieh, B. A. & Lin, Y-S., 2014 三月 21, 於 : PloS one. 9, 3, e92495.

研究成果: Article

Dengue virus
Dengue Virus
Virus Diseases
Viruses
antibodies
3 引文 (Scopus)

Ripple structure-generated hybrid electrokinetics for on-chip mixing and separating of functionalized beads

Cheng, I. F., Chiang, S. C., Chung, C. C., Yeh, T-M. & Chang, H-C., 2014 十二月 30, 於 : Biomicrofluidics. 8, 6, 066501.

研究成果: Article

Electroosmosis
Convection
Microfluidics
electrokinetics
ripples
2013
17 引文 (Scopus)
Herpetic Keratitis
keratitis
Keratitis
neutrophils
cornea
12 引文 (Scopus)
Dengue
Thrombin
Antibodies
Severe Dengue
Dengue Virus
21 引文 (Scopus)

Anti-dengue virus nonstructural protein 1 antibodies cause NO-mediated endothelial cell apoptosis via ceramide-regulated glycogen synthase kinase-3β and NF-κB activation

Chen, C. L., Lin, C. F., Wan, S. W., Wei, L. S., Chen, M. C., Yeh, T-M., Liu, H-S., Anderson, R. & Lin, Y-S., 2013 八月 15, 於 : Journal of Immunology. 191, 4, p. 1744-1752 9 p.

研究成果: Article

Glycogen Synthase Kinase 3
Dengue Virus
Ceramides
Endothelial Cells
Apoptosis
19 引文 (Scopus)

Dengue Virus Enhances Thrombomodulin and ICAM-1 Expression through the Macrophage Migration Inhibitory Factor Induction of the MAPK and PI3K Signaling Pathways

Yeh, T-M., Liu, S. H., Lin, K. C., Kuo, C., Kuo, S. Y., Huang, T. Y., Yen, Y. R., Wen, R. K., Chen, L. C. & Fu, T. F., 2013 一月 28, 於 : PloS one. 8, 1, e55018.

研究成果: Article

Macrophage Migration-Inhibitory Factors
Thrombomodulin
Dengue virus
Dengue Virus
phosphatidylinositol 3-kinase
47 引文 (Scopus)

Dengue virus infection induces autophagy: An in vivo study

Lee, Y. R., Hu, H. Y., Kuo, S. H., Lei, H. Y., Lin, Y-S., Yeh, T-M., Liu, C-C. & Liu, H-S., 2013 九月 11, 於 : Journal of biomedical science. 20, 1, 65.

研究成果: Article

Dengue Virus
Autophagy
Virus Diseases
Viruses
Virus Replication
22 引文 (Scopus)
Propolis
Alveolar Epithelial Cells
Epithelial-Mesenchymal Transition
PPAR gamma
Transforming Growth Factors
2012
45 引文 (Scopus)

Dengue virus nonstructural protein NS1 binds to prothrombin/thrombin and inhibits prothrombin activation

Lin, S. W., Chuang, Y. C., Lin, Y-S., Lei, H. Y., Liu, H-S. & Yeh, T-M., 2012 三月 1, 於 : Journal of Infection. 64, 3, p. 325-334 10 p.

研究成果: Article

Dengue Virus
Prothrombin
Thrombin
Dengue
Hemorrhage
41 引文 (Scopus)

Macrophage migration inhibitory factor induces autophagy via reactive oxygen species generation

Chuang, Y. C., Su, W. H., Lei, H. Y., Lin, Y-S., Liu, H-S., Chang, C-P. & Yeh, T-M., 2012 五月 22, 於 : PloS one. 7, 5, e37613.

研究成果: Article

Macrophage Migration-Inhibitory Factors
autophagy
Autophagy
reactive oxygen species
Reactive Oxygen Species
8 引文 (Scopus)

Macrophage migration inhibitory factor induces ICAM-1and thrombomobulin expression in vitro

Shyu, L. Y., Yeh, T-M., Chang, H. H., Lin, D. P. C., Teng, Y. H., Chen, L. C. & Lee, H. H., 2012 一月 1, 於 : Thrombosis Research. 129, 1, p. 43-49 7 p.

研究成果: Article

Macrophage Migration-Inhibitory Factors
Thrombomodulin
Intercellular Adhesion Molecule-1
Human Migration
Blood Coagulation Factors
2011
27 引文 (Scopus)

Dengue virus-induced autoantibodies bind to plasminogen and enhance its activation

Chuang, Y. C., Lei, H. Y., Lin, Y. S., Liu, H. S., Wu, H. L. & Yeh, T. M., 2011 十二月 15, 於 : Journal of Immunology. 187, 12, p. 6483-6490 8 p.

研究成果: Article

Severe Dengue
Dengue Virus
Plasminogen
Autoantibodies
Fibrinolysin
46 引文 (Scopus)

Macrophage migration inhibitory factor induced by dengue virus infection increases vascular permeability

Chuang, Y. C., Lei, H. Y., Liu, H-S., Lin, Y-S., Fu, T-F. & Yeh, T-M., 2011 五月 1, 於 : Cytokine. 54, 2, p. 222-231 10 p.

研究成果: Article

Macrophage Migration-Inhibitory Factors
Dengue Virus
Capillary Permeability
Virus Diseases
Viruses
4 引文 (Scopus)

Zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1

Lin, C. J., Hsiao, T. H., Chung, Y. S., Chang, W. N., Yeh, T-M., Chen, B. H. & Fu, T-F., 2011 三月 1, 於 : Protein Expression and Purification. 76, 1, p. 36-43 8 p.

研究成果: Article

Zebrafish
Zebrafish Proteins
Recombinant Proteins
Proteins
Sp1 Transcription Factor
2010
10 引文 (Scopus)
Annexin A2
Severe Acute Respiratory Syndrome
Coronavirus
Epithelial Cells
Lung
50 引文 (Scopus)

Characteristic of dengue disease in Taiwan: 2002-2007

Lin, C. C., Huang, Y. H., Shu, P. Y., Wu, H. S., Lin, Y-S., Yeh, T-M., Liu, H-S., Liu, C-C. & Lei, H. Y., 2010 四月 1, 於 : American Journal of Tropical Medicine and Hygiene. 82, 4, p. 731-739 9 p.

研究成果: Article

Dengue
Taiwan
Dengue Virus
Infection
Severe Dengue
8 引文 (Scopus)

The dengue virus envelope protein induced PAI-1 gene expression via MEK/ERK pathways

Shyu, H. W., Lin, Y. Y., Chen, L. C., Wang, Y. F., Yeh, T-M., Su, S. J., Cheng, W. C., Chen, C. Y., Lin, K. H. & Chou, M. C., 2010 十二月 1, 於 : Thrombosis and Haemostasis. 104, 6, p. 1219-1227 9 p.

研究成果: Article

Viral Envelope Proteins
Dengue Virus
Plasminogen Activator Inhibitor 1
Mitogen-Activated Protein Kinase Kinases
Extracellular Signal-Regulated MAP Kinases
11 引文 (Scopus)

The envelope glycoprotein domain III of dengue virus type 2 induced the expression of anticoagulant molecules in endothelial cells

Chen, L. C., Yeh, T. M., Lin, Y. Y., Wang, Y. F., Su, S. J., Chen, C. Y., Lin, K. H., Chou, M. C. & Shyu, H. W., 2010 九月 1, 於 : Molecular and Cellular Biochemistry. 342, 1-2, p. 215-221 7 p.

研究成果: Article

Dengue Virus
Endothelial cells
Severe Dengue
Viruses
Anticoagulants
2009
50 引文 (Scopus)

Anti-dengue virus nonstructural protein 1 antibodies recognize protein disulfide isomerase on platelets and inhibit platelet aggregation

Cheng, H. J., Lei, H. Y., Lin, C. F., Luo, Y. H., Wan, S. W., Liu, H-S., Yeh, T-M. & Lin, Y-S., 2009 十二月 1, 於 : Molecular Immunology. 47, 2-3, p. 398-406 9 p.

研究成果: Article

Protein Disulfide-Isomerases
Dengue Virus
Platelet Aggregation
Blood Platelets
Antibodies
46 引文 (Scopus)

Deletion of the C-terminal region of dengue virus nonstructural protein 1 (NS1) abolishes anti-NS1-mediated platelet dysfunction and bleeding tendency

Chen, M. C., Lin, C. F., Lei, H. Y., Lin, S. C., Liu, H-S., Yeh, T-M., Anderson, R. & Lin, Y-S., 2009 八月 1, 於 : Journal of Immunology. 183, 3, p. 1797-1803 7 p.

研究成果: Article

Dengue Virus
Blood Platelets
Protein C
Hemorrhage
Proteins
24 引文 (Scopus)

Dengue virus induces thrombomodulin expression in human endothelial cells and monocytes in vitro

Chen, L. C., Shyu, H. W., Lin, H. M., Lei, H. Y., Lin, Y-S., Liu, H-S. & Yeh, T-M., 2009 五月 1, 於 : Journal of Infection. 58, 5, p. 368-374 7 p.

研究成果: Article

Thrombomodulin
Dengue Virus
Monocytes
Endothelial Cells
Virus Diseases

Enterovirus 71 Infection of Human Immune Cells Induces the Production of Proinflammatory Cytokines

貢獻的翻譯標題: 腸病毒71型感染人類免疫細胞引起發炎細胞激素的產生Chen, L-C. & Yeh, T-M., 2009 九月 1, 於 : Journal of Biomedical & Laboratory Sciences = 生物醫學暨檢驗科學雜誌. 21, 3, p. 82-90

研究成果: Article

Enterovirus Infections
Cytokines
Enterovirus
Human Enterovirus A
Tumor Necrosis Factor-alpha
48 引文 (Scopus)

Proteomic analysis of endothelial cell autoantigens recognized by anti-dengue virus nonstructural protein 1 antibodies

Cheng, H. J., Lin, C. F., Lei, H. Y., Liu, H-S., Yeh, T-M., Luo, Y. H. & Lin, Y-S., 2009 一月 1, 於 : Experimental Biology and Medicine. 234, 1, p. 63-73 11 p.

研究成果: Article

Dengue Virus
Endothelial cells
Autoantigens
Viruses
Proteomics
2008
2 引文 (Scopus)

Anti-platelet and anti-endothelial cell autoantibodies in Vietnamese infants and children with dengue hemorrhagic fever

Hung, N. T., Lan, N. T., Lin, Y-S., Lin, C. F., Lien, L. B., Huang, K. J., Yeh, T-M., Ha, D. Q., Huong, V. T. Q., Chen, L. C., My, L. T., Huang, J. H., Liu, C-C. & Lei, H. Y., 2008 一月 1, 於 : American Journal of Infectious Diseases. 4, 1, p. 41-49 9 p.

研究成果: Article

Severe Dengue
Autoantibodies
Blood Platelets
Endothelial Cells
Dengue Virus
8 引文 (Scopus)

Anti-prM antibody as an autoantibody in dengue virus infection

Huang, K. J., Cheng, Y. T., Lin, Y-S., Huang, J. H., Liu, H-S., Yeh, T-M., Liu, C-C. & Lei, H. Y., 2008 一月 1, 於 : American Journal of Infectious Diseases. 4, 1, p. 60-68 9 p.

研究成果: Article

Dengue Virus
Virus Diseases
Autoantibodies
Anti-Idiotypic Antibodies
Dengue
214 引文 (Scopus)

Autophagic machinery activated by dengue virus enhances virus replication

Lee, Y. R., Lei, H. Y., Liu, M. T., Wang, J-R., Chen, S., Jiang-Shieh, Y. F., Lin, Y-S., Yeh, T-M., Liu, C-C. & Liu, H-S., 2008 五月 10, 於 : Virology. 374, 2, p. 240-248 9 p.

研究成果: Article

Dengue Virus
Autophagy
Virus Replication
Virus Diseases
Electrons
2 引文 (Scopus)
Severe Dengue
Dengue
Serum
Proteins
Dengue Virus
10 引文 (Scopus)
Molecular Mimicry
Dengue Virus
Endothelial Cells
Dengue
Proteins
4 引文 (Scopus)
Macrophage Migration-Inhibitory Factors
Dengue Virus
Virus Diseases
Dengue
Severe Dengue
31 引文 (Scopus)

Dengue virus infection induces passive release of high mobility group box 1 protein by epithelial cells

Chen, L. C., Yeh, T-M., Wu, H. N., Lin, Y. Y. & Shyu, H. W., 2008 二月 1, 於 : Journal of Infection. 56, 2, p. 143-150 8 p.

研究成果: Article

HMGB1 Protein
Dengue Virus
Virus Diseases
Epithelial Cells
Severe Dengue
9 引文 (Scopus)
Epitope Mapping
Peptide Library
Dengue Virus
Blocking Antibodies
Bacteriophages
3 引文 (Scopus)

Generation of anti-platelet autoantibody during dengue virus infection

Huang, K. J., Lin, Y-S., Liu, H-S., Yeh, T-M., Liu, C-C. & Lei, H. Y., 2008 十二月 1, 於 : American Journal of Infectious Diseases. 4, 1, p. 50-59 10 p.

研究成果: Article

Dengue Virus
Virus Diseases
Autoantibodies
Severe Dengue
Blood Platelets